Financial Data and Key Metrics Changes - The company reported total revenue of $97.7 million for Q2 2025, representing a 33% year-over-year growth compared to $73.2 million in Q2 2024 [25] - The net loss for Q2 2025 was approximately $19.1 million, or $0.08 per share, compared to a net loss of $16.5 million, or $0.07 per share in the same period last year [31] - The company ended Q2 2025 with $238.5 million in cash, cash equivalents, and short-term investments, including $48.7 million of incremental debt [32] Business Line Data and Key Metrics Changes - Ibsrela generated $65 million in net sales revenue for Q2 2025, reflecting an 84% year-over-year growth and a 46% quarter-over-quarter growth [6][11] - Exposa recorded net sales revenue of $25 million in Q2 2025, a 7% increase compared to Q1 2025, and a 27% increase when excluding a one-time reserve release from Q1 [7][28] Market Data and Key Metrics Changes - The demand for Ibsrela in Israel showed broad-based growth with record highs across all key indicators, leading to an increase in full-year guidance for net sales revenue to $250 million to $260 million [6] - Exposa's performance was driven by improved access for patients and growth in non-Medicare payer segments, indicating a positive response to promotional messaging from the sales team [18][19] Company Strategy and Development Direction - The company is focused on executing its commercial strategy effectively, with plans to continue expanding the prescribing base for both Ibsrela and Exposa [15][21] - The leadership team has been strengthened with new appointments to support the next phase of growth, including the promotion of Mike Kelleher to Chief Business Officer [8] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in achieving peak sales of over $1 billion for Ibsrela and $750 million for Exposa, citing strong patient demand and improved prescription pull-through [16][21] - The company is optimistic about continued growth throughout 2025, with a focus on maintaining high execution levels [21] Other Important Information - The company has drawn an additional $50 million of debt to enhance financial flexibility, bringing total outstanding debt to $200 million [32] - The company has completed its $75 million royalty obligation to AstraZeneca, which is now behind them [30] Q&A Session Summary Question: Update on potential EU partner and cash flow positive status - Management indicated that achieving cash flow breakeven is a near-term goal and that they are evaluating opportunities in Europe [38] Question: Clarification on new guidance for Ibsrela - Management stated that the $10 million increase in guidance reflects a meaningful step forward and is based on thoughtful analysis [44] Question: Sales growth attribution to expanded sales team - Management confirmed that the expanded sales team has significantly contributed to the increase in prescriptions and expects this trend to continue [50][52] Question: Contribution from transitional scripts for Exposa - Management noted that there was an inconsequential amount of transitional scripts in Q2 and that the mix is roughly 50/50 between Medicaid and commercial [60][118] Question: Confidence in new peak estimate for Exposa - Management expressed confidence in the new peak estimate for Exposa, citing a total available market of 220,000 patients and strong performance indicators [86] Question: Update on CMS legal proceedings - Management confirmed that arguments for the ongoing CMS case will be heard on September 25, with no statutory requirement for a response timeframe [79]