Core Insights - The top three companies with the highest short positions as of October 24 are ZTE Corporation (00763), Vanke Enterprises (02202), and COSCO Shipping Holdings (01919), with short ratios of 15.82%, 15.47%, and 15.42% respectively [1][2] - The companies with the largest increase in short positions are InnoCare Pharma-B (09606), Sanhua Intelligent Controls (02050), and Giant Biogene (02367), with increases of 2.41%, 2.04%, and 1.06% respectively [1][2] - The companies with the largest decrease in short positions are Junshi Biosciences (01877), Mingyuan Cloud (00909), and Shandong Gold (01787), with decreases of -0.95%, -0.94%, and -0.93% respectively [1][3] Top 10 Short Positions - The top 10 companies with the highest short ratios include: - ZTE Corporation (00763): 15.82% - Vanke Enterprises (02202): 15.47% - COSCO Shipping Holdings (01919): 15.42% - Contemporary Amperex Technology Co., Ltd. (03750): 13.88% - Ganfeng Lithium (01772): 13.55% - Ping An Insurance (02318): 13.03% - Fuyao Glass (06865): 12.01% - Zijin Mining (02899): 11.94% - Heng Rui Medicine (01276): 11.05% - MicroPort Medical (00853): 10.94% [2] Largest Increases in Short Positions - The companies with the largest increases in short ratios are: - InnoCare Pharma-B (09606): from 1.39% to 3.80% - Sanhua Intelligent Controls (02050): from 8.14% to 10.18% - Giant Biogene (02367): from 7.56% to 8.62% - Pop Mart International (09992): from 3.91% to 4.88% - GCL-Poly Energy Holdings (03800): from 7.92% to 8.77% - Fourth Paradigm (06682): from 1.20% to 1.96% - Yidu Tech (02158): from 2.64% to 3.38% - Yanzhou Coal Mining Company (01171): from 7.52% to 8.24% - Laopu Gold (06181): from 2.35% to 3.02% - Aluminum Corporation of China (02600): from 5.85% to 6.48% [2] Largest Decreases in Short Positions - The companies with the largest decreases in short ratios are: - Junshi Biosciences (01877): from 5.50% to 4.55% - Mingyuan Cloud (00909): from 4.52% to 3.58% - Shandong Gold (01787): from 8.17% to 7.24% - Kelaiying (06821): from 9.14% to 8.23% - Ganfeng Lithium (01772): from 14.32% to 13.55% - Zijin Mining (02899): from 12.62% to 11.94% - Luoyang Molybdenum (03993): from 6.20% to 5.53% - Yiming Anke-B (01541): from 1.13% to 0.49% - Innovent Biologics (09969): from 6.38% to 5.80% - ZhongAn Online (06060): from 7.11% to 6.57% [3][4]

Market Overview - The Hang Seng Index fell by 0.89%, down 232 points, closing at 26,050 points, while the Hang Seng Tech Index dropped by 1.91% [1] - The early trading volume in the Hong Kong stock market reached HKD 142.3 billion [1] Biotechnology Sector - The Hang Seng Biotechnology Index rebounded by 2.16%, with notable gains in several stocks: - InnoCare Pharma (09606) surged by 10.88% - 3SBio (01530) increased by over 10% - Innovent Biologics rose by 6.82% - Kelun-Biotech (06990) gained 5.69% [1] - Fosen Pharmaceuticals (01652) saw a significant increase, with a peak rise of nearly 74% and an early gain of 59.42% following the approval of Enzalutamide soft capsules and the potential selection of Metformin and Empagliflozin for national procurement [1] - Rongchang Biopharma (09995) rose by 6.75%, reporting a 40% year-on-year revenue growth and a significant reduction in losses for the first three quarters [1] Medical Sector - Spring Medical (01858) increased by over 21%, turning a profit of HKD 77.06 million in the third quarter as the company actively expands its international market [2] New Stocks Performance - Newly listed Dipo Technology (01384) continued to rise, gaining 18.97% and doubling its stock price within three days of listing [3] Financial Sector - China Everbright Bank (06818) fell by 5% post-earnings, with both revenue and profit declining in the third quarter, facing pressure from fair value changes [4] Other Notable Stocks - Huahao Zhongtian Pharmaceutical-B (02563) experienced a significant drop of over 37% due to a large unlock of shares after one year of listing [5] - Lion Holdings (02562) plummeted over 24% to a new low, planning to issue convertible bonds to raise approximately HKD 260 million for investments in gold and related products [6] - Air China (00753) dropped over 8%, with a more than 11% decline in net profit for the third quarter, and plans to raise up to HKD 20 billion through A-share placement [7]

