5月1日，诺和诺德宣布，美国最大的药品福利管理公司 (PBM) CVS Caremark 将自 2025 年 7 月 1 日起，在其主要商业处方集中将 Wegovy® （司美格鲁肽）2.4 毫克指定为首选 GLP-1 减肥药物。 "Wegovy® 为肥胖症患者提供独特的益处，我们致力于扩大其可及性，"诺和诺德公司美国运营执行副总裁兼总裁 Dave Moore 表示。"作为肥 胖症护理领域的长期领导者，我们的目标是继续与整个医疗保健系统合作，确保患者能够便捷且经济地获得 FDA 批准的 Wegovy®。" 整理 | GLP1减重宝典内容团队 除了此次处方集决定之外，诺和诺德还将继续与 CVS 合作，探索其他可能改善更多人获得 Wegovy® 可及性的策略。 在以往努力的基础上，公司正积极探索帮助患者以合理价格获得正品、FDA 批准的 Wegovy® 的方法。2 月，FDA 确认所有剂量规格均可供 应。3 月，诺和诺德推出了 NovoCare® 药房，这是一个直接面向消费者的平台，为自费患者提供所有 Wegovy® 剂量的送货上门服务，每月仅 需 499 美元。最近，一项节省计划的更新将同样的价格扩展到选择在零售 ...

Core Viewpoint - Novo Nordisk has submitted a New Drug Application (NDA) to the FDA for the oral formulation of Wegovy® (semaglutide) aimed at chronic weight management in adults with obesity or overweight and associated comorbidities, potentially becoming the first oral GLP-1 treatment for this purpose [1][3]. Group 1 - The FDA has accepted the NDA for Wegovy®, which is intended for adults with obesity (BMI ≥ 30 kg/m²) or overweight (BMI ≥ 27 kg/m²) and one or more comorbidities [1][3]. - The application is based on the results of the OASIS 4 trial, a 64-week Phase 3 randomized controlled trial involving 307 participants [3][4]. - The OASIS 4 trial included a 12-week dose escalation period and a 7-week follow-up after treatment, with participants randomly assigned to receive either the oral semaglutide or a placebo [4]. Group 2 - The FDA is expected to make a decision on the approval of the oral formulation of Wegovy® in the fourth quarter of 2025 [4]. - Novo Nordisk's senior vice president emphasized the importance of personalized treatment options for obesity, highlighting the company's extensive experience and innovation in this field [3].

Group 1 - The core focus of JR Research is on identifying attractive risk/reward opportunities that can generate alpha above the S&P 500 through robust price action [1][2] - The investment strategy emphasizes growth investing, combining price action analysis with fundamental investing while avoiding overhyped and overvalued stocks [2] - JR Research runs the Ultimate Growth Investing group, which specializes in high-potential opportunities across various sectors with a 18 to 24 month outlook for investment theses [3] Group 2 - The group targets stocks with strong growth potential and contrarian plays that have been beaten down, aiming for robust fundamentals and attractive valuations [3] - The investment approach is designed for investors looking to capitalize on growth stocks with buying momentum and turnaround potential [3]

Group 1 - Novo Nordisk's oral weight loss drug Wegovy has had its application formally accepted by the FDA, with a decision expected in Q4 [1] - If approved, Wegovy will be the first oral GLP-1 receptor agonist for chronic weight management globally [1] - Novo Nordisk's stock price rose by 5.53% to $69.23 following the announcement [1] Group 2 - The company currently markets Rybelsus, an oral GLP-1 drug approved for blood sugar control in adults with diabetes [1] - The global obesity treatment market is projected to exceed $150 billion in the coming years [1] - Eli Lilly's experimental oral drug orforglipron showed an average weight loss of 16 pounds (approximately 7.3 kg) in type 2 diabetes patients after 40 weeks [1] Group 3 - Novo Nordisk's application is based on a pivotal Phase III clinical trial involving 307 obese adults with at least one comorbidity, comparing 25 mg oral semaglutide to a placebo [2] - The company is also developing a new generation weight loss drug, amycretin, which targets both GLP-1 and the pancreatic hormone amylin to regulate hunger [2] - Concerns have arisen among investors regarding competition from Eli Lilly and disappointing clinical trial data for Novo Nordisk's candidate CagriSema, which was expected to be a strong alternative to Wegovy [2]

Novo Nordisk A/S’ NVO Canada unit on Thursday announced that Health Canada has accepted for review, under the Priority Review policy, its supplemental new drug submission (sNDS) for semaglutide 2.4 mg, a once-weekly therapy for people living with MASH (metabolic dysfunction-associated steatohepatitis).“Semaglutide 2.4 mg represents a therapeutic advancement for patients living with MASH, addressing a critical unmet medical need,” says Vince Lamanna, President of Novo Nordisk Canada Inc. “Health Canada’s acc ...

