（於開曼群島註冊成立的有限公司） （股份代號：3696） 自願公告 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 INSILICO MEDICINE InSilico Medicine Cayman TopCo 英矽智能 英矽智能與太景的合作達成里程碑， 對外授權的CKD貧血新藥ISM4808完成I期臨床首例受試者入組並給藥 本公告由英矽智能（「本公司」，連同其附屬公司統稱「本集團」）自願作出，以告知 本公司股東及潛在投資者有關本集團的最新業務更新。 本公司董事會（「董事會」）欣然宣佈，公司此前對外授權給太景（股票代碼：4157. TWO）的慢性腎病(CKD)貧血創新藥ISM4808已達成首個協議里程碑。近日，太 景已順利完成該項AI驅動的PHD抑制劑I期臨床試驗的首例受試者入組及給藥。 該項臨床試驗為隨機、雙盲、安慰劑對照研究，包含單次給藥(SAD)及多次給藥 (MAD)部分，旨在評估ISM4808在健康成年人中的安全性、耐受性及藥代動力學 特徵。 ...

Core Insights - The report from Zhonghang Securities highlights the ongoing integration of AI products and services in the healthcare sector, focusing on areas such as medical imaging, clinical decision support, precision medicine, health management, medical information technology, drug development, and medical robotics. AI is evolving from a "technical assistant" role to becoming a core driver of "value reshaping" and "efficiency revolution" in the medical industry, with its commercial value permeating from research to clinical, payment, and patient levels [1] International Developments - In the international arena, significant advancements are noted in AI medical imaging diagnostics and AI-assisted drug discovery. AI systems for abdominal CT multi-disease triage and fetal abnormal ultrasound imaging have received FDA approval, indicating a shift from single-disease assistance to comprehensive triage and decision support systems. Collaborations between pharmaceutical companies and AI tech firms are enhancing cancer early screening capabilities, potentially increasing cancer diagnosis rates and accessibility to treatment drugs. Additionally, AI imaging diagnostics for stroke have gained recognition at top academic conferences, reflecting the growing acceptance of AI technology in clinical and research communities [1] - In drug discovery, international pharmaceutical companies are partnering with AI tech firms to accelerate new drug development. The world's first fully AI-designed antibody drug, GB-0895, has entered Phase III clinical trials, marking a significant breakthrough from concept to clinical practice. Google has also launched two open-source AI models for medical applications, enhancing capabilities in multi-modal analysis and voice interaction [1] Domestic Developments - Domestically, the value of AI in early drug development is being clinically validated, with companies like InSilico Medicine receiving FDA approval for new drug applications via AI platforms. AI-assisted diagnosis is expanding into various medical scenarios, with recent approvals for AI software in cervical cell digital pathology and accelerated AI healthcare initiatives from leading in vitro diagnostic companies. The emergence of large AI models in China is also noteworthy, with local teams publishing evaluation standards in international journals, showcasing the competitive edge of Chinese medical AI models [2] - Significant advancements are being made in AI imaging, surgical robots, and brain-computer interfaces, with AI accelerating the development of medicine and drug research. Recent policies related to AI in healthcare are being actively discussed, focusing on the reliability and compliance of AI-assisted diagnosis and the use of medical data [2] Investment Opportunities - Key investment opportunities identified include: 1) AI drug development: companies like Crystal Technology, Hongbo Pharmaceutical, Chengdu XianDao, and InSilico Medicine 2) AI medical imaging and assisted diagnosis: companies such as United Imaging Healthcare and Wandong Medical 3) Medical information technology and smart hospitals: firms like Jiahe Meikang, Chuangye Huikang, Donghua Software, and Weining Health 4) Internet healthcare and health platforms: including JD Health, Alibaba Health, and Ping An Good Doctor 5) Precision medicine and AI-driven medical services: companies like Kingmed Diagnostics, Runda Medical, and Meinian Health 6) Technology/data platform enterprises: such as iFlytek Medical and Yidu Technology [4] AI Medical Core Themes - The core themes in AI healthcare investment revolve around addressing industry pain points. AI-assisted diagnosis enhances diagnostic efficiency and consistency, supporting grassroots healthcare with clear cost-reduction and efficiency benefits. In cancer early screening, companion diagnostics, and efficacy prediction, AI contributes