Company and Industry Summary Company: 百济神州 (BeiGene) Key Financial Performance - Total revenue for 2025 reached $5.34 billion, representing a 40.2% increase year-over-year [1] - Product revenue for 2025 was $5.28 billion, up 39.8% compared to the previous year [1] - Net profit for 2025 was $290 million, a significant recovery from a net loss of $640 million in the same period last year [1] - Q4 2025 revenue was $1.5 billion, reflecting a 32.8% year-over-year increase and a 6.1% quarter-over-quarter increase [1] - Q4 2025 product revenue was $1.48 billion, up 32.1% year-over-year and 5.8% quarter-over-quarter [1] - Q4 2025 net profit was $66 million, compared to a net loss of $150 million in the same quarter last year [1] Product Performance - Revenue from the drug Tislelizumab for 2025 was $740 million, an 18.8% increase year-over-year [1] - Q4 2025 revenue for Tislelizumab was $180 million, an 18.3% increase year-over-year but a 4.5% decrease quarter-over-quarter [1] Company: 其他药品 (Other Drugs) Key Financial Performance - Revenue from the drug Zebrutinib for 2025 was $3.93 billion, a 48.6% increase year-over-year [2] - Breakdown of Zebrutinib revenue: - United States: $2.83 billion (+45.1%) - Europe: $600 million (+66.2%) - China: $340 million (+33.3%) - Rest of the World (ROW): $160 million (+105.8%) [2] - Q4 2025 revenue for Zebrutinib was $1.15 billion, a 38.4% increase year-over-year and a 10.1% increase quarter-over-quarter [2] - Q4 2025 revenue breakdown for Zebrutinib: - United States: $840 million (+37.1%, +14.4% QoQ) - Europe: $170 million (+47.2%, +2.2% QoQ) - China: $90 million (+26.0%, -5.5% QoQ) - ROW: $160 million (+61.0%, +1.8% QoQ) [2] Other Drug Revenues - XGEVA revenue for 2025 was $310 million (+36.4%), with Q4 revenue of $70 million (+12%, -16.9% QoQ) [2] - BLINCYTO revenue for 2025 was $100 million (+40.2%), with Q4 revenue of $24 million (+17.6%, -20.4% QoQ) [2] Cost and Profitability Metrics - Product gross margin for 2025 was 87.3%, an increase of 3 percentage points [2] - Selling and administrative expense ratio was 39.0%, a decrease of 9.1 percentage points [2] - R&D expense ratio was 40.2%, a decrease of 11.1 percentage points [2] - Q4 2025 product gross margin improved to 90.4% (+4.5 percentage points QoQ) [2] - Q4 2025 selling and administrative expense ratio was 37.1% (-0.5 percentage points QoQ) [2] - Q4 2025 R&D expense ratio was 41.1% (+4 percentage points QoQ) [2] Future Outlook - For 2026, total revenue is projected to be between $6.2 billion and $6.4 billion, with a gross margin above 80% [3] - GAAP operating profit is expected to be between $700 million and $800 million, while non-GAAP operating profit is projected to be between $1.4 billion and $1.5 billion [3]

