EQ504: A Novel AhR Modulator for Ulcerative Colitis - Equillium, Inc is developing EQ504, a novel aryl hydrocarbon receptor (AhR) modulator for ulcerative colitis [1] - EQ504 is derived from ITE, a naturally-occurring, endogenous, non-toxic AhR modulator synthesized in the gut & lungs, and is a highly potent and selective modulator of AhR [143][144] - EQ504 has a multi-modal mechanism of action in mucosal homeostasis, modulating immune cell responses and promoting barrier function & tissue repair [148][149][150] - In vitro, EQ504 increases the number and function of suppressive Treg cells that inhibit activity of Th1 and Th17 cells and promote tissue homeostasis [156] - In a DSS colitis animal model, EQ504 blocks weight loss and induces anti-inflammatory cytokines in colon tissue [158][160] Clinical Validation and Market Opportunity - Modulation of AhR has been clinically validated in skin diseases, with up to 34% of patients achieving a PGA-Pso score of 0-1 by week 12 in psoriasis and up to 34% of patients achieving a vIGA-AD score of 0-1 by week 8 in atopic dermatitis [134][136] - Phase 2 trials of Indigo Naturalis in ulcerative colitis showed up to 50% of patients achieved clinical remission with total Mayo score ≤ 2, no individual subscore > 1, and up to 27% of treatment refractory patients achieved clinical remission with total Mayo score < 3, no individual subscore > 1 [138] - Studies of ulcerative colitis patients treated with indigo naturalis demonstrate on-target engagement of AhR through increased intestinal CYP1A1 and high levels of clinical remission [142] - In vivo experiments demonstrate localized delivery of EQ504 directly to the colon of rats, results in >25X greater peak exposures in colon tissues versus blood [167] - The US market for ulcerative colitis treatments is approximately $6 billion, with a substantial unmet need for new oral agents in the pre-biologic setting and opportunities in biologic failure patients and combination therapy [172][173]

Company Overview - Trinity Capital has provided over $5.1 billion in fundings across 449 investments with 257 exits[8] - The company's portfolio includes $1,678.3 million in secured loans across 97 companies, $318.2 million in equipment financings across 24 companies, and $195.9 million in equity & warrants across 152 companies[8] - As of September 30, 2025, Trinity Capital had $2.6 billion in assets under management[8] - The company's Net Asset Value (NAV) per share was $13.31, with an annualized dividend yield of 13.2%[8] Financial Performance (Q3 2025) - Total investment income reached $75.6 million, resulting in a net investment income (NII) of $37.0 million[44] - The company's net interest margin (NIM) was 10.9%, with a consistent third quarter regular dividend distribution of $0.51 per share[44] - Trinity Capital made $773.0 million in debt & equity commitments, funding $470.6 million in debt & equity across 17 new portfolio companies[44] - Total platform assets under management reached $2,550.5 million at fair value[44] Portfolio Composition & Credit Quality - Total debt investments at cost amounted to $2,034.0 million, with total investments at cost reaching $2,204.8 million[44] - The portfolio is diversified across investment type, industry, and geography, with tech lending, equipment finance, life sciences, asset-based lending and sponsor finance[16] - The company maintains disciplined underwriting standards, resulting in an annualized loss rate of 26 bps[24] - As of September 30, 2025, 82.4% of the debt investment portfolio was floating rate[98]

Financial Performance - Sempra reported Q3 2025 adjusted EPS of $1.11 and YTD 2025 adjusted EPS of $3.45[13, 31] - The company is affirming FY 2025 adjusted EPS guidance range of $4.30 - $4.70 and FY 2026 EPS guidance range of $4.80 - $5.30[13, 31] - Sempra is also affirming guidance at the high-end or above projected EPS CAGR of 7% - 9% for 2025 through 2029[13, 31] Strategic Initiatives - Sempra is investing $13 billion this year, prioritizing utility investments and improved returns[14] - The company has deployed approximately $9 billion in CapEx YTD[14] - A definitive equity sales agreement has been announced to unlock value in the LNG franchise, and FID has been reached for Port Arthur LNG Phase 2[14] - Sempra is targeting Ecogas sale close in mid-2026 to sell non-core assets in Mexico, simplifying the business and reducing portfolio risk[14] - The company is executing Fit for 2025 to reduce costs and improve productivity, including reducing full-time and contracted workforce and implementing new technologies[14] Business Updates - Sempra has signed a definitive sales agreement to sell a 45% stake in SI Partners for $10 billion[17] - Oncor invested $4.5 billion CapEx YTD, with Q3 premise count increasing by approximately 16,000 and building or upgrading approximately 660 circuit miles of T+D lines[19] - Oncor's 2026-2030 capital plan is expected to increase by over 30%, driven by transmission expansion plans[19, 20, 31]

