Core Insights - MIRXES-B (02629) has entered into a joint venture agreement with Xeraya Opportunities Fund PCC Limited to establish MYRNA DIAGNOSTICS SDN.BHD, with Mirxes holding 40% and Xeraya 60% of the equity [1] - The joint venture aims to address the urgent need for early cancer detection and other nucleic acid-based testing in Malaysia, a country facing a significant cancer burden [1][2] Company Strategy - The joint venture will leverage Xeraya's regional expertise in life sciences and healthcare to create a leading cancer omics platform in Malaysia, focusing on advanced miRNA-based multi-omics technology and validated blood cancer early detection [3] - The company plans to establish a localized omics testing business to enhance turnaround time and cost-effectiveness for existing clinical operations, while expanding into new market segments, including public healthcare institutions [3] - The strategy includes utilizing Malaysia's thriving biotech ecosystem to accelerate the development of clinical pipelines for colorectal, breast, liver, and multi-cancer types [3] - The joint venture aims to integrate R&D and clinical operations across Singapore, China, and Malaysia to expedite regulatory approvals for in vitro diagnostics (IVDs) and laboratory-developed tests (LDTs) [3] - The company envisions establishing a scalable regional platform in Malaysia as a springboard for expansion into neighboring ASEAN countries and other Asian markets with similar epidemiological characteristics and unmet screening needs [3] Industry Context - Malaysia, with a population exceeding 35 million, is facing a rising cancer burden, with over 51,650 new cancer cases and 31,633 cancer deaths reported in 2022 [2] - More than 60% of cancer cases in Malaysia are diagnosed at advanced stages (Stage III or IV), which severely limits patient survival outcomes and places a heavy burden on the healthcare system [2] - The cancer incidence rate in Malaysia is projected to increase by over 70% by 2050, highlighting the critical unmet need for early detection, particularly for high-incidence cancers such as lung, colorectal, breast, liver, and stomach cancers, which together account for nearly 50% of total cases [2]

Core Insights - MIRXES-B has entered into a joint venture agreement with Xeraya Opportunities Fund to establish MYRNA DIAGNOSTICS SDN. BHD., focusing on cancer early detection and nucleic acid-based testing in Malaysia [1] Company Summary - The joint venture will be owned 40% by Mirxes International Holding Limited and 60% by Xeraya, with a total capital injection of approximately $5 million [1] - The establishment of the joint venture aligns with the company's mission to make early disease detection solutions accessible globally, starting with addressing critical healthcare gaps in Malaysia [4] Industry Summary - Malaysia faces a significant cancer burden, with over 51,650 new cases and 31,633 deaths reported in 2022, and more than 60% of cases diagnosed at advanced stages [2] - The cancer incidence rate in Malaysia is projected to increase by over 70% by 2050, highlighting the urgent need for early detection, particularly for prevalent cancers such as lung, colorectal, breast, liver, and stomach cancers [2] - The joint venture aims to leverage Malaysia's strong life sciences and healthcare expertise to establish a leading cancer omics platform and enhance localized testing services [3] - The initiative will also integrate R&D and clinical operations across Singapore, China, and Malaysia to expedite regulatory approvals and innovation in diagnostic testing [3]

Mirxes Holding Company Limited （ 於 開 曼 群 島 註 冊 成 立 的 有 限 責 任 公 司 ） （股份代號：2629） 自願性公告 成立合營企業 本公告乃由Mirxes Holding Company Limited（「本公司」，連同其附屬公司統稱「本 集團」）自願刊發，旨在知會本公司股東及潛在投資者有關本集團的最新業務 發展。 成立合營企業 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因 依賴該等內容而引致的任何損失承擔任何責任。 – 2 – (i) 建立馬來西亞領先的癌症組學平台，以本公司先進且以miRNA為中心的多 組學技術平台及經驗證的血液癌症早期檢測為基礎，解決馬來西亞在癌 症早期檢測及精準醫學方面未被滿足的關鍵臨床需求； (ii) 在馬來西亞建立強大且具在地化的專業組學檢測業務， a. 透過在地化檢測服務擴展現有臨床業務的規模，為現有客戶改善週 轉時間及成本效益； b. 加速拓展業務合作並涉足包括公立醫療機構等新市場領域； (iii) 善用馬來西 ...

Mirxes Holding Company Limited 股份代號 : 2629 （於開曼群島註冊成立的有限責任公司） C M Y CM MY CY CMY K Mirxes Holding Company Limited (Incorporated in the Cayman Islands with limited liability) Stock Code : 2629 「CRC-1」 指 CRC-1為一種我們正在開發的用於結直腸癌篩查的基於miRNA 的檢測試劑盒 2025年中期報告 Mirxes Holding Company Limited 2 「無症狀」 指 並無產生或顯示症狀 「審核委員會」 指 董事會審核委員會 「BC-1」 指 BC-1為一種根據我們專有RT-qPCR技術用於乳腺癌篩查的基於 miRNA的檢測 「董事會」 指 本公司董事會 「乳腺癌」 指 自乳房發展而來的癌症 「癌症篩查」 指 對並無明顯癌症症狀的個體進行檢查或檢測，以確定此類疾病 的任何潛在跡象或早期階段 「CE-IVD證」 指 表明符合歐盟體外診斷醫療器械法規(IVDR 2017/746)的認證標 誌，其概述有關I ...

