Group 1 - The stock price of BeiGene reached a historical high during trading, increasing by over 10% to 275.55 yuan [1]

每经AI快讯，百济神州A股盘中股价创历史新高，现涨超10%，报272.68元。 ...

Core Viewpoint - The European Commission has approved the innovative drug Baiyue An (Tislelizumab) for use in neoadjuvant therapy combined with platinum-based chemotherapy for adult patients with resectable non-small cell lung cancer (NSCLC) at high risk of recurrence, further expanding its application in the European oncology market [1] Group 1: Market Context - Lung cancer is the most common cancer globally, with NSCLC accounting for 80%-90% of all lung cancer types, and approximately 25%-30% of NSCLC patients are eligible for surgical resection [1] - The treatment needs of this patient group represent a significant market opportunity for related drugs [1] Group 2: Product Approval and Market Expansion - Tislelizumab has received a total of 9 approvals for solid tumor indications in the EU, including 5 for lung cancer and others for gastric or gastroesophageal junction adenocarcinoma, unresectable esophageal squamous cell carcinoma, and nasopharyngeal carcinoma [2] - Tislelizumab is the first PD-(L)1 inhibitor from China to enter the global market and is a core product developed by the company following the BTK inhibitor Zebutini [2] - The global market presence of Tislelizumab has expanded to 47 countries and regions, including major markets in Europe, the United States, the United Kingdom, and Japan [2]

Group 1: Shuoshi Biotech - Shuoshi Biotech reported a significant decline in net profit for the first half of 2025, with a net profit of 3.99 million yuan, down 86.35% year-on-year [1] - The company’s non-recurring net profit was -28.05 million yuan, a staggering decrease of 1219.78% year-on-year [1] - Eight senior executives voluntarily reduced their salaries by 5% to 50% to demonstrate solidarity during challenging times, indicating a need for innovation and market expansion to find new profit growth points [1] Group 2: BeiGene - BeiGene announced that the European Commission has approved its PD-1 monoclonal antibody, Tislelizumab, for use in neoadjuvant therapy for adult patients with resectable non-small cell lung cancer (NSCLC) at high risk of recurrence [2] - This approval marks a significant step for the internationalization of domestic PD-1 therapies, benefiting patients in Europe [2] Group 3: Shenzhou Cell - Shenzhou Cell reported a revenue of 972 million yuan for the first half of 2025, a decrease of 25.5% year-on-year, with a net profit of -33.77 million yuan, down 126.87% [3] - The second quarter saw a revenue of 452 million yuan, a decline of 34.66% year-on-year, and a net profit of -97.54 million yuan, down 289.37% [3] - Despite the revenue and profit decline, the company is actively advancing its R&D pipeline and exploring international markets [3] Group 4: Sali Medical - Sali Medical reported a revenue of approximately 584 million yuan for the first half of 2025, a decrease of 40.2% year-on-year, with a net loss of approximately 56.12 million yuan [4] - The company’s revenue and gross profit declined due to the transfer of some subsidiaries and challenges in its transformation, compounded by slow accounts receivable collection and difficulties in business renewals [4] - The company needs to accelerate its transformation efforts to improve performance [4]

