Denmark’s largest pension fund has boosted its stake in Novo Nordisk this year, betting the obesity drugmaker will outpace rivals beyond the US market where its struggles have led to two profit warnings https://t.co/9x3WojLrC1 ...

Cytokinetics (CYTK) Update Summary Company Overview - **Company**: Cytokinetics (CYTK) - **Focus**: Development of aficamtan for the treatment of obstructive hypertrophic cardiomyopathy (OHCM) Key Industry Insights - **Industry**: Cardiovascular Medicine - **Event**: European Society of Cardiology (ESC) Conference Core Findings from the Call 1. **Presentation of Data**: Cytokinetics presented four oral presentations and one poster on aficamtan, with three publications in leading cardiac journals, emphasizing its potential as a treatment for OHCM [7][8][27] 2. **MAPLE HCM Study**: The Phase III trial compared aficamtan to metoprolol, showing aficamtan's superiority in improving exercise capacity and reducing symptoms [8][26] 3. **Efficacy Results**: - Aficamtan showed a mean increase in peak VO2 of 1.1 mL/kg/min, while metoprolol showed a mean decrease of 1.2 mL/kg/min, with a statistically significant difference of 2.3 mL/kg/min (p < 0.001) [21][26] - Aficamtan improved NT proBNP levels by 81% compared to baseline, while metoprolol's levels increased [24][26] 4. **Safety Profile**: Aficamtan was well tolerated with a low incidence of adverse events, contrasting with metoprolol, which had a higher rate of dose reductions due to side effects [25][26] 5. **Long-term Data**: Data from FORWEST HCM indicated sustained hemodynamic benefits and low incidence of new onset atrial fibrillation over a mean follow-up of 62 weeks [11][12] Implications for Treatment 1. **Shift in Treatment Paradigm**: The results challenge the long-standing use of beta blockers as first-line therapy for symptomatic obstructive HCM, suggesting aficamtan as a more effective alternative [8][31] 2. **Guideline Updates**: Anticipation of updates to clinical guidelines to incorporate findings from MAPLE HCM and other studies, with a focus on aficamtan as a first-line therapy [77][79] Additional Insights 1. **Expert Perspectives**: Panelists highlighted the importance of randomized clinical trials in reshaping treatment approaches and the surprising underperformance of beta blockers in the study [33][36] 2. **Future Studies**: Ongoing studies, including Acacia HCM, are expected to provide further insights into the efficacy of aficamtan in different patient populations [82] 3. **Regulatory Pathway**: Cytokinetics is preparing a supplemental NDA to include MAPLE HCM results in labeling following the potential approval of aficamtan [81][82] Conclusion - The data presented at the ESC conference significantly bolster the case for aficamtan as a first-line treatment for obstructive HCM, potentially leading to a paradigm shift in clinical practice and future treatment guidelines [26][31][81]

MALVERN, Pa., Sept. 02, 2025 (GLOBE NEWSWIRE) -- Annovis Bio, Inc. (NYSE: ANVS) ("Annovis" or the “Company”), a late-stage clinical drug platform company pioneering transformative therapies for neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), today announced its CEO, Maria Maccecchini, Ph.D., will present at the H.C. Wainwright 27th Annual Global Investment Conference happening September 8-10, 2025 in Lotte New York Palace Hotel, New York City. Presentation details D ...

TEL AVIV, Israel, Sept. 02, 2025 (GLOBE NEWSWIRE) -- Nasus Pharma Ltd. (NYSE: NSRX) (“Nasus Pharma” or the “Company”), a clinical-stage pharmaceutical company focused on the development of innovative intranasal products to treat emergency medical conditions, today announced that company management will present at the H.C. Wainwright 27th Annual Global Investment Conference. Location: VirtualDate: September 5, 2025Time: 07:00-07:30 a.m. ETType: Company presentation Presenter: Dan Teleman, Chief Executive Off ...

BASKING RIDGE, N.J., Sept. 02, 2025 (GLOBE NEWSWIRE) -- Lisata Therapeutics, Inc. (Nasdaq: LSTA) (“Lisata” or the “Company”), a clinical-stage pharmaceutical company developing innovative therapies for the treatment of advanced solid tumors and other serious diseases, today announced that David J. Mazzo, Ph.D., President and Chief Executive Officer of Lisata, will provide a corporate overview in a pre-recorded, on-demand presentation at the H.C. Wainwright 27th Annual Global Investment Conference. The confe ...