Core Viewpoint - Despite achieving profitability in 2025, the stock price of BeiGene has experienced a significant decline, raising concerns among investors about future performance and market competition [1][3]. Financial Performance - In 2025, BeiGene reported total revenue of 38.205 billion yuan, a year-on-year increase of 40.4% - The net profit attributable to shareholders was 1.422 billion yuan, marking a turnaround from a loss of 5.379 billion yuan in the previous year - The adjusted net profit, excluding non-recurring items, was 1.381 billion yuan [1]. Stock Market Reaction - On February 26, 2025, BeiGene's Hong Kong stock price fell sharply, closing down 9.16% at 200 HKD, resulting in a market capitalization drop below 300 billion HKD - The stock continued to decline on February 27, closing at 192.3 HKD, a further decrease of 1.08%, with a market cap of 296.3 billion HKD - The A-share market also saw a decline, with a closing price of 263.44 CNY on February 26, down 5.65%, and a further drop to 257.7 CNY on February 27, down 2.18% [1]. Product Performance and Market Competition - BeiGene's core product, Zebrutinib (Brukinsa), is expected to face challenges in 2026, with sales projections falling short of expectations - In 2025, Zebrutinib generated revenue of 39.3 billion yuan, accounting for 73.5% of the company's total revenue, with a year-on-year growth rate of 48.8% - However, the quarterly growth rate for Zebrutinib in Q4 2025 was only 10.1%, significantly lower than the 20% growth in Q2 [3]. Competitive Landscape - Zebrutinib is facing increased competition, particularly from AstraZeneca's Acalabrutinib and Johnson & Johnson's Ibrutinib - AstraZeneca has recently launched a combination therapy involving Acalabrutinib, which has gained approval in key markets, posing a threat to Zebrutinib's market share [4]. Future Prospects - BeiGene's second major product, Tislelizumab (PD-1 inhibitor), is projected to have a global sales figure of 5.297 billion yuan in 2025, with an 18.6% year-on-year increase - The company plans to submit a new indication application for Tislelizumab in 2026, which could enhance its market position [6]. - Another product, Sotorasib (BCL-2 inhibitor), has received breakthrough therapy designation from the FDA and is expected to be a new growth driver in 2026, potentially offsetting the slowdown in Zebrutinib's growth [7].

Group 1: Company Performance - 24 innovative drug companies reported their 2025 performance, with 19 achieving positive net profit, representing 79.17% [1] - BeiGene achieved its first annual profit in 2025 with a net profit of 1.422 billion yuan, and total revenue of 38.205 billion yuan, a 40.4% increase year-on-year [1] - Microbio achieved a total revenue of 910 million yuan in 2025, a 38.24% increase, and a net profit of 51.0757 million yuan, marking a turnaround [2] - Shanghai Yizhong reported a revenue of 317 million yuan, an 82.72% increase, and a net profit of 64.132 million yuan, a significant 819.42% increase [2] Group 2: Industry Trends - The overall performance of the innovative drug industry is improving, but significant differentiation exists, with many companies still in a loss-reduction phase [1] - The continuous release of policy dividends is a key driver for performance growth, with nearly 80% of innovative drugs entering the medical insurance directory within two years [2] - The global healthcare industry saw a financing amount of 63.882 billion USD in 2025, a 10.13% increase, while domestic financing in the healthcare sector reached 73.777 billion yuan, a 39.05% increase [3] - The number of new drug IND applications in China reached 2,175 in 2025, an 8.8% increase [3]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 BeOne Medicines Ltd. 百濟神州有限公司 （根據瑞士法律註冊成立的公司） （股份代號：06160） 自願性公告－業務發展最新情況 本公告由百濟神州有限公司（「本公司」）自願作出。請參閱本公告附件根據瑞士法 律準備的瑞士法定財務報表。 承董事會命 百濟神州有限公司 主席 歐雷強先生 香港，2026年2月27日 於本公告日期，本公司董事會包括主席兼執行董事歐雷強先生、非執行董事王 曉東博士，以及獨立非執行董事Olivier Brandicourt博士、Margaret Han Dugan 博士、Michael Goller先生、Anthony C. Hooper先生、Ranjeev Krishana先生、 Alessandro Riva博士、Corazon (Corsee) D. Sanders博士、Shalini Sharp女士及易 清清先生。 Ernst & Young AG Aesch ...

