Group 1: Financial Performance - In 2024, the company achieved a revenue of 970 million CNY, a year-on-year decrease of 14.77% due to challenges in the innovative drug industry and intense market competition [2][3] - The net profit attributable to shareholders was -226 million CNY, a year-on-year improvement of 75.30% due to reduced asset impairment provisions [3] - In Q1 2025, the company reported a revenue of 261 million CNY, a year-on-year increase of 11.37%, and a net profit of 6.64 million CNY, marking a return to profitability [3] Group 2: Strategic Planning - The company is upgrading its comprehensive service strategy to differentiate itself from competitors, leveraging 20 years of CRO experience to provide integrated solutions from target identification to IND [4] - AI technology is being integrated into drug development processes to enhance operational efficiency and market competitiveness, with ongoing deployment of DeepSeek technology [4] - The company aims to strengthen its domestic and international business development (BD) systems, focusing on major clients domestically and expanding its European team [4] Group 3: Market and Business Development - The company plans to increase its domestic market share, currently below 20%, by enhancing comprehensive service orders and local channel development [5] - The global market, including domestic demand, is showing signs of recovery in 2025, prompting the company to intensify its domestic market development efforts [9] - The company has seen an increase in orders in the ADC and peptide sectors, with strategic expansions into new drug platforms [8] Group 4: Technological Advancements - The company has developed comprehensive capabilities in new molecular and modality areas, including ADC, peptides, and PROTAC, with over 2,000 linker-payload designs completed [7][11] - The company has established a complete one-stop service platform for ADC/XDC drug development, covering all stages from target validation to clinical application [10] - Continuous investment in new modalities and technologies is planned to maintain competitive advantages in drug development [11] Group 5: Collaboration and Partnerships - The company has maintained a long-term partnership with Eli Lilly, successfully passing their site audit, and continues to collaborate with various subsidiaries [11] - Strategic collaborations with universities enhance the company's technical reserves and support future order acquisition [12]

Group 1: Company Performance and Orders - In 2024, the company expects to achieve approximately 1.515 billion CNY in new orders, representing a year-on-year growth of about 30.07% [2] - The company anticipates that the growth rate for new orders in the traditional Chinese medicine CRO sector will be around 20%, accounting for approximately 30% of total new orders in 2024 [3] - As of the end of 2024, the company has unrecognized revenue from contracts amounting to approximately 2.759 billion CNY, with an expected 682 million CNY to be recognized as revenue in 2025 [4] Group 2: Market Conditions and Competition - The CRO market remains highly competitive, with some smaller CRO companies facing operational difficulties, layoffs, or even liquidation, leading to an expected increase in industry concentration [3] - The company maintains a strong competitive advantage due to its established presence and resources in the CRO market [3] - The nuclear medicine CRO market is emerging, with few companies having relevant project experience, which positions the company favorably for future projects [8] Group 3: Profitability and Margins - The company expects the gross margin for clinical business to slightly decline due to ongoing market competition, while the gross margin for preclinical business remains stable [4] - Despite the anticipated decline in gross margin, the company is focused on reducing costs and believes that net profit margins will not decrease [4] Group 4: Future Plans and Innovations - The company plans to continue focusing on clinical services while also developing preclinical research and drug evaluation services, as well as contract development and manufacturing organization (CDMO) services [6] - There are ongoing discussions for the transfer of self-developed projects, with expectations to achieve significant milestones in 2025 [5] - The company is actively exploring AI applications in clinical trial design and data analysis, with plans to expand its use in clinical monitoring and preclinical compound screening [9]

希格玛会计师事务所(特殊普通合伙) Xigema Cpas(Special General Partnership) 关于新疆百花村医药集团股份有限公司 非公开发行股票申请之二次反馈意见回复 中国证券监督管理委员会: 贵会 2022 年 6 月 24 日下发的《中国证监会行政许可项目审查二次反馈意 见通知书》(220241 号)(以下简称"《二次反馈意见》")收悉。根据贵会《二次 反馈意见》提出的要求,我们在审慎核查的基础上,就《二次反馈意见》中的有 关问题回复说明如下: 反馈意见 1:2018年至2021年,申请人实现的净利润分别为:亏损67,529.15 万元,盈利 3,438.47 万元、亏损 31,976.55 万元及盈利 5,987. 43 万元;过往 4 年申请人收入存在巨幅波动,2020年营业收入为8,453.04万元,远小于当期结 转的营业成本 22,143.09万元。截止 2021年12月31日,发行申请人存货余额 19,404.78 万元,主要为在研项目《占比 99.67%);合同资产余额 14,554. 33 万 元,全部为研发项目。 请申请人:(1)说明过往 4年经营业绩大幅波动的原因 ...