Summary of Nerdy Conference Call Company Overview - **Company**: Nerdy, operating under the consumer-facing name Varsity Tutors, is a leading platform for live learning in the United States, connecting users with experts across 3,000 subjects through a vertically integrated marketplace model [4][10]. Go-to-Market Strategy - **Consumer Model**: Direct-to-consumer internet model focusing on parents purchasing tutoring for their children based on significant educational goals [5][10]. - **Institutional Model**: Direct engagement with school districts and institutions, providing tools for data-driven interventions and personalized learning experiences [8][10]. Revenue Breakdown - **Revenue Composition**: Consumer business accounts for 85% of total revenue, while institutional business represents 15% [10]. - **Active Families**: Approximately 35,000 active families as of Q3, with an average monthly payment of $375 for tutoring services [10]. AI Integration - **AI Utilization**: AI is central to enhancing the learning experience, allowing for personalized and bespoke educational journeys. The company has transitioned to AI-native services, improving customization and operational efficiency [11][12][15][20]. - **Impact on Experience**: The integration of AI enables real-time lesson preparation, personalized content delivery, and improved tutor-student interactions [16][17]. Market Trends and Opportunities - **Consumer Expectations**: Rising expectations for personalization in education driven by AI advancements [27][28]. - **Institutional Market**: Increased openness to AI in education, with a focus on high-dosage tutoring to address learning gaps [31][33][35]. Financial Performance - **Revenue Growth**: Sequential improvement in revenue growth rates throughout 2025, with expectations for continued acceleration into 2026 [22][23]. - **Gross Margins**: Significant improvements in gross margins due to strategic investments in tutor compensation and technology enhancements [39][40]. - **Operating Efficiency**: Adjusted EBITDA margin improved by 960 basis points year-over-year, driven by operational efficiencies and cost reductions [41][42]. Leadership and Strategy - **New Leadership**: Introduction of a new COO and operational team focused on enhancing efficiency and customer experience [45]. - **Balance of Growth and Profitability**: The company aims to be more aggressive in growth while maintaining profitability through scalable systems and improved operational discipline [43][44]. Investment and Financial Flexibility - **Term Loan Agreement**: A recent term loan enhances financial flexibility, allowing for offensive growth strategies and potential M&A opportunities [48][49]. - **Stock Purchases**: CEO Chuck Cohn has invested over $80 million in stock purchases, indicating strong confidence in the company's future [55]. Future Outlook - **Catalysts for Growth**: Investors should focus on revenue acceleration, operating leverage, and the impact of AI on product offerings as key indicators of success [57][59]. - **Product Quality**: Anticipated improvements in product quality and execution pace are expected to drive future growth [66]. This summary encapsulates the key points discussed during the conference call, highlighting Nerdy's strategic direction, financial performance, and market opportunities.

Summary of Worthington Steel Investor Call on M&A Announcement Company and Industry - **Company**: Worthington Steel (NYSE: WS) - **Acquisition Target**: Klöckner, a company listed on the Frankfurt Stock Exchange Core Points and Arguments 1. **Strategic Acquisition**: Worthington Steel is acquiring Klöckner to strengthen its position in high-value metals processing, enhance shareholder value, and create new opportunities for employees [3][4] 2. **Market Position**: Post-acquisition, Worthington Steel expects to become the second largest service center in North America, expanding its geographic reach and product offerings [4][12] 3. **Synergies and Growth Initiatives**: The acquisition is anticipated to generate approximately $150 million in annual run-rate synergies by the end of 2028, with about 50% expected to be realized in the first year [15][17] 4. **Financial Structure**: The transaction is an all-cash acquisition valued at approximately $2.4 billion, with an expected EBITDA margin of 7% and combined sales of $9.5 billion [15][16] 5. **Cultural Alignment**: Both companies share a focus on safety, operational excellence, and innovation, which is expected to facilitate a smooth integration process [3][5] 6. **Diversification**: The acquisition will broaden Worthington's product portfolio to include aluminum, stainless steel, long products, and downstream fabrication, enhancing resilience against market cyclicality [10][12] 7. **Geographic Expansion**: Klöckner's operations will enhance Worthington's presence, particularly in the southern U.S., where demand is growing due to manufacturing activity and reshoring trends [9][12] 8. **Operational Efficiency**: The integration is expected to improve operational efficiency through procurement savings, logistics optimization, and reduced administrative costs [18][20] Additional Important Content 1. **Shareholder Support**: Klöckner's largest shareholder, Swactim, has agreed to tender their shares in support of the acquisition [8] 2. **Market Dynamics**: The acquisition is seen as timely due to favorable market conditions for consolidation in the steel industry [53] 3. **Long-term Goals**: Worthington aims to achieve over 10% group EBITDA margins, which the acquisition is expected to accelerate [45][46] 4. **Integration Management**: A dedicated integration management office will oversee the synergy capture process, ensuring accountability and clear goals [26][60] 5. **European Market Exposure**: Approximately 20% of the combined company's revenue is expected to come from Europe, with a focus on North America for synergy realization [30][39] This summary encapsulates the key points discussed during the investor call regarding Worthington Steel's acquisition of Klöckner, highlighting the strategic rationale, expected synergies, and operational benefits of the transaction.

