李楠表示，合理用药需要遵循安全、有效、经济、适当的原则，能不用就不用，能口服就不肌内注射， 能肌内注射就不输液。任何药物都有不良反应，用药过程中如果有任何不适要及时咨询医生或药师。买 药要去正规的药店和医院，用药之前要仔细阅读说明书，检查药品的有效期，不要服用过期药品。药品 要妥善存放，避免药品变质或者失效。一旦发现误服药品，要及时携带药品和包装就医。合理用药还要 关注特殊群体的用药，比如老人、儿童、孕妇、哺乳期妇女、肝肾功能不全患者等群体在用药时要谨遵 医嘱，不能按常规剂量服用。还需要关注抗生素药物，抗生素药物在抗感染的同时都有不同程度的不良 反应，甚至会有毒性反应。为了有效进行抗感染治疗、减少不良反应、预防滥用，必须在医生的指导下 规范合理用药。 李楠提醒，日常生活中，服药期间要注意饮食禁忌，例如服用华法林药物期间，尽量避免大量食用西兰 花和菠菜；服用头孢类药物不能喝酒，否则可能引发双硫仑样反应，导致严重健康风险甚至危及生命； 服用安眠类药物期间，不建议饮用咖啡，饮用咖啡可能削弱安眠类药物的镇静效果，导致睡眠质量下降 或失眠症状加重。用药安全无小事，务必严格遵循医嘱，仔细阅读药品说明书，确保用药安全合理。 ...

Core Viewpoint - The article discusses the potential drug interactions of Semaglutide, emphasizing the importance of understanding how it may interact with other commonly used medications, which could affect its efficacy or increase the risk of side effects [2][4]. Group 1: Severe Drug Interactions - Semaglutide has significant interactions with several classes of medications, particularly insulin and other diabetes drugs, which may lead to hypoglycemia if used together [5]. - Patients using anticoagulants and antiplatelet drugs, such as Warfarin and Aspirin, should be cautious as these can increase the risk of gastrointestinal bleeding and may alter the absorption and metabolism of Semaglutide [6][7]. - Opioid medications may have moderate interaction risks with Semaglutide, potentially affecting the absorption and elimination of these pain relievers due to delayed gastric emptying [8]. Group 2: Moderate Drug Interactions - Statins, such as Atorvastatin and Simvastatin, may have moderate interaction potential with Semaglutide, possibly affecting their absorption in the intestine [12]. - Hormonal contraceptives may be less effective when used with Semaglutide, increasing the risk of unintended pregnancy [15][16]. - Thyroid medications and certain antiepileptic drugs may require monitoring and potential dosage adjustments when used alongside Semaglutide due to absorption changes [17][18]. Group 3: Over-the-Counter Drug Interactions - Common over-the-counter medications, including NSAIDs and laxatives, may exacerbate gastrointestinal side effects associated with Semaglutide, such as diarrhea and nausea [20][21].