Summary of Wuxi Apptec Conference Call Company Overview - **Company**: Wuxi Apptec - **Industry**: Pharmaceutical R&D services - **Market Position**: Largest chemical drug contract research, development, and manufacturing organization (CRDMO) in China [12][13] Key Financial Highlights - **Q3 2025 Performance**: - Revenue: Rmb12.1 billion, up 15.3% YoY and 8.2% QoQ, exceeding estimates [2] - Net Profit: Rmb3.5 billion, up 53.3% YoY, also beating estimates [2] - Adjusted non-IFRS net profit: Rmb4.2 billion, up 42.0% YoY [2] - Adjusted non-IFRS gross margin: 44.5%, improved by 6.1 percentage points YoY [2] - Backlog for continuing operations: Rmb59.9 billion, a strong 41.2% YoY increase [2] Business Segment Performance - **Wuxi Chemistry**: - Revenue: Rmb9.7 billion, up 15.3% YoY and 8.6% QoQ - TIDES business revenue: Rmb2.8 billion, up 91.2% YoY, contributing 29% to Wuxi Chemistry revenue [3] - TIDES backlog: Increased by 17.1% YoY [3] - **Wuxi Testing**: - Revenue: Rmb1.5 billion, up 2.1% YoY and 6.1% QoQ - CRO/SMO segment revenue: Down 6.4% YoY [3] - **Wuxi Biology**: - Revenue: Rmb696 million, up 5.9% YoY [3] Geographic Performance - **US Market**: Key growth driver with revenue up 31.9% YoY to Rmb22.2 billion [3] - **Europe**: Revenue increased by 13.5% YoY to Rmb3.8 billion [3] - **China**: Returned to positive growth with revenue of Rmb5.0 billion, up 0.5% YoY [3] Future Guidance and Strategic Moves - **Revenue Guidance for 2025**: Raised from Rmb42.5-43.5 billion to Rmb43.5-44.0 billion [4] - **Continuing Revenue Growth Guidance**: Increased from 13%-17% to 17%-18% YoY [4] - **Divestiture**: Announced divestiture of clinical CRO/SMO business for Rmb2.8 billion, allowing focus on core CRDMO business [4] Valuation and Investment Outlook - **Price Target**: Increased to HK$138.4 from HK$136.1, rated as "Buy" [5] - **EPS Forecast Adjustments**: Increased by 23.4% for 2025, with slight adjustments for subsequent years [5][10] - **Market Capitalization**: Approximately HK$326 billion (US$42.0 billion) [7] Risks and Considerations - **Key Risks**: Include potential project delays, geopolitical uncertainties, and lower-than-expected R&D spending by pharmaceutical companies [13] - **Market Sentiment**: Positive outlook with expectations of improved global biopharma funding [15] Additional Insights - **Analyst Ratings**: 12-month rating of "Buy" with a forecast stock return of 27.1% [11][19] - **Market Performance**: Stock price as of October 24, 2025, was HK$110.50, within a 52-week range of HK$121.40-45.65 [7]

Core Insights - The company achieved a revenue of 32.86 billion yuan in Q1-Q3 2025, representing an 18.6% year-on-year increase, with a net profit attributable to shareholders of 12.076 billion yuan, up 84.84% [1] - The company has raised its full-year guidance, expecting a 17-18% growth in continuous operating revenue for 2025, up from the previous estimate of 13-17% [2] Financial Performance - Q3 revenue reached 12.06 billion yuan, a 15.3% increase year-on-year, with a net profit of 3.515 billion yuan, up 53.27% [1] - Adjusted net profit for Q3 was 4.22 billion yuan, reflecting a 42% increase [1] - The adjusted net profit margin improved by 1.7 percentage points to 32.1% [2] Business Segments - The chemical business generated 25.98 billion yuan in revenue for the first three quarters of 2025, a 29.3% increase, with a gross margin of 51.3% [2] - Small molecule D&M revenue was 14.24 billion yuan, up 14.1%, while TIDES revenue surged by 121.1% to 7.84 billion yuan [2] - The Testing business reported revenue of 4.17 billion yuan for Q1-Q3 2025, with a gross margin of 26.5% [3] - The biological segment generated 1.95 billion yuan in revenue, with a gross margin of 37% [3] Order Backlog and Growth Prospects - The company had an order backlog of 59.88 billion yuan as of Q3 2025, a 41.2% year-on-year increase [2] - The TIDES order backlog grew by 17.1% year-on-year, indicating strong short-term performance certainty [3] Profit Forecast - Revenue projections for 2025-2027 are 45.036 billion yuan, 52.98 billion yuan, and 61.18 billion yuan, with respective year-on-year growth rates of 14.77%, 17.64%, and 15.48% [4] - Net profit forecasts for the same period are 14.346 billion yuan, 16.033 billion yuan, and 19.093 billion yuan, with year-on-year growth rates of 51.8%, 11.76%, and 19.09% [4]

