Core Insights - T-cell engagers (TCEs) are a focus in precision immunotherapy, showing rapid market growth and clinical advancements in cancer and autoimmune disease treatments [1][4] Market Overview - The global TCE market is projected to reach $5.6 billion by 2025 and $9.5 billion by 2026, with China's market expected to grow to $300 million and $600 million respectively [1][4] - Since 2024, the TCE sector has seen significant transaction activity, with 28 transactions recorded in 2024 and a total of 179 transactions from 2013 to 2024 [4][5] Clinical Trials - In 2024, there were 175 TCE clinical trials initiated globally, with 115 focused on hematological cancers, representing 65% of the market share [4] - The number of clinical trials for autoimmune diseases is expected to grow significantly, matching the 32 trials for solid tumors initiated in 2024 [4] Industry Definition and Classification - TCEs are a subgroup of immunotherapy that utilize bispecific antibodies to direct T-cells to kill tumor cells, classified into three main types: IgG-like TCEs, Fv-based TCEs, and combination-based TCEs [2][3] Industry Development - The development of TCEs has evolved over 40 years, from the initial concept in 1961 to clinical applications, with significant milestones in 1985 and 2008 marking key advancements [5][6] Competitive Landscape - Over ten TCEs have been approved globally, with a surge in approvals since 2022, particularly in the hematological cancer space [7] - Key companies involved in TCE development include Amgen, Roche, Johnson & Johnson, and several domestic firms in China such as Guangdong Fipeng Pharmaceutical and Aimi Biotechnology [7][8] Future Trends - TCEs are increasingly being explored for various diseases beyond hematological cancers, including autoimmune diseases, and are becoming a significant area of research in the biopharmaceutical sector [8][9]

Core Insights - Amgen Inc. presented positive findings from the Phase 2 Study of MariTide, an investigational obesity treatment, at the J.P. Morgan Healthcare Conference, indicating strong weight loss maintenance among participants [1][2] Group 1: Study Results - The majority of participants maintained weight loss for an additional 52 weeks on lower doses of MariTide [1] - The second year of treatment was well tolerated, with low incidence of nausea and no new safety signals [2] - MariTide demonstrated up to 20% average weight loss in individuals with obesity without Type 2 diabetes, and up to 17% in those with the condition, significantly outperforming placebo [3] Group 2: Ongoing Research - Amgen is conducting six Phase 3 studies of MariTide across obesity and related conditions, including diabetes, heart disease, and sleep apnea [4] Group 3: Analyst Perspectives - Analysts express that the 52-week data update aligns with previous observations, but there are questions regarding the necessary dose for quarterly maintenance [5] - A differentiated product profile for MariTide compared to existing GLP-1 therapies suggests potential for significant market share and multibillion-dollar peak sales opportunities [6] - Amgen's stock showed a slight increase of 0.46%, reaching $325.80 at the time of publication [6]

