本公告由宜明昂科生物醫藥技術（上海）股份有限公司（「本公司」，連同其附屬 公司統稱「本集團」）自願作出，以告知本公司股東及潛在投資者有關本集團的 最新業務發展情況。 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因 倚賴該等內容而引致的任何損失承擔任何責任。 ImmuneOnco Biopharmaceuticals (Shanghai) Inc. 宜明昂科生物醫藥技術（上海）股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：1541） 自願公告 收到與AXION BIO的授權及 合作協議項下里程碑付款 茲提述本公司日期為2024年8月1日、2024年8月22日、2024年9月11日、2025年5 月7日及2025年7月2日的公告，內容有關（其中包括）(i)與Instil Bio, Inc.（「Instil」， NASDAQ：TIL)的全資附屬公司Axion Bio, Inc.（「Axion Bio」，前稱SynBioTx Inc.） 訂立日期為2024年8月1日的授權及合作協 ...

Group 1 - The core viewpoint of the news is the significant performance and growth of the Hong Kong Innovative Drug ETF, which has seen a cumulative increase of over 100% in the past year, reflecting strong investor interest in the innovative drug sector [1][2] - As of July 15, 2025, the Hong Kong Innovative Drug ETF has a net asset value increase of 108.39% over the past year, ranking 1st out of 122 QDII equity funds, indicating its strong performance relative to peers [2] - The Hong Kong Innovative Drug ETF closely tracks the CSI Hong Kong Innovative Drug Index, which includes up to 50 listed companies primarily engaged in innovative drug research and development, providing a comprehensive view of the sector's performance [2] Group 2 - Recent measures introduced by the National Healthcare Security Administration and the National Health Commission aim to support the high-quality development of innovative drugs, including increased R&D support and inclusion in insurance directories [3] - The current market rally in Hong Kong's innovative drug sector is driven by a revaluation of value, with expectations for a new commercial insurance directory for innovative drugs to be launched in 2025, potentially creating a more favorable pricing environment [3] - The Hong Kong Innovative Drug ETF supports T+0 trading, enhancing liquidity and allowing investors to conduct multiple transactions within a trading day, thereby improving capital efficiency [3]

Core Viewpoint - The company has received approval from the U.S. Food and Drug Administration (FDA) for a new drug clinical trial (IND) for IMM2510/AXN-2510, which is expected to start by the end of 2025 [1] Group 1 - The clinical trial is a Phase 1b/2 study aimed at evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of IMM2510/AXN-2510 in patients with recurrent/refractory solid tumors [1]

Core Viewpoint - The company has received FDA approval for the IND application of IMM2510/AXN-2510, a bispecific antibody developed in collaboration with InstilBio, Inc. [1] Group 1 - The clinical trial for IMM2510/AXN-2510 is planned to start by the end of 2025, focusing on patients with recurrent/refractory solid tumors in a Phase 1b/2 study [1] - The trial aims to evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of the drug in solid tumor patients [1] - Concurrently, a Phase 2 study in China is ongoing, assessing IMM2510/AXN-2510 in combination with chemotherapy for first-line treatment of non-small cell lung cancer (NSCLC), with data expected to be released in the second half of 2025 [1]

Company Overview - Yiming Biopharmaceutical Technology (01541.HK) was established in 2015 and listed on the Hong Kong main board in September 2023, focusing on "immune system activation" to develop innovative drugs that help the body's immune cells attack cancer cells [2] - Key products include IMM01 (activates the immune system to engulf cancer cells) and IMM2510 (a globally pioneering bispecific antibody drug that simultaneously inhibits tumor angiogenesis and activates immunity) [2] Product Pipeline - Currently, there are 6 products in Phase III clinical trials [3] Management and Shareholders - The founder and Chief Scientific Officer, Dr. Tian Wenzhi, holds approximately 17% of the shares and has over 30 years of experience in the biopharmaceutical industry, overseeing the company's overall strategy and clinical progression [5] - Major shareholders include Shanghai Zhangke Leading Investment (approximately 9%) and LAV Asset Management (approximately 6.8%), both of which have a strong focus on early-stage biopharmaceutical investments [6] Financial Performance - The company reported revenues of RMB 538,000 in 2022, with a net loss of RMB 402.894 million, and in 2023, revenues decreased to RMB 386,000 with a net loss of RMB 379.459 million [8][9] - In 2024, revenues are projected to increase significantly to RMB 74.149 million, driven by a licensing agreement with Axion Bio, which contributed approximately RMB 71.342 million [11] - The company has maintained high R&D investment, with expenditures of RMB 320 million in 2024, which is 4.4 times its revenue [11] Product Advantages - IMM2510 employs a dual-pathway immune strategy, combining innate and adaptive immunity, and has completed Phase I dose exploration with promising early data [16] - IMM0306, a CD47×CD20 bispecific fusion protein, has a high effective relief rate of 91%, outperforming competitors [17] Industry Trends - The global immuno-oncology market is expected to grow from approximately USD 126.5 billion in 2024 to about USD 271.1 billion by 2033, with a CAGR of 8.6% to 10.65% [18] - The market is driven by rising cancer incidence rates, with an estimated 20 million new cases in 2022, projected to increase to 35 million by 2050 [18] Competitive Landscape - The company avoids the highly competitive single-pathway PD-1 market and focuses on combination therapies targeting CD47 and CD20, which may qualify for orphan drug status and expedited approval [21] Valuation and Market Performance - The company's stock price has increased by 178.6% year-to-date, driven by significant R&D progress and market interest in the biopharmaceutical sector [24] - Revenue projections for 2025-2027 are estimated at RMB 201 million, RMB 122 million, and RMB 312 million, respectively, with a target market value of HKD 8.915 billion [24]