9月19日，港股通创新药板块早盘冲高回落后，维持红盘震荡。MIRXES-B一枝独秀，午后一度暴拉 25%，诺诚健华、同源康医药-B大涨超5%居前，权重股信达生物涨超2%。 100%创新药研发标的——港股通创新药ETF（520880）盘初一度上探2.57%，截至发稿仍涨超1%，成 交突破3亿元。 消息面，私募排排网数据显示，截至9月12日，全市场股票私募机构平均仓位超过78%，较9月5日上升 近3个百分点，达到今年最高水平。多家百亿级私募近期透露，目前仓位维持中高水平，并逢低加码创 新药等板块的优质标的。业内人士认为，从长期看，中国优势产业的全球竞争力没有变，中国经济修复 趋势未变，A股和港股的结构性行情有望持续演绎。 对此，港股通创新药ETF（520880）近期资金面有所印证。数据显示，截至9月19日，520880已连续14 日吸金，金额合计近6.8亿元。兴证全球策略首席张忆东日前提示，9月份或是创新药布局良机。 港股通创新药ETF（520880）基金经理丰晨成认为，现在应保持对创新药板块的密切关注，而非"退 场"。短期的市场调整，反而可能给真正质优的创新药企业提供了一次难得的买点。具体来看，当前创 新药仍有 ...

Group 1 - Mirxes-B (2629.HK) experienced a significant price surge, rising over 35% to reach 75 HKD, marking a new all-time high since its IPO [1] - The company's market capitalization has surpassed 20 billion HKD [1] - Since its listing on May 23, the stock price has increased by 220% from the IPO price of 23.3 HKD [1] Group 2 - Mirxes is a Singapore-based company specializing in microRNA technology, focusing on making disease screening and diagnostic solutions accessible in key Asian markets [1] - The company was recently included in the Hang Seng Composite Index, effective from September 8, and has officially become a Hong Kong Stock Connect eligible stock [1]

Core Viewpoint - Mirxes-B (02629) has seen a significant stock price increase, rising over 150% from its IPO price of 23.3 HKD, reaching a high of 59.5 HKD, and currently trading at 54.75 HKD with a trading volume of 566 million HKD [1] Company Overview - Mirxes is a Singapore-based company specializing in microRNA (miRNA) technology, focusing on making disease screening and diagnostic solutions accessible in key Asian markets [1] - The company has one core product, GASTROClearTM, along with two other commercialized products, LUNGClearTM and FortitudeTM, and six candidates in preclinical stages [1] Product Details - GASTROClearTM is a blood-based miRNA detection kit consisting of 12 miRNA biomarkers for gastric cancer screening, which received Class C in vitro diagnostic (IVD) certification from the Health Sciences Authority (HSA) of Singapore in May 2019 and has been successfully commercialized in Singapore [1] Market Inclusion - Mirxes has been included in the Hang Seng Composite Index, effective from September 8, which has contributed to its stock price surge and its designation as a stock eligible for the Shanghai-Hong Kong Stock Connect [1]

Group 1 - Mirxes Holding Limited, a leading cancer early screening company in Singapore, was listed on the Hong Kong Stock Exchange on May 23, 2025, and was included in the Hang Seng Composite Index and Hong Kong Stock Connect within four months, indicating strong international market recognition [1] - For the first half of 2025, Mirxes reported revenue of $10.5 million, a 9.4% increase compared to the same period in 2024, with gross profit reaching $7.1 million, up 51.1%, and gross margin significantly improving from 49.0% to 67.6% [1] - The company's loss decreased by 36.3% year-on-year to $28.23 million, reflecting improved financial performance [1] Group 2 - Mirxes was founded in 2014 and is a global leader in RNA liquid biopsy, focusing on the research of blood cfRNA and cfDNA, while integrating information from proteins, imaging, and epidemiology through multi-dimensional machine learning models [1] - The company has developed its proprietary mSMRT-qPCR technology platform and has conducted multiple studies in early screening for gastric, lung, and breast cancers, with research published in international journals such as Gut, PNAS, and Cancers [1] - In 2020, Mirxes initiated the first national standard for microRNA diagnostics in Singapore, collaborating with prestigious institutions, and is set to be included in the ISO certification system [2] - The company launched the world's first serum gastric cancer molecular diagnostic kit, GASTRO ClearTM, in Singapore in 2019 and was recognized by Nature Biotechnology as the only Asian company on the "Global Liquid Biopsy Innovation Companies" list [2]

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年8月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: Mirxes Holding Company Limited (於開曼群島註冊成立的有限責任公司) 呈交日期: 2025年9月4日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 02629 | 說明 | | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 10,000,000,000 | USD | | 0.00001 | USD | | 100,000 | | 增加 / 減少 (-) | | | | | | | USD | | | | 本月底結存 | | | 10,000,000,000 | USD | ...

Core Viewpoint - The Hong Kong IPO market is active, with 57 new listings and a total fundraising amount of 131.9 billion HKD as of August 25. However, many companies face challenges in meeting both domestic and Hong Kong regulatory requirements for listing [1]. Group 1: Hong Kong IPO Overview - As of August 25, 2023, there have been 57 new IPOs on the Hong Kong Stock Exchange, raising a total of 131.9 billion HKD [1]. - There are currently 211 companies that have submitted applications for listing in Hong Kong [1]. Group 2: Listing Challenges - Companies looking to list in Hong Kong must comply with both domestic laws and Hong Kong's regulatory framework, making the IPO preparation process complex and demanding [1]. Group 3: Resources for Companies - A compilation of Hong Kong listing rules and disclosure documents for domestic companies planning to list in Hong Kong has been organized to assist businesses in understanding the latest regulatory dynamics [1].