27 October 2025 | 10:57PM HKT Equity Research WuXi AppTec Co. (2359.HK): 3Q25 Earnings review: Order growth momentum supported by late-stage small molecule D&M Early stage During the results call, management provided further granularity on gross margin performance, new order momentum, and sector recovery. Consistent with our initial take, the company raised full-year revenue guidance and reiterated its target for TIDES revenue growth of 80% for the year. Management indicated that guidance for next year's re ...

Core Insights - The company reported strong financial performance for Q1-Q3 2025, with revenue of 32.86 billion yuan, a year-on-year increase of 18.6%, and a net profit of 12.08 billion yuan, reflecting a significant year-on-year growth of 84.8% [1] - The company has raised its revenue growth guidance for 2025 from 13-17% to 17-18%, driven by robust demand in core business areas and improved operational efficiency [2] - The company plans to divest its clinical research services business for 2.8 billion yuan, which is expected to help focus on core operations and accelerate global capacity expansion [2] Financial Performance - Revenue for Q1-Q3 2025 reached 32.86 billion yuan, with a 22.5% year-on-year increase in continuing operations revenue [1] - Adjusted non-IFRS net profit was 10.54 billion yuan, up 43.4% year-on-year, with a net profit margin of 32.1%, an increase of 5.6 percentage points year-on-year [1] - The company’s continuing operations backlog reached 59.88 billion yuan, a year-on-year increase of 41.2% [2] Business Segments - The small molecule CDMO and TIDES segments showed strong growth, with WuXi Chemistry generating 25.98 billion yuan in revenue, a year-on-year increase of 29.3% [2] - TIDES revenue surged by 121.1% year-on-year to 7.84 billion yuan, while D&M revenue increased by 14.1% year-on-year to 14.24 billion yuan [2] - The drug safety evaluation segment maintained industry leadership, with laboratory analysis and testing revenue of 1.08 billion yuan, reflecting a year-on-year increase of 2.7% [2] Profit Forecast and Valuation - The company has revised its earnings forecasts for 2025 and 2026 upwards by 6.0% and 2.8%, respectively, to 15.63 billion yuan and 14.82 billion yuan [3] - Current A-shares are valued at 19.8x and 20.9x PE for 2025 and 2026, while H-shares are valued at 19.3x and 20.1x PE for the same periods [3] - Target prices for A-shares and H-shares have been raised by 7.4% to 123.5 yuan and 7.1% to 135.0 yuan, respectively, indicating an upside potential of 19.0% and 22.2% [3]

