记者5日从江南大学获悉，该校生物工程学院周楠迪教授团队近日成功构建出一种结合纳米荧光探 针与微流控液滴技术的生物传感器，实现了全血中循环肿瘤细胞（CTCs）的高灵敏度检测。相关研究 成果发表于国际期刊《生物传感器和生物电子学》。 CTCs携带着重要的肿瘤信息，在每毫升血液中，CTCs数量仅有1—10个，却混杂在数十亿正常血 细胞中，对其进行检测好比"大海捞针"。针对这一难题，该研究团队设计出可特异性识别CTCs的纳米 荧光探针，将探针与预处理血液样本混合后，利用微流控液滴技术将其包裹成数万个"单细胞液滴"，在 微型高通量平台上完成CTCs的快速筛选与检测。 值得关注的是，相较于传统免疫磁珠分选技术、微流控免疫芯片及其他已报道的传感器，本研究开 发的液滴传感器在检测灵敏度方面有显著提升，可实现低至5CTCs/mL的稳定检测。该传感器还表现出 良好的普适性，已在结直肠癌、宫颈癌和肝癌3种不同类型的临床样本中得到验证，后续将积极推进其 产业化应用。 "该研究将为癌症的早期预警、疗效动态评估及术后精准治疗提供具有潜力的可靠技术手段，未来 有望助力提升癌症诊疗水平，减轻疾病负担。"周楠迪表示。 周楠迪介绍，癌症导致全球 ...

Core Insights - The construction of the Sanofi Global R&D Center in Changsha High-tech Zone has reached the final stages, with completion expected by the end of the year, marking the full establishment of the Sanofi Biotech Park [1] - The total investment for the third phase of the project is approximately 500 million yuan, focusing on the biosensor industry chain and aiming for a production value of 3 billion yuan annually upon completion [1][2] - Sanofi has established itself as a leader in the blood glucose monitoring system industry in China, holding over 50% market share domestically and exporting products to 187 countries [2] Investment and Economic Impact - The new R&D center will contribute over 200 million yuan in tax revenue and create nearly 2,000 new jobs [1] - The center will integrate software and hardware product development, talent training, testing, and result transformation, enhancing the company's capabilities in diabetes management [2] Company Background - Founded in 2002, Sanofi has become a high-tech enterprise specializing in the research and application of biosensor technology, successfully listed on the Shenzhen Stock Exchange in 2012 [2] - The company has established several national-level R&D platforms, including the National Enterprise Technology Center and the National Engineering Laboratory for Medical Big Data Application Technology [2]

Group 1 - The global market for biosensors is experiencing exponential growth due to increasing demand for physiological monitoring and health management [1] - Biosensors play a crucial role in disease prevention, detection, diagnosis, and monitoring, acting as a "scout" for health management [1] Group 2 - The integration of AI and materials science is driving innovation in biosensor technology, with examples such as graphene-nanoparticle sensors for leukemia diagnosis and silk protein sensors for wearable health monitoring [2] - The combination of biomedical sensors with technologies like cloud computing and machine learning enables continuous monitoring of physiological parameters, enhancing healthcare delivery [2] Group 3 - The Chinese government is promoting the development of intelligent detection equipment, including biosensors, through the "Intelligent Detection Equipment Industry Development Action Plan (2023-2025)" [3] - There is a need to improve the "production, learning, research, and application" transformation in the biosensor industry, with a proposed full-chain approach from basic research to large-scale production [3] Group 4 - Ethical regulations are essential for the development of gene-encoded biosensors to prevent risks such as data breaches and ensure the protection of genetic information [4] - A collaborative approach involving technology, ethics, and policy is necessary for the successful integration of biosensors into everyday life, ensuring they serve as guardians of human health [4]

Core Insights - The development of a new diamond quantum biosensor by the research team at the University of Chicago aims to track cellular changes and enable early detection of diseases like cancer, representing a cutting-edge research direction in the field [1][2] Group 1: Technology and Innovation - The new biosensor can successfully penetrate cells and is more stable and sensitive than previous versions [1] - The sensor's quantum bits maintain coherence even in small particles that can be absorbed by cells, addressing a long-standing issue in the field [1] - Inspired by quantum dot technology used in QLED TVs, the team applied a special shell to the diamond sensor to enhance its performance by suppressing harmful surface effects [1][2] Group 2: Performance Improvements - The new sensor exhibits a fourfold increase in spin coherence, an 1.8 times increase in fluorescence intensity, and significantly improved charge stability [2] - The protective shell not only safeguards the sensor but also facilitates the transfer of electrons from the diamond to the shell layer, enhancing the sensor's performance by reducing interference with quantum signals [2] Group 3: Interdisciplinary Research - This achievement integrates research from cell biology, quantum science, and materials science, addressing the performance drop of diamond quantum sensors at the nanoscale [2] - The advancements open new avenues for applying quantum sensing technology in biomedical fields [2]