Core Viewpoint - Amgen (AMGN) has shown a strong performance recently, with a return of +4.9% over the past month, outperforming the S&P 500 composite's +1.1% change, indicating potential positive momentum for the stock [2]. Earnings Estimate Revisions - For the current quarter, Amgen is expected to report earnings of $5.01 per share, reflecting a year-over-year increase of +6.4%. However, the Zacks Consensus Estimate has decreased by -3.6% in the last 30 days [5]. - The consensus earnings estimate for the current fiscal year stands at $19.56, indicating a year-over-year change of +4.9%, with a slight increase of +0.7% over the past month [5]. - For the next fiscal year, the consensus estimate is $20.52, also showing a +4.9% change from the previous year, with a +0.7% increase in the last month [6]. Revenue Growth Projections - Amgen's consensus sales estimate for the current quarter is $8.84 billion, indicating a year-over-year growth of +7.9%. The estimates for the current and next fiscal years are $33.18 billion and $34.31 billion, reflecting changes of +17.7% and +3.4%, respectively [9]. Last Reported Results - In the last reported quarter, Amgen achieved revenues of $8.5 billion, representing a year-over-year increase of +23.2%. The EPS for this period was $5.58, compared to $4.96 a year ago [10]. - The reported revenues were slightly below the Zacks Consensus Estimate of $8.51 billion, resulting in a surprise of -0.04%. However, the EPS exceeded expectations by +9.2% [11]. Valuation Metrics - Amgen is graded B in the Zacks Value Style Score, indicating that it is trading at a discount compared to its peers [15]. - The evaluation of Amgen's valuation multiples, such as price-to-earnings (P/E), price-to-sales (P/S), and price-to-cash flow (P/CF), suggests that the stock may be undervalued relative to its historical values and peers [13][14]. Conclusion - The current Zacks Rank of 3 suggests that Amgen may perform in line with the broader market in the near term, despite the mixed signals from earnings estimates and valuation metrics [16].

Stock Performance - Amgen's stock ended the recent trading session at $277 88, showing a +1 62% increase from the previous day's closing price [1] - The stock outperformed the S&P 500, which gained 0 53%, while the Dow gained 0 93% and the Nasdaq added 0 22% [1] - Over the past month, Amgen's shares gained 3 38%, outperforming the Medical sector's 1 49% gain and the S&P 500's 2 69% gain [1] Earnings and Revenue Projections - Amgen's upcoming earnings report is scheduled for February 4, 2025, with projected earnings per share (EPS) of $5 01, reflecting a 6 37% increase from the same quarter last year [2] - Revenue is expected to be $8 84 billion, indicating a 7 86% increase compared to the same quarter of the previous year [2] Analyst Estimates and Valuation Metrics - Recent shifts in analyst projections for Amgen indicate changing near-term business trends, with upbeat changes reflecting a favorable outlook on the company's business health and profitability [3] - The Zacks Consensus EPS estimate has moved 0 43% higher within the past month, and Amgen currently holds a Zacks Rank 3 (Hold) [5] - Amgen's Forward P/E ratio is 13 36, representing a discount compared to the industry average of 23 22 [6] - The company's PEG ratio is 2 78, higher than the industry average of 1 36, reflecting its expected earnings growth trajectory [7] Industry Performance - The Medical - Biomedical and Genetics industry, part of the Medical sector, holds a Zacks Industry Rank of 74, placing it in the top 30% of all 250+ industries [8] - The Zacks Industry Rank shows that the top 50% rated industries outperform the bottom half by a factor of 2 to 1 [8]

Core Insights - Scientists at deCODE genetics and Amgen have created a comprehensive map of human DNA recombination, enhancing the understanding of genetic diversity and its implications for health and fertility [1][2][3] Group 1: Research Findings - The new recombination map is the first to include shorter-scale shuffling of grandparental DNA, which is challenging to detect due to high sequence similarity [3] - The map identifies regions of DNA that lack significant reshuffling, likely to safeguard critical genetic functions and prevent chromosomal issues [3] - The research highlights that errors in the recombination process can lead to reproductive challenges, contributing to infertility affecting approximately 10% of couples globally [4] Group 2: Gender Differences - The study reveals distinct patterns of genome recombination between men and women, with women experiencing fewer non-crossover recombinations that increase with age, potentially explaining higher risks of pregnancy complications in older mothers [5] - Men do not exhibit age-related changes in recombination frequency, although both sexes can pass mutations to their offspring [5] Group 3: Evolutionary Implications - Understanding the recombination process is crucial for insights into human evolution and individual health differences, as all human genetic diversity stems from recombination and de novo mutations [6] - The map indicates that mutations are more frequent near regions of DNA mixing, suggesting a strong correlation between recombination and mutation processes [6] Group 4: Company Background - deCODE genetics, based in Reykjavik, Iceland, is a leader in human genome analysis and has identified genetic risk factors for numerous common diseases [7] - The company's goal is to leverage genetic insights to develop new diagnostic, treatment, and prevention methods for diseases [7]