Summary of WuXi AppTec Co. Earnings Call Company Overview - **Company**: WuXi AppTec Co. (2359.HK) - **Industry**: Biotechnology and Pharmaceutical Services Key Financial Highlights - **2Q25 Sales**: Rmb11.1 billion, representing a **20.4% year-over-year (y/y)** increase [1] - **Adjusted Net Profit (NP)**: Rmb6.3 billion, up **44.4% y/y** with an adjusted net margin (NM) of **30.4%** [1] - **Gross Margin**: Increased to **45.8%** from **41.6%** in 1Q25, driven by process improvements and cost management [1] - **Revenue Guidance for FY25**: Raised to **+13%-17% y/y** from **10%-15% y/y**, with full-year revenue expected to reach Rmb42.5-43.5 billion [2] Growth Drivers - **TIDES Revenue Growth**: Management raised TIDES revenue growth guidance to **>80% y/y** for FY25, indicating strong momentum in the second half of the year [8] - **New Orders**: Increased by **12% y/y** excluding foreign exchange (FX) effects, with a backlog for continuing operations growing **37.2% y/y** to Rmb56.69 billion [5] - **Pipeline Opportunities**: Focus on complex oral small molecule GLP-1 programs and other indications such as PCSK9 and autoimmune diseases [6] Regional Performance - **US Market Growth**: Notably outperformed other regions with a **48% y/y** increase, while China saw a **9% y/y** decline and Europe a **7% y/y** decline [1] Operational Insights - **Capacity Utilization**: Full utilization of 1H capacity, with growth in 2H contingent on new capacity validation [5] - **Early-Stage Services**: Recovery remains slow due to biotech funding constraints, but demand for high-quality programs is resilient [8] Capital Expenditure and Shareholder Returns - **Capex**: 2Q25 capex was Rmb1.37 billion, with full-year guidance maintained at Rmb7-8 billion [8] - **Shareholder Returns**: Over Rmb1 billion in A-share repurchase completed in 1H25, with additional Rmb1 billion planned [8] Risks and Valuation - **Valuation**: Target price raised to HK$96.90 from HK$85.50, based on a forward P/E of 17x [11] - **Key Risks**: Include potential legislative impacts from the US Biosecure Act, pricing pressures, and regulatory risks [11] Additional Insights - **Management's Conservative Approach**: Despite raising guidance, management remains cautious due to ongoing policy uncertainties [2] - **Focus on High-Quality Clients**: The company is prioritizing differentiated capabilities and high-quality clients to navigate market challenges [8] This summary encapsulates the key points from the earnings call, highlighting the company's performance, growth strategies, and market outlook.

Group 1 - The core viewpoint of the report highlights the impressive year-on-year growth in revenue and profit for WuXi AppTec in Q2 [2] - The revenue growth of small molecule drug development (DM) exceeded expectations, while TIDES continued to show strong growth [2] - The laboratory business remained stable, although competition in the clinical CRO market continues to be a factor that needs to be addressed [2]

Core Viewpoint - WuXi AppTec reported strong financial results for 1H25, exceeding expectations, with significant revenue and profit growth, prompting an upward revision of full-year guidance for 2025 [1][2]. Financial Performance - Revenue increased by 20.6% YoY, with continuing operations growing by 24.2% YoY [1] - Adjusted non-IFRS net profit surged by 44.4% YoY [1] - Revenue from continuing operations and adjusted non-IFRS net profit accounted for 47.5% and 54.4% of full-year forecasts, respectively, both higher than historical ranges [1] Operational Highlights - Management raised full-year guidance for 2025, expecting revenue growth for continuing operations to be between 13-17%, up from the previous 10-15% [2] - The demand for late-stage clinical and commercial manufacturing has been a key growth driver for the global CXO industry post-COVID [2] - TIDES revenue surged by 141.6% YoY due to faster-than-expected manufacturing capacity ramp-up [2] - Revenue from small molecule D&M grew by 17.5% YoY, indicating a recovery from previous negative growth [2] Capacity Expansion - WuXi AppTec's backlog grew by 37.2% YoY, with TIDES backlog increasing by 48.8% YoY [3] - Plans to increase peptide capacity to over 100k liters by the end of 2025 to meet demand [3] - Ongoing capacity expansion at multiple sites, including locations in China, Singapore, the US, and Switzerland [3] - Capex target reaffirmed at RMB7-8 billion for 2025, with potential increases anticipated in the coming years [3] Early-stage R&D Insights - Revenue from early-stage R&D services showed sequential improvements but a meaningful recovery is expected to take time [4] - Early-stage R&D services contribute approximately 30% of the company's total revenue [4] Investment Outlook - Target price raised from RMB77.22 to RMB116.56 based on upgraded guidance and improved macro environment [5] - Expected revenue growth from continuing operations of 16.0%/15.9%/15.8% YoY and adjusted non-IFRS net profit growth of 16.2%/17.6%/16.4% YoY for 2025E/26E/27E, respectively [5]

