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Core Insights - ZyVersa Therapeutics, Inc. has initiated patient recruitment for its VAR 200 Phase 2a clinical study targeting diabetic kidney disease (DKD) [1][2] - VAR 200 is designed to address renal lipotoxicity by removing excess lipids from the kidneys, which is a significant factor in the progression of kidney diseases [3][7] - The study aims to evaluate the efficacy and safety of VAR 200 in patients with type 2 diabetes and DKD, with preliminary data expected in the second half of 2025 [7] Company Overview - ZyVersa is a clinical stage specialty biopharmaceutical company focused on developing first-in-class drugs for renal and inflammatory diseases with significant unmet medical needs [8] - The company is advancing a therapeutic pipeline that includes VAR 200 and another program targeting inflammation [8] Clinical Study Details - The VAR 200 Phase 2a trial will be an open-label study conducted at one to two US sites, enrolling an adequate number of subjects to complete eight [2][7] - The primary efficacy endpoint is the percent change from baseline to week 12 in urinary albumin to creatinine ratio, with treatment lasting 12 weeks followed by a four-week follow-up [2][7] Drug Mechanism and Indications - VAR 200, a Cholesterol Efflux Mediator™, is an injectable drug that aims to reduce renal lipid accumulation, which damages the kidney's filtration system [3][5] - Preclinical studies have shown that VAR 200 can reduce cholesterol and lipid levels, protect against renal injury and fibrosis, and improve proteinuria in various kidney disease models [4][7] Future Prospects - The lead indication for VAR 200 is focal segmental glomerulosclerosis (FSGS), with plans to expand indications based on the results of the ongoing trials [5][7] - The initiation of patient recruitment is considered a key milestone in the development of VAR 200, with the potential to be a first-in-class treatment for kidney disease [7]

Anonymity and Online Behavior - Anonymity allows individuals to pursue goals they might find unattainable when identifiable [1] - One in five (20%) Australian teens have experienced cyberbullying or trolling [1] - One in seven (approximately 14%) Australian teens have been the bully or troll at least once [1] - Anonymity can amplify toxicity, especially when individuals with malicious intentions are placed in situations where they can act without social cost [1][2] Positive Aspects of Anonymity - Anonymity provides a safety net for creativity, allowing individuals to experiment and master skills without fear of judgment [2] - Anonymous platforms enable individuals to explore different facets of their identity, especially for those with lower self-esteem or social anxiety [2] - Anonymity is crucial for the safety and connectedness of marginalized groups, such as queer communities, providing spaces for community building and self-discovery [2] Social Media and Identity - Social media's "context collapse" can limit self-expression, leading individuals to create anonymous accounts to explore different aspects of their identity [2]

Core Insights - Fennec Pharmaceuticals reported first quarter 2025 total net revenues of $8.8 million, representing an 18% increase year over year from $7.4 million in the first quarter of 2024 [1][5][10] - The company has successfully launched PEDMARQSI in Germany and the United Kingdom, enhancing access to its product for cancer patients at risk of hearing loss [1][6][29] - The revamped Fennec HEARS™ patient support program aims to improve the experience for adolescent and young adult cancer patients [2][6] Financial Results - Net product sales for the first quarter of 2025 were approximately $8.8 million, up from $7.4 million in the same period last year [5][10] - Total revenue for the first quarter was $8.8 million, with no licensing revenue recorded compared to $17.96 million in the first quarter of 2024 [10] - Operating expenses totaled $9.56 million, down from $11.63 million in the previous year, with selling and marketing expenses decreasing to $2.95 million from $5.21 million [11][10] Business Highlights - The company has strengthened its segmentation model and data-driven target lists, leading to the addition of multiple new accounts across academic and community providers [6][7] - The commercial launch of PEDMARQSI in Europe marks a significant step in expanding access to the product [6][29] - Fennec will participate in the ASCO 2025 Annual Meeting and other investor conferences, indicating ongoing engagement with the medical and investment communities [6][4] Upcoming Events - Fennec will host a conference call on May 13, 2025, at 8:30 a.m. ET to discuss its financial results and business updates [1][8] - The Annual General Meeting is scheduled for June 3, 2025, in New York, providing an opportunity for shareholder engagement [6][4]

Fennec Pharmaceuticals Inc. (NASDAQ:FENC) Q4 2024 Earnings Conference Call March 10, 2025 8:30 AM ET Company Participants Robert Andrade - CFO Jeff Hackman - CEO and Board Member Conference Call Participants Chase Knickerbocker - Craig-Hallum Raghuram Selvaraju - H.C. Wainwright Felix Ampomah - Stephens Michael Okunewitch - Maxim Group Operator Good morning, ladies and gentlemen, and welcome to Fennec Pharmaceuticals Fourth Quarter and Full Year 2024 Earnings and Corporate Update Conference Call. At this ti ...