每经记者｜陈星 每经编辑｜董兴生 NO.2 *ST赛隆董事长等辞职 *ST赛隆公告，公司董事会于近日收到公司董事长兼总裁陈科、副总裁兼董事会秘书张旭、副总裁段代 风的书面辞职报告。因工作调整原因，陈科和张旭将继续分别担任公司总裁、董事会秘书等职务。因个 人职业发展规划原因，段代风辞职后将不在公司担任任何职务。 点评：董事长陈科与董秘张旭保留原有经营层职位，此举或为满足公司治理要求。而副总裁段代风的彻 底离职则反映真实人事变动。这种"名退实留"的调整虽属常见操作，但仍需关注其是否伴随战略分歧。 NO.3 百济神州专利案结案 10月8日晚间，百济神州发布关于公司涉及诉讼的进展公告，Pharmacyclics LLC公司（申诉方）决定不 对美国专利商标局的最终书面决定提起上诉。申诉方和被申诉方（百济神州及全资子公司）于2025年9 月30日（美国时间）向美国特拉华州地方法院提交一份共同协议，自愿撤回诉讼案件，案件已做出终局 处理。 点评：作为被申诉方的百济神州在本次诉讼中并未受到不利影响，百悦泽®在美国的研发和销售未受到 影响，且未对公司的生产经营产生重大不利影响。 | 2025年10月9日 星期四 | NO.1 ...

10月8日晚间，百济神州（688235）发布关于公司涉及诉讼的进展公告，Pharmacyclics LLC公司（作为申诉方，以下简称"Pharmacyclics"）决定不对美国 专利商标局（以下简称"USPTO"）的最终书面决定提起上诉。申诉方和被申诉方于2025年9月30日（美国时间）向美国特拉华州地方法院提交一份共同协 议，自愿撤回诉讼案件，案件已做出终局处理。 百济神州表示，本次诉讼未对百悦泽®在美国的研发和销售产生不利影响，且未对公司的生产经营产生重大不利影响。 不过，百济神州提示风险称，由于生物医药行业具有研发周期长、投入大、风险高的特点，公司的药物产品需完成药物早期发现、临床前研究、临床开 发、监管审查、生产、商业化推广等多个环节，容易受到一些不确定性因素的影响。因此，公司业务运营、财务状况和经营业绩可能会受到上述不确定因 素以及其他目前未能预测的因素的影响。公司未来的业务计划、实际业绩表现、财务状况或经营结果可能与公司预期情况有重大差异。 2021年12月，百济神州成功登陆科创板，成为首家在美股、港股及A股三地上市的企业。 然而，百济神州一直处于亏损状态，2017年至2020年，公司净利润分别亏 ...

Core Insights - The Chinese biopharmaceutical market has become the second largest globally, with innovative drugs accounting for approximately 30% of global research and development [1] - During the "14th Five-Year Plan" period, China approved 210 innovative drugs and 269 innovative medical devices, showing a trend of accelerated growth [1] - The total amount of innovative drug licensing from China reached nearly $66 billion in the first half of 2025, indicating increasing global recognition of Chinese innovative drugs [1] R&D Investment - In the chemical preparation sector, the top ten pharmaceutical companies spent a total of 17.636 billion yuan on R&D in the first half of 2025, a year-on-year increase of 12.66% [2] - BeiGene led the sector with R&D expenses of 7.278 billion yuan, accounting for 41.54% of its total revenue, marking a 9.8% increase year-on-year [2] - Other companies like Hengrui Medicine and Fosun Pharma also invested over 1 billion yuan in R&D, reflecting a strong emphasis on innovation [1][2] Oncology Drug Development - Oncology remains a core focus for Chinese innovative pharmaceutical companies, with significant investments in R&D from firms like BeiGene and Hengrui Medicine [3] - BeiGene is developing several promising products in the hematological oncology space, including the BTK inhibitor Bruton and two late-stage products with global potential [3] - The global oncology drug market is expected to reach $328.6 billion by 2026, with China's market projected to grow to 376 billion yuan by 2026 and further to 755.1 billion yuan by 2031, reflecting a compound annual growth rate of 16.0% from 2024 to 2031 [4] Market Dynamics - The demand for oncology products is driving revenue for many pharmaceutical companies, with Hansoh Pharmaceutical reporting that its innovative oncology product Ameluz generated approximately 4.531 billion yuan in revenue, accounting for 60.9% of total revenue [5] - The industry is entering a phase of diverse development, with significant opportunities in ADC (antibody-drug conjugates) and other innovative therapies [5] - The five-year survival rate for cancer patients in China has improved from 40.5% in 2018 to 43.7% in 2022, indicating progress in cancer prevention and treatment [5] Technological Advancements - AI and digital technologies are reshaping the pharmaceutical R&D landscape, with new guidelines from the FDA aimed at integrating AI into preclinical research [7] - The competition in the oncology sector is intensifying, with a significant number of similar products in development, particularly in the dual-antibody and single-antibody markets [8] - The industry is focusing on creating a closed-loop research ecosystem that connects clinical needs with laboratory innovations to accelerate the translation of research into clinical applications [9]

