Group 1: Johnson & Johnson - Johnson & Johnson has seen a significant price increase of 44% in 2025, with a price target bump to $217, approaching recent highs of around $215 [1][2] - The stock is currently trading below a key level of $207, which was previously an old high, indicating a potential resistance point [2][3] - Important moving averages are converging around $206-$207, suggesting this could be a pivotal point for future price movements [4] Group 2: SanDisk - SanDisk has demonstrated significant outperformance, rising from approximately $28 in April to over $284, although it has recently pulled back to around $245 [7][8] - The stock has established a trend line across its lows, indicating a strong upward trajectory despite recent fluctuations [9][10] - Notable resistance levels are identified at $240 and $283.10, with a potential breakout point above the downward sloping trend line [11][12] Group 3: Twilio - Twilio has received a price target increase from Citizens, raising it to $185 from $165, driven by optimism around AI integration in its business [16] - The stock has shown notable price activity, with key support levels around $140 and $130, while currently trading near $147 [21][23] - Technical indicators suggest that Twilio is in a bullish trend, with the RSI making new relative highs, indicating strength in the market [20][22]

Core Viewpoint - Pomerantz LLP is investigating potential securities fraud or unlawful business practices by Rezolute, Inc. and its officers or directors following disappointing clinical trial results that led to a significant drop in the company's stock price [1][3]. Group 1: Company Overview - Rezolute, Inc. is a publicly traded company on NASDAQ under the ticker RZLT [1]. - The company recently announced topline results from its Phase 3 sunRIZE study evaluating ersodetug for congenital hyperinsulinism [3]. Group 2: Clinical Trial Results - The Phase 3 study did not meet its primary endpoint, which was to assess the change in average weekly hypoglycemia events, showing only a 45% reduction in events at the highest dose of ersodetug (10 mg/kg), which was not statistically significant compared to a 40% improvement in the placebo group [3]. - The study also failed to meet its key secondary endpoint, with a 25% reduction in average daily percent time in hypoglycemia at the 10 mg/kg dose, again not statistically significant compared to a 5% increase in the placebo group [3]. Group 3: Stock Market Reaction - Following the announcement of the clinical trial results, Rezolute's stock price fell by $9.44 per share, or 87.2%, closing at $1.77 per share on December 19, 2025 [3].

Core Viewpoint - Pomerantz LLP is investigating claims of potential securities fraud or unlawful business practices involving LENZ Therapeutics, Inc. following a significant drop in its stock price due to adverse event reports related to its product [1][3]. Group 1: Investigation Details - Pomerantz LLP is representing investors of LENZ Therapeutics, Inc. and is looking into whether the company and its officers or directors have engaged in fraudulent activities [1]. - The investigation was prompted by a report of a retinal tear associated with LENZ's VIZZ eye drop, which was recorded in the FDA's adverse event reporting systems [3]. Group 2: Stock Price Impact - Following the adverse event report on December 12, 2025, LENZ's stock price decreased by $6.36 per share, representing a decline of 25.96%, closing at $18.14 per share on that date [3]. Group 3: Firm Background - Pomerantz LLP is recognized as a leading firm in corporate, securities, and antitrust class litigation, with a history of recovering significant damages for victims of securities fraud and corporate misconduct [4].

NEW YORK, Dec. 30, 2025 (GLOBE NEWSWIRE) -- Pomerantz LLP is investigating claims on behalf of investors of Insmed Incorporated (“Insmed” or the “Company”) (NASDAQ: INSM).  Such investors are advised to contact Danielle Peyton at newaction@pomlaw.com or 646-581-9980, ext. 7980. The investigation concerns whether Insmed and certain of its officers and/or directors have engaged in securities fraud or other unlawful business practices.  [Click here for information about joining the class action] On December 17 ...

Sanofi (NASDAQ:SNY) is among the ridiculously cheap stocks to buy now. On December 28, Jefferies reiterated its ‘Buy’ rating on Sanofi (NASDAQ:SNY) with an unchanged price target of €100. This reaffirmation comes despite worries about the FDA’s Complete Response Letter (CRL) for tolebrutinib, which the firm believes raises “tough questions about management communication.” The firm believes these concerns will continue to negatively impact market sentiment toward the company. Earlier, on December 23, Sano ...

