| 证券代码：300725 | 证券简称：药石科技 | 公告编号：2024-023 | | --- | --- | --- | | 债券代码：123145 | 债券简称：药石转债 | | 南京药石科技股份有限公司 关于公司续聘 2024 年度审计机构的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚 假记载、误导性陈述或重大遗漏。 特别提示： 1、根据财政部、国务院国资委、证监会印发的《国有企业、上市公司选聘 会计师事务所管理办法》（财会[2023]4 号）及公司《会计师事务所选聘制度》的 相关规定。公司对 2024 年年审会计师事务所进行了邀请招标，根据中标结果， 公证天业会计师事务所（特殊普通合伙）排名第一位，拟续聘公证天业会计师事 务所（特殊普通合伙）为公司 2024 年度审计机构。 2、公司董事会审计委员会、董事会、监事会对本次拟续聘会计师事务所不 存在异议，本议案尚需提交公司 2023 年度股东大会审议。 南京药石科技股份有限公司（以下简称"公司"或"药石科技"）于 2024 年 4 月 23 日召开的第三届董事会第三十次会议、第三届监事会第十八次会议，审 议通过了《关于公司聘 ...

| 证券代码：300725 | 证券简称：药石科技 | 公告编号：2024-030 | | --- | --- | --- | | 债券代码：123145 | 债券简称：药石转债 | | 南京药石科技股份有限公司 关于使用部分暂时闲置募集资金及自有资金进行现金管理的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有 虚假记载、误导性陈述或重大遗漏。 重要内容提示 1、投资种类：拟在不影响募集资金投资项目建设和正常经营的前提下，利 用部分暂时闲置募集资金购买安全性高、流动性好、有保本约定的投资产品；利 用自有资金购买安全性高、流动性好、中低风险理财产品等。 2、投资金额：拟使用不超过人民币4.5亿元的暂时闲置募集资金、不超过9.5 亿元的自有资金，该投资额度在投资期限内可循环使用。 3、风险提示：尽管相关产品风险较低，但金融市场受宏观经济的影响较大， 不排除该项投资受到市场波动的影响，敬请投资者注意投资风险。 南京药石科技股份有限公司（以下简称"公司"或"药石科技"）于2024 年4月23日召开的第三届董事会第三十次会议、第三次监事会第十八次会议，审 议通过了《关于使用部分暂时闲置募集资金进行 ...

目 录 1、募集资金存放与实际使用情况专项报告的鉴证报告…… 1 2、2023 年度募集资金存放与使用情况的专项报告…………3 3、事务所营业执照复印件 4、事务所执业证书复印件 5、签字注册会计师资质证明复印件 公证天业会计师事务所（特殊普通合伙） Gongzheng Tianye Certified Public Accountants, SGP 南京药石科技股份有限公司 2023 年度募集资金存放与实际使用情 况专项报告的鉴证报告 苏公 W[2024]E1192 号 中国．江苏．无锡 Wuxi．Jiangsu．China 总机：86（510）68798988 Tel：86（510）68798988 传真：86（510）68567788 Fax：86（510）68567788 电子信箱：mail@gztycpa.cn E-mail：mail@gztycpa.cn 募集资金存放与使用情况鉴证报告 苏公W[2024]E1192号 南京药石科技股份有限公司全体股东： 我们接受委托，对后附的南京药石科技股份有限公司（以下简称"药石科 技"）2023年度《2023年度募集资金存放与实际使用情况的专项报告》（以下简 ...

