2025 年 8 月 28 日，哥本哈根大学的研究人员在 Cell 子刊 Cell Metabolism 上发表了题为： Effect of ultra-processed food consumption on male reproductive and metabolic health 的研究论文。 撰文丨王聪 编辑丨王多鱼 排版丨水成文 全球范围内， 超加工食品 （ Ultra-processed food， UPF） 的消费量显著上升，超加工食品被定义为经过工业加工且由高度转化、衍生或合成成分组成的食 品，其含有与不良代谢健康相关的宏量营养素和微量营养素，包括饱和脂肪、精制碳水化合物和高能量配方。此外，超加工食品被怀疑含有诸如 增塑剂 （ 邻苯 二甲酸酯 ） 之类的污染物，可能是在加工或包装过程中渗入。食用超加工食品后， 尿液中的邻苯二甲酸 酯 水平会升高，并可能通过干扰内分泌激素而损害 代 谢 和 生殖功能 。 越来越多的横断面研究和前瞻性研究发现，超加工食品 （UPF） 摄入量增加与慢性疾病风险升高有关，这些慢性疾病包括心血管疾病、代谢疾病、某些癌症以及 精神健康障碍。尽管许多研究已表明超加工食品 ...

Core Viewpoint - The excessive consumption of sugar-sweetened beverages (SSBs) is leading to a significant increase in chronic diseases globally, including diabetes and cardiovascular diseases, with alarming trends observed particularly in China [5][8][11]. Group 1: Global Impact of Sugar-Sweetened Beverages - A study published in *Nature Medicine* analyzed health data from 118 countries and found that in 2020, SSBs were responsible for 220,000 new cases of type 2 diabetes (T2D), accounting for 9.8% of global new cases, and 120,000 new cases of cardiovascular diseases (CVD), representing 3.1% [8][9]. - The research also indicated that SSBs were linked to approximately 340,000 deaths globally, with T2D-related deaths at 80,278 and CVD-related deaths at 257,962 [8][9]. Group 2: The Situation in China - A study by the Chinese Center for Disease Control and Prevention revealed that from 1990 to 2019, deaths related to SSB consumption in China surged by 95%, rising from a low base to 46,633 deaths in 2019 [11]. - The proportion of deaths attributable to SSBs increased from 0.34% to 0.46%, indicating that nearly 1 in every 200 deaths is directly related to these beverages [11]. - Ischemic heart disease (IHD) and diabetes were identified as the two leading causes of death linked to SSBs, with IHD-related deaths reaching 42,098 in 2019, reflecting a 95% increase over 30 years [12]. Group 3: Health Risks Associated with SSBs - A long-term study published in *The American Journal of Clinical Nutrition* found that daily consumption of over 500ml of SSBs increases the risk of asthma by 19% and chronic obstructive pulmonary disease (COPD) risk by 53% [13][14]. - The study also highlighted that artificially sweetened beverages (ASBs) pose even greater risks, with a 34% increase in COPD risk and a 10% increase in asthma risk for those consuming two cups daily [13][14].