值得注意的是，东阳光药近日公告，集团持续深化AI战略布局，推出面向PROTAC机制的AI智能研发平 台，实现从数据底座到"干湿闭环"，数据规模与结构粒度均显着领先于现有公开数据库，为AI驱动的 PROTAC理性设计提供了全面、系统的数据基础，加速PROTAC先导化合物的理性设计与临床转化。 东阳光（600673）药(06887)午后涨超6%，截至发稿，涨6.55%，报46.2港元，成交额3062.89万港元。 消息面上，1月16日，自主研发的1类创新药奥洛格列净胶囊已获国家药监局批准上市，用于单药或联合 二甲双胍改善成人2型糖尿病患者的血糖控制。东阳光药相关负责人表示，奥洛格列净的获批是东阳光 药在慢性病长期管理版图中迈出的扎实一步。 ...

值得注意的是，东阳光药近日公告，集团持续深化AI战略布局，推出面向PROTAC机制的AI智能研发平 台，实现从数据底座到"干湿闭环"，数据规模与结构粒度均显着领先于现有公开数据库，为AI驱动的 PROTAC理性设计提供了全面、系统的数据基础，加速PROTAC先导化合物的理性设计与临床转化。 智通财经APP获悉，东阳光药(06887)午后涨超6%，截至发稿，涨6.55%，报46.2港元，成交额3062.89万 港元。 消息面上，1月16日，自主研发的1类创新药奥洛格列净胶囊已获国家药监局批准上市，用于单药或联合 二甲双胍改善成人2型糖尿病患者的血糖控制。东阳光药相关负责人表示，奥洛格列净的获批是东阳光 药在慢性病长期管理版图中迈出的扎实一步。 ...

Core Insights - The company is advancing its AI strategy by launching an AI-driven research platform focused on PROTAC mechanisms, which enhances the rational design of lead compounds and clinical translation through a comprehensive data foundation [1][2] Group 1: AI Strategy and Platform Development - The AI platform aims to create a high-quality, structured PROTAC-specific database (HEC-PROTACDB) that integrates molecular structures, degradation activities, physicochemical properties, and pharmacokinetic parameters from clinical pipelines, patents, and literature [2] - The database currently includes over 30,000 PROTAC molecules, more than 500 POI ligands, over 1,000 types of linkers, 200 E3 ligands, and more than 150 targets, significantly surpassing existing public databases in data scale and structural granularity [2] Group 2: Drug Development and Collaborations - The company is enhancing its AI drug development strategy through collaborations with industry leaders such as Beijing DeepTech and Huawei Cloud, establishing six proprietary models that cover the entire drug discovery process from molecular design to prescription design [3] - The first AI-driven small molecule drug, HEC169584, targeting metabolic-associated fatty liver disease (MASH), has entered clinical phase I, showing high in vitro activity against THR-β cells and strong liver targeting, with reduced impact on the thyroid axis and heart [3]