Group 1 - The core innovation vitality of the pharmaceutical industry in the Zhongguancun Life Science Park continues to thrive, with 22 innovative drugs approved for clinical trials by 2025, focusing on breakthroughs in oncology and rare diseases [1][4] - Innovative drug company Nocare Biopharma has completed patient enrollment for its Phase III clinical trial of the new BCL2 inhibitor mesutoclax combined with BTK inhibitor ibrutinib for treating chronic lymphocytic leukemia/small lymphocytic lymphoma, marking a significant step towards market launch [2][3] - BeiGene, a leading innovative drug company from the park, announced its first annual profit since establishment, driven by the strong sales of its core innovative drug products, including a global sales revenue of 28.067 billion yuan for its drug zanubrutinib, which saw a 49% year-on-year increase [4] Group 2 - The Zhongguancun Life Science Park has showcased its 2025 innovation report, highlighting 22 innovative drugs in clinical trials across various cutting-edge fields, including rare diseases, mRNA vaccines, and cell therapy, with several achieving dual clinical trial approvals in China and the U.S. [4][5] - The rare disease drug TollB-001 developed by TuoLing BoTai has received clinical trial approvals in both China and the U.S., targeting systemic sclerosis and offering new treatment options for rare disease patients [5] - The GLP-1/FGF21 dual agonist ZT003 has been approved for clinical trials in the U.S., representing a breakthrough in metabolic disease treatment with multiple benefits including blood sugar control and weight loss [6]

Ernst & Young AG Aeschengraben 27 P.O. Box CH-4002 Basel Phone: +41 58 286 86 86 www.ey.com/en_ch 致百济神州有限公司 股东大会，巴塞尔 巴塞尔，2026 年 2 月 26 日 法定审计师的报告 财务报表审计报告 审计意见 我们审计了百济神州有限公司（贵公司）的财务报表，包括截至 2025 年 12 月 31 日的资产负债表， 2025 年 5 月 27 日至 2025 年 12 月 31 日期间的利润表以及相关财务报表附注（包括重要会计政策摘 要）。 我们认为，后附的贵公司财务报表符合瑞士法律和贵公司章程的规定。 形成审计意见的基础 我们按照瑞士法律和瑞士审计准则（SA-CH）的规定执行了审计工作。审计报告的"审计师对财务 报表审计的责任"部分进一步阐述了我们在这些法条和准则下的责任。按照瑞士法律的规定和瑞士 审计行业对公共利益实体财务报表审计的要求，我们独立于贵公司，并履行了职业道德方面的其他 责任。 我们相信，我们获取的审计证据是充分、适当的，为发表审计意见提供了基础。 关键审计事项 关键审计事项是我们根据职 ...

Core Insights - BeiGene has become a focal point in China's innovative drug sector, achieving significant revenue and profit growth driven by its core products and strategic market positioning [1][11] - The company's total global revenue for 2025 reached $5.3 billion, marking a 40% year-on-year increase, primarily due to the strong performance of its flagship product, Brukinsa (Zebutinib) [1][11] - Brukinsa generated $3.9 billion in global sales, a 49% increase year-on-year, solidifying its role as the main driver of revenue growth [1][11] Revenue Growth - The two main self-developed products contributed over 90% of total revenue, with Brukinsa accounting for more than 70% [2][12] - The product matrix's synergy and the launch of new products, such as the BCL-2 inhibitor, have established a sustainable growth model for the company [2][12] Market Positioning - Brukinsa is recognized as the most widely approved BTK inhibitor globally, benefiting from its efficacy and safety, which has helped it secure a leading market position [3][13] - The BTK inhibitor market is experiencing a structural shift, with new-generation products gaining traction as first-generation products lose market share, providing a favorable environment for Brukinsa's growth [3][14] Product Development - The approval of the BCL-2 inhibitor, BeiGene's new product, in January 2026, fills a gap in the domestic treatment landscape and is expected to contribute to future revenue growth [5][15] - The steady growth of the other core product, Tislelizumab (Breztri), in the solid tumor space, further supports the company's dual-driven growth strategy [4][15] Industry Trends - The global demand for oncology drugs is expanding, driven by an aging population and increasing healthcare awareness, creating a broad market opportunity for innovative drug companies [6][16] - The competitive landscape in the innovative drug sector is intensifying, with both domestic and international companies vying for market share, leading to a phenomenon of "Matthew Effect" where established players gain more advantages [6][17] Future Outlook - The company projects total revenue for 2026 to be between $6.2 billion and $6.4 billion, indicating continued growth potential [9][20] - Future growth will rely on multiple product launches and expansions into new therapeutic areas, including autoimmune diseases, which could open new revenue streams [8][19]