SES AI (NYSE:SES) FY Conference Summary Company Overview - **Company**: SES AI - **Industry**: Battery Technology - **Focus**: Accelerating energy transition through AI, specializing in lithium metal battery chemistry and energy storage solutions Key Points Industry and Market Insights - The energy storage system (ESS) market is projected to be over **10 times** the size of the electric vehicle (EV) market [2][3] - The battery markets for ESS and drones are expected to experience significant growth [3] - The company is uniquely positioned due to over a decade of experience in battery technology and AI integration [2] Financial Performance - In the first three quarters of 2025, SES AI reported a revenue of **$16.4 million** and provided guidance of **$22.5 million** for the full year [3] - The company anticipates doubling its revenue in 2026 compared to 2025 [34] Product Development and Innovations - SES AI has developed a platform called **Molecular Universe**, which focuses on material discovery and battery health management [3][6] - The company has made **six breakthroughs** in battery materials, enhancing performance for various applications including EVs, drones, and consumer electronics [8][9] - The company has established three business units focusing on ESS, drones, and materials to drive revenue generation [6][12] Strategic Partnerships and Acquisitions - SES AI acquired **UZ**, a company with strong hardware capabilities, to enhance its ESS offerings [7][18] - The partnership with **HySun** aims to commercialize materials discovered through Molecular Universe [9][27] Market Opportunities - The company sees military drones and data centers as the most exciting market opportunities [13][14] - SES AI is focusing on **NDAA-compliant** cells, which are priced **2 to 3 times** higher than non-compliant cells [15][16] - The company is targeting about **100 key accounts** for NDAA-compliant cells, focusing on larger clients rather than numerous small accounts [16] Technology and Competitive Advantage - SES AI's **Molecular Universe** is the first AI for science platform that has made actual breakthroughs in material discovery, unlike other platforms that are still in development [9][11] - The company emphasizes the importance of having a combination of model, data, and domain expertise to succeed in the AI for science space [11] Future Outlook - SES AI aims to create a closed-loop system integrating hardware and software solutions for data centers and commercial applications [17][18] - The company plans to leverage its software for recurring revenue through updates and maintenance subscriptions [23] - SES AI is confident in its ability to achieve break-even cash flow within the next **one to two years** [34] Conclusion - The battery industry is undergoing a significant transition, with SES AI focusing on ESS, drones, and materials as key growth areas [34] - The integration of AI with battery technology presents a unique opportunity for SES AI to capitalize on emerging market trends and drive innovation in energy storage solutions [34]

Summary of Shanghai Henlius Biotech FY Conference Call Company Overview - **Company Name**: Shanghai Henlius Biotech (SEHK: 02696) - **Industry**: Biopharmaceuticals - **Key Products**: Four products approved by the U.S. FDA, seven by China NMPA, and four by EU EMA - **Clinical Trials**: Over 30 ongoing clinical trials and more than 50 early-stage assets - **Global Workforce**: Approximately 4,000 employees - **Manufacturing Capacity**: 80,000 liters facility in China - **Patient Impact**: Products have benefited over 950,000 patients globally [2][3][26] Core Competencies - **Clinical Operations**: In-house team operating across China, U.S., Australia, Japan, with 1,000 clinical research centers in 20 countries [3] - **R&D Capabilities**: 50+ early-stage molecules, with 70% aimed to be first best in class and 15% first in class [3] - **Regulatory Affairs**: 66 NDA approvals globally, including four BLA approvals by FDA last year [3] - **Manufacturing**: More than 1,150 commercial GMP batches certified by multiple regulatory authorities [3] Product Pipeline Highlights - **Serplulimab**: Approved for small cell lung cancer in China and EU, with ongoing studies for additional indications [4][5] - **Clinical Data**: Four-year overall survival (OS) rate of 21.9 months compared to standard care of 7.2 months [5] - **HELIX-22**: A novel HER2 mAb with a dual epitope strategy, currently in global phase three trials [7][9] - **Safety Profile**: Better safety compared to competitors, with ongoing recruitment of 600 patients [9] - **HELIX-43**: PD-L1 ADC targeting solid tumors, with significant