Core Viewpoint - Amgen's KRAS inhibitor, Lumakras, has received FDA approval for use in combination with Vectibix for treating KRAS G12C-mutated metastatic colorectal cancer, marking a significant advancement in targeted therapy for this patient population [1][3]. Group 1: Product Approval and Clinical Data - The FDA approved Lumakras in combination with Vectibix for adult patients with KRAS G12C-mutated metastatic colorectal cancer who have previously undergone chemotherapy [1]. - The approval was based on the phase III CodeBreaK 300 study, which demonstrated superior progression-free survival (PFS) for the Lumakras and Vectibix combination compared to standard-of-care treatments [3][4]. - The study evaluated two doses of Lumakras (960 mg daily or 240 mg daily) and showed favorable overall survival and overall response rates as key secondary endpoints [5]. Group 2: Market Performance and Sales - In the first nine months of 2024, Lumakras generated sales of $265 million, reflecting a year-over-year increase of 30.5% [7]. - Amgen's shares have decreased by 12.2% over the past year, slightly better than the industry decline of 14.1% [2]. Group 3: Future Prospects and Studies - Ongoing label expansion studies for Lumakras aim to broaden the addressable patient population, which could significantly enhance future sales [7]. - Amgen is also exploring Lumakras in phase I and II studies for non-small cell lung cancer (NSCLC), both as a monotherapy and in combination with other therapies, which may lead to additional approvals [8].

Company Performance - Amgen's stock closed at $272.11, with a daily increase of 0.99%, underperforming the S&P 500 which gained 1% [1] - Over the past month, Amgen's shares increased by 3.15%, outperforming the Medical sector's decline of 1.36% and the S&P 500's drop of 2.14% [1] Upcoming Earnings - Amgen is set to release its earnings on February 4, 2025, with an expected EPS of $5.02, reflecting a growth of 6.58% year-over-year [2] - The consensus estimate for quarterly revenue is $8.85 billion, indicating a 7.92% increase compared to the same quarter last year [2] Analyst Estimates - Changes in analyst estimates for Amgen are crucial as they often reflect short-term business dynamics, with positive revisions signaling a favorable business outlook [3] Valuation Metrics - Amgen has a Zacks Rank of 3 (Hold), with a Forward P/E ratio of 13.23, which is lower than the industry average of 21.97 [5] - The company has a PEG ratio of 2.75, compared to the industry average of 1.43, indicating a higher expected earnings growth rate relative to its price [6] Industry Context - The Medical - Biomedical and Genetics industry, which includes Amgen, has a Zacks Industry Rank of 56, placing it in the top 23% of over 250 industries [6] - Research indicates that the top 50% rated industries outperform the bottom half by a factor of 2 to 1 [7]

Pivotal Study Demonstrated the Combination More Than Doubled Progression-Free Survival Compared to Investigated SOCTHOUSAND OAKS, Calif., Jan. 17, 2025 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced that the U.S. Food and Drug Administration (FDA) has approved LUMAKRAS® (sotorasib) in combination with Vectibix® (panitumumab) for the treatment of adult patients with KRAS G12C-mutated metastatic colorectal cancer (mCRC), as determined by an FDA-approved test, who have received prior fluoropyrimidine-, ox ...

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The latest trading session saw Amgen (AMGN) ending at $267.10, denoting a -1.14% adjustment from its last day's close. The stock fell short of the S&P 500, which registered a gain of 0.12% for the day. At the same time, the Dow added 0.52%, and the tech-heavy Nasdaq lost 0.23%.The world's largest biotech drugmaker's stock has climbed by 1.38% in the past month, exceeding the Medical sector's loss of 2.25% and the S&P 500's loss of 3.45%.The investment community will be closely monitoring the performance of ...

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Company Overview - Amgen is focused on serious diseases, particularly in four key areas: heart attack, stroke, cancer, osteoporosis, and rare diseases [3][4] - The company has a portfolio of 38 innovative and biosimilar medicines, each contributing significantly to addressing these serious diseases [4] Community Engagement - Amgen has committed $10 million to support the rebuilding efforts in Southern California following the devastating wildfires [3] Leadership and Presentation - Robert Bradway, Chairman, CEO & President of Amgen, presented at the 43rd Annual J.P. Morgan Healthcare Conference on January 13, 2025 [1][2]