Group 1: Company Performance - BeiGene reported a total revenue of 38.205 billion yuan for 2025, a 40.4% increase from 27.214 billion yuan in the previous year, with a net profit of 1.422 billion yuan compared to a loss of 4.978 billion yuan in the prior year [1] - United Imaging achieved a total revenue of 13.821 billion yuan in 2025, reflecting a year-on-year growth of 34.18%, with a net profit of 1.888 billion yuan, up 49.6% [2] - Innovent Biologics expects a profit increase of 80%-94% to between 1.3 billion and 1.4 billion yuan for 2025, with total revenue projected at approximately 7.7-7.8 billion yuan, a growth of 16.0%-17.6% [3] - Zai Lab reported a total revenue of $460 million for 2025, a 15% increase, with significant growth in product sales driven by the performance of its drugs [4] Group 2: Product and Market Developments - BeiGene's global sales of its product, Baiyueze®, reached 28.067 billion yuan, marking a 48.8% year-on-year increase, establishing its leadership in the BTK inhibitor market [1] - United Imaging's growth was attributed to the continuous launch of innovative products and enhanced market recognition of high-end products [2] - Zai Lab's revenue growth was primarily due to increased sales of its products, including significant gains in the fourth quarter [4] - Innovent Biologics noted that revenue growth was driven by increased income from innovative drugs and licensing agreements [3] Group 3: Strategic Moves and Collaborations - Hengrui Medicine signed an exclusive licensing and equity cooperation agreement with Solstice Oncology, with a total transaction value exceeding $1.2 billion [6] - Aibo Medical plans to acquire a 68.31% stake in Demei Medical for 683 million yuan, aiming to expand into the sports medicine sector [7] - The target company in the acquisition has 276 patented technologies and is recognized as a leading enterprise in the domestic sports medicine field [8]

Core Insights - The company reported a total revenue of 38.205 billion yuan for 2025, representing a 40.4% increase from 27.214 billion yuan in the previous year [1] - The net profit attributable to shareholders was 1.422 billion yuan, a significant improvement from a loss of 4.978 billion yuan in the same period last year [1] Revenue Growth - The global sales of Baiyueze® reached 28.067 billion yuan, marking a year-on-year growth of 48.8% [1] - The company has established a leading position in the BTK inhibitor market globally [1] Operational Efficiency - The company improved operational efficiency through revenue growth and cost management [1] - Successful profitability was achieved during the reporting period [1]

Core Viewpoint - BeiGene reported a total revenue of 38.205 billion yuan for the fiscal year 2025, representing a year-on-year growth of 40.4% driven by product revenue growth and improved operational efficiency through cost management [1] Group 1: Financial Performance - The net profit attributable to the parent company reached 1.422 billion yuan during the reporting period [1] - Product revenue amounted to 37.77 billion yuan, showing a year-on-year increase of 39.9% [1] Group 2: Product Sales - The global sales of the product Brukinsa® (Zebutinib) reached 28.067 billion yuan, with a year-on-year growth of 48.8% [1] - In the U.S. market, Brukinsa® sales were 20.206 billion yuan, reflecting a year-on-year increase of 45.5% [1] - In Europe, Brukinsa® sales reached 4.265 billion yuan, growing by 66.4% year-on-year [1] - In China, Brukinsa® sales were 2.472 billion yuan, with a year-on-year growth of 33.1% [1] - Another core product, Tislelizumab (百泽安®), achieved global sales of 5.297 billion yuan, marking an 18.6% increase year-on-year [1] Group 3: Future Prospects - BeiGene plans to submit a new indication application for Tislelizumab combined with Zanidatamab (Zanidatamab) for first-line treatment of HER2-positive gastric adenocarcinoma in adults in the U.S. and China in the first half of 2026 [1] - The company anticipates a regulatory decision in Japan for the same indication in the second half of 2026 [1]