Core Insights - re+PLAY is a CBD wellness brand founded by NBA veteran Al Harrington, utilizing Avicanna's proprietary CBD formulations [1][2] - The brand's initial product launch in the United States includes two products available online and at select retailers [1][2] - The collaboration between Avicanna LATAM SAS and Harrington Wellness focuses on developing CBD-based topicals for the athletic community [3][4] Company Overview - Avicanna LATAM SAS is a biopharmaceutical company based in Colombia, specializing in plant-derived cannabinoid products [2][6] - The company has a scientific platform that supports the development and commercialization of over thirty proprietary cannabinoid-based products [6] - Avicanna's subsidiaries include Santa Marta Golden Hemp, which provides high-quality CBD, THC, and CBG for various applications [6][7] Product Details - Initial re+PLAY products include a 3% CBD localized cream and a 2% CBD and 1% CBG transdermal gel, utilizing patented deep tissue technology [5] - The CBD and CBG in these formulations are derived from USDA organic certified hemp cultivated in Colombia [5] - The re+PLAY brand emphasizes THC-free products that have been endorsed by medical professionals and athletes [8]

Core Insights - The iShares U.S. Pharmaceuticals ETF (IHE) is a passively managed fund launched on May 1, 2006, aimed at providing broad exposure to the Healthcare - Pharma segment of the equity market [1] - The Healthcare - Pharma sector is ranked 7th among the 16 Zacks sectors, placing it in the top 44% [2] Fund Overview - Sponsored by Blackrock, IHE has assets exceeding $578.73 million, categorizing it as an average-sized ETF [3] - The fund seeks to match the performance of the Dow Jones U.S. Select Pharmaceuticals Index, which is a free-float adjusted market capitalization-weighted index [4] Cost Structure - IHE has an annual operating expense ratio of 0.38%, making it one of the cheaper options in the ETF space [5] - The ETF offers a 12-month trailing dividend yield of 1.64% [5] Sector Exposure and Holdings - The ETF is fully allocated to the Healthcare sector, with approximately 100% of its portfolio [6] - Johnson & Johnson (JNJ) constitutes about 25.45% of total assets, followed by Eli Lilly (LLY) and Viatris Inc (VTRS), with the top 10 holdings accounting for approximately 78.07% of total assets [7] Performance Metrics - As of September 2, 2025, IHE has gained roughly 9.19% this year but is down about 0.74% over the past year [8] - The ETF has traded between $61 and $72.85 in the last 52 weeks, with a beta of 0.54 and a standard deviation of 15.83% over the trailing three-year period, indicating a higher risk profile [8] Alternatives - IHE carries a Zacks ETF Rank of 3 (Hold), suggesting it is a reasonable option for investors seeking exposure to the Healthcare ETFs area [9] - Other ETF options include Invesco Pharmaceuticals ETF (PJP) and VanEck Pharmaceutical ETF (PPH), with respective assets of $259.99 million and $620.64 million [10]

WEST CHESTER, Pa., Sept. 02, 2025 (GLOBE NEWSWIRE) -- Verrica Pharmaceuticals Inc. (“Verrica”) (Nasdaq: VRCA), a dermatology therapeutics company developing and selling medications for skin diseases requiring medical interventions, today announced that Jayson Rieger, PhD, MBA, President and Chief Executive Officer of Verrica Pharmaceuticals, will present at the H.C. Wainwright 27th Annual Global Investment Conference in New York City. H.C. Wainwright 27th Annual Global Investment Conference, September 8-10, ...

At Wide Moat Research, there are several key principles that guide our approach to investing. We believe these are instrumental to long-term investing success.Hi, my name is Kody. Aside from my articles here on Seeking Alpha, I am also a regular contributor to Sure Dividend, The Dividend Kings, and iREIT+Hoya Capital. I have been investing since September 2017 (age 20) and interested in dividend investing since about 2009.Since July 2018, I have ran Kody's Dividends. This is a blog that is documenting my jo ...

Core Viewpoint - The announcement highlights that Jiangsu Shenhua Pharmaceutical Co., Ltd., a wholly-owned subsidiary of Huaren Health, has received the acceptance notice for the drug registration application of Fumaric Acid Vonoprazan Tablets from the National Medical Products Administration of China, indicating a significant step towards market entry for this new medication [1] Group 1: Drug Information - Fumaric Acid Vonoprazan is a novel potassium-competitive acid blocker (P-CAB) that can reversibly inhibit the H+/K+-ATPase on gastric parietal cells in a potassium-competitive manner without relying on an acidic environment [1] - The drug is stable in highly acidic environments and can rapidly, effectively, and durably suppress gastric acid secretion from gastric parietal cells, significantly reducing the occurrence of nighttime gastric acid elevation [1] - It was officially approved for marketing in China on December 18, 2019, for the treatment of gastroesophageal reflux disease, making it the first P-CAB to enter the Chinese market [1]