Core Viewpoint - The article outlines the 2025 project application guidelines for the National Key R&D Program on Disruptive Technology Innovation, emphasizing the need for strategic breakthroughs in various fields to foster new industries and production capabilities [1][2]. Group 1: Overall Goals - The initiative aims to address major national needs and health issues while exploring global technological frontiers, focusing on selecting and nurturing disruptive technologies with significant strategic value [2]. Group 2: Project Requirements and Layout - The program is exploratory and nurturing in nature, without specific project or topic guidelines, allowing for open discovery and systematic layout of key technologies [3]. Subgroup: Brain-Computer Interface - The brain-computer system is a key focus area, aiming to develop disruptive technologies for brain analysis, protection, and development, thereby establishing a leading global technology cluster [3][4]. Subgroup: Cell and Gene Therapy - The cell and gene therapy sector is targeted for key technological advancements, focusing on creating a new technology lineage and industry chain to promote precision medicine and regenerative medicine [5][6]. Subgroup: AI-Driven Scientific Research - The AI-driven scientific research area aims to combine artificial intelligence with theoretical deduction and scientific experimentation to create disruptive technologies that can transform research paradigms [8][9]. Subgroup: Clean and Efficient Use of Coal - The clean and efficient utilization of coal is another focus, targeting key technologies for safe production and high-value utilization, contributing to carbon management strategies [10][11].