Group 1 - Shuoshi Biotech reported a significant decline in net profit for the first half of 2025, with a net profit of 3.99 million yuan, down 86.35% year-on-year, and a non-recurring net profit of -28.05 million yuan, down 1219.78% year-on-year [1] - Eight senior executives, including the honorary chairman and the chairman, voluntarily reduced their salaries by 5% to 50%, demonstrating a commitment to overcoming current challenges [1] - The company faces pressure from industry-wide price reductions and tax rate adjustments, leading to a decline in gross margin, necessitating a focus on innovation and market expansion for future growth [1] Group 2 - BeiGene announced that the European Commission has approved its PD-1 monoclonal antibody, Tislelizumab, for use in neoadjuvant therapy for adult patients with resectable non-small cell lung cancer (NSCLC) at high risk of recurrence [2] - This approval marks a significant step for the internationalization of domestic PD-1 therapies, benefiting patients in Europe [2] Group 3 - Shenzhou Cell reported a revenue of 972 million yuan for the first half of 2025, a decrease of 25.5% year-on-year, with a net profit of -33.77 million yuan, down 126.87% year-on-year [3] - The second quarter saw a revenue of 452 million yuan, down 34.66% year-on-year, and a net profit of -97.54 million yuan, down 289.37% year-on-year [3] - Despite the revenue decline, the company is actively advancing its R&D pipeline and exploring international markets, indicating potential for future growth [3] Group 4 - Sali Medical reported a revenue of approximately 584 million yuan for the first half of 2025, a decrease of 40.2% year-on-year, with a net loss of approximately 56.12 million yuan [4] - The company experienced a significant increase in net loss compared to the previous year, where the net loss was approximately 477,000 yuan [4] - Challenges include slow accounts receivable collection and difficulties in business renewals, necessitating a faster transformation to improve performance [4]

Financial Performance - Total revenue reached $2.433 billion, a year-on-year increase of 44.7%, with product revenue at $2.411 billion, also up 44.5% [1][2] - The company achieved a net profit of $95.6 million, a significant turnaround from a net loss of $372 million in the same period last year [1] - Cash and cash equivalents stood at $2.756 billion, an increase of $129 million from the beginning of the year [1] - Gross margin improved from 84.3% in the previous year to 86.4% [1] Core Business Progress - Baiyueze continued to lead with revenue of $1.742 billion, accounting for 72% of product revenue, and a year-on-year growth of 54.7% [1][4] - The U.S. market showed strong performance with revenue of $1.249 billion, a 50.1% increase, surpassing the Chinese market for the first time [1][4] - Collaboration revenue from Amgen increased significantly to $14.55 million, compared to $840,000 in the previous year [1] - Operating expenses grew by 12.2% to $2.004 billion, significantly lower than the revenue growth rate [1] Development Strategy - The company deepened its global layout by relocating its registered office to Switzerland and adopting the new name "BeOne Medicines Ltd." [1][5] - Capital commitments for capacity construction reached $62 million, with ongoing investments in infrastructure [1][5] - R&D expenses amounted to $1.007 billion, representing 41.4% of total revenue, with a year-on-year increase of 10% [1] - The company anticipates over 20 R&D milestone events in the next 18 months [1][5] Future Focus Areas - Sustainability of growth in the U.S. market and risks associated with reliance on a single product [1][8] - Progress in establishing a second growth curve and the commercialization timeline for new products [1][8] - Challenges in cost control due to the complexities of global operations [1][5][8] - The impact of stock incentive expenses amounting to $246 million on actual cash generation capabilities [1][3][8]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 BeOne Medicines Ltd. 百濟神州有限公司 （根據瑞士法律註冊成立的公司） （股份代號：06160） 截至2025年6月30日止六個月 中期業績公告 百濟神州有限公司連同其子公司（「本公司」或「百濟神州」或「我們」）謹此公佈本 公司截至2025年6月30日止六個月（「報告期」）的未經審核簡明綜合業績連同2024 年相應期間的比較數字，其乃根據美國公認會計原則（「美國公認會計原則」或 「GAAP」）編製並由本公司董事會（「董事會」）審計委員會（「審計委員會」）審閱。 財務摘要 1 • 截至2025年6月30日止六個月的收入合計較截至2024年6月30日止六個月增 加約751.8百萬美元或約44.7%至約2,432.6百萬美元。產品收入較截至2024 年6月30日止六個月增加約742.5百萬美元或約44.5%至約2,410.6百萬美元。 • 截至2025年6月30日止六個月的經營費用合計較截至 ...