Core Insights - The performance of companies listed on the Sci-Tech Innovation Board (STAR Market) in the first half of the year shows positive signals, with over 60% of the 589 companies reporting profits [1] - High-growth sectors such as artificial intelligence and innovative pharmaceuticals are demonstrating strong growth momentum [1] Group 1: Company Performance - Cambricon Technologies achieved significant growth, with revenue of 2.881 billion yuan, a year-on-year increase of 4347.82%, and a net profit of 1.038 billion yuan, marking a turnaround from losses [1] - BeiGene reported revenue of 17.518 billion yuan, a 46.03% increase year-on-year, and a net profit of 450 million yuan, also turning from losses to profits [1] - Orbbec achieved revenue of 435 million yuan, a 104.14% increase year-on-year, and a net profit of 60.19 million yuan, marking its first half-year profit [2] - Henan Shijia Photon Technology reported revenue of 993 million yuan, a 121.12% increase year-on-year, and a net profit of 217 million yuan, a significant increase of 1712.00% [2] - Shaanxi Yuanjie Semiconductor Technology saw revenue growth of 70.57% year-on-year, with net profit increasing by 330.31% and non-recurring net profit up by 379.16% [2] Group 2: Market Trends - The rapid development of many STAR Market companies is attributed to breakthroughs in core technologies and large-scale applications, which are gradually demonstrating profitability [3] - The focus on "hard technology" and the institutional design of the STAR Market have contributed to the emergence of numerous technology leaders [3]

Core Viewpoint - The Hong Kong stock market experienced a slight rebound, particularly in the innovative drug sector, driven by expectations of a more accommodative monetary policy from the Federal Reserve, which is anticipated to boost liquidity and investment opportunities in the biotech industry [1][5]. Group 1: Market Performance - The Hong Kong innovative drug ETF (520880) saw a significant increase, reaching a peak of 4.66% during the day and closing up 4.41%, recovering both the 5-day and 20-day moving averages [1]. - Major stocks in the sector, such as Innovent Biologics and CSPC Pharmaceutical Group, rose over 6%, while others like 3SBio and China Biologic Products increased by more than 5% [2][3]. Group 2: Federal Reserve Policy Impact - Market speculation regarding the Federal Reserve's easing policy is growing, with over 80% probability of a rate cut in September according to the Chicago Mercantile Exchange [1][5]. - Historical data indicates that during previous Fed rate cuts, the Nasdaq Biotechnology Index outperformed the Nasdaq Composite by approximately 40% and 20% in the 2001-2003 and 2008-2009 periods, respectively [5]. Group 3: Company Performance - BeiGene reported a revenue of 2.433 billion yuan for the first half of the year, a year-on-year increase of 44.73%, with a net profit of $95.59 million, exceeding market expectations [5][6]. - Innovent Biologics also showed strong performance with a revenue of 5.95 billion yuan, a 50.6% increase year-on-year, and a net profit of 1.21 billion yuan, surpassing market forecasts [6]. Group 4: Investment Opportunities - The innovative drug sector is expected to benefit from a combination of domestic policy support, international expansion, and enhanced global competitiveness, which may drive a revaluation of the sector [5][6]. - The Hong Kong innovative drug ETF is the first of its kind to track the Hang Seng Hong Kong Stock Connect Innovative Drug Select Index, focusing on companies primarily engaged in innovative drug development [7]. Group 5: Index Performance - The Hang Seng Hong Kong Stock Connect Innovative Drug Select Index has seen a cumulative increase of 101.58% year-to-date as of July 31, significantly outperforming the Hang Seng Index and the Hang Seng Tech Index by 78.08 and 79.53 percentage points, respectively [9][10].

