香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因 依賴該等內容而引致的任何損失承擔任何責任。 Mirxes Holding Company Limited （ 於 開 曼 群 島 註 冊 成 立 的 有 限 責 任 公 司 ） （股份代號：2629） 自願性公告 有關可能合作事項的諒解備忘錄 諒解備忘錄之主要條款如下： – 1 – 主要合作範圍 雙方同意在（其中包括）下列活動（統稱及各自稱為「合作活動」）方面開展真誠 合作： PT DIASTIKA BIOTEKINDO的資料 PT DIASTIKA BIOTEKINDO為一間根據印尼法律註冊成立之有限公司，主要於 印尼從事實驗室設備及試劑、製藥設備以及醫療設備及器械之批發業務。 PT DIASTIKA BIOTEKINDO的醫院網絡覆蓋逾300間醫院（其中70%位於爪哇， 居住57%印尼人口），實現即時規模效益醫療服務，而外島服務不足則蘊藏90% 尚未開發商機。 本公告乃由Mirxes Holding Company Limited（「本公司」， ...

Core Viewpoint - MIRXES-B (02629) has seen a significant increase in stock price, reaching a new high of 40.66 HKD, which is over 70% higher than its IPO price of 23.3 HKD [1] Company Overview - Mirxes is a Singapore-based RNA biotechnology company focused on developing and commercializing precise, non-invasive, and affordable blood miRNA tests for early cancer and disease screening [1] - The flagship product, GASTROClear™/觅小卫™, is a blood miRNA-based molecular diagnostic kit for gastric cancer screening, approved in multiple countries including Singapore and the EU, and has received breakthrough medical device certification from the US FDA [1] - GASTROClear™ has completed a prospective clinical trial with a sample size of 9,472 in China and is currently in the registration application process [1] Market Position - The company is recognized as a global leader in the field of early cancer detection based on miRNA, possessing significant technological, product, and market advantages [1] - The global cancer screening market is noted to have vast potential with high entry barriers [1] - GASTROClear™ is the only approved molecular diagnostic IVD product for gastric cancer screening in the global market, holding the largest market share of 66.3% in the Southeast Asian miRNA-based liquid biopsy gastric cancer screening market as of 2023 [1]

Core Viewpoint - Mirxes-B (02629) has seen a significant increase in stock price, reaching a new high of 40.66 HKD, which is over 70% higher than its IPO price of 23.3 HKD [1] Company Overview - Mirxes is a Singapore-based RNA biotechnology company focused on developing and commercializing precise, non-invasive, and affordable blood miRNA tests for early cancer and disease screening [1] - The flagship product, GASTROClear, is a blood miRNA-based molecular diagnostic kit for gastric cancer screening, approved in multiple countries including Singapore and the EU, and has received breakthrough medical device certification from the FDA in the US [1] - GASTROClear has completed a prospective clinical trial with a sample size of 9,472 in China and is currently in the registration application process [1] Market Position - Guoyuan International believes that the company has significant technological, product, and market advantages in the field of miRNA-based early cancer detection, positioning it as one of the global leaders in this sector [1] - Everbright Securities International previously noted the vast market potential for global cancer screening, highlighting high industry entry barriers [1] - GASTROClear is the only approved molecular diagnostic IVD product for gastric cancer screening in the global market, holding the largest market share (66.3%) in the Southeast Asian miRNA-based liquid biopsy gastric cancer screening market as of 2023 [1]

Core Viewpoint - MIRXES-B (02629) has seen a significant increase in stock price, reaching a new high of 40.66 HKD, which is over 70% higher than its IPO price of 23.3 HKD [1] Company Overview - Mirxes is a Singapore-based RNA biotechnology company focused on developing and commercializing precise, non-invasive, and affordable blood miRNA tests for early cancer and other disease screening [1] - The flagship product, GASTROClear™/觅小卫™, is a blood miRNA-based molecular diagnostic kit for gastric cancer screening, approved in multiple countries including Singapore and the EU, and has received breakthrough medical device certification from the US FDA [1] - GASTROClear™ has completed a prospective clinical trial with a sample size of 9,472 in China and is currently in the registration application process [1] Market Position - According to Guoyuan International, the company holds significant technological, product, and market advantages in the field of miRNA-based early cancer detection, positioning it as a global leader [1] - Everbright Securities International noted the vast market potential for global cancer screening, highlighting high industry entry barriers [1] - GASTROClear™ is the only approved molecular diagnostic IVD product for gastric cancer screening globally, holding the largest market share of 66.3% in the Southeast Asian miRNA liquid biopsy gastric cancer screening market as of 2023 [1]

