2025 年 8 月 28 日，哥本哈根大学的研究人员在 Cell 子刊 Cell Metabolism 上发表了题为： Effect of ultra-processed food consumption on male reproductive and metabolic health 的研究论文。 撰文丨王聪 编辑丨王多鱼 排版丨水成文 全球范围内， 超加工食品 （ Ultra-processed food， UPF） 的消费量显著上升，超加工食品被定义为经过工业加工且由高度转化、衍生或合成成分组成的食 品，其含有与不良代谢健康相关的宏量营养素和微量营养素，包括饱和脂肪、精制碳水化合物和高能量配方。此外，超加工食品被怀疑含有诸如 增塑剂 （ 邻苯 二甲酸酯 ） 之类的污染物，可能是在加工或包装过程中渗入。食用超加工食品后， 尿液中的邻苯二甲酸 酯 水平会升高，并可能通过干扰内分泌激素而损害 代 谢 和 生殖功能 。 越来越多的横断面研究和前瞻性研究发现，超加工食品 （UPF） 摄入量增加与慢性疾病风险升高有关，这些慢性疾病包括心血管疾病、代谢疾病、某些癌症以及 精神健康障碍。尽管许多研究已表明超加工食品 ...

Core Viewpoint - The article highlights the significant health risks associated with the consumption of ultra-processed foods (UPF), linking it to obesity, cardiovascular diseases, and increased mortality rates. It emphasizes the need for dietary guidelines to recommend a reduction in UPF intake due to its adverse health effects [2][3][12]. Group 1: Research Findings - A recent study published in Nature Medicine indicates that consuming UPF can hinder weight loss efforts, even when adhering to national dietary guidelines. In contrast, a diet based on minimally processed foods (MPF) may facilitate weight loss [3][6]. - The study involved 55 adults following UK dietary guidelines, where participants consumed UPF for 8 weeks and MPF for another 8 weeks. Results showed an average weight loss of 0.88 kg during the UPF phase compared to 1.84 kg during the MPF phase [11][12]. - The research found that while both diets led to weight loss, the MPF diet resulted in significant improvements in cardiovascular health indicators, such as total fat, body fat percentage, visceral fat, and triglycerides, which were not observed during the UPF diet [11][12]. Group 2: Implications of Food Processing - The study suggests that the degree of food processing affects weight management and cardiometabolic health, indicating that even healthy dietary guidelines may not mitigate the negative impacts of UPF [12][14]. - The mechanisms behind the weight changes between UPF and MPF diets remain unclear, but factors such as texture, structure, and the presence of additives in UPF may lead to increased calorie intake and delayed satiety [14]. - The research underscores the importance of considering food processing as a unique dimension of dietary quality, suggesting that policies focusing solely on reformulating processed foods to meet nutritional standards may overlook the behavioral and physiological impacts of food processing methods [14][15].