efficacy data reported [10][11] - **Efficacy Rates**: ORR of 47.4% for EGFR wild type patients and 70% for cervical cancer at 3.0 mg/kg [11] Upcoming Milestones - **Regulatory Approvals**: Expecting accelerated approval for perioperative gastric cancer and additional indications for non-small cell lung cancer in the EU [14][15] - **Clinical Trials**: Initiating global phase 3 trials for various non-small cell lung cancer indications [12][16] - **Data Readouts**: Anticipated data from multiple studies at ASCO, including non-small cell lung cancer and ovarian cancer [17] Strategic Focus - **Next Generation Immuno-Oncology**: Emphasis on improving clinical responses to immunotherapy-resistant diseases [18][19] - **AI Technology**: Investment in generative AI for toxicity prediction and efficient screening [19] - **Biosimilars and Innovative Compounds**: Plans for 10 biosimilar launches and five innovative compound launches in the next five years [26][27] Financial Outlook - **Revenue Growth**: Projected double-digit growth with $0.7 billion in revenue for 2024 [26] - **Global Expansion**: Vision to launch over 20 products globally by 2030, with overseas revenue expected to exceed domestic contributions [26][27] Funding Strategies - **Revenue Utilization**: Leveraging sales revenue from biosimilars to fund innovative compound trials [27] - **Partnerships**: Open to licensing discussions and new collaborations to support development [27][28]

Aytu Biopharma FY Conference Summary Company Overview - **Company**: Aytu Biopharma (NasdaqCM:AYTU) - **Focus**: Launch of Exua, a new antidepressant targeting major depressive disorder (MDD) Key Points Exua Launch and Market Positioning - Exua was discovered at the JPMorgan Healthcare Conference and is positioned as a unique antidepressant that does not fall under the SSRI or SNRI categories, which dominate the market with over 345 million prescriptions annually in the U.S. [3][6] - The drug specifically targets the 5-HT1A serotonin receptors, aiming to reduce common side effects associated with traditional antidepressants, such as sexual dysfunction and weight gain [7][8] - Aytu Biopharma has a sales force of approximately 44 representatives already aligned with psychiatry, facilitating a smooth transition to marketing Exua [9][10] Commercial Strategy - The company has established a focused commercial infrastructure that includes a patient access program called RxConnect, designed to simplify the prescription process for physicians and patients [25][26] - The sales team is fully aligned with high-prescribing psychiatrists, ensuring targeted marketing efforts [11][12] - Aytu aims to position Exua as a second or third-line therapy initially, with potential to move up the treatment hierarchy as familiarity with the drug increases [20][21][22] Financial Performance and Legacy Business - Aytu's legacy business, primarily in ADHD medications, generated approximately $55.5 million over the last 12 months, with stable performance despite a highly genericized market [34][35] - The company also has a smaller pediatric product line generating around $8 million, which is not a focus for resource allocation [36] - Aytu has raised $17 million gross for the Exua launch and ended the last quarter with $32.6 million in cash, indicating no immediate need for additional funding [47][48] Competitive Landscape and Risks - The ADHD market faces generic competition, particularly from Teva, which has launched an authorized generic for Adzenis. However, Aytu's RxConnect program is expected to mitigate the impact of this competition [38][39][40] - The company anticipates that Exua's unique mechanism of action and patient access program will help it capture market share in the antidepressant space, which is significantly larger than the ADHD market [44][46] Future Outlook - Aytu Biopharma is optimistic about Exua's potential to transform the company, with expectations of achieving multiples of its current business revenue [44][46] - The company is focused on maintaining a strong market presence and ensuring that Exua is accessible to patients through its innovative RxConnect program [31][32] Additional Insights - The company emphasizes a strategic focus on psychiatry, avoiding a broad approach to maximize efficiency and effectiveness in marketing [14][15] - Aytu's approach to patient access and cost predictability is designed to alleviate common barriers faced by physicians when prescribing new medications [27][30] This summary encapsulates the key discussions and insights from the Aytu Biopharma FY Conference, highlighting the company's strategic direction, market positioning, and financial outlook.

