NatWest Group (NYSE:NWG) Q4 2025 Earnings call February 13, 2026 04:00 AM ET Speaker9Good morning, and welcome to NatWest Group's full year 2025 results management presentation. Today's presentation will be presented by CEO, Paul Thwaite, and CFO, Katie Murray. After the presentation, we will take questions.Speaker11Good morning, and thank you for joining us today. As usual, I'm here with Katie, who will take you through the full year performance. After that, I'll talk about our strategy and our new 2028 ta ...

Financial Data and Key Metrics Changes - In 2025, total revenue reached $7.2 billion, a 9% year-over-year increase [14] - Subscription and services revenue hit $2.8 billion, up 23% year-over-year, and more than 5.5 times higher than the peak in 2021 [14][16] - Q4 total revenue was $1.8 billion, down 5% quarter-over-quarter [17] - Q4 transaction revenue was $983 million, down 6% quarter-over-quarter, while subscription and services revenue was $727 million, down 3% quarter-over-quarter [18] - Adjusted EBITDA in Q4 was $566 million, and adjusted net income was $178 million [19] - The company ended the year with $11.3 billion in cash and cash equivalents, and total available resources of approximately $14.1 billion [20] Business Line Data and Key Metrics Changes - The company has 12 products generating over $100 million in annualized revenue, with half of those exceeding $250 million [17] - Subscription and services revenue reached all-time highs, up 5.5 times from the peak in 2021 [16] - Derivatives volume and revenue hit all-time highs in Q4, indicating strong growth in this segment [9] Market Data and Key Metrics Changes - Global trading volume and market share doubled year-over-year, reaching new all-time highs [3] - The crypto market cap was down 11% quarter-over-quarter, but the company outperformed the market on total trading volume [16] Company Strategy and Development Direction - The company aims to grow the Everything Exchange, which integrates various asset classes including crypto, equities, and commodities [8] - Focus on scaling stablecoins and payments, with USDC reaching an all-time high market cap of about $75 billion [10] - The strategy includes bringing the world on-chain, emphasizing DeFi and self-custodial wallets [12] - The company plans to continue investing in its product offerings and expanding its market presence internationally [4][10] Management's Comments on Operating Environment and Future Outlook - Management remains optimistic about regulatory clarity and the growth of crypto adoption [3] - The company is prepared for market volatility and has diversified its revenue streams [16] - Management believes that stablecoins will become the default payment method for AI agents [11] - The company is confident in its ability to drive growth through its diversified revenue base and strong balance sheet [23] Other Important Information - The company has repurchased $1.7 billion of its common stock to offset dilution from stock-based compensation [20] - The company is exploring a Base token and improving developer tools to incentivize builders on the Base platform [28] Q&A Session Summary Question: Are you making any headway on positive outcomes regarding the CLARITY Act? - Management is optimistic about progress on the CLARITY Act and believes there is a good path to a positive outcome [24] Question: What percentage of overall subscription and services revenue do you expect Layer 2 activity from Base to contribute in 2026? - Base revenue is monetized both directly and indirectly, but no specific forecast was provided [26] Question: What product or platform initiative are you most excited about that investors may be underestimating today? - Management highlighted the Everything Exchange and stablecoin payments as key initiatives with significant growth potential [29] Question: Could your economic relationship with Circle change depending upon language in a market structure bill? - Management does not foresee any changes to the economic relationship with Circle due to the market structure legislation [34] Question: How does Coinbase think about the opportunities in larger scale buybacks and M&A? - The company is focused on buybacks and opportunistic M&A, having completed 10 acquisitions in 2025 [37] Question: Can you talk about your 2026 spending plans? - The company plans to maintain flat expenses in Q1 2026 while being nimble in response to market conditions [44] Question: Was the Coinbase issue just a tech mishap and not a more severe issue? - A technical issue caused brief interruptions for some users, but trading remained unaffected [48] Question: How should we think about the strength of the casual crypto trader in this winter? - Retail consumers tend to hold through price declines and are currently net buyers [67]

