In this article, we will look at the 10 Best Performing Pharma Stocks in 2025.On January 8, Michael Yee, global head of biotech research at UBS, appeared on CNBC’s ‘Squawk on the Street’ to discuss his bullish outlook on biopharma stocks in 2026 and the pharma M&A outlook. He stated that M&A activity started off strong in the year, and that pharma stocks are set to take off in 2026.In addition to the big pharma companies, he believes that biotech, which had a really tough past 3-4 years, is ready to take of ...

Key Takeaways AMGN agreed to lower U.S. drug prices, align them with other developed markets and offer deep DTC discounts.AMGN expanded its AmgenNow program to Repatha, Aimovig and Amjevita with discounts of up to 80%.Amgen plans $2.5B in U.S. manufacturing and R&D investments tied to tariff exemptions.Amgen (AMGN) recently signed a landmark agreement with the Trump administration to lower drug prices in the United States.Through this deal, Amgen addresses the two major concerns that have plagued Big Pharma ...

Despite pressure from the administration, a rough start to the year, biotech has seen a rebound this year. Our next guest is betting that that recovery will continue into 2026. So joining us now, Salivine Richtor.She is the lead US biotech analyst at Goldman Sachs Research. And Salivine, it's great to have you on the show. Welcome.>> Thank you for having me. What's interesting to me is that these names of these, you know, these stocks of these pharma companies that did inc this deal with the president just ...

Despite pressure from the administration, a rough start to the year, biotech has seen a rebound this year. Our next guest is betting that that recovery will continue into 2026. So joining us now, Salivine Richtor.She is the lead US biotech analyst at Goldman Sachs Research. And Salivine, it's great to have you on the show. Welcome.>> Thank you for having me. What's interesting to me is that these names of these, you know, these stocks of these pharma companies that did inc this deal with the president just ...

Ah, the stock market. A fickle beast, driven by algorithms, analyst whispers, and, occasionally, a presidential tweet. In the grand theater of global finance, few figures command the stage quite like Donald J. Trump, whose pronouncements often send markets into a dizzying tango of anticipation and apprehension. The latest round of policy pronouncements, particularly concerning tariffs and drug pricing, has once again proven that under the Trump administration, predictability is merely a quaint notion, and c ...

Core Insights - Shares of Novo Nordisk and Eli Lilly declined after both companies agreed to lower prices for their GLP-1 weight-loss drugs, Wegovy and Zepbound, to between $149 and $350 from previous prices of $500 to $1,000 for U.S. government programs and cash payers [1][3] Pricing and Market Impact - The price reduction is expected to have a "low single-digit" negative impact on Novo's global sales growth next year, but increased volumes under Medicare are anticipated in the mid to long-term [3] - Eli Lilly will set a net price of $245 for Zepbound, representing a 20% to 35% discount compared to its diabetes drug Mounjaro, which contains the same active ingredient [3] - The lowest dose of Zepbound will be priced at $299 per month, with higher doses at $449, reflecting a $50 discount from current direct-to-patient prices [8] Competitive Landscape - Novo Nordisk faces heightened competition from Eli Lilly's Zepbound and other copycat drugs in the weight-loss market, having seen its market value decrease by 70% since last year due to supply constraints and commercial challenges [6] - Despite the price cuts, analysts believe that the deals may yield more positive outcomes than negative for both companies, as expanded access is expected to boost sales volume [4] Stock Performance - Following the announcement, Novo's shares fell by 3.7%, reaching their lowest level since the new CEO took office, while Eli Lilly's shares dropped by 2.7% [5] - Eli Lilly's shares had previously gained over 15% in the week leading up to the announcement, with the recent dip attributed to profit-taking by investors [7]

Summary of Vivani Medical Conference Call Company Overview - **Company**: Vivani Medical (NasdaqCM: VANI) - **Focus**: Addressing medication adherence in chronic disease treatments, particularly in the GLP-1 receptor agonists space [2][12] Industry Context - **Chronic Disease Treatment**: Over 50% of patients do not adhere to their medication regimens, leading to an estimated $500 billion in avoidable costs to the U.S. healthcare system annually [2] - **GLP-1 Receptor Agonists**: This class of drugs has shown significant effectiveness in treating obesity and related conditions, with three approved injectables: Wegovy, Zepbound, and Saxenda [3] Core Product and Technology - **Product**: A six-month semaglutide implant aimed at improving patient outcomes through better adherence, tolerability, and convenience [12] - **Technology**: NanoPortal drug delivery system, allowing for sustained release of medication without the complications of traditional delivery methods [18] Key Differentiators - **Adherence**: The implant aims to reduce missed doses, which is a significant issue with current GLP-1 therapies, where over 50% of patients miss doses [9][21] - **Tolerability**: The implant is designed to minimize gastrointestinal side effects commonly associated with GLP-1 drugs by stabilizing drug levels [7][9] - **Cost-Effectiveness**: The implant could potentially lower manufacturing costs and improve pricing flexibility compared to current injectable therapies [11] Clinical Development and Market Potential - **Clinical Trials**: Anticipated initiation of clinical development for the semaglutide implant in the first half of next year [13][29] - **Market Growth**: GLP-1 products are expected to see a 32% compounded annual growth rate, indicating strong market potential [21] - **Patient Persistence**: Current persistence rates for semaglutide are low, with only 40% remaining on treatment after one year and 25% after two years [22][23] Competitive Landscape - **Market Activity**: Over 50 companies are developing new GLP-1 injectables, but many are likely to fail due to lack of differentiation [4] - **Unique Offering**: Vivani Medical's implant is the only GLP-1 implant in development for obesity, with a unique dosing schedule of once or twice a year [33] Future Directions - **Expansion Plans**: Potential to explore the use of the implant in other chronic diseases and patient populations, including type 2 diabetes and psychiatric conditions [12][14] - **Animal Health**: Collaboration with a small animal health company to develop similar implants for pets, tapping into a growing market [14] Conclusion - Vivani Medical is positioned to address significant unmet needs in chronic disease management through its innovative implant technology, targeting improved medication adherence and patient outcomes in the growing GLP-1 market [33]