智通财经APP获悉，映恩生物-B(09606)盘中涨超13%，截至发稿，涨11.1%，报314.4港元，成交额5.73 亿港元。 消息面上，映恩生物此前公告称，公司董事会决议拟在科创板上市，该事项需视市场状况，并获董事会 进一步批准、股东大会批准及监管机构许可。据悉，今年4月15日，映恩生物在港交所主板正式挂牌， IPO募资总额超15亿港元，是近四年来港股18A板块募资规模最大的IPO之一。 国金证券发布研报称，快速的创新步伐刺激了ADC技术领域的大规模交易，公司已与全球多家行业领 先企业达成多项对外许可及合作协议，包括与BioNTech、百济神州、Adcendo、GSK及Avenzo， 2023/2024/2025上半年确认BD收入合计分别为17.81/19.37/12.27亿元，总交易价值超60亿美元。 ...

10月31日盘中，创新药概念股集体走高。截至发稿，三生国健20%涨停，舒泰神涨超14%，透景生命、 迈威生物、泽璟制药、荣昌生物等多股涨超10%。 | 代码 | 名称 | 涨幅 | 现价 | | --- | --- | --- | --- | | 688336 | 三生国健 | +20.00% | 72.96 | | 300204 | 舒泰神 | +14.29% | 36.47 | | 300642 | 透景生命 | +11.97% | 24.78 | | 688062 | 迈威生物-U | +11.69% | 47.23 | | 688266 | 泽璟制药-U | +11.06% | 99.18 | | 688331 | 荣昌生物 | +10.87% | 98.30 | | 300683 | 海特生物 | +10.33% | 34.24 | | 688321 | 微粒化工艺物 | +10.19% | 31.46 | | 600513 | 联环药业 | +10.01% | 21.77 | | 002940 | 昂利康 | +9.99% | 39.73 | | 002370 | 亚太药业 | +9.99% | ...

港股方面，制药概念股持续走强。截至发稿，福森药业大涨超53%，映恩生物涨超12%，药捷安康涨超 9%，信达生物、劲方医药等跟涨。 | 代码 | 名称 | 涨幅 | 现价 | | --- | --- | --- | --- | | 01652 | 福森药业 | +53.62% | 1.060 | | 09606 | 映图生物-B | +12.44% | 318.200 | | 02617 | 药捷家康-B | +9.45% | 190.000 | | 01801 | 信达生物 | +8.18% | 87.200 | | 06990 | 科伦博泰生物-B | +8.16% | 456.000 | | 02595 | 劲方医药-B | +8.05% | 28.720 | | 02696 | 复宏汉霖 | +6.81% | 70.600 | | 02196 | 复 ■ 医药 | +6.36% | 23.740 | | 01167 | 加科 思-B | +6.11% | 7.610 | | 02256 | 和誉-B | +6.02% | 14.800 | | 08329 | 海王英特龙 | +5.80% | 0.146 ...

智通财经APP获悉，根据2025年10月28日披露数据，三花智控（02050）、赤峰黄金（06693）、趣致集 团（00917）港股通持股占比增加值最大，分别增加0.85%、0.66%、0.58%；中铝国际（02068）、上海 復旦（01385）、东江环保（00895）港股通持股占比减少值最大，分别减少-2.21%、-1.19%、-1.16%。 在最近有统计数据的5个交易日内，德林控股（01709）、映恩生物-B（09606）、秦港股份（03369）港 股通持股占比增加值最大，分别增加7.70%、3.45%、3.12%；昊天国际建投（01341）、龙蟠科技 （02465）、恆生中国企业（02828）港股通持股占比减少值最大，分别减少-7.61%、-2.49%、-2.21%。 具体数据如下（交易所数据根据T+2日结算）： 1、港股通最新日占比增持榜（前20名） | 公司名称 | 占比值变动 | 最新持股比例 | | --- | --- | --- | | 德林控股(01709) | +7.70% | 34.03% | | 映恩生物-B(09606) | +3.45% | 20.26% | | 秦港股份(0336 ...

