Summary of Supernus Pharmaceuticals (SUPN) Conference Call Company Overview - Supernus Pharmaceuticals is a CNS-focused biopharmaceutical company with a portfolio of about eight to nine products on the market [2][3] - The company is profitable and has a clean balance sheet, recently completing the acquisition of Sage Therapeutics [2][3] - Supernus has transitioned from the loss of exclusivity on two legacy products and is now in a re-accelerated growth phase driven by key products like Qelbree, Gocovri, Onapgo, and ZURZUVAE [3] Key Products and Market Insights Qelbree (ADHD Treatment) - Qelbree is a novel non-stimulant ADHD medication that works as early as week one, addressing a significant market need for effective non-stimulant options [7][8] - The ADHD market consists of approximately 100 million prescriptions annually, with Supernus currently holding less than 2% market share, indicating substantial growth potential [8][19] - The adult segment represents 67% of the ADHD market, and Supernus has seen growth in this segment, with 35% of their business coming from adults [18][19] - Qelbree has shown a growth rate of 20% plus, with recent data indicating a 25-26% growth during the back-to-school season [18][19] Onapgo (Parkinson's Treatment) - Onapgo is a new continuous infusion device for apomorphine, launched in April, aimed at treating off episodes in Parkinson's patients [23][24] - The device has received positive initial responses, and its market potential is still being evaluated, with estimates ranging from $200 to $300 million [29][30] - The product is designed for advanced patients but may also be used for earlier-stage patients, which could expand its market opportunity [29][30] ZURZUVAE (Postpartum Depression) - ZURZUVAE is the first oral medication approved for postpartum depression (PPD), a condition affecting 1 in 7 women [31] - There is a significant lack of awareness and education regarding PPD, with only about 40% of women diagnosed over the years [31][32] - Supernus is actively working on educating healthcare providers and patients about PPD, emphasizing the importance of screening and diagnosis [32][38] Industry Dynamics and Challenges - The ADHD treatment landscape has historically relied on stimulants, which do not work for 15-30% of patients, creating a demand for effective non-stimulant alternatives [9][10] - In the Parkinson's space, approximately 90-95% of patients experience off episodes after five years of diagnosis, highlighting the need for effective treatments [22][25] - The company is addressing the stigma around ADHD and PPD through influencer partnerships and educational initiatives [21][38] Conclusion - Supernus Pharmaceuticals is positioned for significant growth with its innovative product offerings in ADHD, Parkinson's, and postpartum depression - The company is focused on expanding its market share and improving patient outcomes through education and effective treatment options, indicating a strong potential for future success in the biopharmaceutical industry [3][19][31]

Core Insights - Supernus Pharmaceuticals reported $165.45 million in revenue for Q2 2025, a year-over-year decline of 1.7% but exceeding the Zacks Consensus Estimate of $154.14 million by 7.34% [1] - The company achieved an EPS of $0.91, significantly higher than the $0.36 from the previous year, resulting in an EPS surprise of 93.62% compared to the consensus estimate of $0.47 [1] Revenue Breakdown - Trokendi XR generated $11.2 million in net product sales, surpassing the average estimate of $9.74 million, but reflecting a year-over-year decline of 34.5% [4] - Oxtellar XR reported $11.6 million in net product sales, exceeding the estimated $8.43 million, with a significant year-over-year decrease of 60.7% [4] - Qelbree achieved $77.6 million in net product sales, outperforming the $71.25 million estimate, marking a year-over-year increase of 30.6% [4] - Total net product sales amounted to $158 million, above the average estimate of $148.32 million, but showing a year-over-year decline of 2.8% [4] - Royalty revenues reached $7.46 million, exceeding the estimated $5.33 million, with a year-over-year increase of 28.6% [4] - GOCOVRI net product sales were $36.7 million, surpassing the $33.51 million estimate, reflecting a year-over-year increase of 15.8% [4] - Other net product sales totaled $6.5 million, below the estimated $8.21 million, with a year-over-year decline of 13.3% [4] - APOKYN generated $12.8 million in net product sales, below the average estimate of $15.6 million, with a year-over-year decrease of 26% [4] Stock Performance - Supernus shares have returned +17.8% over the past month, significantly outperforming the Zacks S&P 500 composite's +1% change [3] - The stock currently holds a Zacks Rank 5 (Strong Sell), indicating potential underperformance relative to the broader market in the near term [3]

