Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS FIRST QUARTER 2025 FINANCIAL RESULTS THOUSAND OAKS, Calif. (May 1, 2025) - Amgen (NASDAQ:AMGN) today announced financial results for the first quarter of 2025. "Demand for our products was strong globally in the first quarter. Ongoing new product launches and successful Phase 3 trial results for several products make us feel confident in our long-term growth prospects," said Rober ...

Core Viewpoint - Amgen reported strong financial results for Q1 2025, with total revenues increasing by 9% year-over-year to $8.1 billion, driven by robust product sales and successful new product launches [2][5][22]. Financial Performance - Total revenues for Q1 2025 were $8.1 billion, a 9% increase compared to Q1 2024 [5]. - Product sales grew by 11%, primarily due to a 14% increase in volume, although this was partially offset by a 6% decrease in net selling price [5]. - GAAP earnings per share (EPS) were $3.20, a significant recovery from a loss of $0.21 in Q1 2024, influenced by an unrealized gain on equity investments [5]. - Non-GAAP EPS increased by 24% from $3.96 to $4.90, reflecting higher revenues despite increased operating expenses [5][18]. - Free cash flow for Q1 2025 was $1.0 billion, up from $0.5 billion in Q1 2024, attributed to improved business performance [22]. Product Sales Performance - Repatha® sales rose by 27% year-over-year to $656 million, driven by a 41% increase in volume [6]. - TEPEZZA® sales decreased by 10% year-over-year to $381 million, primarily due to lower volume and inventory levels [4]. - Fourteen products achieved double-digit sales growth, including Repatha®, BLINCYTO®, TEZSPIRE®, and EVENITY® [5]. - IMDELLTRA® generated $81 million in sales during its launch quarter, with positive Phase 3 trial results [5]. Operating Expenses and Margins - Total operating expenses increased by 8% year-over-year, with cost of sales as a percentage of product sales decreasing by 7.3 percentage points [18]. - GAAP operating income rose from $1.0 billion to $1.2 billion, with an operating margin increase of 1.1 percentage points to 15.0% [5][18]. - Non-GAAP operating income increased from $3.1 billion to $3.6 billion, with a non-GAAP operating margin of 45.7%, up 2.5 percentage points [5][18]. Guidance for 2025 - The company expects total revenues for 2025 to be in the range of $34.3 billion to $35.7 billion [23]. - GAAP EPS is projected to be between $12.21 and $13.46, while non-GAAP EPS is expected to range from $20.00 to $21.20 [23]. - Capital expenditures are anticipated to be approximately $2.3 billion for the year [23].

Core Viewpoint - Amgen is set to report its first-quarter 2025 results on May 1, with expectations of strong sales driven by volume growth in key products, although pricing pressures may impact overall revenue [1][4]. Sales Estimates - The Zacks Consensus Estimate for first-quarter sales is $7.96 billion, with earnings expected at $4.16 per share [1]. - Specific sales estimates for key products include Evenity at $406 million, Repatha at $616 million, Kyprolis at $381 million, and Blincyto at $333 million [2]. Patent Expiration Impact - Patents for Prolia and Xgeva expired in February 2025 in the U.S., leading to anticipated significant sales erosion due to biosimilar competition, with estimates of $990 million for Prolia and $542 million for Xgeva [3]. New Product Contributions - Newer drugs like Tezspire and Tavneos are expected to contribute positively to top-line growth, alongside the successful launch of Imdelltra for advanced small cell lung cancer [4]. Declining Sales of Established Products - Sales of Enbrel and Otezla are projected to decline due to price reductions and historical trends related to benefit plan changes and increased co-pay expenses [5][6]. Biosimilars Performance - Increased competition is expected to negatively impact revenues from oncology biosimilars, while sales of Amjevita/Amgevita are likely to have increased [7]. - Amgen launched biosimilars Wezlana and Pavblu, with investors keenly observing their sales performance [8]. Operating Margin Expectations - Amgen anticipates the lowest operating margin of the year at around 42% for the first quarter, with R&D costs expected to rise while SG&A costs as a percentage of sales are projected to decline [9]. Earnings Surprise History - Amgen has a strong earnings surprise history, beating estimates in the last four quarters with an average surprise of 5.23% [10]. Earnings Prediction Model - The current model does not predict a definitive earnings beat for Amgen, with an Earnings ESP of -0.05% and a Zacks Rank of 3 [12].