Financial Performance - Total revenue decreased to $186.6 million compared to $200.4 million primarily due to asset sales and lower office occupancy[14] - Net loss attributable to common stockholders was $136.5 million or $0.30 per diluted share compared to a net loss of $97.9 million or $0.69 per diluted share mostly attributable to a loss on the deconsolidation of Sunset Glenoaks[14] - Same-store cash NOI decreased by 10.7% to $89.3 million compared to $100.0 million primarily due to lower office occupancy[7] - FFO excluding specified items was $16.7 million or $0.04 per diluted share compared to $14.3 million or $0.10 per diluted share mostly due to general and administrative and interest expense savings and higher studio NOI[14] - AFFO was $12.3 million or $0.03 per diluted share compared to $15.8 million or $0.11 per diluted share mostly due to lower GAAP non-cash revenue partially offset by the items affecting FFO as well as lower recurring capital expenditures[7] Portfolio & Leasing - In-service office portfolio ended the quarter at 75.9% occupied and 76.5% leased up sequentially from 75.1% occupied and 76.2% leased in the second quarter this year[14] - In-service studio portfolio and stages were 64.6% and 65.8% leased respectively over the trailing 12 months up sequentially from 63.0% and 63.6% for the same metrics in the second quarter this year[14] - Executed 75 new and renewal leases totaling 515450 square feet including a 106000-square-foot new lease with an AI company at Page Mill Center in Palo Alto[14] - GAAP and cash rents on new leases signed were 6.3% and 10.0% lower respectively compared to prior levels primarily attributable to several small leases signed in Palo Alto rolling from peak market rents to still healthy rents of approximately $80 per square foot NNN[14] Balance Sheet & Capital Structure - The company has $1 billion of total liquidity comprised of $190.4 million of unrestricted cash and cash equivalents and $795.3 million of undrawn capacity under the unsecured revolving credit facility[7] - HPP's share of net debt to HPP's share of undepreciated book value was 32.2% with 100.0% of debt fixed or capped with a weighted average interest rate of 5.0% and no debt maturities until third quarter 2026[7]

Financial Performance - The company reported adjusted EBITDA of $77.1 million[33] - The company's cash flow from operations reached $110.3 million[33] - The company's adjusted net income per share was $0.27[33] Production Highlights - Consolidated copper production reached 9,073 ounces[31] - Gold production was 2000 ounces[31] - Caraíba Operations achieved record plant throughput, processing nearly 1.0 million tonnes, a 26% increase compared to Q2 2025[54] - Tucumã Operation saw a 19% sequential quarterly production growth due to higher plant throughput[63] - Xavantina Operations experienced a 17% quarter-over-quarter increase in production, driven by higher processed grades and throughput[72] Strategic Objectives - The company aims to achieve commercial production at Tucumã[36] - The company is focused on deleveraging the balance sheet, with the net debt leverage ratio decreasing to 1.9x at the end of Q3 2025[37] - The company plans to continue gold concentrate sales from Xavantina over the next 12–18 months[43]

Financial Performance - Q3 2025 silver production reached 3.9 million ounces, a 96% year-over-year increase [19] - Q3 2025 silver equivalent production was 7.7 million ounces, and year-to-date production was 23.2 million ounces, representing 73% of the revised guidance mid-point [15] - Record Q3 2025 quarterly revenue of $285 million, up 95%, driven by higher production (+$73 million) and higher metal prices (+$66 million) [15] - Record Q3 2025 cash flow from operations was $141 million ($0.29/share) [15] - The company ended Q3 2025 with a record cash position of $569 million, including $435 million in cash and cash equivalents and $133 million in restricted cash [15] - All-in sustaining costs (AISC) decreased by 1% year-over-year to $20.90 per silver equivalent ounce [19] - The company returned $12 million to shareholders year-to-date in Q3 2025, including $7.3 million in dividends and $4.3 million in share buybacks [15] - Available liquidity stands at $682 million, excluding $133 million in restricted cash [31] Operational Updates - The company is on track to achieve upwardly revised 2025 production guidance [20] - The company is converting to owner haulage at La Encantada Silver Mine to support increased mill throughput rates [23] Other Considerations - The company achieved a 30.0 ESG risk rating with Sustainalytics, placing it in the Medium risk category and in the top 40% of its peer group [28]