Financial Data and Key Metrics Changes - In 2025, total revenue reached $7.2 billion, a 9% year-over-year increase [14] - Subscription and services revenue hit $2.8 billion, up 23% year-over-year, and more than 5.5 times higher than the peak in 2021 [14][16] - Q4 total revenue was $1.8 billion, down 5% quarter-over-quarter [17] - Q4 transaction revenue was $983 million, down 6% quarter-over-quarter, while subscription and services revenue was $727 million, down 3% quarter-over-quarter [18] - Adjusted EBITDA in Q4 was $566 million, and adjusted net income was $178 million [19] - The company ended the year with $11.3 billion in cash and cash equivalents, and total available resources of approximately $14.1 billion [20] Business Line Data and Key Metrics Changes - The company has 12 products generating over $100 million in annualized revenue, with half of those exceeding $250 million [17] - Subscription and services revenue reached all-time highs, up 5.5 times from the peak in 2021 [6] - Derivatives volume and revenue hit all-time highs in Q4, indicating strong growth in this segment [9] Market Data and Key Metrics Changes - Global trading volume and market share doubled year-over-year, reaching new all-time highs [3] - The crypto market cap was down 11% quarter-over-quarter, but the company outperformed the market on total trading volume [16] Company Strategy and Development Direction - The company aims to grow the Everything Exchange, which integrates various asset classes including crypto, equities, and commodities [8] - Focus on scaling stablecoins and payments, with USDC reaching an all-time high market cap of about $75 billion [10] - The strategy includes bringing the world on-chain, emphasizing DeFi and self-custodial wallets [12] - The company is positioned to capitalize on the transformation of financial services through crypto [4] Management's Comments on Operating Environment and Future Outlook - Management remains optimistic about regulatory clarity and the growth of crypto adoption [3] - The company is prepared for market volatility and has diversified its revenue streams [16] - Management believes that stablecoins will become the default payment method for AI agents [11] Other Important Information - The company has repurchased $1.7 billion of its common stock to offset dilution from stock-based compensation [20] - The company is exploring a Base token and improving developer tools to incentivize builders [28] Q&A Session Summary Question: Are you making any headway on positive outcomes regarding the CLARITY Act? - Management is optimistic about progress on the CLARITY Act and appreciates the efforts of the Senate and administration [24][25] Question: What percentage of overall subscription and services revenue do you expect Layer 2 activity from Base to contribute in 2026? - Base revenue is monetized both directly and indirectly, but no specific forecast was provided [26] Question: What product or platform initiative are you most excited about that investors may be underestimating today? - Management highlighted the Everything Exchange and stablecoin payments as key initiatives [29][30] Question: Could your economic relationship with Circle change depending upon language in a market structure bill? - Management does not foresee changes in the economic relationship with Circle due to the market structure legislation [34][35] Question: How does Coinbase think about the opportunities in larger scale buybacks and M&A? - The company is focused on buybacks and opportunistic M&A, having completed 10 acquisitions in 2025 [37][38] Question: What have you seen in terms of prediction market adoption to date among Coinbase customers? - Prediction markets were recently rolled out to all customers, and initial interest has been positive [39][40] Question: Do you think we're heading into another crypto winter? - Management does not predict the future but emphasizes the importance of building great products regardless of market conditions [41][42] Question: Can you talk about your 2026 spending plans? - The company plans to be prudent with spending, focusing on flat expenses in Q1 2026 [44][45] Question: Was the Coinbase issue just a tech mishap and not a more severe issue? - A technical issue caused brief interruptions for some users, but it was unrelated to trading volume or market conditions [46][48] Question: How do you work with Circle and USDC on real-world volume commercialization? - The company is focused on driving payments verticals and creating a strong go-to-market strategy for USDC [66]