Group 1: Financial Performance - The company reported a total revenue increase of approximately $751.8 million or about 44.7% to approximately $2,432.6 million for the six months ending June 30, 2025 [1] - Product revenue increased by approximately $742.5 million or about 44.5% to approximately $2,410.6 million during the same period [1] - The net profit for the period was approximately $95.6 million, a significant recovery from a net loss of approximately $371.6 million for the six months ending June 30, 2024 [1] Group 2: Research and Development Expenses - Research and development expenses increased by $91.7 million (or 10.0%) from $915.1 million in the previous year to $1,006.8 million for the six months ending June 30, 2025 [1] - Internal R&D expenses grew by $21.5 million (or 3.7%) to $606.5 million, primarily due to the expansion of global R&D facilities and an increase in clinical and preclinical candidates [1] Group 3: Gross Profit and Margin - Gross profit from product sales increased to $2,081.0 million, up from $1,405.0 million in the same period last year, driven by the increase in product revenue [2] - The gross margin improved from 84.2% in the previous year to 86.3% for the six months ending June 30, 2025, attributed to a higher sales proportion of Baiyueze compared to other products [2] Group 4: Sales Performance of Baiyueze - Global sales of Baiyueze reached $1,741.5 million, a growth of 54.7% compared to the same period last year [3] - U.S. sales of Baiyueze totaled $1,246.9 million, a 50.1% increase from $830.8 million, driven by robust demand across all indications and moderate net pricing benefits [3] - European sales of Baiyueze amounted to $266.4 million, a year-on-year increase of 79.7%, benefiting from market share growth in major European markets [3]

Core Insights - The company reported a total revenue of 2.433 billion RMB for the six months ending June 30, 2025, representing a year-on-year increase of 44.73% [1] - Gross profit reached 2.103 billion USD, up 48.33% compared to the previous year [1] - The net profit was 95.59 million USD, a turnaround from a net loss of 372 million USD in the same period last year, with basic earnings per share of 0.07 USD [1] Revenue Breakdown - The increase in total revenue was primarily driven by sales growth of the company's self-developed products, Baiyueze and Trelatuzumab, as well as an increase in sales from licensed products, mainly from Amgen [1] - Product revenue net increased by 44.5% to 2.4106 billion USD, compared to 1.6681 billion USD in the same period last year, largely due to significant sales growth of Baiyueze in the US and Europe [1] - Baiyueze's global sales reached 1.7415 billion USD, a 54.7% increase year-on-year, with US sales totaling 1.2469 billion USD, up 50.1% from 830.8 million USD last year [2] Market Position - Baiyueze continues to maintain a leading market share among new patients in the BTK inhibitor class, supported by robust demand across all indications and moderate gains from net pricing [2]

Group 1 - The core viewpoint of the articles highlights the significant financial performance of BeiGene, with a total revenue of 2.433 billion RMB for the six months ending June 30, 2025, representing a year-on-year increase of 44.73% [1] - Gross profit reached 2.103 billion USD, an increase of 48.33% compared to the previous year [1] - The net profit for the period was 95.59 million USD, a turnaround from a net loss of 372 million USD in the same period last year, with basic earnings per share of 0.07 USD [1] Group 2 - The increase in total revenue is primarily attributed to the sales growth of the company's self-developed products, including Baiyueze® and Tislelizumab, as well as the sales of licensed products, mainly from Amgen [1] - For the six months ending June 30, 2025, product revenue net increased by 44.5% to 2.4106 billion USD, up from 1.6681 billion USD in the same period last year [1] - Baiyueze® global sales reached 1.7415 billion USD, a 54.7% increase year-on-year, with U.S. sales totaling 1.2469 billion USD, up 50.1% from 830.8 million USD in the previous year [2] Group 3 - The robust growth in Baiyueze® sales is attributed to strong demand across all indications and moderate gains from net pricing [2] - Baiyueze® continues to maintain a leading market share among new patients in the BTK inhibitor class due to its differentiated and best-in-class clinical characteristics [2]