Core Insights - Novo Nordisk has made an unsolicited bid of $6.5 billion for Metsera, a company focused on obesity treatments, challenging Pfizer's previous bid of $4.9 billion for the same target [1][6] - The bid includes a 50% termination fee, which is a significant aspect of the proposal [1][7] - Metsera's stock surged over 24% following the news, while Novo Nordisk's stock fell by more than 2% [2] Company Strategies - Novo Nordisk's bid for Metsera is seen as a strategic move to bolster its position in the obesity treatment market, especially as it faces competition from generic versions of its leading drug, semaglutide [3][6] - Pfizer's acquisition of Metsera would enhance its obesity pipeline, which has been lagging behind competitors like Novo Nordisk and Eli Lilly [6] Regulatory Environment - The Centers for Medicare and Medicaid Services is set to negotiate the price of Ozempic, which could impact Novo Nordisk's pricing strategy [4] - Pfizer has accused Novo Nordisk of attempting to suppress competition and circumvent antitrust laws with its bid for Metsera [8] Market Reactions - Metsera's stock performance indicates strong market interest, with its shares rising from an initial public offering price of $18 to $65 [2][9] - Analysts have rated Metsera stock as an outperform, highlighting its recent strong performance [9]

Market Overview - Stock index futures are down, with S&P 500 futures declining by 1%, Nasdaq 100 futures by 1.2%, and Dow futures by 0.75% due to concerns regarding the health of regional banks [3] - Major averages on Wall Street closed lower on the previous day [4] Banking Sector - Bank stocks are predominantly losers in early trading, reflecting negative sentiment in the market [5] - Zions Bancorp reported a $50 million charge-off, and Western Alliance alleged fraud on loans, raising concerns reminiscent of the regional bank stress following the SVB collapse in March 2023 [6] Pharmaceutical Sector - Novo Nordisk's stock fell by 4% after President Trump announced a potential reduction in the price of Ozempic, a leading weight-loss medication, which currently has a list price of approximately $1,000 per month [7][10] - Eli Lilly's shares dropped by 5% in premarket trading, as it also produces similar treatments [10] Automotive Sector - Ford is recalling nearly 625,000 vehicles in the U.S. due to seatbelt and rear-view camera display issues [11] - The recall includes 332,778 Ford Mustang cars for seatbelt concerns and 291,901 F-Series trucks for faulty camera displays, with dealers set to address these issues at no charge [12] Technology Sector - Micron Technology's shares decreased by 4% following reports of halting sales of server chips to data centers in China due to a business slump linked to a ban on its products in critical infrastructure [14]

Cancer Drug Approval & Efficacy - Half of approved cancer drugs lack proof of extending survival for any approved uses [1][15] - The FDA's accelerated approval process, used heavily for cancer drugs in the last 20 years, relies on preliminary data like tumor shrinkage or progression-free survival, which may not accurately predict actual survival [13][14] - There's growing recognition that some cancer treatments may not be as helpful as expected, potentially reducing quality of life without extending lifespan [12] Pharmaceutical Industry & Financial Incentives - The pharmaceutical industry's primary motive is generating profits, potentially leading to pressure to expedite clinical trials and approve medicines on uncertain evidence [2][9] - Lower dosages of drugs could mean less revenue for pharmaceutical companies [3][25] - The median initial price of cancer drugs in the US has quadrupled over the last two decades, without a proven correlation to improved survival [26] Cost & Accessibility of Cancer Treatment - High treatment costs can significantly affect patients and their families [2][19] - Doctors in countries like India are experimenting with lower doses of cancer drugs due to affordability issues, where treatments can cost tens of thousands of dollars per year [16] - Lower dosing of just one drug could save $825 million per year in the US alone [22] - Implementing lower dosages can face pushback from manufacturers due to reduced revenue [24][25] Alternative Treatment & Research - A clinical trial in India showed that low-dose immunotherapy combined with standard treatment more than doubled the percentage of head and neck cancer patients alive after one year [20] - Using 25% less drug can achieve the same output and save significant healthcare resources [25] - Lower dose immunotherapy could allow access to life-extending drugs for a large segment of the world that currently cannot afford them, potentially saving billions of dollars and benefiting hundreds of thousands of people [21][27]