瑞银分析师认为，MariTide的优势在于可能实现每月给药。尽管试验结果中出现了耐受性方面的担忧， 但安进倾向于采用一种新的"三步滴定制剂方案"，该方案能显著改善耐受性、降低停药率，支持在第三 阶段试验中实现15%-20%的积极减重效果，同时保持每月给药频率以及类似礼来(LLY.US)替尔泊肽的不 良反应特征。 资料显示，MariTide(AMG 133)是一种用于治疗肥胖和2型糖尿病的GLP-1R激动剂/GIPR拮抗剂。数据显 示，未合并2型糖尿病的肥胖/超重患者通过该药物治疗52周后，平均减重达20%，且未出现减重平台期; 合并2型糖尿病的患者平均减重17%。 olpasiran(AMG 890)是一款在研的小干扰RNA(siRNA)疗法，旨在通过靶向脂蛋白(a)(Lp(a))基因转录的 mRNA来减少Lp(a)的产生——Lp(a)是一种基因决定的心血管疾病独立危险因素。研究结果显示，与安 慰剂组相比，每12周皮下注射75mg或更高剂量olpasiran的患者在第36周时Lp(a)降低达95%及以上;在 75mg或更高剂量下，超过98%的患者Lp(a)水平在第36周降至125nmol/L或更低。 智通财经 ...

Amgen Inc. (NASDAQ:AMGN) is included among the 14 Best Pharma Dividend Stocks to Buy in 2026. Strong Results and Pipeline Momentum Power Amgen’s (AMGN) 2025 Rally Amgen Inc. (NASDAQ:AMGN) has outperformed the broader market this year, supported by strong financial results and steady clinical progress, even as investors keep an eye on upcoming patent expirations. The stock is up more than 27% since the start of 2025. In the third quarter, revenue rose 12% from a year earlier to $9.6 billion. Several of t ...

Core Insights - Amgen is developing MariTide, a late-stage obesity candidate, to compete with Eli Lilly and Novo Nordisk in the GLP-1 therapy market [1] - MariTide's long-acting profile allows for monthly or less frequent dosing, potentially improving patient adherence compared to weekly injectable options [2] - The drug is being evaluated in pivotal studies for obesity and other cardiometabolic conditions, with strong enrollment interest [3][4] Group 1: Product Development and Market Position - MariTide is part of Amgen's MARITIME phase III program, focusing on obesity and related cardiometabolic indications [1][3] - The drug has shown predictable and sustained weight loss in earlier studies, positioning it as a convenient long-term treatment option [2] - Enrollment for MARITIME-1 and MARITIME-2 studies has been completed with approximately 5,000 patients participating [3] Group 2: Competitive Landscape - Novo Nordisk has received FDA approval for an oral version of Wegovy, enhancing competition in the obesity treatment market [5] - Eli Lilly is also advancing its oral obesity candidate, orforglipron, with a potential launch next year [6] - Both market leaders continue to invest in next-generation therapies, indicating a robust competitive environment [7][8] Group 3: Financial Performance and Valuation - Amgen's shares have outperformed the industry year to date, reflecting positive market sentiment [9] - The company is trading at a P/E ratio of 15.20, which is below the industry average of 17.56, indicating a potential valuation opportunity [12] - EPS estimates for 2025 and 2026 have increased in the past 60 days, suggesting positive growth expectations [14]

In this article, we will take a look at some of the best dividend stocks.Drug pricing has become one of the biggest pressure points for pharmaceutical companies this year, as the U.S. moves to rein in what consumers pay at the pharmacy counter.For most drugmakers, the US is the largest single market. Prices there are often close to three times higher than in other developed countries. Branded medicines carry even steeper premiums. That gap explains why so much of the industry’s revenue still depends on Amer ...

Key Takeaways NVO leans on GLP-1 leadership, with Ozempic, Wegovy and Rybelsus driving growth but facing rising competition.AMGN benefits from diversification, with oncology, rare disease, biosimilars, and obesity studies underway.NVO shares fell sharply over six months, while AMGN stock gained as earnings estimates trended higher.Both Novo Nordisk (NVO) and Amgen (AMGN) are large-cap, innovation-driven healthcare leaders with global scale, strong balance sheets, and a track record of turning scientific bre ...

The Dow Jones Industrial Average (^DJI) was up 56.19 (0.1174%) points today, as Wall Street continued its quiet ascent, flirting with all-time highs. The market's main narrative was a blend of robust corporate earnings reports and encouraging economic data, alongside anticipation for key inflation figures. Investors closely monitored the Personal Consumption Expenditure (PCE) price index data, the Federal Reserve's preferred inflation gauge, and awaited signals ahead of next week's Fed meeting, where a 25 b ...