to achieving precision medicine. The maturity of AI applications varies, with AI medical imaging evolving from single-disease assistance to multi-disease integration and comprehensive management. AI-assisted drug discovery is transitioning from early discovery to clinical validation, necessitating attention to platform technology validation and deep collaborations with top pharmaceutical companies [3] - The development of large medical AI models and multi-modal AI, capable of processing diverse medical data, is crucial. The focus should be on the accuracy of these models in specialized fields, their integration with existing hospital information systems, and their potential to build an ecosystem as foundational "medical intelligent agents" [3]

全年共发生731 起融资事件，较2024年同比大幅增长 31%；涉及融资金额约593.78亿元人民币，同比增长 17%；平均单笔融资额达 8213 万元人民币，资 金配置效率稳步提升。 回顾近五年行业融资轨迹，2021 年堪称行业 "黄金峰值期"—— 受益于新冠疫情催化的疫苗及生物技术研发热潮，叠加科创板、港交所新政释放的政策红 利，资本市场对创新药赛道的追捧推动行业融资额攀升至1348.57亿元的历史高点。 然而，2022-2023 年行业进入深度调整期：一方面受资本市场整体寒冬影响，风险投资趋于保守；另一方面，创新药在医保谈判中面临超预期的价格降 幅，商业化前景的不确定性进一步抑制了资本投入，融资额连续两年下滑，2023年降至 570.04 亿元。 博远资本创始合伙人陶峰认为："创新药研发，归根到底是拼试错效率。中国创新药企当前的效率，从时间维度上讲是历史最强，从空间维度上看是全球 最强，这是毫无疑问的。成本、速度、质量，是创新药研发的三个关键。二十年前中国的质量和国际水平有差距，今天基本一致，同时成本低很多，这是 我们的核心优势。" 当资本市场的目光从"追热点" 转向 "看价值"，生物医药行业在2025 ...

Investment Rating - The report does not explicitly state an investment rating for the biopharmaceutical industry or Semaglutide specifically. Core Insights - The report analyzes the market dynamics and sales performance of Semaglutide in China for the first quarter of 2025, highlighting the competitive landscape and emerging trends in the biopharmaceutical sector [3][10]. Summary by Sections Research Purpose and Hot News - The report focuses on the Semaglutide drug market in China, reviewing market trends and sales performance in Q1 2025 to analyze the current state and future market directions [3][4]. Key Findings - Dual-target and multi-target drugs are becoming research hotspots in the weight loss medication field, with drugs like Eli Lilly's Tirzepatide showing stronger weight loss effects [5]. - The patent for Semaglutide is set to expire in March 2026, prompting several domestic companies to prepare for market entry with generic versions [7]. - Import pharmaceutical companies are proactively reducing prices to maintain market share against upcoming generics, with significant price cuts reported for Novo Nordisk's and Eli Lilly's products [7]. - Oral weight loss medications are emerging as a new trend, with Novo Nordisk's oral Semaglutide (Wegovy) receiving FDA approval and set to launch in January 2026 [7]. Sales Analysis - In Q1 2025, Semaglutide's sales in China showed fluctuations, with January sales reaching 33,700.7 million yuan, driven by strong brand reputation and the launch of the oral formulation [46][48]. - February saw a significant drop in sales due to competitive pressure from the launch of Tirzepatide and a negative incident affecting patient adherence [48]. - March sales rebounded, indicating a stabilization in the market after initial fluctuations [48]. Regional Insights - There are significant regional disparities in Semaglutide sales across China, with Beijing leading in per capita sales at 5.9 yuan, while Chongqing lagged at 0.6 yuan [53]. Drug Applications and Approvals - Semaglutide received FDA approval for chronic kidney disease (CKD) indications, with a corresponding application accepted in China, which could expand its market potential significantly [23][24][25]. - The report notes that the first domestic application for Semaglutide has not yet been approved, indicating challenges in the regulatory landscape [26][28]. Competitive Landscape - The launch of Eli Lilly's Tirzepatide in China is expected to intensify competition in the GLP-1 market, prompting Semaglutide to accelerate its innovation and market strategies [34][38]. - Novo Nordisk's introduction of the first oral GLP-1RA in China represents a significant advancement in drug delivery methods, enhancing patient compliance and expanding market reach [38]. Conclusion - The report emphasizes the evolving landscape of the biopharmaceutical market in China, particularly for weight loss and diabetes medications, highlighting the need for companies to adapt to competitive pressures and regulatory challenges to maintain market share and drive growth [10][25].

