《金融时报》在美东时间周一报道称，制药巨头默沙东(MRK.US)今年早些时候曾向生物科技公司 MoonLake Immunotherapeutics(MLTX.US)提出收购要约。消息发布后，MoonLake股价在美股盘后交易 中大幅飙升，一度暴涨超30%，截至发稿，该股上涨约20%。 报道称，默沙东提出了一份金额超30亿美元的非约束性报价，但初步报价遭到拒绝。三位知情人士透 露，两家公司之间的谈判仍有可能重启。 值得注意的是，默沙东多年来依赖畅销药Keytruda(可瑞达)驱动增长，但其专利将于2028年开始到期。 此外，该公司在中国市场的Gardasil(佳达修)疫苗收入近期持续下滑。 今年4月，默沙东称拟斥资10亿美元在美国建厂，以确保Keytruda供应免受关税冲击。随着针对行业的 关税迫在眉睫，默沙东成为最新一家增加美国国内投资的制药公司。该工厂将生产一种新型的、用户友 好的该公司重磅癌症治疗药物Keytruda的配方;该工厂还将成为该公司在美国的第一个Keytruda内部生产 基地，确保美国患者获得国内生产的药物。 截至发稿，默沙东美股盘后微跌0.07%。 《金融时报》分析称，默沙东在MoonLa ...

Financial Data and Key Metrics Changes - In 2024, the company achieved a strong top line growth of 10%, with sales increasing to CAD 64.2 billion, despite a significant decline in GARDASIL demand in China [7][12] - Non-GAAP EPS was CAD 7.65, which included a net charge of CAD 1.28 per share for certain business development related transactions [7] Business Line Data and Key Metrics Changes - The oncology segment continues to lead, with Keytruda prescribed to over 2.6 million patients globally and FDA approvals for 41 indications [9] - The cardiometabolic disease area saw significant momentum with the successful launch of WinRiver, which received regulatory approvals in over 40 countries [10][24] - The Animal Health business is positioned for consistent above-market growth driven by new product launches [14] Market Data and Key Metrics Changes - GARDASIL and GARDASIL nine remain robust in most major regions, although demand in China slowed in 2024 [12] - The FDA accepted the Biologics License Application for klezrovimab, with a PDUFA action date set for June [12] Company Strategy and Development Direction - The company is committed to a science-driven strategy, focusing on investing in medicines and vaccines that save and improve lives [6] - The pipeline is the most diversified in recent history, with nearly 20 potential new products on the horizon, most representing blockbuster opportunities [8] - Business development remains a priority, with over CAD 40 billion invested since 2021 to expand the pipeline [14] Management's Comments on Operating Environment and Future Outlook - Management acknowledged challenges in the pharmaceutical industry, including regulatory changes and specific issues with the GARDASIL franchise in China, but expressed confidence in the overall health of the business [64] - The company remains focused on scientific excellence and disciplined operational execution to deliver long-term value for patients and shareholders [19] Other Important Information - The company reached nearly half a billion people globally with its products through various channels [16] - Significant investments in manufacturing and R&D capabilities are planned, including a $1 billion vaccine manufacturing facility and a $895 million expansion of the animal health manufacturing facility [18] Q&A Session Summary Question: What caused the recent share price decline and what plans are there to address it? - Management attributed the decline to various factors affecting the stock market and the pharmaceutical industry, including regulatory actions and challenges with the GARDASIL franchise in China, but emphasized the strength of the overall business [64] Question: What is the Board's process for communicating with shareholders? - The Board welcomes input from shareholders and provides information on communication processes in the proxy statement [67] Question: Does DEI further the business? - Management reaffirmed the company's commitment to diversity and inclusion as a core value and strategic imperative [68] Question: What is the Board's plan for profits downstream of AI? - The company is investing in AI to enhance innovation and productivity across its value chain, which is expected to drive shareholder value [70][71] Question: How is the Board of Directors selected? - All Board members are shareholders, and the selection process aims for a balance of skills and experience [72] Question: Why give shares to executives at a reduced rate? - The Compensation and Management Development Committee regularly reviews the long-term incentive plan to align management interests with those of shareholders while managing dilution [75]