Financial Data and Key Metrics Changes - Total revenue for 2025 was $7.2 billion, a 9% year-over-year increase [15] - Subscription and services revenue reached $2.8 billion, up 23% year-over-year, and more than 5.5 times higher than the peak in 2021 [15][19] - Q4 total revenue was $1.8 billion, down 5% quarter-over-quarter [18] - Q4 transaction revenue was $983 million, down 6% quarter-over-quarter, while subscription and services revenue was $727 million, down 3% quarter-over-quarter [19] - Adjusted EBITDA in Q4 was $566 million, and adjusted net income was $178 million [20] Business Line Data and Key Metrics Changes - The company has 12 products generating over $100 million in annualized revenue, with half of those exceeding $250 million [15][18] - Subscription and services revenue hit all-time highs, up 5.5 times from the peak in 2021 [7] - Derivatives volume and revenue reached all-time highs in Q4 [10] Market Data and Key Metrics Changes - Global trading volume and market share doubled year-over-year, reaching new all-time highs [4] - The crypto market cap was down 11% quarter-over-quarter [16] - USDC market cap reached an all-time high of about $75 billion [11] Company Strategy and Development Direction - The company aims to grow the Everything Exchange, which integrates various asset classes including crypto, equities, and commodities [8][10] - Focus on scaling stablecoins and payments, with plans to expand stablecoin utility and payment infrastructure [11][12] - Emphasis on bringing the world on-chain, promoting decentralized technology and self-custodial wallets [13] Management's Comments on Operating Environment and Future Outlook - Management remains optimistic about regulatory clarity and the growth of crypto adoption [4][25] - The company is prepared for market volatility and has diversified its revenue streams [17][23] - Management believes that stablecoins will become the default payment method for AI agents [12] Other Important Information - The company ended the year with $11.3 billion in cash and cash equivalents, and total available resources of approximately $14.1 billion [21] - The company has repurchased $1.7 billion of its common stock to offset dilution from stock-based compensation [21] Q&A Session Summary Question: Are you making any headway on positive outcomes regarding the CLARITY Act? - Management is optimistic about progress on the CLARITY Act and appreciates the efforts of the Senate and administration [24][25] Question: What percentage of overall subscription and services revenue do you expect Layer 2 activity from Base and partners to contribute in 2026? - Base revenue is monetized both directly and indirectly, but no specific forecast was provided [27] Question: What product or platform initiative are you most excited about that investors may be underestimating today? - Management highlighted the Everything Exchange and stablecoin payments as key initiatives [30][32] Question: Could your economic relationship with Circle change depending upon language in a market structure bill? - Management does not foresee changes in the economic relationship with Circle due to market structure legislation [36] Question: How does Coinbase think about the opportunities in larger scale buybacks and M&A? - The company is focused on buybacks and opportunistic M&A, having completed 10 acquisitions in 2025 [39] Question: Can you talk about your 2026 spending plans? - The company plans to maintain flat expenses in Q1 2026 while being nimble in response to market conditions [47] Question: Was the Coinbase issue just a tech mishap and not a more severe issue? - A technical issue caused brief interruptions for some users, but it was unrelated to trading volume or market conditions [49] Question: How should we think about the strength of the casual crypto trader in this winter? - Retail consumers tend to hold through price declines and are currently net buyers [68]