GIP（葡萄糖依赖性促胰岛素多肽）与GLP-1（胰高血糖素样肽-1）同属肠促胰岛素家族，其受体GIPR 在人体代谢调节中发挥着多维度的核心作用：在脂肪组织中促进脂质摄取与储存；在骨骼中调节骨形成 与转换；并在中枢神经系统（CNS）中参与食欲调节。近日，英矽智能宣布发现创新GIPR拮抗剂 ISM0676，该候选分子在临床前小鼠模型中实现用药27天减重31%的强大疗效，为评估GIPR通路在减重 治疗中的作用提供了新的临床前数据。 据披露，ISM0676由英矽智能(03696)借助其Pharma.AI人工智能药物发现平台赋能设计，从立项到临床 前候选化合物提名耗时14个月，累计合成测试不超过200个分子，体现了其以AI辅助提升早期研发效率 的探索路径。那么，GIPR拮抗剂是否会成为行业竞相追逐的下一款"神药"？ 人工智能在机制探索与分 子优化等环节，又将发挥多大作用？ GLP-1困局：减重数据的B面 在狂飙猛进的减重药物市场，GLP-1作为数十年前被发现、机制相对成熟的靶点，率先进入临床应用阶 段，吸引初创公司、制药巨头甚至跨界玩家纷纷入局。仅2025年，礼来、诺和诺德等全球顶尖药企的 GLP-1产品销售额已经突破 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 英矽智能 （於開曼群島註冊成立的有限公司） （股份代號：3696) 自願公告 英矽智能與齊魯製藥達成超過9.31億港元的藥物研發合作 加速心血管與代謝類疾病創新療法開發 本公告由英矽智能（「本公司」，連同其附屬公司統稱「本集團」）自願作出，以告知 本公司股東及潛在投資者有關本集團的最新業務更新。 本公司董事會（「董事會」）欣然宣佈，英矽智能已與齊魯製藥集團及其附屬公司上 海齊魯製藥研究中心（「齊魯製藥」），達成藥物研發戰略合作（「該合作」）並簽署相 關協議（「該協議」）。 透過該合作，雙方將依託英矽智能自有Pharma.AI解決方案，針對特定靶點開展小 分子抑制劑合作開發，關注心血管與代謝類疾病領域管理。 根據該協議的條款，英矽智能將利用自主搭建的Pharma.AI平台，關注用於代謝疾 病領域的新穎小分子藥物設計與優化，齊魯製藥將負責後續開發與商業化工作。 該協議總額超9.31億港元，包含開發和銷售里程碑 ...