Group 1 - The core viewpoint of the article highlights the continued upward trend of Hong Kong pharmaceutical stocks, with specific companies showing significant gains [1] - Bohan Bio (06955.HK) experienced an increase of 8.96%, indicating strong market performance [1] - Other notable performers include Yiming Anke-B (01541.HK) with a rise of 7.67%, Tiger Med (03347.HK) up by 5.32%, and Zhaoyan New Drug (06127.HK) increasing by 5.41% [1]

Investment Rating - The report maintains a "Buy" rating for the company, with a target price of HKD 21.89 per share, indicating a potential upside of 55% from the current price of HKD 14.12 [4][7][16]. Core Insights - The company is advancing its CD47xCD20 bispecific antibody, IMM0306, which shows promising results in clinical trials for autoimmune diseases, particularly systemic lupus erythematosus (SLE) [8][4]. - The IMM2510, a PD-L1xVEGF bispecific antibody, has demonstrated an objective response rate (ORR) of 23% in previously treated non-small cell lung cancer (NSCLC) patients, with expectations for further data release in late 2025 [10][11]. - The safety and efficacy of the CD47 fusion protein, IMM01, are highlighted, showing an ORR of 69.7% in relapsed/refractory classical Hodgkin lymphoma when combined with PD-1 antibodies [13][14]. Summary by Sections Clinical Development - IMM0306 is currently in Phase Ib trials for autoimmune diseases, with 10 patients enrolled in SLE trials and positive response rates expected to be reported in June [8]. - The company is the first globally to enter clinical trials with a CD47xCD20 bispecific antibody, which has shown an ORR of 88.2% and a complete response (CR) of 52.9% when used with lenalidomide for refractory follicular lymphoma [8]. Financial Projections - Revenue projections for the company from 2025 to 2027 are estimated at RMB 2.01 billion, RMB 1.22 billion, and RMB 3.12 billion, respectively, with net losses expected to decrease over the same period [4][16]. - The report anticipates a significant increase in revenue, with a year-on-year growth of 18912% in 2024 and 171.1% in 2025 [5][18]. Market Position - The company is positioned as a leader in the development of CD47 fusion proteins, with a competitive landscape that includes only a few other players in the CD47 target research [16]. - The report notes a growing interest in bispecific antibodies within the autoimmune sector, with significant business development (BD) opportunities anticipated due to the scarcity of innovative biological drugs in this field [8][16].

Group 1 - Kingsoft Software (03888) saw a nearly 5% drop in stock price, with Q1 revenue increasing by 9% year-on-year to 2.338 billion yuan, but net profit attributable to the parent company slightly decreased by 0.24% to 284 million yuan. Office software and services revenue grew by 6% year-on-year but fell by 13% quarter-on-quarter, while online gaming and other revenue increased by 14% year-on-year but decreased by 20% quarter-on-quarter [1] - Li Auto-W (02015) rose over 7%, reporting a 1.1% year-on-year revenue increase and a 9.4% rise in net profit for Q1. The company expects Q2 delivery volume to increase by 13.3%-17.9% year-on-year, with revenue projected to grow by 2.5%-6.7%. CEO Li Xiang expressed confidence in restoring monthly sales to 50,000 units and plans to launch the pure electric SUV i8 in July [1] - Hand Return Group (02621) debuted on the market but fell over 7% on its first day. The company is an internet-based life insurance intermediary with platforms like Xiaoyusan, Kachaba, and Niubao100, raising approximately 134 million HKD from its listing [1] - Yiming Anke-B (01541) surged over 13%, with its stock price doubling within the month. The company announced preliminary efficacy and safety data for its core product IMM2510 in treating non-small cell lung cancer (NSCLC) during I/II phase clinical trials [1] Group 2 - Meizhong Jiahe (02453) increased by over 7%, having developed a proprietary proton therapy language model successfully deployed in a Guangzhou hospital. The company plans to raise approximately 93.94 million HKD through a discounted share placement for equipment procurement, loan repayment, and working capital [2] - Gome Retail (06808) rose over 6%, with reports indicating that after a major shareholder change, the company is on track to transform its business, focusing on sales scale and absolute gross profit by FY2026. The company turned profitable in the second half of the last fiscal year, reporting a net profit of 199 million yuan, and plans to distribute 1.5 billion yuan in dividends for FY2025 [2] - Sany International (00631) saw a rise of over 4%, reporting a 14.6% year-on-year revenue increase to 5.876 billion yuan and a 23.2% rise in net profit to 635 million yuan for Q1. Growth was attributed to global expansion, digitalization, and low-carbon strategies [2] Group 3 - Dekang Agriculture (02419) surged over 8%, with analysts noting that April pig prices remained strong despite the seasonal downturn, and May's supply-demand dynamics are expected to support rising pig prices. The company is recognized for its leading breeding costs, projected to be below 13 yuan per kilogram, with an estimated 30% growth in pig output over the next three years [3] - Fubo Group (03738) increased by over 13%, completing an oversubscribed financing of over 500 million HKD for AI research and financial optimization. The company reported a total revenue increase of approximately 23% year-on-year, with mainland China revenue growing by about 21% and monthly recurring revenue (MRR) increasing by around 30% [3] - Gako Si-B (01167) rose over 8%, with a cumulative increase of over 25% this week. The company received domestic approval for its KRAS G12C inhibitor, used in specific non-small cell lung cancer treatments [3] - Fosun Pharma (02196) increased by over 6%, announcing that its self-developed new drug, Luwo Meitini tablets, has been approved for market release by the National Medical Products Administration [3] Group 4 - The smartphone supply chain stocks collectively fell, with companies like Hillstone Technology dropping over 5% and Sunny Optical, BYD Electronics, and GoerTek all declining over 3%. This decline was attributed to market concerns following the reinstatement of tariffs from the Trump administration [4] - Xiansheng Pharmaceutical (02096) rose over 8%, with five of its drugs selected for the 2025 ASCO annual meeting. The company's innovative drug BD's international expansion has garnered attention, including a deal with AbbVie worth over 1 billion USD [4] - Yika (09923) surged over 10%, following a 27% increase the previous day. The company recently obtained a payment license in Arizona, USA, with a projected nearly 5-fold increase in overseas transaction volume in 2024 [4] - Stone Pharmaceutical Group (01093) rose over 7%, with ongoing negotiations for three potential transactions involving products like EGFR-ADC, with total potential payments reaching approximately 5 billion USD, one of which is expected to be completed in June [4]