华泰联合证券有限责任公司 （一）纳入评价范围的主要单位 关于南京药石科技股份有限公司 2023 年度内部控制自我评价报告的核查意见 华泰联合证券有限责任公司（以下简称"华泰联合"、"保荐机构"）作为南 京药石科技股份有限公司（以下简称"药石科技"、"公司"）2020 年度创业板向 特定对象发行股票、2022 年度向不特定对象发行可转换公司债券的保荐机构， 根据《深圳证券交易所创业板股票上市规则》《深圳证券交易所上市公司自律监 管指引第 2 号—创业板上市公司规范运作》等有关法律法规规定，对药石科技 2023 年度内部控制自我评价报告进行了核查，具体如下： 一、内部控制评价工作的总体情况 公司在建立健全内部控制体系的基础上，为了进一步强化内部控制机制，提 高风险管理水平，增强业务、财务和管理信息的真实性、完整性和及时性，促进 公司严格遵守国家法律法规，公司董事会授权内部审计部遵照《企业内部控制基 本规范》的要求，结合公司的实际情况，对公司及所属公司各种业务事项所涉及 的内部控制，从健全性、合理性、有效性等三方面全面进行了自我评价，覆盖了 公司内部控制体系范围内的所有活动，包括控制环境、风险识别与评估、控制活 动 ...

| 章程修改前后对照表 | | | --- | --- | | 原《南京药石科技股份有限公司章程》内容 | 修改后《南京药石科技股份有限公司章程》内容 | | 第七条 公司注册资本为人民币 19,966.4344 万 | 第七条 公司注册资本为人民币 19,966.4658 | | 元。 | 万元。 | | 公司因增加或减少注册资本而导致注册资本总 | 公司因增加或减少注册资本而导致注册资本 | | 额变更的，可以在股东大会通过同意增加或减少注册 | 总额变更的，可以在股东大会通过同意增加或减少 | | 资本决议后，再就因此需要修改公司章程的事项通过 | 注册资本决议后，再就因此需要修改公司章程的事 | | 一项决议，并说明授权董事会具体办理注册资本的变 | 项通过一项决议，并说明授权董事会具体办理注册 | | 更登记手续。 | 资本的变更登记手续。 | | 第十五条 经依法登记，公司的经营范围是：生 | 第十五条 经依法登记，公司的经营范围是：生 | | 物医药专业领域内的技术开发、技术咨询、技术服务、 | 物医药专业领域内的技术开发、技术咨询、技术服 | | 技术转让；生物医药中间体（除药品）研发、生产、 ...

欢迎广大投资者积极参与本次网上说明会。 南京药石科技股份有限公司 关于举行 2023 年度网上业绩说明会的公告 | 证券代码：300725 | 证券简称：药石科技 | 公告编号：2024-034 | | --- | --- | --- | | 债券代码：123145 | 债券简称：药石转债 | | 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有 虚假记载、误导性陈述或重大遗漏。 南京药石科技股份有限公司（以下简称"公司"）定于2024年5月7日（星期 二）15:00至17:00在价值在线举办2023年度业绩网上说明会，本次年度业绩说明 会将采用网络远程的方式举行，投资者可登录 价值在线 （ https://eseb.cn/1doCh5CkcuI）参与本次年度业绩说明会。 出席本次业绩说明会的人员有：公司董事长、总经理杨民民先生、财务总监 兼董事会秘书吴奕斐女士、独立董事金力先生、保荐代表人唐澍女士。 为充分尊重投资者，进一步提升本次业绩说明会的交流效果及针对性，现就 公司2023年度业绩说明会提前向投资者公开征集问题，广泛听取投资者的意见和 建 议 。 投 资 者 可 于 2024 年 5 月 ...

