格隆汇2月17日｜近日，中国农业科学院作物科学研究所作物精准育种技术创新团队在我国自主知识产 权基因编辑工具Cas12i3的基础上，成功开发出新型碱基编辑系统，并利用该系统创制出抗除草剂水稻 新种质。 作为我国自主研发的基因编辑工具，Cas12i3相较于国外主流工具，具有体积更小、编辑适用 范围更广等独特优势。然而，依托Cas12i3的腺嘌呤碱基编辑器目前尚未成功开发，Cas12i3的胞嘧啶碱 基编辑器在植物中编辑效率比较低。因此，针对Cas12i3开发高效的碱基编辑系统，对丰富我国育种技 术工具箱具有重要意义。 研究团队构建了5个不同版本碱基编辑器，并分别对他们进行编辑效率系统评 估。其中一种结合了两个特定功能单元的架构表现最优，能显著提升腺嘌呤、胞嘧啶碱基编辑效率，并 扩大碱基编辑窗口。在稳定遗传的水稻植株中，优化后的碱基编辑工具可将原有编辑效率分别提升4.78 倍和3.35倍。 业内人士认为，这项研究为作物基因功能解析和精准遗传改良提供了重要工具和技术支 撑。国际学术期刊《植物学报》日前发表了相关研究成果。 ...

Core Viewpoint - The "Changping Model" selection activity for 2025 has recognized exemplary individuals who contribute to the spirit of the times and promote the development of Changping District through their dedication and actions [1]. Group 1: Recognition of Exemplary Individuals - The event has highlighted a diverse group of individuals from various sectors, showcasing their impactful stories and contributions to society [1]. - The selected individuals include Zhao Tianmeng, Xu Peng, Zhang Nan, and others, who have demonstrated commitment and innovation in their respective fields [1]. Group 2: Contributions in Science and Technology - Zhao Tianmeng, CTO of Beijing Qihe Biotechnology Co., has made significant advancements in gene editing, developing a new base editing system recognized as a milestone in the field [5][6]. - His work has led to the creation of the "PrimeRoot" technology, which drastically reduces the time for gene insertion in rice from years to weeks, earning accolades in scientific publications [6]. Group 3: Community and Emergency Services - Xu Peng, a firefighter, has excelled in both administrative and operational roles, improving documentation processes and training programs within the fire department [10][11]. - Zhang Nan, a police officer, has implemented innovative risk management mechanisms, effectively resolving numerous community disputes and enhancing public safety [15][16]. Group 4: Cultural Preservation and Education - Gao Xuhong, a villager, has dedicated her life to preserving traditional cultural practices, creating educational materials, and training new generations in the art of Huabao drum [20][21]. - Her initiatives have fostered community engagement and cultural continuity, impacting nearly a thousand students across various educational institutions [21]. Group 5: Healthcare and Medical Innovation - He Baowei, a physician, has significantly improved healthcare access in Xinjiang through his medical expertise and community outreach, increasing patient visits and establishing a robust healthcare framework [30][31]. - His efforts have led to the establishment of a medical work studio, enhancing the local healthcare system and benefiting thousands of residents [31]. Group 6: Environmental and Renewable Energy Initiatives - Jiang Hechuan, a senior engineer at China Huaneng Group, has developed a flexible photovoltaic support system that optimizes land use and reduces material costs in solar energy projects [25][26]. - His contributions have been recognized as pivotal in advancing the renewable energy sector, with numerous patents and published research [26]. Group 7: Social Responsibility and Community Service - Lan Dong, a business owner, has integrated social responsibility into his operations by providing free haircuts to the elderly and underprivileged, demonstrating a commitment to community welfare [51][52]. - His initiatives have served over 80,000 elderly individuals, showcasing the impact of local businesses in addressing social needs [52]. Group 8: Future Directions - The Changping District aims to continue promoting the "Changping Model" initiative, fostering a culture of learning from exemplary figures and encouraging civic engagement for high-quality development [54].