Liquidia R&D Day Webcast presentation October 28, 2025 ©2025 LIQUIDIA CORPORATION ALL RIGHTS RESERVED Forward-looking statements This presentation includes, and our response to questions may include, forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 ("PSLRA"). All statements contained in this presentation other than statements of historical facts, including statements regarding our future results of operations and financial position, our strategic and fina ...

Performance Overview - Arquitos achieved a net return of 29.6% in Q2 2025, with a year-to-date return of 66.8% [3] - The fund's performance is evaluated on an absolute basis rather than relative to market indices [4][5] - The S&P 500 has returned 14.4% annually since the fund's inception, while small caps, represented by the Russell 2000, have returned 10.0% annually [7] Benchmarking Strategy - The Russell 2000 Small Cap Index will be used as the primary benchmark for Arquitos, reflecting the focus on smaller companies [9] - The fund's strategy involves holding investments for extended periods, allowing for business evolution and market recognition [10] Key Holdings Liquidia Corporation (LQDA) - Liquidia's share price increased from $11.76 to $22.74 in 2025, primarily through long-dated call options [10] - The FDA approved Liquidia's product Yutrepia in May 2025, which has shown strong initial demand with over 900 prescriptions in the first 11 weeks [11][12] - The share price may be affected by the upcoming ruling in the '327 patent dispute, with expectations of a favorable outcome [14] ENDI Corp (OTCQB:ENDI) - ENDI's share price rose from $11.43 to $17.50, with assets under management increasing to $4.2 billion [18][19] - The company holds approximately $53 million in cash and investments, with a market capitalization of about $95 million [20] Finch Therapeutics (OTCPK:FNCH) - Finch's share price increased from $11.30 to $12.28, following a jury trial win against Ferring Pharmaceuticals [21][22] - The potential for enhanced damages from the trial verdict could significantly increase Finch's share value [23] Investment Philosophy - The investment strategy emphasizes patience and long-term value, with a focus on total return over the holding period [24][25] - The fund's performance has been strong in 2025, with expectations for continued undervaluation in core holdings [25]

Key Takeaways United Therapeutics' TETON-2 study showed Tyvaso improved lung function in IPF patients.Benefits were consistent across subgroups, with safety aligning with prior Tyvaso studies.UTHR plans FDA talks this year, with TETON-1 study results expected in early 2026.United Therapeutics (UTHR) remains poised to expand Tyvaso’s label in the respiratory disease space. It recently unveiled results from the late-stage TETON-2 study, which showed clinical benefit in idiopathic pulmonary fibrosis (IPF) pati ...

Arquitos Capital Management, an investment management firm, released its second-quarter 2025 investor letter. During the period, the fund delivered a net return of 13.1%, bringing year-to-date gains to an impressive 28.8% as of June 30, 2025. The firm highlighted that individual investor returns may differ depending on the timing of capital inflows, and encouraged clients to review their statements for personalized results. In addition, you can check the fund’s top 5 holdings to find out its best picks for ...

Core Insights - United Therapeutics (UTHR) shares increased by 33% following the announcement of positive results from the late-stage TETON-2 study for nebulized Tyvaso in idiopathic pulmonary fibrosis (IPF) patients [1][9] - The study demonstrated that Tyvaso outperformed placebo in improving lung function, as measured by forced vital capacity (FVC), with a change of 95.6 mL after 52 weeks [2][9] - The safety profile of Tyvaso remained consistent with previous studies, and benefits were observed across various patient subgroups [3] Study Details - The TETON-2 study met its primary endpoint and several key secondary endpoints, including time to first clinical worsening event and changes in lung diffusion capacity [2][3] - United Therapeutics is also conducting the TETON-1 study, with results expected in the first half of 2026, and plans to meet with the FDA to expedite regulatory review [5][6] Market Potential - Approximately 100,000 IPF patients are estimated to be in the United States, indicating a significant market opportunity for Tyvaso, which could exceed its current sales in pulmonary arterial hypertension (PAH) indications [8] - Year-to-date, UTHR shares have risen 15%, outperforming the industry growth of 12% [8] Financial Performance - In Q2 2025, United Therapeutics generated nearly $470 million from Tyvaso sales, reflecting an 18% year-over-year increase driven by patient demand [11] Industry Impact - Following UTHR's positive results, shares of other treprostinil manufacturers, Insmed (INSM) and Liquidia Corporation (LQDA), also saw increases of 7% and 3%, respectively [12] - Insmed is developing a prodrug of treprostinil, which may offer advantages in dosing frequency compared to Tyvaso [13] - Liquidia has received FDA approval for its inhaled treprostinil product, Yutrepia, marking a new competitor in the market [15]

Financial Performance - Liquidia Corporation reported a second-quarter loss of $0.49, missing the consensus estimate of a loss of $0.43 [1] - Sales reached $8.84 million, significantly exceeding the consensus of $3.86 million [1] - The net product revenue for the three months ending June 30, 2025, was $6.5 million, following the full FDA approval for Yutrepia on May 23, 2025 [1] Product Development and Clinical Trials - The company analyzed interim data from the ASCENT study, which enrolled 54 patients with pulmonary hypertension associated with interstitial lung disease (PH-ILD) [3] - The tolerability profile of Yutrepia in PH-ILD was consistent with initial observations, with 18.5% of patients discontinuing the study, none due to drug-related adverse events [4] - The median improvements in six-minute walk distance were 21.5 meters at week 8 and 31.5 meters at week 16, indicating positive efficacy [5] Market Reaction - LQDA stock increased by 14.13%, reaching $24.20 at the time of publication [6]