Core Viewpoint - The Hong Kong stock market experienced a slight rebound on August 29, with innovative drug stocks leading the way, particularly the Hong Kong Stock Connect Innovative Drug ETF (520880), which rose by 4.41% and recovered from previous losses [1][5]. Market Performance - The trading volume for the day reached 658 million yuan, an increase of 65% compared to the previous day [1]. - Major stocks in the innovative drug sector saw significant rebounds, with companies like Innovent Biologics and CSPC Pharmaceutical rising over 6%, and others like 3SBio and China Biologic Products increasing by more than 5% [2][3]. Stock Highlights - Notable stock performances included: - Green Leaf Pharmaceutical (7.78% increase) - WuXi Biologics (6.96% increase) - Innovent Biologics (6.84% increase) - CSPC Pharmaceutical (6.67% increase) - BeiGene (nearly 4% increase) [4]. Federal Reserve Policy Impact - Following dovish signals from Federal Reserve Chairman Jerome Powell, market expectations for a 25 basis point rate cut in September have risen to over 80% [5]. - The innovative drug sector, being capital-intensive, is expected to benefit from the anticipated easing of monetary policy, which could lead to increased liquidity and growth opportunities [5]. Historical Context - Historical data indicates that during previous Federal Reserve rate cuts (2001-2003, 2008-2009), the Nasdaq Biotechnology Index outperformed the Nasdaq Composite by approximately 40 and 20 percentage points, respectively [5]. - The low-interest-rate environment from 2020 to 2021 led to record high financing in the global innovative drug primary market [5]. Company Performance - BeiGene reported a revenue of 2.433 billion yuan for the first half of the year, a year-on-year increase of 44.73%, with a net profit of 95.59 million USD, exceeding market expectations [6]. - Innovent Biologics also showed strong performance with a revenue of 5.95 billion yuan, a 50.6% year-on-year increase, and a net profit of 1.21 billion yuan [6]. Future Outlook - The innovative drug sector is expected to continue benefiting from domestic policy support, international expansion, and enhanced global competitiveness, which may drive valuation re-rating [6]. - Key catalysts for the second half of the year include medical insurance negotiations, academic conferences, and the implementation of innovative drug directories [6]. ETF Performance - The Hong Kong Stock Connect Innovative Drug ETF (520880) has seen a year-to-date increase of 101.58%, significantly outperforming other indices [9][10]. - The ETF tracks the Hang Seng Hong Kong Stock Connect Innovative Drug Select Index, which focuses on innovative drug companies and has a high concentration of leading stocks [7].