2023 年，公司董事会严格按照《公司法》《证券法》等法律法规以及《公司 章程》等规章制度的规定，切实履行股东大会赋予的董事会职责，勤勉尽责地开 展各项工作，促进公司持续、健康、稳定的发展。现将公司董事会 2023 年工作 情况汇报如下： 一、 2023 年公司经营情况概述 公司"以分子砌块为抓手，以化学和技术创新为驱动，全程服务药物发现、 开发到商业化"的一体化战略，持续巩固分子砌块业务技术优势，完善药物发现 技术服务平台，进一步夯实 CRDMO 业务布局，不断加强各个业务模块和技术平台 能力建设，搭建有特色和差异化的药物研发和生产的服务平台。 报告期内，面对宏观经济环境波动以及生物医药投融资下滑对需求端的影响， 公司不断提高技术能力，增强经营的确定性，报告期内公司实现营业收入 17.25 亿元，较去年同期增长 8.18%。由于公司目前仍处于能力建设阶段，固定资产折 旧规模较大，当期折旧金额 1.09 亿元，较去年同期增长 34.06%。公司持续优化 人才结构，提升对高素质人才的吸引力，人员规模和薪资待遇较去年同期有一定 增长，人力资源支出 5.95 亿元，较去年同期增长 0.81 亿元，增幅 15.77% ...

Financial Performance - The company's revenue for Q1 2024 was ¥377,460,431.51, a decrease of 1.56% compared to ¥383,440,937.44 in the same period last year[6] - Net profit attributable to shareholders was ¥49,485,359.20, down 14.32% from ¥57,755,969.84 year-on-year[6] - Basic earnings per share decreased to ¥0.25, a decline of 13.79% from ¥0.29 in the previous year[6] - Total operating revenue for Q1 2024 was CNY 377,460,431.51, a decrease of 1.5% compared to CNY 383,440,937.44 in Q1 2023[22] - Net profit for Q1 2024 was CNY 49,485,359.20, down 14.3% from CNY 57,755,961.44 in the same period last year[23] - The total comprehensive income for the first quarter of 2024 was CNY 49,626,884.56, a decrease from CNY 56,505,995.48 in the same period last year, representing a decline of approximately 12.5%[24] Cash Flow - The net cash flow from operating activities was ¥55,330,257.73, down 26.24% from ¥75,015,353.97 in the same period last year[6] - The company's cash and cash equivalents were CNY 792,815,660.74, down from CNY 988,200,226.50, a decrease of approximately 19.7%[20] - Cash inflow from investment activities totaled CNY 478,661,207.44, significantly higher than CNY 119,249,255.06 in the previous year, marking an increase of about 301.5%[27] - The net cash flow from investment activities was CNY 68,930,043.73, a substantial improvement from a negative CNY 539,946,998.48 in the same period last year[27] - Cash and cash equivalents at the end of the period were CNY 440,098,278.17, down from CNY 820,190,549.66 at the end of the previous year, representing a decrease of approximately 46.4%[27] - Total cash outflow from operating activities was CNY 409,432,971.35, compared to CNY 352,108,930.74 in the previous year, indicating an increase of approximately 16.3%[27] - The company incurred a cash outflow of CNY 196,106,641.68 from financing activities, a significant increase from CNY 62,089,206.73 in the previous year, representing an increase of about 215.5%[27] Assets and Liabilities - Total assets at the end of the period were ¥4,962,143,722.24, a decrease of 2.78% from ¥5,104,032,178.39 at the end of the previous year[6] - Total liabilities decreased to CNY 2,086,964,595.18 from CNY 2,271,754,945.18, a reduction of about 8.1%[20] - The company’s long-term borrowings were CNY 47,740,277.77, a slight decrease from CNY 50,034,657.53[20] Shareholder Information - The total number of common shareholders at the end of the reporting period was 36,447, with no preferred shareholders[11] - The largest shareholder, Yang Minmin, holds 20.69% of shares, amounting to 41,307,019 shares, with 8,300,000 shares pledged[11] - The top 10 shareholders collectively hold a significant portion of the company's shares, with the largest holding being 20.69%[11] - The company reported a total of 5,756,792 shares held by Henan Hengtong Boyuan Venture Capital Partnership, accounting for 2.88% of total shares[12] Revenue Breakdown - Revenue from drug research stage products and services was CNY 85,365,502.77, accounting for 22.62% of total revenue, up 5.45% year-over-year[16] - Revenue from drug development and commercialization stage products and services was CNY 291,938,068.80, down 3.45% from the previous year[16] Operating Costs and Expenses - Total operating costs decreased to CNY 325,204,409.51 from CNY 344,985,836.29, reflecting a reduction of approximately 5.8%[22] - Research and development expenses were CNY 34,513,051.40, a decrease of 28.6% compared to CNY 48,393,224.73 in Q1 2023[23] - The company reported a gross profit margin of 13.8% for Q1 2024, compared to 10.0% in Q1 2023[22] Taxation - The company recorded a 54.13% increase in taxes and surcharges, amounting to ¥5,103,201.63, in line with the company's expanded scale[9] - The company experienced a 68.07% decrease in tax refunds received, totaling ¥9,329,340.32, due to reduced export tax rebates[10]