Cadrenal Therapeutics FY Conference Summary Company Overview - **Company**: Cadrenal Therapeutics (Ticker: CVKD) - **Focus**: Bridging critical gaps in anticoagulation for rare and high-risk patients, particularly those with end-stage renal disease (ESKD) and atrial fibrillation (AFib) [3][4] Core Programs 1. **Tecarfarin**: - Phase 3 program targeting kidney-impaired patients with AFib and those with implanted left ventricular assist devices (LVADs) - Orphan drug designation received for ESKD and AFib [4][5] 2. **VLX-1005**: - Acquired from Verilux, recently completed Phase 2 trials for Heparin-Induced Thrombocytopenia (HIT) - Received Orphan and Fast Track designations [5][6][14] 3. **Fruinexian**: - Short-acting Factor XI candidate acquired in Fall 2025, aimed at cardiovascular surgery [5][6] Market Context - **Anticoagulation Landscape**: - Direct Oral Anticoagulants (DOACs) have dominated the market since their introduction, but gaps remain for patients who cannot use them, such as those with mechanical heart valves and LVADs [4][5] - Warfarin, a vitamin K antagonist, is still widely used despite its limitations, particularly in patients with kidney issues [4][5] Regulatory Advantages - **Orphan Drug and Fast Track Designations**: - These designations allow for smaller, more flexible trials, tax credits, fee waivers, and market exclusivity, reducing development costs and risks [21][22] - Fast Track designation enables earlier FDA interactions and rolling submissions [21][22] Unmet Needs and Market Opportunity - **HIT Market**: - Approximately 50,000 new HIT patients are confirmed annually in the U.S., indicating a significant unmet need for effective treatments that do not exacerbate bleeding risks [19][20] - Current treatments are often ineffective, leading to high morbidity and mortality rates [14][19] Future Outlook - **Long-term Strategy**: - Cadrenal aims to provide alternatives to long-standing anticoagulants like warfarin and heparin, particularly for patients with specific needs [25][27] - The company is excited about the potential for oral applications of 12-LOX inhibitors for chronic conditions [32] Key Milestones - **Upcoming Developments**: - Analysis and publication of VLX-1005 Phase 2 data - Ongoing interactions with the FDA for both VLX-1005 and tecarfarin [30][31] Conclusion - **Vision for Impact**: - In five years, Cadrenal aims to be recognized for addressing the needs of patients with HIT, ESKD, and advanced mechanical heart valves, providing effective therapeutic options where larger pharmaceutical companies have not ventured [32]

Summary of Alpha Tau Medical FY Conference Call Company Overview - **Company**: Alpha Tau Medical (Ticker: DRTS) - **Technology**: Alpha DaRT, a novel method for delivering alpha particles directly into solid tumors, aiming for more efficient local radiation therapy compared to traditional gamma rays or beta particles [5][6] Core Points and Arguments Technology and Applications - **Alpha DaRT Mechanism**: Utilizes a small pin coated with Radium-224 to release isotopes that diffuse into tumors, allowing for a more effective radiation dose with lower activity levels [6] - **Broad Applicability**: Preclinical tests across 20 tumor types have shown positive responses, focusing on high unmet needs like pancreatic and brain tumors [7][8] Clinical Progress - **Skin Cancer Trials**: Ongoing pivotal study for recurrent squamous cell carcinoma (SCC) with near 100% response rates in previous trials. Recruitment completion targeted for Q1 2026 [10][12] - **Pancreatic Cancer Study**: Recent ASCO GI presentations reported over 80% disease control and 20% response rates in a safety and feasibility study, indicating promising results with minimal immune system impact [18][21] - **Glioblastoma (GBM) Trials**: Initial treatments have begun, with successful delivery and 95% tumor coverage in the first patient, highlighting the potential for effective treatment in a challenging cancer type [23][24] Regulatory and Manufacturing Updates - **FDA Submission Strategy**: A modular PMA application allows for rolling submissions, with preclinical data already submitted while awaiting clinical trial results [15][16] - **Manufacturing Expansion**: A new facility in New Hampshire is being developed to meet commercial production needs, with a focus on scaling up capacity for future demand [25][26] Market Strategy - **Go-to-Market Approach**: Plans to build an internal sales force for U.S. markets