Market Overview - US stock index futures are all down, with Dow futures down 0.32%, S&P 500 futures down 0.42%, and Nasdaq futures down 0.63% [1] - The German DAX index is down 0.41%, while the UK FTSE 100 is up 0.26%, and the French CAC40 is up 0.03% [2][3] - WTI crude oil has increased by 1.19%, priced at $61.88 per barrel, and Brent crude oil has also risen by 1.19%, priced at $66.25 per barrel [3][4] Economic Insights - Expectations for Federal Reserve interest rate cuts have shifted, with traders increasingly betting that the Fed will maintain rates throughout the year, influenced by recent labor market data and CPI indicating stable inflation [4] - A prominent investor predicts a potential 20% decline in the Dow Jones index by the end of the year, citing pressures on ordinary consumers due to high living costs [5] Debt Market Concerns - Morgan Stanley reports that the size of basis trading in US Treasuries has ballooned to approximately $1.5 trillion, necessitating close monitoring to avoid a repeat of market volatility seen in 2020 [6] Commodity Market Developments - Silver prices have surged nearly 4%, reaching $90.36 per ounce, with a peak at $91.56, driven by rising safe-haven demand amid geopolitical tensions [7] - LME tin prices have reached a historical high of $51,675 per ton, reflecting a significant increase driven by Chinese investor interest in commodities [7] Company Earnings Reports - Bank of America reported Q4 net revenue of $28.37 billion, exceeding market expectations of $27.76 billion, and net interest income of $15.75 billion, also above expectations [8] - Wells Fargo's Q4 revenue was $21.29 billion, falling short of the expected $21.64 billion, with net interest income of $12.33 billion, below the anticipated $12.43 billion [9] - Tesla is shifting its Full Self-Driving (FSD) sales model to a subscription service, effective February 14, significantly lowering the entry cost for consumers [9] - Netflix is exploring an all-cash acquisition of Warner Bros. to expedite the deal process amid competitive pressures [10] - Citigroup is set to lay off approximately 1,000 employees as part of a broader plan to reduce its workforce by 20,000 by the end of the year [10] Pharmaceutical Innovations - Amgen's experimental weight loss drug MariTide shows promise with a monthly injection regimen that helps patients maintain weight loss over two years, contrasting with the more frequent injections of existing weight loss medications [11]

Core Viewpoint - Amgen's experimental weight loss drug MariTide shows promising results in clinical trials, allowing obese patients to maintain weight loss with monthly injections, contrasting with the weekly injections of current popular weight loss medications [1][2][4] Group 1: Drug Mechanism and Administration - MariTide is a GLP-1 related drug that activates GLP-1 receptors while blocking GIP receptors, offering a dual mechanism that differs from traditional GLP-1 agonists [2][3] - The drug is currently in Phase 3 clinical trials and has not yet received FDA approval for clinical sales [2] - The convenience of administration is highlighted, with potential for monthly or even quarterly injections, which could improve patient adherence compared to weekly injections required by existing treatments [1][4] Group 2: Clinical Efficacy - In the Phase 2 trial, participants experienced an average weight loss of approximately 20% over 52 weeks, with no plateau in weight loss observed, indicating sustained effectiveness [4] - The dual mechanism of action is expected to provide a more durable intervention compared to existing weight loss drugs [3][4] Group 3: Market Potential - Goldman Sachs projects the global anti-obesity drug market could reach $90 billion to $100 billion by 2030, significantly higher than the current market size [5][6] - The market is viewed as having substantial growth potential, with Amgen's MariTide expected to play a key role in this expansion, potentially leading to a revaluation of the company's stock [6] - The increasing global obesity rates and the demand for effective weight loss treatments are driving the market growth, with predictions of a large patient population beginning treatment in the coming years [6][7] Group 4: Competitive Landscape - Goldman Sachs expresses a more favorable outlook on MariTide compared to existing drugs like Novo Nordisk's Wegovy and Eli Lilly's Zepbound, suggesting greater upside potential for Amgen's stock [6] - The market is entering a new phase characterized by "price for volume" strategies, driven by policy changes and the introduction of oral weight loss medications, which are expected to lower barriers for patient access [7]

Core Insights - U.S. telehealth firm Ro has initiated a research collaboration with drugmaker Amgen to address the challenges faced by patients and providers in accessing obesity treatments, particularly focusing on GLP-1 medications [1] Group 1 - The collaboration aims to explore the barriers to accessing obesity treatments, which is a growing concern in the healthcare industry [1] - Ro's partnership with Amgen highlights the increasing importance of telehealth solutions in managing chronic conditions like obesity [1] - The research will likely provide insights that could enhance patient access to effective obesity treatments, potentially impacting market dynamics [1]

Core Insights - Amgen is optimistic about 2026, viewing it as a pivotal year with significant clinical data expected to be generated [2] Group 1: Company Overview - Amgen operates in four general therapeutic areas, focusing on diseases with high unmet medical needs [3] - The company offers first-in-class and best-in-class innovative medicines, including branded biosimilars [4] Group 2: Financial Performance - Over the past decade, Amgen has achieved consistent revenue and earnings growth, reflecting the success of its product offerings [4]