Amgen FY Conference Summary Company Overview - **Company**: Amgen (NasdaqGS:AMGN) - **Date of Conference**: December 03, 2025 - **Focus**: Discussion on financial performance, product pipeline, and market dynamics Key Points Financial Performance - Amgen reported a **10% revenue growth** for the first nine months of 2025, with **11% product sales growth** driven by **14% volume growth** [2][3] - **12 products** experienced double-digit growth, and **14 products** are annualizing at over **$1 billion** [3] - The company successfully reduced debt related to the acquisition of Horizon, achieving this a quarter early [4] Growth Drivers - Key growth drivers identified include: - **Repatha**: Grew over **30% year-over-year**, now annualizing at nearly **$3 billion** [6] - **Evenity**: Achieved **30% year-over-year growth**, leading the bone builder segment with over **60% market share** in the U.S. [7] - **Tezspire**: Grew nearly **50% year-over-year**, exceeding **$1 billion** year-to-date [7] - **Rare Disease Portfolio**: Annualizing at almost **$5 billion**, with a **12% year-over-year growth** [8] - **Innovative Oncology Portfolio**: Grew **11% year-over-year**, with Imdeltra becoming a standard of care in small cell lung cancer [9] - **Biosimilars Portfolio**: Grew over **40% year-over-year**, now annualizing at roughly **$3 billion** [10] Pipeline Updates - **Repatha**: Significant cardiovascular outcomes data showing a **25% reduction in MACE** and a **36% reduction in heart attacks** [11] - **MariTide**: Ongoing studies in obesity and type 2 diabetes, with updates expected in the new year [12][63] - **Olpasiran**: In phase 3 development, showing promise in Lp(a) lowering therapy [12] - **Xaluritamig**: Progressing in phase 3 studies for prostate cancer [12] Market Dynamics - The company anticipates competition from oral PCSK9 inhibitors but believes the overall market for LDL-C treatment is underpenetrated, with over **100 million patients** globally not at their LDL-C goal [33][40] - Amgen's access strategies for Repatha include a direct-to-patient program priced at **$239 per month**, with low copays for insured patients [34] Competitive Landscape - The entry of biosimilars for Prolia and Xgeva is expected to impact sales, with a sharper decline anticipated for Xgeva due to consolidated buying power in oncology [20] - Amgen is confident in maintaining market share and growth despite new entrants, citing strong data and physician acceptance [35][39] Future Outlook - Amgen plans to continue investing in innovation, with a research and development budget expected to grow in the mid-20s percentage year-over-year [4] - The company is optimistic about its growth trajectory into 2026, supported by its six identified growth drivers [18][25] Additional Insights - The company is preparing for the launch of Uplizna in generalized myasthenia gravis, with a PDUFA date set for December 14 [18] - The management emphasized the importance of maintaining competitive pricing and access strategies in the evolving market landscape [55] This summary encapsulates the key discussions and insights from the Amgen FY Conference, highlighting the company's strong performance, growth strategies, and future outlook in the biopharmaceutical industry.

Core Viewpoint - Amgen Inc. is recognized as one of the Best Low Volatility Investments for December 2025, with Goldman Sachs maintaining a $400 price target and a Buy rating ahead of important updates on its obesity medication, MariTide [1]. Group 1: Investment Potential - Goldman Sachs anticipates long-term weight loss results with reduced or occasional dosage and minimal gastrointestinal side effects from the obesity maintenance data [2]. - The Phase 2 study of MariTide demonstrated an average weight loss of up to 20% in patients with obesity without Type 2 diabetes (T2D) and approximately 17% in those with T2D, alongside improvements in cardiometabolic parameters such as waist circumference and blood pressure [3]. Group 2: Company Overview - Amgen Inc. is involved in the discovery, development, manufacturing, and delivery of human therapeutics globally, serving healthcare providers including physicians, dialysis centers, hospitals, and pharmacies [4].

Core Insights - Amgen's stock has increased nearly 16% in one month due to strong Q3 2025 results, with both revenue and earnings surpassing expectations, and the company has raised its sales guidance for the year [1][10] - The drug and biotech sector has shown recovery, with major companies like Pfizer and AstraZeneca entering pricing agreements with the Trump administration, which may lead to a sustainable sector recovery [2][3] Financial Performance - Amgen's revenues grew by 10.5% in the first nine months of 2025, driven by strong demand for its innovative medicines [4] - Key drugs such as Repatha, Evenity, and new products like Tavneos and Tezspire are significantly contributing to revenue growth, alongside biosimilars [5][7] - Biosimilars generated approximately $2.2 billion in sales in the first nine months of 2025, with annualized sales expected to reach around $3 billion [17] Product Pipeline - Amgen is focusing on expanding the indications for several key drugs, which could further enhance revenue growth [6][7] - The company is developing MariTide, an obesity treatment, which has shown promising results in clinical studies and is expected to differentiate itself from competitors [8][9][11] - Ongoing phase III studies for MariTide and other candidates could provide important catalysts for future growth [12][14] Market Position and Valuation - Amgen's stock has outperformed the industry and S&P 500, with a year-to-date increase of 32.5% compared to 17.7% for the industry [22] - The stock is currently trading at a price/earnings ratio of 15.97, which is lower than the industry average of 17.26, indicating reasonable valuation [25] - Consensus estimates for earnings have been revised upward for 2025 and 2026, reflecting positive market sentiment [28][30] Challenges and Competitive Landscape - The expiration of patents for key drugs like Prolia and Xgeva is expected to lead to revenue erosion due to the introduction of biosimilars [19] - Pricing pressures from Medicare Part D redesign and the Inflation Reduction Act may adversely impact sales of certain drugs [20]

Key Takeaways NVO shares fell 10.2% in three months amid guidance cuts and weaker momentum for key GLP-1 drugs.Rising competition, slower Wegovy uptake and pricing pressure hit NVO's Q3, driving a second guidance cut.Novo Nordisk announced restructuring and a U.S. pricing deal as margin and execution risks mount.Novo Nordisk (NVO) shares have plunged 10.2% over three months as regulatory setbacks, a 2025 guidance cut, and softer demand for its blockbuster semaglutide-based (GLP-1) drugs, Ozempic (for type I ...