英矽智能 （於開曼群島註冊成立的有限公司） （股份代號：3696） 自願公告 英矽智能與衡泰生物達成超過 5 億港元的全球戰略合作 共同開發新型血腦屏障穿透性 NLRP3 抑制劑 本公告由英矽智能（「本公司」，連同其附屬公司統稱「本集團」）自願作出，以告知 本公司股東及潛在投資者有關本集團的最新業務更新。 本公司董事會（「董事會」）欣然宣佈，英矽智能已與深圳衡泰生物科技有限公司 （「衡泰生物」），一家由深圳市鵬復生物醫藥產業私募股權投資基金合夥企業（有 限合夥）與復星醫藥聯合孵化的企業，就英矽智能的ISM8969項目達成獨家許可與 共同開發合作協議（「該協議」）（「該合作」）。 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 INSILICO MEDICINE InSilico Medicine Cayman TopCo 關於英矽智能 英矽智能是一家全球先鋒生物科技公司，致力於整合人工智能和自動化技術，加 速藥物發現並推動生命科學領域的創新，賦能人類擁 ...

Summary of Shanghai Henlius Biotech FY Conference Call Company Overview - **Company Name**: Shanghai Henlius Biotech (SEHK: 02696) - **Industry**: Biopharmaceuticals - **Key Products**: Four products approved by the U.S. FDA, seven by China NMPA, and four by EU EMA - **Clinical Trials**: Over 30 ongoing clinical trials and more than 50 early-stage assets - **Global Workforce**: Approximately 4,000 employees - **Manufacturing Capacity**: 80,000 liters facility in China - **Patient Impact**: Products have benefited over 950,000 patients globally [2][3][26] Core Competencies - **Clinical Operations**: In-house team operating across China, U.S., Australia, Japan, with 1,000 clinical research centers in 20 countries [3] - **R&D Capabilities**: 50+ early-stage molecules, with 70% aimed to be first best in class and 15% first in class [3] - **Regulatory Affairs**: 66 NDA approvals globally, including four BLA approvals by FDA last year [3] - **Manufacturing**: More than 1,150 commercial GMP batches certified by multiple regulatory authorities [3] Product Pipeline Highlights - **Serplulimab**: Approved for small cell lung cancer in China and EU, with ongoing studies for additional indications [4][5] - **Clinical Data**: Four-year overall survival (OS) rate of 21.9 months compared to standard care of 7.2 months [5] - **HELIX-22**: A novel HER2 mAb with a dual epitope strategy, currently in global phase three trials [7][9] - **Safety Profile**: Better safety compared to competitors, with ongoing recruitment of 600 patients [9] - **HELIX-43**: PD-L1 ADC targeting solid tumors, with significant efficacy data reported [10][11] - **Efficacy Rates**: ORR of 47.4% for EGFR wild type patients and 70% for cervical cancer at 3.0 mg/kg [11] Upcoming Milestones - **Regulatory Approvals**: Expecting accelerated approval for perioperative gastric cancer and additional indications for non-small cell lung cancer in the EU [14][15] - **Clinical Trials**: Initiating global phase 3 trials for various non-small cell lung cancer indications [12][16] - **Data Readouts**: Anticipated data from multiple studies at ASCO, including non-small cell lung cancer and ovarian cancer [17] Strategic Focus - **Next Generation Immuno-Oncology**: Emphasis on improving clinical responses to immunotherapy-resistant diseases [18][19] - **AI Technology**: Investment in generative AI for toxicity prediction and efficient screening [19] - **Biosimilars and Innovative Compounds**: Plans for 10 biosimilar launches and five innovative compound launches in the next five years [26][27] Financial Outlook - **Revenue Growth**: Projected double-digit growth with $0.7 billion in revenue for 2024 [26] - **Global Expansion**: Vision to launch over 20 products globally by 2030, with overseas revenue expected to exceed domestic contributions [26][27] Funding Strategies - **Revenue Utilization**: Leveraging sales revenue from biosimilars to fund innovative compound trials [27] - **Partnerships**: Open to licensing discussions and new collaborations to support development [27][28]

Macro Economic Group - The U.S. Department of Justice has initiated a criminal investigation into Federal Reserve Chairman Jerome Powell, focusing on the $2.5 billion renovation project at the Fed's headquarters and whether Powell lied to Congress about project details. Powell responded strongly, claiming the investigation is a pretext to undermine the Fed's independence in setting interest rates based on public interest rather than presidential preferences [2][3] - The investigation was approved in November 2022 and is seen as a move to establish rules for current and future Fed officials, potentially impacting the