本报记者 袁传玺 6月20日，江苏联环药业股份有限公司（以下简称：联环药业）针对投资者提问公司一类创新药LH-1801片研发进展一事进 行了回复。公司披露的信息显示，LH-1801片联合二甲双胍用药治疗项目（以下简称"联合用药治疗项目"）三期临床试验的已 于2025年1月份完成615例患者入组（60家中心）。 全球范围内的SGLT2抑制剂上市产品包括阿斯利康的达格列净、强生的卡格列净等。若LH-1801片成功上市，将有望满足 国内巨大的未满足临床需求。 （编辑 张伟） 上海九水投资管理合伙企业（有限合伙）执行事务合伙人黄建忠向《证券日报》记者表示，联环药业的一类新药LH-1801 跳过Ⅱ期临床试验直接进入Ⅲ期临床，可见药物在Ⅰ期临床试验中表现出非常理想的药代动力学特性和安全性，如药物的吸 收、分布、代谢和排泄过程符合预期，且在人体内的耐受性良好，没有出现严重的不良反应，同时初步的药效学指标也显示出 潜在的治疗作用。 本次全国多中心Ⅲ期临床研究由北京大学人民医院纪立农教授担任主要研究者（LeadingPI），联合全国70多家顶尖医院的 内分泌领域权威专家共同开展，确保了研究的科学性和严谨性。 当前，继肿瘤、心脑 ...

Group 1 - The company is actively expanding its international market presence, particularly in the U.S. insulin market through strategic partnerships and ongoing clinical trials for three types of insulin [1] - The company has achieved sales of approximately 200,000 units of liraglutide injection in Q1 2025, with a strong foundation for annual sales growth due to successful procurement results [2] - The company is focusing on the sales of insulin analog products and expanding its market presence for GLP-1 receptor agonists and SGLT-2 inhibitors to meet diverse patient needs [2] Group 2 - The company has received approvals for insulin products in several developing countries, including Nicaragua and Uzbekistan, and is working on expanding registrations for insulin products in these markets [1] - The company is advancing its clinical trials for new products, including THDBH120 for weight loss, which has completed its Phase II clinical trial [2][3] - The company is not currently developing oral insulin products due to technical challenges but will monitor industry advancements for potential future adjustments in R&D strategy [3] Group 3 - The company’s parent group, Dongbao Group, is working to reduce its share pledge ratio, which is currently high due to long project cycles and financial pressures [3] - The long-term outlook for Dongbao Group is positive, with ongoing projects and products expected to enter a recovery phase, improving operational capabilities [4]