Financial Data and Key Metrics Changes - Consolidated revenue for Q4 2025 was $98.7 million, up 6% year-over-year, with all three segments contributing [9] - Q4 gross profit was $24.1 million, up 14% year-over-year, supported by a favorable mix [9] - Adjusted EBITDA for Q4 was $11.1 million, down 14% year-over-year, while total consolidated adjusted EBITDA for fiscal 2025 was $50.6 million, which was $3.6 million above guidance and represented a 45% increase from fiscal 2024 [10][11] Business Segment Data and Key Metrics Changes - Tucows Domains reported Q4 revenue of $66.4 million, a modest increase from $65.7 million, with gross profit rising 4% to $19.2 million [12] - Wavelo achieved Q4 revenue of $11.7 million, a 19% increase year-over-year, with gross profit up 7% to $6.6 million [14] - Ting Internet's Q4 revenue was $18.5 million, up 18% year-over-year, with gross profit improving to $1.6 million from a loss of $1.2 million in Q4 2024 [14] Market Data and Key Metrics Changes - Domains under management and transactions are normalizing at a modestly lower level due to a customer taking their business in-house, but margins remain healthy due to a diverse reseller base [5] - Wavelo's performance was driven by renewing its inaugural customer and aligning incentives, indicating a strong market position [6] Company Strategy and Development Direction - The company aims to transition into a capital-light business with a lean operating model, focusing on recurring revenue and strong customer retention [22][24] - The strategy includes leveraging technical expertise and operational capabilities to build technology services that benefit from shared infrastructure [23] Management's Comments on Operating Environment and Future Outlook - Management acknowledged the complexity of the current operating environment but expressed confidence in the company's ability to execute and innovate [4] - The outlook for fiscal 2026 includes an Adjusted EBITDA range of $47 million-$49 million for Tucows Domains and $14.5 million-$15.5 million for Wavelo, with corporate expectations of -$6 million to -$9 million [18][19] Other Important Information - The company ended the quarter with cash and restricted cash of $64.2 million, down from $73.2 million in Q4 of the previous year [16] - Corporate net debt, excluding Ting, was $189.5 million, with compliance maintained under the TCX syndicated facility [16] Q&A Session Summary - There was no live Q&A session; however, shareholders and analysts were invited to submit questions via email, with responses to be posted on the company's website [2][27]

Financial Data and Key Metrics Changes - Consolidated revenue for Q4 2025 was $98.7 million, up 6% year-over-year, with all three segments contributing [9] - Q4 gross profit was $24.1 million, up 14% year-over-year, supported by a favorable mix [9] - Adjusted EBITDA for Q4 was $11.1 million, down 14% year-over-year, while total consolidated adjusted EBITDA for fiscal 2025 was $50.6 million, which was $3.6 million above guidance and represented a 45% increase from fiscal 2024 [10][11] Business Segment Data and Key Metrics Changes - Tucows Domains revenue grew to $66.4 million in Q4 2025 from $65.7 million in Q4 2024, with a 4% increase in gross profit to $19.2 million [12] - Wavelo's Q4 revenue was $11.7 million, a 19% increase year-over-year, with adjusted EBITDA of $3.4 million [14] - Ting Internet's Q4 revenue was $18.5 million, up 18% year-over-year, with an adjusted EBITDA loss of $0.9 million, an improvement from a $1.5 million loss in Q4 2024 [15] Market Data and Key Metrics Changes - Domains under management and transactions are normalizing at a modestly lower level due to a customer taking their business in-house, but margins remain healthy [5] - Wavelo's performance was driven by renewing its inaugural customer and aligning incentives, indicating a strong market position [6] Company Strategy and Development Direction - The company aims to transition into a capital-light business with a lean operating model, focusing on recurring revenue and strong customer retention [22][24] - The strategy includes leveraging technical expertise and operational capabilities to build technology services that benefit from shared infrastructure [23] Management's Comments on Operating Environment and Future Outlook - Management acknowledged the complexity of the current operating environment but expressed confidence in the company's ability to execute and innovate [4] - The outlook for fiscal 2026 includes an adjusted EBITDA range of $47 million-$49 million for Tucows Domains and $14.5 million-$15.5 million for Wavelo, with corporate adjusted EBITDA expected to be between -$6 million and -$9 million [18][19] Other Important Information - The company ended the quarter with cash and restricted cash of $64.2 million, down from $73.2 million in Q4 of the previous year [16] - Corporate net debt, excluding Ting, was $189.5 million, with compliance maintained under the TCX syndicated facility [16] Q&A Session Summary - There was no live Q&A session; however, shareholders and analysts were invited to submit questions via email, with responses to be posted on the company's website [2][27]

