Group 1 - Allka Research has over two decades of experience in investment, focusing on uncovering undervalued assets in ETFs, commodities, technology, and pharmaceutical sectors [1] - The company adopts a conservative investment approach, aiming to deliver substantial returns and strategic insights to clients [1] - Allka Research is committed to simplifying investment strategies, making them accessible for both seasoned and novice investors [1] Group 2 - The mission of Allka Research includes contributing thought-provoking analyses and informed perspectives to the Seeking Alpha community [1] - The company aims to demystify investing, inspiring confidence in readers and fostering a community of informed investors [1] - Allka Research continues to explore and reveal the complexities of the financial world through its contributions on Seeking Alpha [1]

1、 《 Comac Medical Group 收购 ILIFE Consulting 》 摘要 ■ 英国总部、由 EdgeCap Partners 支持的 Comac Medical Group 宣布收购法国巴黎的专业合同研究 组织（CRO） ILIFE Consulting 。 ■ ILIFE 专注于 肿瘤学 、 罕见病 和 复杂的早期生物技术临床试验 ，这些均为创新密集、增长潜力大 的医疗细分领域。 ■ ILIFE 拥有深厚的法国及西欧市场经验，增强 Comac 在西欧地区的立足点，与其在英国、德国和美 国的近期扩展形成协同效应。 ■ ILIFE 创始人兼 CEO Marina Iché 将继续担任领导职务并成为集团重要股东，有助于确保企业文化与 服务连续性，支持未来增长战略。 ■ 背后私募股权基金 EdgeCap Partners 专注于欧洲高质量中型企业，管理层具有 Morgan Stanley、 Citi、Goldman Sachs 等顶级机构背景，具备强大资本与并购执行力。 ■ 对投资者而言，此次并购显著加强了 Comac 在早期临床试验领域的技术与服务能力，提升其吸引 新兴生物技术客户的竞争 ...

以下文章来源于凤凰网财经 ，作者凤凰网财经 凤凰网财经 . 你好，我们是凤凰网财经，全球华人都在看的财经公众号，传播最有价值的财经报道，你值得关注！欢 迎访问：http://finance.ifeng.com/ 本文来自微信公众号： 凤凰网财经 （ID：finance_ifeng） ，作者：凤凰网财经，头图来自：AI生 成 一、打了三针，就赶紧停了 "还是停针吧。"医生的话让王艳松了一口气。 2025年3月，她怀着期待将第一针"减重版司美格鲁肽" （以下简称司美格鲁肽） 注入体内——这款 被视为"打针就能减肥"的药物，在2024年11月17日正式登陆中国市场后，迅速成为众多减肥者的新 希望。 新闻曾报道，临床试验显示，该药物能实现"平均17%的体重降幅"，效果可持续至少2年，而且还能 带来多重健康获益，包括但不限于减少腰围、降低内脏脂肪等。 只是去医院检查的王艳，在医生的推荐下，花费1900元购买了一支1.7mg剂量的司美格鲁肽。 按照医嘱，她需要每周注射一次，连续六周。"配合控制饮食，三个月预计能减20斤"——医生的承 诺让她心动不已。 然而第一针下去，不良反应就出现了。 二、不是所有人都适合减肥针 在社交 ...

Industry Overview - The obesity market is rapidly expanding, driven by the success of GLP-1 therapies Wegovy and Zepbound, and is projected to reach $100 billion by 2030 [1] - There is a growing interest in cannabinoid (CBD)-based therapies as companies seek to innovate beyond GLP-1s for weight management [2] - The cannabis industry is also experiencing significant growth, expected to surpass $200 billion by 2032, although direct investments in cannabis companies have been challenging due to regulatory issues [3] Company Analysis Novo Nordisk - Novo Nordisk is a leader in obesity treatments with its semaglutide products, Wegovy and Ozempic, but faces increasing competition from Eli Lilly [5] - The company entered the CBD space by acquiring Inversago Pharmaceuticals in 2023, adding monlunabant, an investigational oral cannabinoid drug for metabolic diseases [6] - A phase IIa study on monlunabant showed statistically significant weight loss compared to placebo, but higher doses had diminishing returns; a phase IIb study is planned to find an optimal dose [7] - EPS estimates for 2025 have increased from $3.81 to $3.84, while 2026 estimates have slightly decreased from $4.66 to $4.64; the stock has declined about 21% year to date due to competition and regulatory challenges [8] Corbus Pharmaceuticals - Corbus' lead CBD candidate, CRB-913, targets the same CB1 receptor as monlunabant and is currently in phase I studies, with results expected in Q3 2025 [9] - Preclinical data suggest CRB-913 may have advantages over previous therapies, with a significantly lower brain-to-plasma ratio, indicating reduced neuropsychiatric side effects [10] - Corbus is also developing two oncology drugs, CRB-701 and CRB-601, with CRB-701 in phase I/II studies [11] - Loss per share estimates for 2025 have increased from $5.47 to $6.34, and for 2026 from $5.30 to $5.39; the stock has declined 36% year to date, reflecting regulatory volatility [12][13] Skye Bioscience - Skye Bioscience is developing nimacimab, a monoclonal antibody targeting the CB1 pathway, currently in a phase II study evaluating its efficacy as a monotherapy and in combination with Wegovy [14] - Nimacimab is designed to minimize brain penetration while maintaining metabolic effects, with early studies showing no adverse psychiatric events [15] - Loss per share estimates for 2025 have widened from $1.27 to $1.31, and for 2026 from $1.48 to $1.52; the stock has lost 27% year to date due to financial concerns and lack of commercial revenues [16]