Core Insights - The CD47 target was once highly sought after by global pharmaceutical companies, likened to the next PD-1, but has since faced significant challenges and failures in drug development [1][3][14] - Despite the setbacks, companies like I-Mab and Kangfang Biotech remain optimistic about the potential of CD47-targeted therapies, with ongoing clinical trials [5][9][14] Industry Overview - CD47 is a transmembrane glycoprotein expressed on various cancer cells, which helps tumors evade the immune system by sending a "don't eat me" signal to macrophages [3][5] - Major pharmaceutical companies, including Gilead and Pfizer, have made substantial investments in CD47-targeted therapies, with Gilead acquiring Forty Seven for $4.9 billion, but faced failures in clinical trials [3][5][12] - In China, over 20 clinical approvals for CD47-targeted drugs have been granted, but many companies, including Hengrui and Innovent, have halted their trials due to disappointing results [4][5][12] Company Developments - I-Mab is advancing two Phase III clinical trials for its CD47-targeted therapies, while Kangfang Biotech is conducting multiple trials for its drug, Lefanlimab [5][9] - I-Mab's approach to CD47 is distinct, as it utilizes a non-antibody drug that binds more selectively to cancer cells, potentially reducing toxicity and improving dosing [8][9] - Kangfang Biotech is optimizing its drug structure to minimize red blood cell aggregation, which is a significant issue with CD47 antibodies [9][12] Market Sentiment - The global pharmaceutical industry has invested nearly 100 billion RMB in CD47 research without a successful drug to date, leading to a cautious approach from investors and companies [5][12] - There is a growing sentiment that the investment climate for innovative drugs is improving, with increased activity from investment funds in the sector [11][16]

Core Viewpoint - The company, along with InstilBio, Inc., announced updates on the clinical status and future plans for IMM2510/AXN-2510, particularly focusing on its application in treating non-small cell lung cancer (NSCLC) Group 1: Clinical Trial Updates - The Phase 2 trial for IMM2510/AXN-2510 in combination with chemotherapy for first-line NSCLC is expected to complete patient enrollment of approximately 60 patients by Q3 2025 in China [1] - As of the end of March 2025, over 30 NSCLC patients have been enrolled, with more than 20 first-line NSCLC patients having received treatment [1] - Preliminary safety and efficacy results from this Phase 2 trial are anticipated to be announced in the second half of 2025 [1] Group 2: Single-Agent Treatment Data - The objective response rate (ORR) for IMM2510/AXN-2510 as a monotherapy for recurrent/refractory NSCLC is reported to be 23%, based on a data set similar to that of a competing PD-(L)1x VEGF bispecific antibody [2] Group 3: Future Clinical Plans - The company plans to initiate a Phase 3 trial for IMM2510/AXN-2510 in combination with chemotherapy for first-line NSCLC in mid-2026, pending discussions with regulatory authorities [3] - Preclinical experiments have demonstrated that IMM2510/AXN-2510 can synergistically bind with PD-L1 in the presence of VEGF in vitro [3] - Additional preclinical data indicating a potentially best-in-class mechanism of action for IMM2510/AXN-2510 is expected to be presented at future medical or scientific conferences [3]