Group 1 - Company reported a revenue of 2.433 billion RMB for the six months ending June 30, 2025, representing a year-on-year increase of 44.73% [1] - Gross profit reached 2.103 billion USD, up 48.33% year-on-year [1] - Net profit was 95.59 million USD, a turnaround from a net loss of 372 million USD in the same period last year, with basic earnings per share of 0.07 USD [1] Group 2 - Company signed a royalty purchase agreement with Royalty Pharma, receiving an upfront payment of 885 million USD for the rights to Tarlatamab outside of China [2] - The transaction is expected to secure 950 million USD in cash flow from Tarlatamab, covering nearly 80% of the 1.25 billion USD development costs committed in partnership with Amgen [2] - The deal is anticipated to strengthen the company's balance sheet and enhance operational and strategic flexibility, supporting ongoing innovation pipeline development [2]

Group 1 - The core viewpoint of the articles highlights the significant financial performance of BeiGene, with a total revenue of 2.433 billion RMB for the six months ending June 30, 2025, representing a year-on-year increase of 44.73% [1] - Gross profit reached 2.103 billion USD, an increase of 48.33% compared to the previous year [1] - The net profit for the period was 95.59 million USD, a turnaround from a net loss of 372 million USD in the same period last year, with basic earnings per share of 0.07 USD [1] Group 2 - The increase in total revenue is primarily attributed to the sales growth of the company's self-developed products, including Baiyueze® and Tislelizumab, as well as the sales of licensed products, mainly from Amgen [1] - For the six months ending June 30, 2025, product revenue net increased by 44.5% to 2.4106 billion USD, up from 1.6681 billion USD in the same period last year [1] - Baiyueze® global sales reached 1.7415 billion USD, a 54.7% increase year-on-year, with U.S. sales totaling 1.2469 billion USD, up 50.1% from 830.8 million USD in the previous year [2] Group 3 - The robust growth in Baiyueze® sales is attributed to strong demand across all indications and moderate gains from net pricing [2] - Baiyueze® continues to maintain a leading market share among new patients in the BTK inhibitor class due to its differentiated and best-in-class clinical characteristics [2]

《科创板日报》8月21日讯（记者 黄修眉） 8月20日，中共中央政治局常委、国务院总理李强在北京调研生物医药产业发展情况。 "对于百济神州自己来说，全球化的征途才刚刚开始。公司正在早期研发、多中心临床、联合治疗等方面持续发力，希望能够以新一代全球药企的身份，成 为行业发展中不可或缺的力量。"百济神州全球研发负责人汪来曾表示，"所谓新一代，则是指遵循研发科学规律的新药物开发模式。" 在未来18个月内，百济神州预计将达成多项研发里程碑。 李强强调，要加大高质量科技供给和政策支持，充分发挥企业创新主体作用，着力推动生物医药产业提质升级，研发生产更多优质高效的好药新药；要加 强原始创新和关键核心技术攻关，运用人工智能赋能产业发展，优化政策衔接和协同配合，促进中医药振兴发展。 其中，在百济神州（北京）生物科技有限公司（下称："百济神州"），李强了解有关新药研发情况，察看药物化学实验室，细致询问生产流程。 百济神州：百悦泽®位居全球BTK抑制剂市场第一位 百济神州专注于开发及商业化用于治疗癌症的创新型分子靶向及肿瘤免疫治疗药物，拥有广泛全面的产品组合，是一家美股、H股、A股三地上市的创新药 企。 其是唯一一家在CLL治疗 ...

Group 1 - Since August, 26 stocks have been investigated by overseas institutions, with notable interest in companies like Huaming Equipment, BeiGene-U, and Jereh Group, each receiving over 10 institutional inquiries [2][3] - The average increase in stock prices for the investigated companies since August is 4.62%, with BoRui Pharmaceutical, Jereh Group, and Greenway Technology showing significant gains of 19.13%, 17.7%, and 13.44% respectively [4] - The pharmaceutical and electronic sectors have attracted considerable attention from overseas institutions, with 4 and 5 stocks investigated respectively [3][4] Group 2 - BeiGene-U has received approvals for its products in 75 global markets, with recent expansions in reimbursement coverage in 5 markets this quarter [3] - Huaming Equipment reported strong growth in its power equipment business, with Europe being the largest market for its direct exports [2][3] - The semiconductor sector is experiencing upward momentum, with global semiconductor sales projected to reach $179.7 billion in Q2 2025, reflecting a nearly 20% year-on-year increase [4]