格隆汇8月13日丨MIRXES-B(02629.HK)公布，公司将于2025年8月25日召开董事会会议，以（其中包 括）审议及通过集团截至2025年6月30日止六个月的中期业绩及其发布。 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或依 賴該等內容而引致的任何損失承擔任何責任。 （股份代號：2629） 董事會召開日期 Mirxes Holding Company Limited（「本公司」）董事（「董事」）會（「董事會」）謹此宣 佈，謹定於2025年8月25日（星期一）舉行董事會會議，藉以（其中包括）考慮及 通過本公司及其附屬公司截至2025年6月30日止六個月的中期業績以供發佈， 以及處理任何其他事項。 承董事會命 Mirxes Holding Company Limited （ 於 開 曼 群 島 註 冊 成 立 的 有 限 責 任 公 司 ） Mirxes Holding Company Limited 執行董事兼首席執行官 周礪寒博士 香港，2025年8月13日 於本公告日期，董事會包括(i)執行董事周礪寒博士、鄒瑞陽博士及何豪傑先生；(ii)非執行董 事朱興奮博士、樂貝林博士及柳達先生；及(iii)獨立非執行董事林倩麗博士、方曉先生及馬 露玲女士。 ...

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年7月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: Mirxes Holding Company Limited (於開曼群島註冊成立的有限責任公司) 呈交日期: 2025年8月6日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 02629 | 說明 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 10,000,000,000 | USD | | 0.00001 USD | | 100,000 | | 增加 / 減少 (-) | | | | | | USD | | | | 本月底結存 | | | 10,000,000,000 | USD | | 0.00001 USD | ...

Core Viewpoint - The Hong Kong stock market is experiencing an unprecedented capital boom in the biotechnology sector, with multiple pharmaceutical companies rushing to list, making it a strategic high ground for industry capitalization [1][2]. Group 1: Industry Capitalization Process - The IPO wave is intensifying, with three biopharmaceutical companies—Hengrui Medicine, Mirui, and PegBio—successfully listing on the Hong Kong stock exchange between May 23 and 27, 2023 [2]. - Hengrui Medicine's total market capitalization has surpassed 360 billion yuan, establishing it as an industry benchmark [2]. - Numerous companies, including AI drug leader Insilico Medicine and immunotherapy firm Kewen Pharma, are currently advancing their IPO processes in Hong Kong [2]. Group 2: Policy and Capital Drivers - Recent policy relaxations have facilitated the listing of unprofitable biotech companies on the Hong Kong stock exchange, a first among major global capital markets [3]. - A fast-track listing channel for A-share companies with a market value of over 10 billion yuan will be introduced in October 2024, significantly improving listing efficiency [3]. - The tightening of A-share IPO reviews and geopolitical uncertainties affecting the U.S. market have made Hong Kong a more attractive financing destination due to its high degree of internationalization and capital flow freedom [3]. Group 3: Globalization Strategy - The surge in Hong Kong listings reflects a deepening globalization strategy within China's biopharmaceutical industry [4]. - The Hong Kong market serves as an international capital hub, providing a platform for direct dialogue between pharmaceutical companies and international investors, with foreign ownership in the healthcare sector reaching 34% in Q1 2025 [4]. - Listing in Hong Kong helps companies establish international market recognition, facilitating overseas clinical trials and patent negotiations, as evidenced by Junshi Biosciences' record overseas licensing deal for its PD-1 antibody [4]. Conclusion - The continuous policy iterations by the Hong Kong Stock Exchange have aligned with the capital needs of the industry, enabling pharmaceutical companies to expand their global resource allocation and participate in international competition [5]. - The current influx of companies into the Hong Kong market represents not only an expansion of financing channels but also a strategic pivot for Chinese innovative pharmaceutical firms aiming to secure a position in the global biopharmaceutical landscape [5].