Core Insights - Supernus Pharmaceuticals reported strong operating performance in Q2 2025, driven by significant sales growth of Qelbree and GOCOVRI, which together accounted for 72% of total net sales [2][5] - The company completed the acquisition of Sage Therapeutics on July 31, 2025, enhancing its portfolio in neuropsychiatric conditions with the innovative product ZURZUVAE and a novel CNS discovery platform [3][5] - Supernus is focused on the launch of ONAPGO and the integration of Sage Therapeutics while continuing to drive growth from existing products [2][3] Financial Performance - Qelbree net sales increased by 31% year-over-year to $77.6 million in Q2 2025, with total sales for the first half of 2025 reaching $142.3 million [5][11] - GOCOVRI net sales rose by 16% year-over-year to $36.7 million in Q2 2025, totaling $67.4 million for the first half of 2025 [5][11] - Total revenues for Q2 2025 were $165.5 million, a slight decrease from $168.3 million in Q2 2024, while total revenues for the first half of 2025 were $315.3 million, up from $312.0 million in the same period last year [11][12] Product Pipeline and Developments - The company is conducting a Phase 2b study for SPN-817, a novel AChE inhibitor for epilepsy, with a targeted enrollment of approximately 258 patients [7] - SPN-820, a novel molecule for depression, is set to enter a Phase 2b trial by the end of 2025, targeting around 200 adults with major depressive disorder [8] - SPN-443, a novel stimulant for ADHD/CNS, has completed a Phase 1 pharmacokinetic study, with plans to disclose a lead indication by the end of 2025 [9] Guidance and Future Outlook - Supernus updated its full-year 2025 revenue guidance to $670 - $700 million, reflecting strong first-half performance and the impact of the Sage acquisition [13][20] - The company anticipates combined R&D and SG&A expenses to be between $505 - $530 million for the year [13] - Adjusted operating earnings guidance for 2025 is projected to be between $105 - $135 million, consistent with previous expectations [13][37]

Core Viewpoint - The acquisition of Sage Therapeutics by Supernus Pharmaceuticals enhances its position in neuropsychiatric conditions, introducing the innovative product ZURZUVAE® and a new CNS discovery platform, which is expected to drive revenue and cash flow growth while diversifying the revenue base [1][2]. Acquisition Details - Supernus completed the acquisition of Sage for $8.50 per share in cash, plus a contingent value right (CVR) that could yield up to an additional $3.50 per share based on specific milestones [3][4]. - A total of 36,313,509 shares, representing approximately 58% of Sage's outstanding shares, were validly tendered in the offer [10]. Strategic Rationale - The acquisition adds a significant fourth growth product to Supernus's portfolio, expected to be accretive in 2026 due to anticipated cost synergies of up to $200 million annually [2][7]. - ZURZUVAE is the first FDA-approved oral medication for postpartum depression, which strengthens Supernus's psychiatry portfolio [7]. Milestone Payments - The CVR includes milestone payments based on ZURZUVAE's commercial success, including: - $0.50 per CVR upon the first commercial sale in Japan by June 30, 2026 [5]. - $1.00 per CVR if U.S. net sales reach $250 million by December 31, 2027 [6]. - $1.00 per CVR if U.S. net sales reach $300 million by December 31, 2028 [8]. - $1.00 per CVR if U.S. net sales reach $375 million by December 31, 2030 [8]. Company Overview - Supernus Pharmaceuticals focuses on developing and commercializing products for CNS diseases, with a diverse portfolio that includes treatments for ADHD, Parkinson's disease, postpartum depression, and more [13][14].