Core Viewpoint - Amgen is set to report its first quarter 2025 financial results on May 1, 2025, followed by a conference call with senior management [1] Group 1: Financial Reporting - Amgen will announce its Q1 2025 financial results after the close of U.S. financial markets on May 1, 2025 [1] - A conference call will take place at 4:30 p.m. ET, featuring CEO Robert A. Bradway and other senior management members [1] Group 2: Conference Call Details - The conference call will be broadcast live over the internet, accessible to media, investors, and the general public [2] - The webcast will be archived for at least 90 days for replay [3] Group 3: Company Overview - Amgen is a leader in biotechnology, focusing on innovative medicines for serious diseases, with over 40 years of industry experience [4] - The company has a diverse pipeline targeting cancer, heart disease, osteoporosis, inflammatory diseases, and rare diseases [4] Group 4: Recognition and Index Inclusion - In 2024, Amgen was recognized as one of the "World's Most Innovative Companies" by Fast Company and one of "America's Best Large Employers" by Forbes [5] - Amgen is part of the Dow Jones Industrial Average and the Nasdaq-100 Index, highlighting its market capitalization and innovation [5]

Industry Overview - The first-quarter earnings season for the drug and biotech sector is underway, with major companies like Pfizer, Eli Lilly, Amgen, Biogen, and Regeneron set to announce results [1] - Johnson & Johnson and Merck have reported results, both exceeding first-quarter estimates for earnings and sales, while Sanofi had mixed results, beating earnings estimates but missing sales [1] Earnings Trends - As of April 23, 15% of companies in the Medical sector, representing 33.8% of the sector's market capitalization, reported quarterly earnings, with 77.8% surpassing estimates for both earnings and revenues [3] - Year-over-year earnings increased by 4.7%, and revenues rose by 9.4% [3] - Overall, first-quarter earnings for the Medical sector are expected to increase by 35%, while sales are projected to rise by 7.8% compared to the previous year [3] Company Performance Pfizer (PFE) - Pfizer has consistently exceeded earnings expectations in the last four quarters, with an average earnings surprise of 44.16% [5] - The Zacks Consensus Estimate for first-quarter sales and earnings is $13.88 billion and 64 cents per share, respectively [6] - Non-COVID operational revenues are driving growth, supported by products like Vyndaqel, Padcev, and Eliquis, despite a decline in sales of COVID products [7] Eli Lilly (LLY) - Eli Lilly has had mixed performance, exceeding earnings expectations in three of the last four quarters, with an average earnings surprise of 8.47% [8] - The Zacks Consensus Estimate for sales and earnings is $12.62 billion and $3.52 per share, respectively [8] - Growth is expected to be driven by demand for FDA-approved tirzepatide medicines, although sales of Mounjaro and Zepbound were below expectations [9][10] Amgen (AMGN) - Amgen has shown strong performance, beating earnings estimates in each of the last four quarters, with an average earnings surprise of 5.23% [11] - The Zacks Consensus Estimate for first-quarter sales and earnings is $7.96 billion and $4.15 per share, respectively [11] - Product sales are expected to be driven by strong volume growth, although prices may decline due to higher rebates [12] Biogen (BIIB) - Biogen has consistently beaten earnings estimates in the last four quarters, with an average earnings surprise of 11.80% [13] - The Zacks Consensus Estimate for sales and earnings is $2.23 billion and $3.52 per share, respectively [13] - Lower sales of multiple sclerosis drugs are likely to be offset by revenues from new drugs [14] Regeneron (REGN) - Regeneron has had mixed results, surpassing earnings expectations in three of the last four quarters, with an average earnings surprise of 3.23% [16] - The Zacks Consensus Estimate for first-quarter sales and earnings is $3.28 billion and $8.43 per share, respectively [17] - Sales of Eylea are expected to have declined due to competition, but sales of Eylea HD and Dupixent are likely to have surged [18][19]