Financial Performance - Total revenue decreased by 11% year-over-year to $36.2 million, primarily due to a strategic shift away from hardware-led growth [6, 9] - SaaS revenue grew by 7% year-over-year to $14.2 million, representing 39% of total revenue [4, 10, 13, 19] - Annual Recurring Revenue (ARR) increased by 7% year-over-year to $56.9 million [4, 6, 19] - Net loss improved by $3.6 million year-over-year, from $(9.9) million to $(6.3) million [6] - Adjusted EBITDA improved by $0.9 million year-over-year to $(2.9) million [6] - The company maintains a strong cash balance of $100 million with no debt and a $75 million credit facility [4, 6, 21] Operational Metrics - Units deployed increased by 11% year-over-year to approximately 870,000 units [4, 6, 15, 22] - Customer Net Revenue Retention is greater than 100%, indicating strong customer loyalty [4, 15, 19] - Customer Churn is 0.05%, demonstrating high customer retention [4, 15, 19] Strategic Initiatives - The company completed a $30 million cost reduction plan, positioning it for run-rate neutrality exiting 2025 [4, 20] - The company is focused on shifting away from hardware-only sales towards a recurring revenue model [4, 7, 13]

Financial Performance Highlights - Net earnings for the third quarter of 2025 were $215 million, compared to $181 million for the same period in 2024[3, 5] - Core net operating earnings for the third quarter of 2025 were $224 million, versus $194 million in 2024[3, 5] - Property and Casualty net written premiums for the third quarter of 2025 reached $2,252 million, slightly lower than the $2,353 million in 2024[3, 8] - Diluted earnings per share were $2.58 for the third quarter of 2025, compared to $2.16 in 2024[3, 6] - Book value per share, excluding AOCI, was $57.59 as of September 30, 2025, a slight decrease from $57.71 on September 30, 2024[3, 12] Property and Casualty Insurance Segment - Underwriting profit for Property and Casualty Insurance in Q3 2025 was $138 million, compared to $115 million in Q3 2024[5, 7] - Net investment income for Property and Casualty Insurance was $205 million in Q3 2025, equal to Q3 2024[5, 17] - The combined ratio for Specialty Property and Casualty was 930% for the third quarter of 2025, compared to 943% for the same period in 2024[3, 7, 8] Investment Portfolio - Total cash and investments amounted to $16,761 million as of September 30, 2025, compared to $15,741 million as of September 30, 2024[3, 16] - Fixed maturities constituted 64% of the total investment portfolio, with a fair value of $10,598 million as of September 30, 2025[20] - Average yield on the overall investment portfolio, net, was 497% for the three months ended September 30, 2025[17]

Transaction Overview - PEDEVCO and Juniper have merged, creating a Rockies-focused company poised for growth [11, 26] - Juniper and its affiliates will own approximately 53% of the pro forma shares after conversion, while existing PEDEVCO shareholders will own about 47% [15] - The merger is funded via an expanded $250 million reserve-based lending (RBL) facility, with an initial $120 million borrowing base [15] Pro Forma Company Highlights - The combined company boasts over 328,000 net acres, primarily in the DJ Basin and Powder River Basin [14] - Second quarter of 2025 net production reached 7,404 Boepd, a roughly 388% increase compared to PEDEVCO alone [13] - Liquids account for approximately 88% of the pro forma company's production [13] - Last Twelve Months (LTM) EBITDA is approximately $96 million [13] Financial Position - Pro forma net leverage is approximately 0.8x LTM EBITDA [14] - The company has $87 million in debt and $43 million in liquidity [47] - $35 million in new equity was provided by existing and new members of PEDEVCO management and Juniper [15]

Business Overview - Chord Energy is a premier Williston Basin operator focused on enhancing free cash flow generation[1,9] - The company has a large acreage position in the Williston Basin, with over 1.3 million net acres and approximately 278 thousand barrels of oil equivalent per day (MBoepd) production, with oil accounting for approximately 56% of production[18] - Chord Energy has a diversified commodity mix with 56% oil, 26% gas, and 18% NGL[15] Financial Performance and Capital Allocation - Chord Energy has returned over $5 billion to shareholders since 2021[20,25] - The company maintains a strong balance sheet with approximately 0.6x leverage[20,26,71] - Chord Energy's capital expenditure for 2025 is projected to be approximately $1.365 billion[131] - The company's free cash flow for 2025 is estimated to be approximately $840 million[131] Operational Efficiency and Improvements - Chord Energy is focused on continuous improvement, driving a projected 20% free cash flow growth in FY25 from controllable items[35] - The company is implementing a 4-mile lateral program, which is expected to improve returns with 90%-100% EUR increase and $8-$12 per barrel lower breakeven compared to 2-mile analogs[52] - Chord Energy is targeting over 80% long-lateral inventory across its acreage[33,116] Marketing and Infrastructure - The company anticipates $30-$50 million in annual free cash flow savings from marketing optimization starting in 2026[43,49] - Chord Energy is involved in gas takeaway projects, including LNG Canada and TC Energy Bison Xpress, which are expected to improve pricing[45] Strategic Acquisitions and Divestitures - Chord Energy closed the XTO asset acquisition in October 2025 for $550 million, adding 48,000 net acres in the Williston core[25,75,76] - Since the Enerplus merger close in May 2024, Chord Energy has reduced its fully diluted shares outstanding by approximately 11%[62,64]