Financial Data and Key Metrics Changes - Consolidated revenue for Q4 2025 was $98.7 million, up 6% year-over-year, with all three segments contributing [10] - Q4 gross profit was $24.1 million, up 14% year-over-year, supported by a favorable mix [10] - Adjusted EBITDA for Q4 was $11.1 million, down 14% year-over-year, while total consolidated adjusted EBITDA for fiscal 2025 was $50.6 million, which was $3.6 million above guidance and represents a 45% increase from fiscal 2024 [11][12] Business Segment Data and Key Metrics Changes - Tucows Domains revenue grew to $66.4 million in Q4 2025 from $65.7 million, with a 4% increase in gross profit to $19.2 million [13] - Wavelo's Q4 revenue was $11.7 million, a 19% increase year-over-year, with adjusted EBITDA of $3.4 million [14][16] - Ting Internet reported Q4 revenue of $18.5 million, up 18% year-over-year, with an adjusted EBITDA loss of $0.9 million, an improvement from a $1.5 million loss in Q4 2024 [16] Market Data and Key Metrics Changes - Domains under management and transactions are normalizing at a modestly lower level due to a customer taking their business in-house [5] - The wholesale channel revenue rose 2% year-over-year to $57 million, supported by strong growth in value-added services [13] Company Strategy and Development Direction - The company aims to transition into a capital-light business with a lean operating model, focusing on recurring revenue and strong customer retention [24][25] - The leadership approach emphasizes customer-centric execution, operational excellence, and financial rigor in decision-making [22][23] Management's Comments on Operating Environment and Future Outlook - Management acknowledged the complexity of the current operating environment and expressed confidence in the company's ability to navigate changes [4] - The outlook for fiscal 2026 includes an adjusted EBITDA range of $47 million-$49 million for Tucows Domains and $14.5 million-$15.5 million for Wavelo, with corporate adjusted EBITDA expected to be between -$6 million and -$9 million [20][21] Other Important Information - The company ended the quarter with cash and restricted cash of $64.2 million, down from $73.2 million in Q4 of last year [18] - Corporate net debt, excluding Ting, was $189.5 million, with compliance maintained under the TCX syndicated facility [18] Q&A Session Summary - There was no live Q&A session; however, shareholders and analysts were invited to submit questions via email, with responses to be posted on the company's website [2][28]

Financial Data and Key Metrics Changes - Total revenue in Q4 was $349 million, up 15.6% year-over-year, with full-year revenue growth of 15% [24][8] - Q4 non-GAAP operating income was $52 million, representing a non-GAAP operating margin of 15%, with a full-year non-GAAP operating margin of 14%, reflecting a year-over-year expansion of 400 basis points [24][8] - Free cash flow for Q4 was $90 million, bringing full-year free cash flow to $215 million, representing 69% year-over-year growth and a 16% free cash flow margin [29][30] Business Line Data and Key Metrics Changes - The U.S. general contractors segment remains a cornerstone of growth, with three new ENR 400 logos added in Q4 and over 70 ENR 400 customers expanding their run rate [8][9] - Procore Pay saw strong momentum, ending the year with nearly 450 customers, representing over 70% year-over-year growth [26] - The total number of $100,000+ ARR customers now exceeds 2,700, with 115 customers spending more than $1 million in ARR, reflecting 34% year-over-year growth [26][27] Market Data and Key Metrics Changes - International revenue grew 14% year-over-year in Q4, impacted by currency headwinds, but grew 15% on a constant currency basis [24] - The owners segment continues to scale, with plans to launch specialized products for portfolio management, planning, funding, and asset management [12] - Data centers currently represent 2% of total U.S. construction activity, with significant growth expected due to AI infrastructure investments [12][13] Company Strategy and Development Direction - The company aims to lead in the AI era, focusing on driving efficiency gains across the construction lifecycle [6][7] - Procore's strategy includes leveraging its position as a system of record and collaboration to enhance AI capabilities, with the recent acquisition of Datagrid to accelerate this strategy [15][66] - The