Core Insights - Amgen's upcoming quarterly earnings report is projected to show earnings of $4.15 per share, a 4.8% increase year-over-year, with revenues expected to reach $7.96 billion, reflecting a 6.8% growth compared to the previous year [1] - Over the last 30 days, the consensus EPS estimate has been revised downward by 1.6%, indicating a reassessment by analysts [1][2] Revenue and Product Sales Estimates - Analysts forecast 'Product Sales- BLINCYTO- Total' to be $332.73 million, marking a 36.4% increase from the prior year [4] - 'Product Sales- Repatha- Total' is expected to reach $616.47 million, indicating a 19.2% year-over-year growth [4] - 'Product Sales- KYPROLIS- Total' is estimated at $381.49 million, reflecting a 1.5% increase from the previous year [4] - 'Product Sales- Vectibix- Total' is projected at $248.09 million, a slight increase of 0.4% year-over-year [5] - 'Product Sales- Neulasta- U.S.' is expected to decline to $67.86 million, a decrease of 22% from the prior year [5] - 'Product Sales- Neulasta- ROW' is estimated at $26.10 million, indicating a 15.8% decline year-over-year [5] - 'Product Sales- EPOGEN- U.S.' is projected to be $30.98 million, reflecting a 24.4% decrease [6] - 'Product Sales- Repatha- ROW' is expected to reach $295.07 million, a 20.9% increase from the previous year [6] - 'Product Sales- Repatha- U.S.' is projected at $331.22 million, indicating a 21.3% increase year-over-year [6] - 'Product Sales- KYPROLIS- ROW' is estimated at $147.40 million, reflecting a 3.8% increase [7] - 'Product Sales- BLINCYTO- U.S.' is expected to be $207.37 million, a 35.5% increase year-over-year [7] - 'Product Sales- BLINCYTO- ROW' is projected at $117.02 million, indicating a 28.6% increase from the prior year [7] Stock Performance - Over the past month, Amgen's shares have decreased by 8.5%, compared to a 4.3% decline in the Zacks S&P 500 composite [7]

Core Points - Amgen announced a $900 million expansion of its manufacturing facility in Ohio, increasing total investment in Central Ohio to over $1.4 billion and creating 750 jobs [1][2] - The expansion is part of Amgen's commitment to U.S. manufacturing and aims to enhance its global biomanufacturing network [2][4] - Since the Tax Cuts and Jobs Act of 2017, Amgen has invested nearly $5 billion in the U.S., generating an estimated $12 billion in additional economic output [3] Company Overview - Amgen has been a leader in biologic medicine manufacturing since 1988 and emphasizes innovation and access to medicines for patients worldwide [2][5] - The company has a strong pipeline targeting various diseases, including cancer and heart disease, and has received multiple accolades for its innovation and workplace environment [6] Economic Impact - Ohio's supportive business climate and skilled workforce have made it an attractive location for Amgen's investments, contributing to the state's economic development [3] - The expansion in Ohio follows a recent announcement of a $1 billion investment for a second manufacturing plant in Holly Springs, NC, indicating a broader strategy to enhance U.S. manufacturing capabilities [4]

Amgen (AMGN) is expected to deliver a year-over-year increase in earnings on higher revenues when it reports results for the quarter ended March 2025. This widely-known consensus outlook gives a good sense of the company's earnings picture, but how the actual results compare to these estimates is a powerful factor that could impact its near-term stock price.The stock might move higher if these key numbers top expectations in the upcoming earnings report, which is expected to be released on May 1. On the oth ...

Today, Amgen (NASDAQ: AMGN ) is a global biopharmaceutical company with a presence in almost a hundred countries and one of the most extensive product portfolios in the industry. Over the past couple of years, the company has competentlyMy professional background spans multiple continents and includes experience in private banking, corporate finance, and strategic advisory. For several years, I developed and led a private banking department in Dubai, where I crafted tailored investment solutions to meet the ...

Core Insights - Amgen's IMDELLTRA® (tarlatamab-dlle) has shown a substantial survival advantage over standard chemotherapy in patients with small cell lung cancer (SCLC) who have progressed after platinum-based chemotherapy, as demonstrated in the Phase 3 DeLLphi-304 clinical trial [1][2][3] Group 1: Clinical Trial Results - The DeLLphi-304 trial met its primary endpoint, showing statistically significant and clinically meaningful improvement in overall survival (OS) compared to local standard-of-care chemotherapy [1][3] - IMDELLTRA is indicated for adult patients with extensive-stage SCLC who have disease progression on or after platinum-based chemotherapy, with approval based on overall response rate and duration of response [5][6] Group 2: Drug Mechanism and Target Population - IMDELLTRA is a first-in-class immunotherapy that targets DLL3 on tumor cells and CD3 on T cells, leading to the destruction of DLL3-expressing SCLC cells [4][6] - DLL3 is expressed on approximately 85-96% of SCLC patients, making it a promising target for therapy [4][6] Group 3: Safety and Efficacy - The safety profile of IMDELLTRA was consistent with its known profile, and detailed data from the trial will be presented at an upcoming medical congress [2][3] - Serious adverse reactions occurred in 58% of patients, with cytokine release syndrome (CRS) being the most common [26][27] Group 4: Future Developments - Amgen is advancing a robust development program for tarlatamab, including multiple ongoing clinical trials evaluating its efficacy in various treatment settings for SCLC [8][9]