Fed's independence [2] - The upcoming midterm elections on November 3, 2022, and Trump's concerns about impeachment following potential election losses indicate a need for favorable economic conditions to boost his approval ratings. This pressure on Powell may lead to further interest rate cuts or his resignation [3] Industry Comprehensive Group - The Ministry of Commerce announced progress in negotiations regarding the export of electric vehicles to the EU, which could significantly benefit China's new energy vehicle exports. The reduction of export tax rebates for battery products in 2026 and their complete cancellation in 2027 is expected to stimulate battery export orders [7] - NVIDIA plans to invest $1 billion with Eli Lilly over the next five years to establish an AI drug laboratory, aiming to accelerate drug discovery through robotics and AI. This collaboration is likely to enhance market expectations for AI applications, particularly in the AI chip sector [7] Advanced Manufacturing Group - Research indicates that the price difference in renewable energy is widening, with wind power at about 80% of long-term contract prices and solar power at 60-70%. The profitability of the energy storage market currently relies on capacity subsidies and peak-shaving fees, with future profitability expected to shift towards arbitrage based on peak and valley price differences [9] - The focus in 2026 is expected to shift from scale expansion to system value, emphasizing the ability to manage and predict fluctuations in energy supply and demand [9] Consumer Group - Google and Walmart have announced a deepened collaboration on AI shopping features, marking a significant step towards the commercialization of AI in e-commerce. This partnership aims to enhance the capabilities of AI assistants in product discovery, recommendations, and transactions [11][12] - Fast Retailing reported strong performance for FY26Q1, with revenues of 1,027.7 billion yen, a year-on-year increase of 14.8%. The core brand Uniqlo showed robust growth, particularly in international markets, which is expected to drive demand in the upstream supply chain [13]

Group 1 - The A-share market experienced fluctuations with the Shanghai Composite Index showing volatility, while trading volume exceeded 1.8 trillion yuan, indicating sustained active trading [1] - The innovative drug sector saw significant strength, with the Science and Technology Innovation Drug ETF Huatai (589120) surging over 3% as funds continued to flow into it for two consecutive days, driven by optimism around "BD going global + AI healthcare + brain-computer interfaces" [1] - The top ten constituent stocks of the Huatai ETF include companies like BeiGene (688235) and Junshi Biosciences (688180), with Rongchang Biopharmaceuticals (688331) leading with a 17.29% increase [1][5] Group 2 - Rongchang Biopharmaceuticals announced a licensing agreement with AbbVie for RC148, which includes a $650 million upfront payment and potential milestone payments up to $4.95 billion, along with double-digit royalties on net sales outside Greater China [1][2] - The transaction size of the upfront payment ranks among the top ten for domestic innovative drug companies going global, indicating the potential of RC148 in the global market [2] - The trend in the industry is shifting from "early licensing" to "deep binding" partnerships, with companies like Hengrui Medicine and Qianxin Biopharmaceuticals actively engaging in new cooperative models that share risks and long-term benefits [4][6] Group 3 - The innovative drug sector is expected to enter a phase of significant growth, with a focus on the lifecycle of BD transactions, which includes achieving overseas clinical validation and profit-sharing from sales [3][4] - The market anticipates a busy period for BD transactions, with 49 deals totaling over $39 billion since October, as multinational corporations continue to expand in China [6] - The upcoming JPM conference in January 2026 is expected to catalyze further activity in the sector, coinciding with the annual report cycle, suggesting a peak in data disclosures and BD transactions [6]