Core Insights - KRTL Holding Group Inc. highlights its subsidiary KRTL Biotech's product ELIXIR as a leading hydration beverage in the Bolivian market, emphasizing its commercial success and strategic positioning [1][2][3] Product Overview - ELIXIR is a non-alcoholic, hypertonic hydration beverage designed to restore essential electrolytes quickly, formulated with glucose, sodium, potassium, calcium, magnesium, and citric acid [1] - The product is available in over 7,000 retail locations in Bolivia and is recognized for its effectiveness in hangover recovery and as a cocktail mixer [2] - ELIXIR offers a variety of flavors and packaging options, including single-serve sachets and 625ml bottles, catering to diverse consumer needs [3] Market Strategy - KRTL Biotech is preparing to enter international markets, including the U.S., by ensuring compliance with regulatory standards and FDA labeling requirements [4] - The U.S. market for hydration solutions and functional wellness beverages is expanding, presenting a significant opportunity for ELIXIR's unique formulation [4] Company Vision - KRTL Holding Group emphasizes the cultural relevance and scientific foundation of ELIXIR, viewing it as a platform for wellness and recovery with potential for global scaling [5] - The company aims to maintain high standards of quality and compliance while expanding its international presence [7]

撰文丨王聪 编辑丨王多鱼 排版丨水成文 离子通道 是细胞膜上的一类特殊蛋白质，负责调控离子的跨膜流动，在维持细胞电生理活动和信号转导中起关键作用，例如 电压门控钠离子通道 （Na V ） ，通 过快速介导钠离子 （Na + ） 内流触发电信号传导，是 调控可兴奋细胞 （例如神经元、心肌、骨骼肌细胞） 动作电位的关键，其功能异常会导致 持续性钠电流 （ I NaL ） 增强，这是导致 心律失常 、 癫痫、 肌强直 、 偏头痛 和 智力障碍 等多种严重疾病的共同分子机制。 能够精准调控离子通道功能的策略备受期待，然而，包括小分子药物学在内的现有方法存在局限性，且常常会产生脱靶效应。在自然界中， 离子通道的功能通过 进化而来的调节蛋白进行定制，以满足不同的生理需求。过去几十年的结构生物学研究为离子通道-调控蛋白的相互作用提供了前所未有的原子级视角，并揭示了 调控机制。然而，从头设计或合成具有高度特异性的离子通道调控蛋白，一直未能实现。 在自然界中，离子通道的功能可塑性是这些蛋白质的一个显著特征，这通常通过与多种辅助亚基或调控蛋白的结合来实现，这些辅助亚基或调控蛋白经过漫长的 进化以微调特定通道的特性。过去几十年的结 ...