Company Overview - Supernus Pharmaceuticals, Inc. is a biopharmaceutical company focused on developing and commercializing products for the treatment of central nervous system (CNS) diseases [4] - The company's diverse neuroscience portfolio includes approved treatments for ADHD, dyskinesia in Parkinson's disease, hypomobility in Parkinson's disease, epilepsy, migraine, cervical dystonia, and chronic sialorrhea [5] Upcoming Financial Results - The company expects to report financial and business results for the second quarter of 2025 after the market closes on August 5, 2025 [1] - A conference call will be hosted by the President and CEO, Jack Khattar, and Senior Vice President and CFO, Tim Dec, on August 5, 2025, at 4:30 p.m. ET to present these results [2] Investor Relations - A live webcast of the conference call will be accessible on the company's Investor Relations website [2] - Participants can pre-register for the call and will receive a dial-in number with a personalized conference code [3]

Acquisition Overview - Supernus Pharmaceuticals is acquiring Sage Therapeutics, Inc for an offer price of $8.50 per share in cash at closing[9] - A contingent value right (CVR) of up to $3.50 per share is payable based on ZURZUVAE U S net sales milestones and commercialization in Japan[9] - $1.00 per share if ZURZUVAE U S net sales reach $250 million or more by YE 2027[9] - $1.00 per share if ZURZUVAE U S net sales reach $300 million or more by YE 2028[9] - $1.00 per share if ZURZUVAE U S net sales reach $375 million or more by YE 2030[9] - $0.50 per share at commercialization in Japan by June 30, 2026[9] - The equity value at closing is $561 million, with a total potential value of up to approximately $795 million[9] - The acquisition is expected to close in Q3 2025[9] Financial Impact and Synergies - The acquisition is expected to be significantly accretive to adjusted operating income (non-GAAP), operating income, and EPS in 2026[9, 11] - Strong fit with existing Supernus infrastructure yields up to $200 million in potential synergies on an annual basis[9, 11] - The transaction will be financed through cash on the balance sheet[9] ZURZUVAE and Market Opportunity - ZURZUVAE is the first and only oral treatment specifically indicated for the treatment of women with PPD (Postpartum Depression)[12] - Approximately 500,000 new women experience symptoms of PPD each year, with approximately 175,000 diagnosed and approximately 100,000 treated[19] - ZURZUVAE demonstrated statistically significant improvement in depressive symptoms vs placebo at day 15 following a 14-day treatment course in clinical trials[12] Revenue and Growth - ZURZUVAE U S collaboration revenue has shown growth since launch, with Q1 2025 reaching $13.8 million[22] - This represents 123% year-over-year growth and 21% quarter-over-quarter growth[22]

Core Viewpoint - Supernus Pharmaceuticals is acquiring Sage Therapeutics for $8.50 per share in cash, totaling approximately $561 million, with additional contingent value rights (CVR) potentially increasing the total consideration to $12.00 per share, or about $795 million, contingent on achieving specific sales milestones for ZURZUVAE [1][5][8] Strategic and Financial Benefits - The acquisition is expected to enhance Supernus' revenue and cash flow growth while diversifying its revenue base [5][6] - ZURZUVAE, the first FDA-approved oral treatment for postpartum depression, will strengthen Supernus' portfolio in neuropsychiatric conditions [2][6] - The deal is projected to be significantly accretive in 2026, with potential annual cost synergies of up to $200 million [5][15] Revenue and Collaboration - Supernus will receive collaboration revenue equal to 50% of the net revenue recorded by Biogen for ZURZUVAE in the U.S., which amounted to $36.1 million in 2024 and $13.8 million in Q1 2025 [2][6] - The acquisition adds a fourth growth product to Supernus' portfolio, which includes Qelbree, ONAPGO, and GOCOVRI, positioning the company for significant future growth [3][6] Terms and Financing - The acquisition will be funded through existing cash on Supernus' balance sheet, with a total upfront cash payment of $8.50 per share and a CVR worth up to $3.50 per share [7][8] - The CVR is contingent on ZURZUVAE achieving specific sales milestones, including reaching $250 million, $300 million, and $375 million in annual net sales in the U.S. by specified years [8] Approvals and Timing - The transaction has been approved by the boards of both companies and is expected to close in Q3 2025, subject to customary closing conditions [9][10] - Following the tender offer, Supernus will acquire any remaining shares of Sage through a second-step merger [9] Advisors - Moelis & Company LLC is the exclusive financial advisor to Supernus, while Goldman Sachs & Co. LLC is advising Sage [11]