Core Viewpoint - Novo Nordisk's stock has experienced a decline of -2.2% over the past month, underperforming the Zacks S&P 500 composite's -0.5% change and the Zacks Large Cap Pharmaceuticals industry's -2% loss, raising questions about its near-term performance [1] Earnings Estimate Revisions - The consensus earnings estimate for the current quarter is $0.91 per share, reflecting a year-over-year increase of +9.6%, with a recent change of +2.2% over the last 30 days [4] - For the current fiscal year, the consensus earnings estimate is $3.85, indicating a +17.4% change from the previous year, with a +1.3% change in the last 30 days [4] - The next fiscal year's consensus earnings estimate is $4.71, showing a +22.4% change from the prior year, with a +2.1% change over the past month [5] - Novo Nordisk holds a Zacks Rank 3 (Hold), influenced by recent changes in consensus estimates and other earnings-related factors [6] Revenue Growth Forecast - The consensus sales estimate for the current quarter is $11.33 billion, indicating a year-over-year increase of +19.1% [10] - The sales estimates for the current and next fiscal years are $50.66 billion and $58.15 billion, reflecting changes of +20.3% and +14.8%, respectively [10] Last Reported Results and Surprise History - In the last reported quarter, Novo Nordisk achieved revenues of $12.26 billion, a year-over-year increase of +28.9%, and an EPS of $0.91 compared to $0.71 a year ago [11] - The reported revenues exceeded the Zacks Consensus Estimate of $11.34 billion by +8.11%, and the EPS surprise was +9.64% [11] - Over the last four quarters, Novo Nordisk surpassed consensus EPS estimates twice and revenue estimates twice [12] Valuation - Novo Nordisk is graded B in the Zacks Value Style Score, indicating it is trading at a discount to its peers [16]

Core Insights - Renaissance Technologies is recognized as one of the world's most successful hedge funds, primarily due to its Medallion Fund, which achieved an annualized return of 39% after fees from 1988 to 2021 [1] - The firm has notable long equity holdings, including significant positions in Novo Nordisk, United Therapeutics, and Palantir Technologies, reflecting its investment strategies and market outlook [2][14] Group 1: Novo Nordisk - At the end of 2024, Renaissance's third-largest long equity holding was Novo Nordisk, with a stake valued at $715 million, indicating strong conviction in the company [3][5] - Novo Nordisk's stock generated a total return of approximately 480% from the end of 2017 to its peak in June 2024, but has since declined by 56% as of April 29 [4] - Renaissance reduced its holdings in Novo by around 9% from Q2 2024 to Q4 2024, while the stock is currently trading at levels similar to the end of 2022 [5] Group 2: United Therapeutics - Renaissance maintained a significant position in United Therapeutics, valued at around $737 million at the end of 2024, with a total return of approximately 285% since Q2 2019 [7][8] - The company has six FDA-approved medications, with its leading product, Tyvaso, generating over $1.6 billion in sales in 2024, reflecting a 31% growth from 2023 [9] - The continued large position in United Therapeutics suggests confidence in the company's ability to grow sales and develop new treatments for rare conditions [9] Group 3: Palantir Technologies - As of Q4 2024, Palantir Technologies became Renaissance's largest holding, with a position valued at over $1.7 billion, having increased by over 1,700% since the end of 2022 [11] - Renaissance reduced its stake in Palantir by over 40% from Q3 2024, which may have been a strategic move given the stock's significant rise of over 200% since that time [12] - Analysts have expressed concerns about Palantir's high forward price-to-earnings multiple, indicating potential downside risks [13]

苹果业绩勉强超预期，宣布千亿美元回购，但关税将导致成本增9亿美元，股价盘后一度跌4%， 电话会仅不到半小时，库克称当下不会宣布涨价。 亚马逊Q1利润率再新高，但利润指引逊色，预警关税冲击，盘后一度跌5%。 马斯克向特朗普"告别"，留下"削减1600亿美元"成绩单，远低于预期。特斯拉董事会开始寻找 CEO继任者，分析称，"厌倦造车"的马斯克需要一个"库克"。微软力邀马斯克Grok AI入驻 Azure，与OpenAI关系再起波澜。 科技巨头资本支出强劲，台积电被摩根士丹利列为"首选股"。 礼来跌超11%，Q1营收猛增45%，但连锁药店巨头CVX决定旗下主要处方药目录将诺和诺德 Wegovy列为首选、Zepbound不在其中。 中国休市，黄金大跌。据高盛，五一假期前夕，中国交易员抛售了近100万盎司黄金，几乎完全逆 清空了上周买入的仓位。 贝森特称市场认为美联储应降息，萨默斯驳斥：不能靠市场指导，下周降息大错。 美国4月ISM制造业PMI创五个月来最大萎缩，产出指数创2020年5月以来新低。美国上周首申失 业金人数大幅高于预期，续请失业金人数创2021年最高。 日本央行一致同意继续维持利率不变，因担心关税大幅下调 ...

Novo Nordisk A/S NVO announced that CVS Health Inc’s CVS CVS Caremark, a Pharmacy Benefit Manager (PBM), has decided that Wegovy (semaglutide) injection 2.4 mg will soon be the preferred GLP-1 medicine on its largest commercial template formularies.This change will take effect on July 1, 2025. “We believe in the unique benefits of Wegovy and the difference this medicine can make for patients seeking treatment,” said Dave Moore, executive vice president of U.S. Operations and president of Novo Nordisk Inc.In ...

Core Insights - CVS Health is expanding access to the weight loss drug Wegovy through its pharmacy benefit manager, Caremark, making it the preferred GLP-1 drug for obesity starting July 1 [2][3] - The partnership aims to enhance patient access to Wegovy, which is no longer in short supply in the U.S., and offers a lower net price compared to competitors [3][4] - Caremark will provide Wegovy at a more affordable price, with potential savings shared with clients through lower premiums or copays [4][5] Company Initiatives - Caremark will combine Wegovy with lifestyle support, including personalized nutrition plans, as part of the CVS Weight Management program [7] - CVS is the first retail pharmacy to partner with Novo Nordisk's direct-to-consumer online pharmacy, NovoCare, to dispense Wegovy at a lower price for cash-paying patients [6] - Novo Nordisk emphasizes the importance of collaborating with the healthcare system to provide affordable access to FDA-approved Wegovy [8]