（2024 年 4 月修订） 第一章 总 则 战略与 ESG 委员会工作 南 京 药 石 科 技 股 份 有 限 公 司 战 略 与 ESG 委 员 会 工 作 制 度 第一条 为适应南京药石科技股份有限公司（以下简称"公司"）战略发展需要， 增强公司核心竞争力，确定公司发展规划，健全投资决策程序，加强决策科学性， 提高重大投资决策的效益和决策的质量，完善公司治理结构，提升公司环境、社会 及公司治理（ESG）能力及可持续发展绩效，实现公司可持续发展目标，根据《中 华人民共和国公司法》（以下简称"《公司法》"）、《上市公司治理准则》等有关国家 法律、法规、规范性文件以及《南京药石科技股份有限公司章程》（以下简称"《公 司章程》"）的规定，公司设置战略与 ESG 委员会，并制订本工作制度。 第二条 战略与 ESG 委员会是公司在董事会中设置的专门工作机构，主要负责 对公司长期发展战略和重大投资决策进行研究并提出建议，拟定公司的可持续发展 目标和发展规划，对公司可持续发展和 ESG 管理重要事项进行评估并对其实施进 行监督，对董事会负责并报告工作。 第二章 人员组成 第三条 战略与 ESG 委员会成员由不少于三名董 ...