Core Insights - Supernus Pharmaceuticals, Inc. has received Paragraph IV Notice Letters from third parties regarding Abbreviated New Drug Applications (ANDAs) for viloxazine extended-release capsules in 100, 150, and 200 mg doses [1][2] - The company is reviewing these Notice Letters and plans to enforce its intellectual property rights related to its product Qelbree, which is protected by six U.S. patents with expiration dates ranging from September 2029 to April 2035 [2] Company Overview - Supernus Pharmaceuticals focuses on developing and commercializing products for central nervous system (CNS) diseases [3] - The company's neuroscience portfolio includes treatments for ADHD, dyskinesia in Parkinson's disease, epilepsy, migraine, and other CNS disorders, with ongoing development of new candidates for epilepsy and depression [4]

Core Insights - Supernus Pharmaceuticals reported $149.82 million in revenue for Q1 2025, a year-over-year increase of 4.3% and a surprise of +2.91% over the Zacks Consensus Estimate of $145.59 million [1] - The company achieved an EPS of $0.42, compared to $0.00 a year ago, with an EPS surprise of +10.53% against the consensus estimate of $0.38 [1] Revenue Breakdown - Trokendi XR generated $12.80 million in net product sales, exceeding the average estimate of $8.58 million, but representing a year-over-year decline of -20% [4] - Oxtellar XR reported $10.20 million in net product sales, below the average estimate of $12.29 million, with a significant year-over-year decrease of -62.1% [4] - Qelbree achieved $64.70 million in net product sales, slightly below the average estimate of $65.54 million, but showing a year-over-year increase of +43.5% [4] - Total net product sales amounted to $141.99 million, surpassing the average estimate of $140.61 million, reflecting a year-over-year growth of +2.6% [4] - Royalty revenues reached $7.84 million, exceeding the estimated $5.80 million, with a year-over-year increase of +51.2% [4] - GOCOVRI net product sales were $30.70 million, above the average estimate of $30.13 million, marking a year-over-year increase of +15.9% [4] - Other net product sales totaled $8.60 million, surpassing the average estimate of $7.38 million, with a year-over-year growth of +19.4% [4] - APOKYN reported $15 million in net product sales, below the average estimate of $16.70 million, reflecting a year-over-year decline of -10.2% [4] Stock Performance - Supernus shares returned +0.4% over the past month, while the Zacks S&P 500 composite increased by +11.5% [3] - The stock currently holds a Zacks Rank 2 (Buy), indicating potential for outperformance against the broader market in the near term [3]

Core Insights - Supernus Pharmaceuticals reported strong financial results for Q1 2025, highlighting double-digit revenue growth from core products and adjusted operating earnings growth [2][7][12] - The company launched ONAPGO, a new treatment for Parkinson's disease, which is expected to drive further growth [2][8] Financial Performance - Q1 2025 net sales of Qelbree increased by 44% to $64.7 million compared to Q1 2024 [7] - Q1 2025 net sales of GOCOVRI increased by 16% to $30.7 million compared to Q1 2024 [7] - Total revenues for Q1 2025 increased by 4% to $149.8 million compared to Q1 2024 [7] - Adjusted operating earnings for Q1 2025 increased by 16% to $25.9 million [12] Product Pipeline - SPN-817, a novel AChE inhibitor for epilepsy, is currently in a Phase 2b study with approximately 258 patients [3] - SPN-820, aimed at treating major depressive disorder, will enter a Phase 2b trial with around 200 adults [4] - SPN-443, a novel stimulant for ADHD, completed a Phase 1 study and will announce a lead indication by the end of 2025 [5] Market and Prescription Trends - Total IQVIA prescriptions for Qelbree reached 214,908 in Q1 2025, a 22% increase year-over-year [8] - The number of prescribers for Qelbree grew to approximately 34,416 in Q1 2025, up from 27,902 in the same period last year [8] Financial Guidance - The company reiterated its full-year 2025 financial guidance, projecting total revenues between $600 million and $630 million [11] - Combined R&D and SG&A expenses are expected to be between $435 million and $460 million [11]