Core Insights - Amgen is developing MariTide, a late-stage obesity candidate, to compete with Eli Lilly and Novo Nordisk in the GLP-1 therapy market [1] - MariTide's long-acting profile allows for monthly or less frequent dosing, potentially improving patient adherence compared to weekly injectable options [2] - The drug is being evaluated in pivotal studies for obesity and other cardiometabolic conditions, with strong enrollment interest [3][4] Group 1: Product Development and Market Position - MariTide is part of Amgen's MARITIME phase III program, focusing on obesity and related cardiometabolic indications [1][3] - The drug has shown predictable and sustained weight loss in earlier studies, positioning it as a convenient long-term treatment option [2] - Enrollment for MARITIME-1 and MARITIME-2 studies has been completed with approximately 5,000 patients participating [3] Group 2: Competitive Landscape - Novo Nordisk has received FDA approval for an oral version of Wegovy, enhancing competition in the obesity treatment market [5] - Eli Lilly is also advancing its oral obesity candidate, orforglipron, with a potential launch next year [6] - Both market leaders continue to invest in next-generation therapies, indicating a robust competitive environment [7][8] Group 3: Financial Performance and Valuation - Amgen's shares have outperformed the industry year to date, reflecting positive market sentiment [9] - The company is trading at a P/E ratio of 15.20, which is below the industry average of 17.56, indicating a potential valuation opportunity [12] - EPS estimates for 2025 and 2026 have increased in the past 60 days, suggesting positive growth expectations [14]

Core Insights - Merck (MRK) is heavily reliant on a drug whose patent is set to expire around 2028, raising concerns about future revenue streams [1] - The company faces significant uncertainties in its pipeline and R&D expenses, which could impact its growth potential [1] - There is a noted dependence on government regulations and policies, adding another layer of risk to the company's operations [1]

Core Insights - Shares of Ultragenyx Pharmaceutical (RARE) and Mereo BioPharma (MREO) fell significantly by 42.3% and 87.6% respectively after disappointing results from phase III studies evaluating setrusumab for osteogenesis imperfecta treatment [1][2] Study Results - The Orbit and Cosmic studies did not achieve statistical significance for their primary endpoints related to annualized clinical fracture rate compared to placebo or bisphosphonates [2][7] - Both studies showed statistically significant improvements in bone mineral density (BMD) as a secondary endpoint, with no changes in safety profiles [2][9] - In the Orbit study, participants had meaningful BMD improvements, but these did not lead to a reduction in fracture rates [9] - The Cosmic study indicated that while BMD improvements were observed in a younger patient population, the reduction in fracture rates compared to bisphosphonates was not statistically significant [10] Company Actions - Ultragenyx is reviewing its operations and will implement significant cost-reduction measures following the study results [3][7] - The company is conducting additional analyses on the data from both studies to explore other bone health and clinical endpoints beyond fractures [10] Stock Performance - Over the past six months, Ultragenyx shares have declined by 45.7%, while Mereo BioPharma shares have dropped by 89.7%, contrasting with a 25.9% increase in the industry [4]

Group 1: Bristol-Myers Squibb (BMY) - Bristol-Myers Squibb (BMY) is expected to benefit from a potential capital rotation towards long-duration, cash-generative equities if interest rates remain lower or stable in 2026 [3] - The stock has reclaimed its 200-month moving average and a long-term trendline, with potential upside of nearly 18% to test March 2025 highs of $63, and up to 40% towards a former long-term high of $75 within the next 12 months [5] Group 2: Cameco (CCJ) - Cameco is experiencing increased demand due to the growing interest in nuclear power as an alternative energy source, supported by geopolitical factors and the AI industry's growth [6] - The stock has risen over 80% year-to-date after breaking out of a trading range, indicating potential for further upward movement [8] Group 3: GigaCloud Technology (GCT) - GigaCloud Technology (GCT) has shown significant growth, breaking through a downtrend and achieving a 112% lead for the year, supported by its 20-day moving average [9] - The stock reached a new 52-week peak in December, significantly above its IPO price, with potential for further analyst attention and a possible short squeeze due to a notable percentage of shares sold short [11] Group 4: Baidu (BIDU) - Baidu has seen over 40% growth in 2025, marking a turnaround after years of underperformance, with momentum expected to continue into 2026 [12] - The stock's 20-week moving average has crossed above its 200-week moving average for the first time since 2020, indicating a positive long-term trend [12]

■张敏 2025年，A股市场交易活跃度持续提升。截至12月30日，全年累计成交金额达417.8万亿元，同比增长超 60%。在此之前，上证指数连续9个交易日上涨，引发市场广泛关注。 在政策护航下，2025年，多个高科技领域迎来了从技术突破到产业落地的关键跨越，生动印证了市场正 在实践的科技叙事。 今年以来，以DeepSeek为代表的国产大模型取得关键突破，推动行业重心从技术攻坚转向真实场景落 地；机器人领域加速从"技术展示"到"商业闭环"的快速演进，以宇树科技为代表的企业不仅产品亮 相"惊艳全场"，更凭借亿元级商业订单，完成了从实验室到规模化赋能产业的进阶；国产创新药全年对 外授权(licence-out)金额突破1000亿元大关，凸显行业全球竞争力提升；商业航天领域，朱雀三号、长 征十二号甲先后发射，不仅实现了技术上的重大突破，更进一步推动可重复使用火箭技术从试验阶段迈 向工程化应用。 这些高新科技产业的崛起，不仅展现了各自鲜明的演进路径，更强劲拉动了上下游产业链的订单增长与 整体价值提升。 制度护航与产业突破形成合力，正深刻改变A股市场的整体生态。 这种变化最直观的体现是A股行业结构的优化。十年前，金融、地 ...