while exploring partnerships in Canada, Israel, and Asia for commercialization [32][34] Important but Overlooked Content - **Financial Position**: As of Q3, the company had approximately $76 million in cash, with a burn rate of $5-5.5 million per quarter, indicating a solid financial foundation for ongoing operations and trials [38] - **Immunological Effects**: Alpha DaRT appears to preserve immune function while reducing inflammatory markers, suggesting a dual benefit of tumor treatment and immune system support [21][22] Key Deliverables and Milestones for 2026 - Completion of pivotal studies in skin cancer and pancreatic cancer, with data expected later in the year [37] - Ongoing monitoring and updates from the GBM study [37] This summary encapsulates the critical insights from the Alpha Tau Medical FY Conference Call, highlighting the company's innovative approach to cancer treatment, clinical advancements, regulatory strategies, and market positioning.

Summary of Ouster's Conference Call Company Overview - Ouster is positioned as a perception solution platform rather than just a sensor company, emphasizing its capabilities in sensing, thinking, and acting through its software layer and hardware [2][3] Market Opportunity - The total addressable market (TAM) is estimated at $70 billion, distributed across four key verticals, each accounting for approximately 25% of the market in 2024 [4] Key Vertical Markets 1. **Automotive**: Focus on robo trucking and robo taxis, not on Advanced Driver Assistance Systems (ADAS) [5] 2. **Smart Infrastructure**: Targeting intelligent transport systems, with over 300,000 intersections in the U.S. using their technology for traffic management [6] 3. **Perimeter Crowd Security**: Engaged in projects for the Los Angeles Olympics and World Cup, focusing on crowd control and analytics [7] 4. **Robotics**: Successful partnerships, such as with Serve Robotics, leading to increased orders and growth in the robotics sector [9] Technology and Product Development - Transition from analog to digital lidar technology, enhancing performance and efficiency [11] - Upcoming L4 chip expected to further improve capabilities and expand market reach [12] - The company has shipped over 100,000 sensors and has a strong patent portfolio following a merger with Velodyne [17] Financial Outlook - Projected growth of 30%-50% across market segments, with gross margins targeted at 35%-40% on a GAAP basis [14][15] - Aiming for profitability in cash flow and EBITDA by late 2027 to early 2028 [16] Investment Strategy - Ouster positions itself as a platform solution provider, focusing on applications that help customers speed their time to market [16] - The company emphasizes fiscal responsibility and maintaining operating expenses to ensure profitable growth [15] Customer Engagement and Partnerships - Ouster has over 1,000 customers, emphasizing long-term partnerships rather than one-time sales [27] - The company’s strong balance sheet provides a competitive advantage, allowing for sustained support and collaboration with clients [27] Unique Selling Proposition - Ouster's technology is integral to the development of physical AI, providing essential perception and sensing capabilities for various applications [18][21] - The Gemini AI engine and Blue City platform are highlighted as key offerings, with Gemini focusing on AI training and Blue City on smart city solutions [23][24] Conclusion - Ouster is well-positioned in the perception and sensing market, leveraging its technology, partnerships, and financial strength to capitalize on the growing demand for physical AI solutions [18][27]

Summary of Jaguar Health FY Conference Call Company Overview - **Company Name**: Jaguar Health (NasdaqCM: JAGX) - **Subsidiary**: Napo Pharmaceuticals - **Key Product**: Crofelemer (brand name Mytesi), FDA-approved for chronic diarrhea in HIV/AIDS patients and chemotherapy-induced diarrhea in dogs under the brand name Canalevia-CA1 [4][5] Core Points and Arguments - **Product Development**: Jaguar Health focuses on drug development from plants traditionally used in tropical areas, with crofelemer being a first-in-class FDA-approved anti-secretory agent [4][5] - **Exclusivity**: The company holds over 150 patents and has exclusivity due to the FDA's botanical guidance, which prevents generics from entering the market [5] - **Recent Licensing Agreement**: An exclusive license agreement with FuturePak could be worth up to $38 million, including