Core Viewpoint - WuXi AppTec reported a significant increase in net profit for the first half of the year, indicating strong business growth and a solid order backlog [1] Financial Performance - The company achieved a net profit attributable to shareholders of 8.561 billion yuan, representing a year-over-year increase of 101.92% [1] - In Q2 2025, the net profit reached 4.89 billion yuan, with a year-over-year growth of 112.78%, exceeding market expectations [1] Order Backlog - As of June 30, 2025, the company's order backlog stood at 56.69 billion yuan, reflecting a year-over-year increase of 37.2%, showcasing robust business development [1] Capacity Expansion - The company is actively expanding its production capacity, with projections indicating that by the end of 2025, the total volume of small molecule API reaction vessels will exceed 4 million liters, and the total volume of peptide solid-phase synthesis reaction vessels will increase to over 100,000 liters [1] Market Position - WuXi AppTec is recognized as a leading one-stop CXO service provider, maintaining stable performance [1] Profit Forecast - Due to rapid growth in TIDES-related performance and capacity, improved gross margins, and one-time gains from the sale of WuXi XDC shares, the net profit forecasts for 2025-2027 have been raised to 15.14 billion, 15.54 billion, and 18.02 billion yuan, respectively, with increases of 37.9%, 24.1%, and 27.3% [1] Valuation Metrics - The corresponding price-to-earnings (PE) ratios for A-shares for 2025-2027 are projected to be 19, 18, and 16 times, while for H-shares, they are expected to be 19, 19, and 16 times [1] - The company maintains a "Buy" rating [1]

Core Viewpoint - The company reported strong financial results for 1H2025, with revenue and profit growth exceeding expectations, leading to an upward revision of the annual performance guidance [1] Financial Performance - 1H2025 revenue reached 20.799 billion yuan, a year-on-year increase of 20.64%, with continuous operations revenue at 20.405 billion yuan, up 24.24% [1] - The net profit attributable to the parent company, excluding non-recurring items, was 5.582 billion yuan, reflecting a growth of 26.47%, while the adjusted net profit was 6.315 billion yuan, up 44.43% [1] - In Q2 alone, revenue was 11.145 billion yuan, a 20.37% increase year-on-year, with adjusted net profit rising to 3.637 billion yuan, a significant increase of 47.90% [1] Business Segments - The chemical segment generated 16.3 billion yuan in 1H2025, a 33.5% increase, driven by strong growth in TIDES and small molecule D&M revenues [2] - TIDES revenue reached 5.03 billion yuan, up 141.6%, with small molecule D&M revenue at 8.68 billion yuan, increasing by 17.5% [2] - The Testing segment reported 2.69 billion yuan in revenue for 1H2025, a slight decline of 1.2%, but showed signs of recovery in Q2 with a 1.6% year-on-year increase [2] - The Biology segment achieved 1.25 billion yuan in revenue, a 7.5% increase, with expectations for accelerated growth as new molecular development demands rise [3] Profitability and Efficiency - The adjusted gross margin for 1H2025 was 44.5%, an increase of 4.7 percentage points [3] - The gross margins for the chemical, Testing, and Biology segments were 49%, 25.1%, and 36.4%, respectively, with the chemical segment benefiting from increased commercial projects [3] Future Outlook - The company has raised its full-year revenue guidance, expecting 2025 revenue to reach between 42.5 billion and 43.5 billion yuan, representing a growth of 13% to 17% [1] - Revenue projections for 2025-2027 are estimated at 43.771 billion, 50.810 billion, and 59.066 billion yuan, with corresponding year-on-year growth rates of 11.54%, 16.08%, and 16.25% [3]