Core Viewpoint - Zhongtai Securities maintains a "Buy" rating for HBM Pharmaceuticals (02142), projecting significant revenue and profit growth from the licensing agreement and milestone payments related to HBM7020 and HBM4003 [1] Group 1: Financial Projections - The company is expected to achieve total revenue of 1.4 billion, 1.594 billion, and 1.485 billion yuan for the years 2025 to 2027, an increase from previous estimates of 1.342 billion, 974 million, and 1.026 billion yuan [1] - Projected net profit attributable to the parent company is estimated at 665 million, 768 million, and 740 million yuan for the same period, up from previous estimates of 621 million, 307 million, and 432 million yuan [1] Group 2: Licensing Agreement - On February 23, 2026, HBM Pharmaceuticals announced a licensing and equity cooperation agreement with Solstice Oncology, granting exclusive development and commercialization rights for HBM4003 outside Greater China [1] - The agreement includes upfront payments totaling over 105 million USD, comprising a 50 million USD cash upfront payment, a 5 million USD near-term payment, and equity valued at over 50 million USD [1] - HBM Pharmaceuticals may also receive up to approximately 1.1 billion USD in milestone payments based on future specific events and tiered royalties based on net sales outside Greater China [1] Group 3: Product Characteristics - HBM4003 is the world's first fully human only heavy chain antibody entering clinical stages, targeting the CTLA-4 pathway, which has regained focus in immuno-oncology [2] - The product demonstrates enhanced antibody-dependent cellular cytotoxicity (ADCC) and high specificity in eliminating Treg cells expressing high levels of CTLA-4 in the tumor microenvironment [2] - Its unique mechanism of action shows potential for improved therapeutic efficacy while significantly reducing drug toxicity [2] Group 4: Clinical Trial Results - HBM4003 has shown good safety and strong efficacy in Phase I monotherapy trials, with potential indications including melanoma, non-small cell lung cancer, hepatocellular carcinoma, and neuroendocrine tumors [3] - Recent Phase II clinical data indicated positive efficacy in MSS colorectal cancer when combined with another treatment, achieving an overall response rate of 34.8% and a median progression-free survival of 4.2 months [3] - This performance is superior to existing CTLA-4 antibodies combined with PD-1 antibodies in treating advanced colorectal cancer, which typically shows progression-free survival of 2 to 3 months [3] Group 5: Cash Flow Impact - The upfront payment of over 105 million USD will directly enhance the company's cash flow [4] - This transaction, combined with the company's previous profit forecast for 2025 (estimated at 88 million to 95 million USD), will further solidify its robust cash flow [4] - The cumulative effects of multiple business development activities are expected to enhance the company's growth prospects in the medium term [4]

Core Viewpoint - Zhongtai Securities maintains a "Buy" rating for HBM Pharmaceuticals-B (02142), projecting revenue growth driven by licensing agreements and milestone payments from HBM7020 and HBM4003, with expected revenues of 1.4 billion, 1.594 billion, and 1.485 billion yuan from 2025 to 2027, and net profits of 666 million, 768 million, and 740 million yuan respectively [1] Group 1: Licensing Agreement and Financial Impact - On February 23, 2026, HBM Pharmaceuticals announced a licensing and equity cooperation agreement with Solstice Oncology, granting exclusive rights for HBM4003 outside Greater China, with upfront payments exceeding $105 million, including a $50 million upfront cash payment and $5 million in recent payments [1] - The agreement also includes potential milestone payments of up to $1.1 billion based on future development and regulatory achievements, along with tiered royalties based on net sales outside Greater China [1] Group 2: Product Characteristics and Clinical Potential - HBM4003 is the world's first fully human heavy-chain antibody targeting CTLA-4, showing enhanced antibody-dependent cellular cytotoxicity (ADCC) and high specificity for CTLA-4 expressing Treg cells in the tumor microenvironment, indicating potential for improved therapeutic efficacy and reduced toxicity [2] - In Phase I trials, HBM4003 demonstrated good safety and strong efficacy, with potential indications including melanoma, non-small cell lung cancer, hepatocellular carcinoma, and neuroendocrine tumors [3] Group 3: Cash Flow and Growth Outlook - The recent payment structure exceeding $105 million will directly enhance the company's cash flow, complementing previous profit forecasts of approximately $88 million to $95 million for 2025, thereby solidifying the company's financial stability and growth potential in the medium term [4]

执业证书编号：S0740519040001 Email：zhujq@zts.com.cn 执业证书编号：S0740524070001 Email：muys@zts.com.cn 仅重链抗体 HBM4003 出海，CTLA-4 经典靶点开新花 ——和铂医药点评报告 生物制品 | 基本状况 | | | --- | --- | | 总股本(百万股) | 869.59 | | 流通股本(百万股) | 869.59 | | 市价(港元) | 12.09 | | 市值(百万港元) | 10,513.36 | | 流通市值(百万港元) | 10,513.36 | 加速兑现》2026-01-11 BD 之王开启新篇章》2025-06-21 和铂医药-B（02142.HK） 证券研究报告/公司点评报告 2026 年 02 月 26 日 | 买入（维持） 评级： | | 公司盈利预测及估值 | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | | | 指标 | | 2023A | 2024A | 2025E | 2026E | 2027E | | 分析师：祝嘉 ...

Core Viewpoint - The company, Yiming Oncology, has reclaimed global rights for IMM2510 (PD-L1/VEGF) and IMM27M (CTLA-4 ADCC+) from Instil Bio, indicating a strategic correction in its licensing approach. This decision allows the company to regain control over its assets and explore new partnerships while managing its development strategy and clinical progress more effectively [1][4]. Group 1: Asset Reclamation - The company has retrieved global rights for IMM2510 and IMM27M, which were previously licensed to Instil Bio for a $50 million upfront payment and additional milestone payments totaling $2 billion. This move is seen as a timely decision to mitigate potential losses due to Instil's slow progress in development [1]. - Instil Bio's slow advancement, with the first patient enrollment in the U.S. not expected until November 2025, raised concerns about its execution capabilities [1]. Group 2: CTLA-4 and Combination Therapy Potential - The IMM27M asset, targeting CTLA-4, has gained renewed attention due to its potential in combination therapies, especially following positive data from BioNTech/OncoC4's new CTLA-4 antibody, Gotistobart. This highlights the significant future potential for combination therapies involving both VEGF/PD-L1 and CTLA-4 [2]. - CTLA-4 as a monoclonal antibody offers flexibility in dosing and administration frequency, which may help reduce safety risks associated with its use [2]. Group 3: CD47 Pipeline and Clinical Progress - The company's core focus includes the CD47 pipeline, particularly the lead product IMM01 (sirpα-Fc fusion protein), which is advancing in Phase III clinical trials for chronic myelomonocytic leukemia (CMML). A mid-term analysis is expected within the year, with promising efficacy and safety data accumulated so far [3]. - The IMM0306 molecule, based on IMM01, is one of the fastest-developing MCE molecules, indicating strategic value in the CD47 space, especially following significant partnerships in the field [3]. Group 4: Autoimmune and Oncology Developments - In the autoimmune sector, IMM0306 has shown promising results in treating systemic lupus erythematosus, with response rates of 71.4% and 80.0% at different dosages, demonstrating its convenience with a dosing schedule of once weekly for four weeks [4]. - In oncology, data presented at the 2025 ASH conference showed a 91.2% overall response rate (ORR) and a 67.6% complete response (CR) rate for IMM0306 in combination with lenalidomide for relapsed refractory follicular lymphoma, with plans for a Phase III trial to start in Q1 2026 [4].