an upfront payment of $16 million and potential milestone payments [6] - **Sales Strategy**: Jaguar has transitioned its commercial responsibilities for Mytesi and Canalevia to FuturePak, allowing it to focus on its pipeline, particularly in rare diseases [11][12] Pipeline Focus - **Rare Disease Programs**: Jaguar is concentrating on ultra-rare diseases, specifically microvillus inclusion disease (MVID) and short bowel syndrome (SBS), with potential FDA filings by the end of 2026 [8][11] - **Market Potential**: The SBS market is estimated to be over $5 billion, with some estimates as high as $12 billion [12] - **Clinical Trials**: Ongoing trials for MVID and SBS are showing promising results, with significant reductions in parenteral nutrition for patients [16][25] Regulatory Pathways - **Breakthrough Designation**: The company is pursuing breakthrough therapy designation from the FDA, which could expedite the approval process for its rare disease treatments [28][29] - **Prime Designation in Europe**: This designation would facilitate communication and speed up the regulatory process across the EU [29] Canalevia-CA1 Update - **FDA Approval**: Canalevia-CA1 received conditional approval for chemotherapy-induced diarrhea in dogs, with ongoing studies required for full approval [32][33] - **Clinical Trial Funding**: Funds from the licensing agreement and grants will support the clinical trial for Canalevia-CA1 [34] Key Milestones for 2026 - **Clinical Trials**: Completion of MVID and SBS trials, with expectations for breakthrough and prime designations [38] - **Business Development**: Focus on securing business development deals independent of Mytesi and Canalevia, targeting rare disease indications [38] Additional Insights - **Patient Impact**: The company emphasizes the importance of supportive care in treating chronic conditions, particularly in the HIV community [10][11] - **Manufacturing as Profit Center**: Jaguar continues to manufacture crofelemer, which has become a profit center due to its commercialization by FuturePak [8] This summary encapsulates the key points discussed during the Jaguar Health FY Conference Call, highlighting the company's strategic focus, product pipeline, and market opportunities.

Summary of ALX Oncology FY Conference Call Company Overview - **Company**: ALX Oncology (NasdaqGS:ALXO) - **Key Programs**: Evorpacept and ALX 2004, both in clinical stages and differentiated in their class [2][3] Core Industry Insights - **Focus on CD47**: Evorpacept targets CD47, a critical immune checkpoint in oncology, which has been challenging to target effectively [3][4] - **EGFR-targeted ADC**: ALX 2004 is a novel antibody-drug conjugate (ADC) targeting EGFR, designed to minimize on-target toxicity while maximizing efficacy [21][22] Key Data and Findings - **Evorpacept Data**: - Presented at SITC with promising results in gastric cancer (Aspen-06) showing a 65% response rate in CD47 overexpressing HER2-positive patients, a significant improvement over the control arm [12][14] - Combination studies with Rituxan and Evorpacept showed complete response rates of 83% and 92% in different settings [13] - **ALX 2004 Progress**: - Currently in phase one trials, with successful completion of initial dose cohorts and a focus on optimizing the linker payload for better delivery and efficacy [4][31] - Preclinical data indicates superior bystander effects and reduced toxicity compared to existing EGFR-targeted therapies [27][29] Market Opportunity - **HER2-positive Breast Cancer**: - Estimated addressable patient population of 20,000, with a market opportunity valued between $2 billion to $4 billion [20] - Current treatments show response rates of 15% to 20%, indicating a significant unmet need for effective therapies post-HER2 treatment [19] Strategic Collaborations - **Partnerships**: Collaborations with Sanofi for combination studies in multiple myeloma, leveraging the high expression of CD47 in hematologic malignancies [46][47] Future Catalysts - **Upcoming Data Releases**: - Interim data for Evorpacept expected in Q3 2026, which will be crucial for validating the biomarker-driven approach [33] - Continued dose escalation and data sharing for ALX 2004 to elucidate its safety profile [34] Conclusion - ALX Oncology is positioned to potentially lead in the CD47 and EGFR-targeted therapy spaces with differentiated mechanisms and promising clinical data, addressing significant unmet medical needs in oncology [35][36]