Summary of the Conference Call for Jianyou Co., Ltd. Company Overview - **Company**: Jianyou Co., Ltd. - **Date**: October 24, 2025 Key Points Financial Performance - Revenue for the first three quarters of 2025 decreased by 5.25% year-on-year to 3.09 billion RMB, while net profit fell by 29% to 430 million RMB, primarily due to increased sales and management expenses, especially in the U.S. market [2][3] - The total assets reached 10.3 billion RMB, with net assets attributable to shareholders at 6.75 billion RMB [3] Sales and Management Expenses - Sales expenses increased by approximately 90 million RMB, and management expenses rose by about 50 million RMB, largely due to investments in the U.S. market for large molecules and innovative drugs [4] - The company expects total revenue for the year to be between 4.2 billion and 4.4 billion RMB, with profits around 600 million to 700 million RMB [4] Raw Material and CDMO Business - The raw material segment saw a revenue decline of 37% year-on-year, with net gross profit down 40%. However, a 15% price increase is anticipated due to rising demand for high-quality raw materials [10] - CDMO business revenue decreased by 60%, but excluding certain sales impacts, it remained stable year-on-year, with future order growth expected at 25%-30% [11] Domestic and International Formulations - Domestic formulation shipments fell by 13% year-on-year, with gross profit declining over 20% due to price reductions following contract renewals [12] - International formulations performed well, with sales volume increasing by 21% and revenue up 32%, significantly driven by the U.S. market [14] Major Products and Market Competition - Three main large molecule products (White Purple, Adalimumab) maintained stable market shares, although White Purple faced pricing competition [8] - The company expects total revenue from these products to be adjusted to 65 million USD, with a net gross profit of 30 million USD for the year [9][16] Innovative Drug Development - The M22 Phase II clinical trial was completed, showing that 50% of patients could discontinue hormone treatment within six months. Discussions with the FDA for Phase III are ongoing [7] - The company plans to launch three insulin products in collaboration with Dongbao, targeting a 15%-20% market share within 4-6 quarters [17] R&D and Future Strategy - R&D expenses increased by 45 million RMB year-on-year, with five new projects initiated in the peptide large molecule field [6] - The company aims for large molecule drugs to account for over 60% of revenue by 2030, with a focus on expanding in the U.S. and European markets [4][22] Market Environment and Regulatory Changes - The FDA's easing of clinical requirements for biosimilars is expected to intensify competition but also provide opportunities for efficient companies [21] - The company is adapting its strategy to increase the proportion of self-completed projects in the large molecule field, aiming for 40%-50% by the end of 2025 [23] Challenges and Opportunities - The company faces challenges from pricing pressures and competition but is optimistic about future growth driven by innovative drug development and market expansion [31][33] - The strategic focus includes enhancing R&D capabilities and leveraging regulatory changes to improve market positioning [32] Conclusion - Jianyou Co., Ltd. is navigating a challenging market environment with a strategic focus on innovation and expansion in large molecule drugs, while addressing cost pressures and competition effectively. The company is well-positioned for future growth, with a clear roadmap for product development and market penetration.

Core Viewpoint - The company, Jianyou Co., Ltd. (健友股份), announced that its subsidiary, Meitheal Pharmaceuticals, Inc., has received approval from the U.S. Food and Drug Administration (FDA) for a new injectable drug, Phosphomycin, 6 g/vial, aimed at treating complex urinary tract infections, including acute pyelonephritis, and inhibiting the development of diseases caused by resistant bacteria [1]. Group 1 - The FDA approval is for Phosphomycin, which is indicated for the treatment of complex urinary tract infections [1]. - The drug is specifically designed to address acute pyelonephritis and combat antibiotic-resistant bacteria [1].

Summary of Key Points from the Conference Call of Jianyou Co., Ltd. Company Overview - Jianyou Co., Ltd. started with heparin raw materials and has gradually developed into enoxaparin sodium injections, small molecule injections, and large molecule biosimilars, establishing three growth curves with significant synergy in the industrial chain, production technology, registration, commercialization, and marketing [2][4] Core Business and Market Position - The company has a strong presence in the U.S. market, with formulation revenue accounting for over 70% and overseas formulation revenue approximately 54% [2][9] - The heparin preparation market has a natural growth rate of about 5%, with a projected global market size of $6.05 billion in 2024, expected to reach around $10 billion by 2034 [5][25] - The biosimilar market is expected to grow significantly, with projections of a market size between $30 billion and $35.5 billion in 2024, potentially reaching over $120 billion by 2032 [11][12] Future Growth Drivers - The U.S. Inflation Reduction Act (IRA) is expected to enhance the profitability of biosimilars by restructuring insurance payment systems, encouraging doctors to prescribe lower-cost biosimilars [2][13] - Jianyou's biosimilar products, such as adalimumab, are anticipated to generate $30 million in sales by 2025, with significant orders for liraglutide and plans for rapid approval of high-concentration adalimumab [2][14][16] Production and Capacity - The company has 12 FDA-approved injection production lines, with capacity utilization expected to reach 80%-90% by the end of 2026 to 2027 [2][21] - The U.S. sterile injection market is in a long-term shortage, providing Jianyou with a competitive advantage due to its strong commercialization capabilities and production capacity [2][21] Financial Performance and Projections - Expected revenues for 2025 and 2026 are projected to be $5.5 billion and $7 billion, respectively, with net profits ranging from $1.15 billion to $1.5 billion [5][29] - The overall revenue growth rate is expected to reach 30%-34.8%, driven by high-margin products and a stable domestic market [29] Strategic Advantages - Jianyou has significant advantages in the industrial chain, including vertical integration from raw materials to finished products, ensuring product quality and pricing power [6] - The company has developed strong sales networks through acquisitions and partnerships, enhancing its market position and reducing sales costs [8][24] Challenges and Risks - The heparin raw material business faces challenges from price fluctuations due to the pig farming cycle and epidemic risks, but a price stabilization is expected by 2025 [28] - The company has taken measures to mitigate risks, including significant inventory write-downs, allowing for flexible price adjustments [28] Conclusion - Jianyou Co., Ltd. is well-positioned for future growth with a strong product pipeline, significant market opportunities in biosimilars, and a robust production capacity. The company is expected to benefit from favorable regulatory changes and market dynamics, making it an attractive investment opportunity [10][29]