Financial Performance - The company's operating revenue for 2023 was ¥1,725,203,986.49, an increase of 8.18% compared to ¥1,594,699,978.41 in 2022[24]. - The net profit attributable to shareholders decreased by 37.19% to ¥197,360,947.76 from ¥314,223,824.02 in the previous year[24]. - The basic earnings per share fell by 37.34% to ¥0.99, down from ¥1.58 in 2022[24]. - The total assets at the end of 2023 were ¥5,104,032,178.39, reflecting a growth of 4.97% from ¥4,862,189,119.46 in 2022[24]. - The net cash flow from operating activities was ¥246,839,976.80, a slight increase of 0.09% compared to ¥246,608,762.55 in 2022[24]. - The company reported a decrease in net profit after deducting non-recurring gains and losses, which was ¥176,044,097.89, down 33.81% from ¥265,972,288.46 in 2022[24]. - The weighted average return on equity decreased to 7.16% from 12.44% in the previous year, a decline of 5.28%[24]. - The company experienced a decline in net profit for the third quarter of 2023, reporting ¥40,155,270.39 compared to ¥56,135,029.49 in the second quarter[28]. - The company achieved revenue of 1.725 billion yuan, an increase of 8.18% year-on-year[64]. - The net profit attributable to shareholders decreased to 197 million yuan, a year-on-year decline of 37.19%[64]. - The total revenue for 2023 reached ¥1,725,203,986.49, representing an 8.18% increase compared to ¥1,594,699,978.41 in 2022[91]. Investment and Cash Management - The company plans to use up to CNY 50,000,000 of temporarily idle raised funds for cash management without affecting normal operations[118]. - The total investment amount for the reporting period was CNY 942,274,358.30, representing a 53.48% increase compared to CNY 613,950,404.97 in the same period last year[109]. - The company raised a net amount of RMB 928,090,177.20 from the issuance of shares, with actual usage of RMB 37,483,455.26 during the reporting period, and a cumulative usage of RMB 530,329,334.17 as of December 31, 2023[119]. - The company has completed the use of all funds raised from the issuance of convertible bonds in 2022[125]. - The company has utilized 40,103.10 million of temporarily idle raised funds for purchasing low-risk financial products as of December 31, 2023[125]. Research and Development - R&D expenses amounted to 169 million yuan, with a R&D expense ratio of 9.81%, maintaining a high level in the industry[64]. - The company synthesized over 6,000 new molecular building blocks during the reporting period[70]. - The company is focusing on the development of high-end injectable formulations, which have longer development cycles[127]. - The company aims to enhance its capabilities in drug development and commercialization through innovative chemical technologies and new drug molecule designs[100]. - The company is increasing R&D investment and expanding its business chain to enhance its technical and service capabilities, thereby improving market competitiveness[137]. Market and Industry Trends - In 2023, global pharmaceutical R&D spending reached $161 billion, with R&D investment accounting for 23.4% of sales revenue, an increase of 4.6 percentage points from 2022[35]. - The number of new drugs launched globally in 2023 was 69, a 10% increase from 2022, with over 40% classified as "first-in-class" therapies, primarily in oncology (30%) and neurology (17%)[35]. - Emerging biotech companies contributed to 56% of new drugs launched in 2023, highlighting their role as innovation engines in the pharmaceutical market[36]. - China's share of global clinical pipelines rose from 3% a decade ago to 28% in 2023, with over 30 new drugs launched annually for six consecutive years[37]. - The Chinese CDMO market is projected to grow at a compound annual growth rate (CAGR) of approximately 20% over the next five years, double the global growth rate, increasing its share of the global market from 11% in 2021 to 16% by 2025[37]. Corporate Governance - The company has a governance structure that complies with legal requirements, ensuring effective decision-making and operational independence from its controlling shareholders[147]. - The company maintains complete independence from its controlling shareholders in terms of assets, personnel, finance, organization, and business operations[148]. - The company has established an independent financial department with specialized personnel, ensuring financial operations are separate from controlling shareholders[149]. - The company has a well-defined corporate governance structure, including a shareholders' meeting, board of directors, and supervisory board, ensuring independent management[149]. - The company has engaged in multiple investor communications, with 248 participants in April 2023 and 68 in October 2023, discussing its annual and quarterly performance[141]. Risk Management - The company faces potential risks including a decline in drug research market demand, changes in industry policies, intensified market competition, and quality control risks[3]. - The company emphasizes the importance of maintaining awareness of investment risks related to forward-looking statements in the annual report[3]. - The company actively tracks regulatory changes in the pharmaceutical industry to adjust its operational strategies accordingly, minimizing adverse impacts from policy shifts[138]. - The company has not experienced major safety or environmental incidents, but it continues to invest in environmental protection and safety production measures as its business scales[139]. Employee and Talent Management - The total number of employees at the end of the reporting period was 2,455, with 1,351 in the parent company and 1,104 in major subsidiaries[184]. - The company employed 1,492 technical personnel, representing approximately 60.8% of the total workforce[184]. - The company has a total of 119 employees with a doctoral degree, contributing to its strong technical capabilities[185]. - The company's compensation policy includes a fixed salary and a variable salary based on project progress and individual performance, ensuring internal fairness and external competitiveness[186]. - The company has designed both technical and management promotion channels to offer employees good career development opportunities[186]. Strategic Initiatives - The company is committed to optimizing operational costs and improving profitability through lean operations and effective resource allocation[136]. - The company plans to implement advanced technologies such as continuous flow chemistry and biocatalysis to reduce project costs and enhance market competitiveness[135]. - The company aims to leverage its experienced management team to drive innovation and operational efficiency in the coming years[156]. - The company anticipates continued growth in revenue and market share as it implements its strategic initiatives[156]. - The company is actively investing in new technologies to improve its product pipeline and meet evolving market demands[156].