company plans to monetize AI offerings through new bundles and consumption-based models, emphasizing the ROI for customers [73] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in Procore's future, highlighting strong customer relationships and the potential for durable growth and margin expansion [5][22] - The company anticipates revenue growth of 13% for fiscal 2026, with non-GAAP operating margin guidance of 17.5%-18% [32] - Management noted that the construction environment remains challenging, but they are focused on delivering durable growth and improving operational efficiency [30][31] Other Important Information - Procore for Government achieved FedRAMP Moderate authorization, expanding opportunities with U.S. federal and state government customers [12] - The company is focused on limiting share count dilution, with a weighted average diluted share count growth of less than 1% in Q4 [29] Q&A Session Summary Question: Customer Conversations on AI - Management noted that customers are focused on construction and do not have the inclination to become AI experts, preferring that their tech vendor leverage AI effectively [38][39] Question: Trends in Volume Commitments During Q4 Renewal Cycle - Management indicated continued strength in ACV commitments, which have grown beyond $1 trillion, reflecting market share gains [63] Question: Datagrid's Role in AI Strategy - Management explained that Datagrid will help integrate data from various systems, enhancing Procore's AI capabilities and overall platform [66] Question: Monetization Strategy for AI - Management discussed plans to establish compelling ROI for AI offerings, with potential inclusion in new bundles and consumption-based pricing models [73] Question: Capacity and Resource Planning for Go-to-Market - Management confirmed sufficient capacity for fiscal 2026, focusing on productivity increases and resource allocation primarily in R&D [75]

Financial Data and Key Metrics Changes - For the full year 2025, total revenues reached $1.64 billion, representing a growth of 28% compared to the previous year, and more than doubling since the end of 2022 [6][23] - Adjusted EBITDA for 2025 grew by 31% to $303 million, outpacing revenue growth [7][23] - System same-shop sales growth was 5.6% for the year, with Q4 showing a growth of 7.7% [6][24] - Company-operated contribution margin was approximately 29% for 2025, reflecting over 400 basis points of margin expansion since 2022 [7][23] Business Line Data and Key Metrics Changes - New shop growth contributed significantly, with 154 new shop openings in 2025, leading to a total of 1,136 system-wide shops [6][24] - Company-operated same-shop sales growth in Q4 was 9.7%, driven by strong transaction growth of 7.6% [27] - System-wide average unit volumes (AUVs) reached a record $2.1 million, indicating strong shop-level economics [8][23] Market Data and Key Metrics Changes - The company expanded into seven contiguous states, including North Carolina, increasing its market presence to 25 states [11] - The new food program has been rolled out to over 300 shops across 11 states, with plans for completion by the end of 2026 [19] Company Strategy and Development Direction - The company aims to reach 2,029 shops by 2029, with a clear strategy focused on growth through people and brand investment [9][19] - A shift towards a foundational top-of-the-funnel paid advertising engine has been implemented to enhance brand awareness [14] - The company is also focusing on expanding its CPG platform, which includes creamers and ready-to-drink offerings, to drive long-term growth [15] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the company's ability to navigate competitive pressures and maintain traffic strength, citing strong same-shop sales performance [38] - The company anticipates continued transaction growth in 2026, with expectations of opening at least 181 new system shops [12][27] - Management acknowledged commodity cost pressures but remains optimistic about achieving long-term contribution margin goals [24][29] Other Important Information - The company has built a strong pipeline of regional operator candidates, increasing from approximately 400 to 475 since the end of 2022 [10] - The loyalty program, Dutch Rewards, surpassed 15 million members, with 72% of system transactions attributed to it [16] Q&A Session Summary Question: How will the company protect traffic during competitive pressures? - Management highlighted the strength of their value proposition and service quality, expressing confidence in maintaining traffic strength