Summary of Amgen's Conference Call Company Overview - **Company**: Amgen - **Industry**: Biotechnology and Pharmaceuticals - **Key Focus Areas**: Therapeutics for unmet medical needs, including cardiovascular diseases, osteoporosis, severe asthma, and rare diseases [2][3] Financial Performance - **2025 Revenue Growth**: 10% increase in revenues, driven by 14 blockbuster products [4] - **Earnings Growth**: 14% increase in earnings per share [4] - **Debt Reduction**: Over $6 billion in debt paid down in 2025 [6] Key Products and Growth Drivers - **Repatha**: - Annualized sales of approximately $3 billion, growing at 33% [7] - Demonstrated a 36% reduction in heart attack risk in primary prevention [5] - Significant market opportunity with over 100 million people at risk of heart attacks [9] - **Evenity**: - Sales growth of over 30%, targeting women at high risk of osteoporotic fractures [10] - Urgent need for treatment due to high mortality rates post-fracture [47] - **Tezspire**: - Innovative treatment for severe asthma and chronic rhinosinusitis with nasal polyps [10] - Strong clinical performance and potential for expansion into COPD and eosinophilic esophagitis [10] - **Biosimilars**: - 42% year-over-year sales growth, contributing $13 billion since entry into the market [15] - **Rare Disease Portfolio**: - Approached $5 billion in sales, with ongoing expansion into new indications [11] Pipeline and Future Prospects - **MariTide**: - Focused on obesity and type 2 diabetes, with six phase 3 studies initiated [19] - Potential for monthly or less frequent dosing, addressing treatment persistence issues [20][21] - **Olpazeran**: - Targets Lp(a) reduction, a significant risk factor for cardiovascular disease, with potential for 95%-100% reduction [38] - Expected to provide a long-acting treatment option for patients [39] - **Imdeltra**: - Bispecific T-cell engager for small cell lung cancer, showing promise in early lines of therapy [13] Market Dynamics and Strategic Focus - **Obesity Market**: - Anticipated growth due to increasing recognition of obesity as a chronic disease [29] - Amgen aims to position itself as a key player in this evolving landscape [30] - **Capital Allocation**: - Focus on investing in innovation and manufacturing capabilities to maintain competitive advantage [25] - **Technological Integration**: - Emphasis on incorporating technology and AI to enhance operational efficiency [24] Conclusion - Amgen is positioned for significant growth in 2026 and beyond, driven by a robust pipeline of innovative therapies and a strong financial foundation. The company is focused on addressing high unmet medical needs across various therapeutic areas, with a commitment to maintaining operational discipline and investing in future growth opportunities [27]

Core Insights - Amgen's experimental obesity drug MariTide has shown effectiveness in helping individuals maintain weight loss in an extension study [1] - A second mid-stage trial indicated that MariTide also reduced blood sugar levels in diabetes patients [1] Summary by Category Drug Efficacy - MariTide assists in weight maintenance post-weight loss, demonstrating its potential as a long-term treatment option for obesity [1] - The drug has shown promising results in lowering blood sugar levels among patients with diabetes, indicating its dual therapeutic potential [1]

Core Insights - Amgen's research chief expressed strong confidence in the company's experimental obesity drug MariTide, indicating positive expectations for its efficacy in weight maintenance [1] Company Summary - Amgen is preparing to unveil results from a mid-stage trial extension for MariTide, aimed at demonstrating the drug's effectiveness in helping individuals maintain weight loss [1]

44TH ANNUAL J.P. MORGAN HEALTHCARE CONFERENCE Provided January 12, 2026, as part of an oral presentation and is qualified by such, contains forward-looking statements, actual results may vary materially; Amgen disclaims any duty to update. 2 We Have a Broad and Deep Portfolio Across Four Therapeutic Areas ROBERT A. BRADWAY, Chairman and Chief Executive Officer January 12, 2026 Safe Harbor Statement This presentation contains forward-looking statements that are based on the current expectations and beliefs o ...