近日，圣因生物宣布已完成超1.1亿美元B轮融资，本轮融资由一家知名产业机构领投，一家国际主权基 金、中国生物制药集团、君联资本、维梧资本、Invus、SymBiosis、苏创投、真脉投资、清池资本跟 投，并获礼来制药公司战略投资。同时，现有股东高瓴创投、启明创投、险峰淇云、泰福资本、元禾控 股、北极光创投等继续支持。 自2021年成立以来，圣因生物凭借其专有的RNAi药物研发平台，致力于开发出靶向肝脏及肝外组织的 同类首创/同类最佳RNAi疗法。基于该平台，公司已构建了涵盖自身免疫疾病、心血管疾病、代谢性疾 病及肥胖等不同治疗领域的多元化产品管线，其中多款已进入临床阶段。此次B轮融资的顺利完成，将 有力推动公司在研及规划中管线的临床开发及全球化布局，并助力公司在RNAi领域持续实现新突破。 "B轮融资完成是公司发展历程中的重要里程碑。"圣因生物创始人、CEO王为民博士表示，获得多家全 球顶尖投资机构的支持，不仅是对公司研发实力与企业愿景的信任与认可，也为公司的长远发展注入了 关键资源。圣因生物始终致力于通过持续创新来拓宽RNAi技术的应用边界，从而解决全球未满足的临 床需求。未来，公司将全力推进在研药物的全球 ...

Core Insights - Eli Lilly (LLY.US) announced a global research and licensing agreement with SanegeneBio worth up to $1.2 billion to jointly develop and commercialize RNAi therapies for metabolic diseases [1] - The agreement includes upfront payments and equity investments from Eli Lilly, which will also take over preclinical research, clinical development, and commercialization of RNAi molecules discovered by SanegeneBio [1] - SanegeneBio is eligible for up to $1.2 billion in milestone payments related to discovery, development, regulatory, and commercialization, along with tiered royalties on future product sales [1] Group 1 - RNAi drugs are a new class of therapies that work by "silencing" messenger RNA molecules that encode disease-related proteins [1] - The collaboration will leverage SanegeneBio's proprietary LEAD™ platform to advance RNAi candidates targeting metabolic diseases [1] Group 2 - The LEAD™ (Ligand and Enhancer Assisted Delivery) platform is a tissue-selective delivery technology developed by SanegeneBio, enabling efficient and specific delivery of RNAi drugs to extrahepatic tissues and cells [2] - This platform has the potential to develop breakthrough therapies for metabolic diseases that require only biannual subcutaneous administration [2] - SanegeneBio will be responsible for screening and identifying optimal RNAi active molecules based on the LEAD™ platform, while Eli Lilly will handle subsequent IND application research, clinical development, and commercialization [2]

Core Viewpoint - Agna Biopharmaceuticals, a Chinese biotech company, is preparing for an IPO in Hong Kong, aiming to raise several hundred million dollars [1] Company Overview - Agna Biopharmaceuticals was established in 2021 and is headquartered in Guangzhou, Guangdong Province [1] - The company focuses on RNAi drugs and mRNA vaccines, leveraging the potential of RNA technology [1] - Agna has developed a diverse range of RNA combinations and efficient drug delivery systems targeting infectious diseases, metabolic diseases, cardiovascular diseases, malignant tumors, and rare diseases [1] Production Capacity - With support from local government, Agna Biopharmaceuticals has built an advanced production line capable of producing over 500 million doses of mRNA vaccines annually [1] IPO Details - The company is collaborating with several investment banks, including Bank of America, CICC, Jefferies, and JPMorgan, for its IPO [1] - Agna has submitted a confidential IPO application, with specific details regarding the scale and timing still under discussion [1]

Core Viewpoint - Agna Biopharmaceuticals, a Chinese biotech company, is planning an IPO in Hong Kong with potential fundraising of several hundred million dollars [1] Company Overview - Agna Biopharmaceuticals was established in 2021 and is headquartered in Guangzhou, Guangdong Province [1] - The company focuses on RNAi drugs and mRNA vaccines, leveraging the potential of RNA and its diverse RNA combinations along with efficient drug delivery systems [1] - Agna is developing RNA drugs and vaccines for infectious diseases, metabolic diseases, cardiovascular diseases, malignant tumors, and rare diseases [1] Production Capacity - With support from the local government, Agna has built an advanced production line capable of producing over 500 million doses of mRNA vaccines annually [1] IPO Details - The company is collaborating with major investment banks including Bank of America, CICC, Jefferies, and JPMorgan for its IPO [1] - Agna has submitted a confidential IPO application, with specific details regarding scale and timing still under discussion [1]