despite competition [38] Question: What is the mandate for the new Chief Shops Officer? - The focus will be on supporting baristas and enhancing operational initiatives, including the food program and mobile ordering [40] Question: What metrics can be shared regarding the food program's impact? - Management is tracking various operational metrics and is pleased with the initial results, indicating a long-term strategy for food offerings [46] Question: How does the company view the Clutch acquisition? - The acquisition is seen as a capital-efficient way to expand into new markets, with plans for conversion and opening in Q2 and Q3 [60][84] Question: What is the outlook for competition in specific markets? - Management noted that they are not currently seeing pressures on site availability or costs due to competition, maintaining a strong position in real estate [71]

Financial Data and Key Metrics Changes - Total revenue for 2025 was reported at $673 million, representing a 20% growth over 2024 and exceeding the upper end of guidance [11] - Net loss for the year was $575 million, or $5.83 per share [12] - Cash, cash equivalents, and marketable securities as of December 31 were $738 million [12] - Guidance for 2026 total revenue is expected to be between $730 million and $760 million, reflecting an 8%-13% growth over 2025 [12][13] Business Line Data and Key Metrics Changes - Crysvita contributed $481 million in revenue, with a 17% growth over 2024 [11] - Dojolvi generated $96 million, representing a 9% growth over 2024 [11] - Evkeeza saw significant growth, contributing $59 million, which is an 84% increase over 2024 [11] - Mepsevii contributed $37 million, continuing to treat patients in an ultra-rare indication [11] Market Data and Key Metrics Changes - The commercial business delivered a significant 20% year-over-year growth in 2025, with treatments reaching over 35 countries [8] - In Latin America, Crysvita's business is anchored in Brazil and Argentina, with solid reimbursement growth in Mexico and Colombia [16][17] - Dojolvi has seen continuous growth in EMEA, with regulatory wins in Kuwait and the U.K. [18] Company Strategy and Development Direction - The company aims for profitability by 2027, implementing a strategic restructuring plan to reduce operating expenses and align resources with high-impact opportunities [9][10] - The plan includes a 10% workforce reduction, impacting approximately 130 employees [10] - The company is focused on launching three additional treatments over the next two years while continuing to grow its base business of four commercial products [10][24] Management's Comments on Operating Environment and Future Outlook - Management highlighted 2026 as a significant year with potential approvals in MPS IIIA and glycogen storage disease type Ia, along with pivotal data readout in Angelman syndrome [4] - The management expressed confidence in the ability to deliver the next phase of growth required to reach profitability [20] - The company is addressing the FDA's incomplete response letter regarding UX111 and is working on resubmitting the BLA with additional documentation [7][21] Other Important Information - The company has a strong commercial infrastructure and experienced team to execute complex rare disease therapies globally [20] - The strategic restructuring is expected to enable the company to diversify its pipeline beyond gene therapy [54] Q&A Session Summary Question: What was the decision behind using cognition as the primary endpoint for the Angelman study? - The decision was based on the belief that cognition is fundamental and intertwined with communication, which takes more time to develop [27] Question: Can you provide insights on the patient baseline profile for the Angelman study? - The baseline data from the phase II trial is reflective of the phase III program, and the company is comfortable with the comparability [33] Question: How does the company plan to achieve profitability in 2027? - The pathway to profitability includes continued growth from current products and a reduction in combined R&D and SG&A expenses [40][42] Question: What is the timeline for the resubmission of the BLA in response to the IRL? - The resubmission is expected to take a couple of weeks for the FDA to determine if all required documents are included, with a PDUFA date set approximately six months after resubmission [72] Question: What is the expected launch trajectory for GSDIa? - The market for GSDIa is expected to develop steadily, with strong demand anticipated, but not as urgent as MPS IIIA [76]