Core Insights - The report highlights significant changes in the Hong Kong Stock Connect holdings, with notable increases and decreases in ownership percentages for various companies [1][2]. Summary by Category Increased Holdings - China Aluminum International (02068) saw an increase of 4.32%, bringing its latest holding percentage to 20.94% [2]. - Shandong Molong (00568) experienced a 2.69% increase, with a current holding of 63.27% [2]. - Beijing Beichen Industrial Holdings (00588) increased by 2.59%, now holding 41.93% [2]. - In the last five trading days, Shandong Molong (00568) had the highest increase at 8.40%, with a holding of 63.27% [3]. - Other notable increases in the last five days include Ying En Bio-B (09606) at 7.65% and Derin Holdings (01709) at 5.55% [3]. Decreased Holdings - Dreamland (01119) reported a decrease of 1.69%, with a current holding of 13.11% [2]. - Chifeng Jilong Gold Mining (06693) decreased by 0.71%, now at 46.23% [2]. - Jiufang Zhitu Holdings (09636) saw a reduction of 0.55%, with a holding of 17.45% [2]. - In the last five trading days, Haotian International Investment (01341) had the largest decrease at -7.78%, now holding 51.05% [3]. - Other significant decreases include Ocean Park (02255) at -5.92% and Goldwind Technology (02208) at -3.19% [3]. Long-term Trends - Over the past 20 days, Canggang Railway (02169) had the highest increase at 31.12%, with a holding of 43.18% [4]. - The largest decrease over the same period was seen in Haotian International Investment (01341) at -9.50%, with a holding of 51.05% [4].

Investment Rating - The report maintains a "Positive" investment rating for the pharmaceutical and biotechnology industry in China [5]. Core Insights - The ESMO conference showcased significant breakthroughs in both foreign and domestic innovative drugs, highlighting the competitive strength of Chinese pharmaceutical companies on the international stage [3][12]. - The report emphasizes the potential of domestic innovative drugs to redefine standard therapies, particularly in the context of PD-1/VEGF dual antibodies and antibody-drug conjugates (ADCs) [8][29]. Summary by Sections 1. PD-1 plus and Domestic Dual Antibodies - The PD-(L)1/VEGF dual antibody, Ivosidenib, demonstrated strong positive results in a Phase III trial for first-line treatment of advanced squamous non-small cell lung cancer (NSCLC), showing a progression-free survival (PFS) improvement of 4.2 months compared to the PD-1 group [13][16]. - SSGJ-707, a PD-1/VEGF dual antibody, showed promising results in treating microsatellite stable (MSS) colorectal cancer, with an overall response rate (ORR) of 68.7% and a disease control rate (DCR) of 98.5% [18][19]. - HB0025, another PD-L1/VEGF dual antibody, reported an ORR of 83.3% in squamous NSCLC patients, indicating strong anti-tumor efficacy [20][21]. 2. ADCs: Accelerated Breakthroughs - SKB264, an ADC, has shown significant PFS and overall survival (OS) benefits in a Phase III trial for EGFR-mutant NSCLC, with PFS HR of 0.49 and OS HR of 0.60, indicating its potential as a new standard therapy [29][30]. - In the breast cancer domain, SKB264 demonstrated an ORR of 41.5% in CDK4/6i pre-treated HR+/HER2- advanced breast cancer, significantly outperforming chemotherapy [31][32]. - The report highlights the global potential of SKB264, with ongoing studies expected to further validate its efficacy and safety profile [23][29].