Core Viewpoint - A total of 9 companies submitted applications to the Hong Kong Stock Exchange from May 19 to May 25, with 1 company passing the hearing, 5 companies undergoing initial public offerings (IPOs), and 3 companies listing [1]. Group 1: Companies Submitting Applications - Fuwai Group Limited, a pan-Asian life insurance company, reported a projected net profit of $10 million for 2024, recovering from previous losses [2]. - Shandong Kuailu Technology Development Co., Ltd. focuses on short-distance green travel solutions, with a market share of 2.2% in mainland China's short-distance green travel technology services [3]. - Jushuitan Group Co., Ltd. is the largest e-commerce SaaS ERP provider in China, holding a 20.7% market share [4]. - Sany Heavy Industry Co., Ltd. ranks first in China and third globally in core engineering machinery revenue from 2020 to 2024, with a projected overseas market revenue share of 62.3% by 2024 [4][5]. - Lezi Tiancheng Cultural Development Co., Ltd. is the second-largest multi-category IP toy company in China, with revenues projected to grow from approximately 463 million RMB in 2022 to 630 million RMB in 2024 [6]. - Furuitek (Zhejiang) Intelligent Technology Co., Ltd. ranks second among third-party suppliers of intelligent driving solutions in China, with a market share of 7.2% [7]. - Shenzhen Huaxida Technology Co., Ltd. is a leading AI Home solution provider, ranking third in China by revenue [7]. - Kewang Pharmaceutical Group is a clinical-stage biopharmaceutical company with significant products in clinical development [8]. - Allianz International Holdings Limited is a Hong Kong security service provider with projected revenues of 114 million HKD in 2023 [9]. Group 2: Companies Passing Hearings and IPOs - Haitian Flavoring and Food Co., Ltd. is a leading condiment company in China, holding a 4.8% market share in the condiment market, which is projected to reach 498.1 billion RMB in 2024 [10]. - The company reported revenues of 25.61 billion RMB in 2022, with profits of 6.198 billion RMB [10]. Group 3: Companies Undergoing IPOs - Hengrui Medicine Co., Ltd. had a public offering that was oversubscribed by approximately 455 times, with a final issue price of 44.05 HKD per share [11]. - MIRXES-B had a global offering of 46.62 million shares, with a public offering oversubscription of 25.51 times [12]. - Jihong Co., Ltd. plans to issue 67.91 million shares, with a price range of 7.48 to 10.68 HKD per share [13]. - Paige Biopharma-B plans to issue 19.28 million shares at a price of 15.60 HKD per share [14]. - Shouhui Group plans to issue 24.36 million shares at a price range of 6.48 to 8.08 HKD per share [15]. Group 4: Companies Listing - CATL officially listed on the Hong Kong Stock Exchange with an opening price of 263 HKD per share, closing at 306.20 HKD, a 16.43% increase on the first day [16]. - MIRXES-B opened at 29 HKD per share and closed at 30 HKD, a 28.76% increase on its first day [17]. - Hengrui Medicine opened at 57 HKD per share and closed at 55.15 HKD, a 25.20% increase on its first day [18].

Core Insights - The Hong Kong stock market welcomed two pharmaceutical companies, Heng Rui Pharmaceutical and MIRXES-B, on May 23, with both stocks experiencing significant price increases on their debut [2] - MIRXES, despite being less well-known, saw its stock price rise over 30% by the time of reporting, achieving a market capitalization exceeding HKD 8 billion [2] - MIRXES successfully raised HKD 880.5 million through the issuance of 46.62 million shares at HKD 23.30 each, with a subscription rate of 25.51 times for the public offering [2][3] Company Overview - MIRXES, founded in 2014 and headquartered in Singapore, specializes in microRNA (miRNA) technology, focusing on disease screening and diagnostic solutions in key Asian markets, including Singapore and China [3] - The company has one core product, GASTROClear™, and two other commercialized products, LUNGClear™ and Fortitude™, along with six candidates in preclinical stages [3][4] Product Details - GASTROClear™ is a blood-based miRNA diagnostic test for gastric cancer screening, consisting of 12 miRNA biomarkers. It was the first and only molecular diagnostic IVD product approved for gastric cancer screening globally [4] - The product received a breakthrough medical device designation from the FDA in May 2023, marking a significant achievement for MIRXES in the miRNA diagnostic field [4] Financial Performance - MIRXES reported revenues of USD 17.76 million, USD 24.19 million, and USD 20.28 million for the years 2022, 2023, and 2024, respectively, with gross profits of USD 9.33 million, USD 13.58 million, and USD 8.89 million [4] - The company is projected to incur losses of USD 56.20 million, USD 69.57 million, and USD 92.21 million over the same period [4] Fund Utilization - The funds raised from the global offering will be allocated to the research and development of GASTROClear™, regulatory filings, production, commercialization, and enhancing the company's end-to-end capabilities, as well as general operational expenses [5]