Group 1: Macro Insights - The report highlights new goals and strategies from the Fourth Plenary Session, including a focus on enhancing national defense capabilities and international influence by 2035, and the establishment of a "strong aerospace nation" [4] - Key tasks have been prioritized, emphasizing the modernization of the industrial system, opening up to the outside world, and improving people's livelihoods, particularly in promoting high-quality development in real estate [4] - The report suggests that while short-term policies may intensify, the overall approach will lean towards gradual adjustments rather than immediate actions, with a focus on laying groundwork for the upcoming year [4] Group 2: Pharmaceutical Industry - The report on InnoCare Pharma (映恩生物-B) indicates that the company has rapidly advanced its clinical development through a self-built ADC platform, with HER2 ADC expected to file for listing in 2025 [5] - Revenue projections for InnoCare Pharma are set at 1.95 billion, 2.15 billion, and 2.90 billion yuan for 2025-2027, with growth rates of 0.5%, 10.3%, and 35.1% respectively, leading to a target market valuation of approximately 42.67 billion yuan [5] Group 3: Power Sector - The report notes a significant increase in electricity consumption in September, particularly in the secondary industry, which grew by 5.7%, driven by improved water conditions boosting hydropower generation [6] - The report recommends focusing on the thermal power sector, highlighting companies like Huaneng International and Huadian International as potential investment opportunities due to their strong performance and favorable market conditions [6] Group 4: Construction and Decoration - China National Materials (中材国际) has shown steady revenue growth in the first three quarters of 2025, with a strong overseas order intake and an attractive dividend yield [10] - The projected net profits for China National Materials are 3 billion, 3.3 billion, and 3.6 billion yuan for 2025-2027, reflecting growth rates of 1.4%, 10.2%, and 9.2% respectively [10] Group 5: Agriculture and Animal Husbandry - Guibao Pet (乖宝宠物) reported a revenue of 4.737 billion yuan for the first three quarters of 2025, marking a year-on-year increase of 29.03%, while net profit reached 513 million yuan, up 9.05% [11] - The company is focusing on high-end brand strategies, with significant sales growth during the Double Eleven shopping festival, indicating a strong market position in the pet food sector [12] Group 6: Textile and Apparel - Tabo (滔搏) experienced a revenue decline of 5.8% in FY2026H1, but maintained a stable profit margin, with a focus on digital capabilities and operational efficiency [16] - Bosideng (波司登) is expected to achieve stable revenue and healthy profit growth as the winter season approaches, with projected net profits of 3.901 billion, 4.392 billion, and 4.951 billion yuan for FY2026-2028 [18] Group 7: Education Sector - Action Education (行动教育) reported a return to positive growth in Q3, driven by its "effectiveness + AI" strategy, with net profits projected to grow by 11.7%, 10.3%, and 10.3% for 2025-2027 [23] Group 8: Electronics - Shannon Semiconductor (香农芯创) reported a significant revenue increase of 59.9% year-on-year for the first three quarters of 2025, with a strong outlook for Q4 driven by rising demand for enterprise-level SSDs and DRAM products [24][25] - Revenue forecasts for Shannon Semiconductor are set at 38.9 billion, 58 billion, and 79.7 billion yuan for 2025-2027, with corresponding net profits of 605 million, 1.204 billion, and 2.025 billion yuan [26]

Core Insights - The company, Ying'en Biotech, is rapidly advancing in the ADC (Antibody-Drug Conjugate) sector with a focus on global expansion and clinical development [1][2][3] Group 1: Company Overview - Ying'en Biotech was established in 2019 and has developed a self-built camptothecin-based ADC platform, leading to swift clinical advancements and international expansion [1] - The company has completed overseas licensing for three ADC products (HER2, B7-H3, Trop2) with BioNTech, aiming to lead in IO (Immuno-Oncology) dual antibody + ADC development [1] Group 2: Product Pipeline - The core product DB-1303, a HER2 ADC, is expected to be submitted for approval in China for breast cancer by 2025, with a projected peak sales exceeding 3 billion yuan [2] - DB-1311, a B7-H3 ADC targeting prostate cancer, has shown promising early clinical data, with a median PFS rate of 58% in a heavily pre-treated patient population [2] - The company has initiated global Phase III clinical trials for DB-1303 targeting HER2 low late-stage breast cancer [2] Group 3: Strategic Partnerships - Ying'en Biotech has partnered with BioNTech, which has significant financial resources, to advance the development of second-generation IO + ADC therapies [3] - BioNTech has already initiated clinical data reading for a combination of PD-L1/VEGF dual antibody with Ying'en's ADC, indicating a strong collaborative advantage [3] Group 4: Financial Projections - Revenue forecasts for Ying'en Biotech are projected at 1.95 billion yuan in 2025, 2.15 billion yuan in 2026, and 2.91 billion yuan in 2027, with year-on-year growth rates of 0.5%, 10.3%, and 35.1% respectively [3] - The estimated reasonable market capitalization for the company is approximately 42.67 billion yuan based on product valuations [3]