Group 1 - Novo Nordisk has entered the 18th and final phase of its long-term Weekly Adhishthana Cycle, indicating a potentially transformative period for the stock [1][2] - The stock has shown an 88.5% alignment with the Adhishthana Principles on the weekly timeframe since the cycle began on December 23, 2013, with Phase 18 expected to run until November 8, 2026 [2] - The trajectory of Phase 18 is influenced by the previous phases, particularly Phases 14, 15, and 16, which exhibited bullish characteristics [5][8] Group 2 - The Guna Triads indicate that the chances of the stock reaching its Nirvana are high due to the SSR formation, which consists of two Satoguna phases followed by a Rajoguna phase [7][8] - However, the monthly charts present a contrasting view, showing that Novo is currently in Phase 11, which typically leads to a peak followed by a correction [11][13] - The monthly alignment is only around 60-65%, significantly lower than the weekly alignment, which raises concerns about the reliability of the monthly signals [14] Group 3 - The Nirvana target on the weekly chart is nearly 129% above current levels, suggesting significant potential for growth [15] - The conflicting signals between the weekly and monthly cycles create a high-risk, high-reward scenario for investors [15][16] - The stock is technically bullish on the weekly chart but structurally unresolved on the monthly chart, indicating a pivotal juncture for Novo Nordisk [16]

特朗普宣称美国的处方药价格将会下降 30%—80% ，他要求美国患者必须有权获得 " 最惠国价格 " ，推 动药企建立直销渠道 Key takeaways: 美东时间5月12日，美国总统特朗普签署了旨在使药价下降的行政令。这项激进的政策如同一颗投入全球医 药市场的深水炸弹，引发资本市场震荡。尽管美股医药板块在政策细则公布后出现短暂反弹，但中国创新 药企的股价仍普遍承压，反映市场对于中国出海药企的盈利前景存在担忧。 根据行政令的核心内容，特朗普要求美国患者必须有权获得"最惠国价格"（Most-Favored-Nation Price，简 称"MFN"），即将美国药价限制在经合组织（OECD）国家中的最低水平，由美国卫生与公众服务部 以美国市场贡献一半以上收入的百济神州为例，其王牌产品BTK抑制剂泽布替尼在美国的定价为120粒 12,935美元（93,255元），这款产品在中国经医保谈判后的定价仅有64粒5,440元，算下来平均每粒药的价格 仅约为美国定价的一成。这种差异化的全球定价体系，意味着百济神州可能会直面MFN政策的冲击，一旦 药价大幅下调，很可能会影响其营收。 （HHS）推动药企建立直销渠道，绕过"中间 ...

Evernorth的许多客户目前向员工提供药物，每月的自付费用低至25美元。对于那些因为成本问题而犹豫 不决的人来说，将员工自付费用限制在200美元，这还不到消费者通过礼来或诺和诺德直接面向消费者 的网站购买药品时现金支付价格的一半。 该公司表示，新协议还将包括简化药物的预授权程序，患者将能够在零售药店以相同的价格购买药物， 或者通过Evernorth送货上门服务。这些新的服务和折扣也将提供给已经使用减肥药的Evernorth客户。 Carter说："今天，我们希望那些购买了减肥保险的客户能看到，你知道，他们的成本减少了近20%…… 通过我们与礼来和诺和诺德达成的最新协议，Evernorth能够在保持两种药物保险的同时获得更优惠的价 格。" 智通财经APP获悉，信诺(CI.US)表示，目前只有一半的客户购买了GLP-1减肥药Wegovy和Zepbound， 因为它们的成本很高。但该医疗保险公司表示，其药品福利部门Evernorth已与制药商礼来(LLY.US)和诺 和诺德(NVO.US)达成协议，这将为雇主和工人降低价格。Evernorth新的减肥定价计划将于今年下半年 开始实施，届时雇主们将开始决定明年计划 ...

Only half of health insurer Cigna's clients currently cover the popular GLP-1 weight loss drugs Wegovy and Zepbound because of their high costs. But the company's pharmacy benefits unit Evernorth has reached a deal with drug makers Ely Lilly and Novo Nordisk which it said will bring prices down for employers and their workers."This solution is really focused towards clients that aren't covering it today, and what it allows us to do is one, to bring it on at a reduced price for the plan sponsor, but also cap ...

证券研究报告 | 2025年05月21日 海外制药企业2025Q1业绩回顾 ——美国药品价格改革叠加不确定的宏观环境 行业研究 · 行业专题 医药生物 投资评级：优于大市（维持评级） 证券分析师：马千里 010-88005445 maqianli@guosen.com.cn S0980521070001 证券分析师：陈曦炳 0755-81982939 chenxibing@guosen.com.cn S0980521120001 证券分析师：彭思宇 0755-81982723 pengsiyu@guosen.com.cn S0980521060003 请务必阅读正文之后的免责声明及其项下所有内容 摘要 请务必阅读正文之后的免责声明及其项下所有内容 2 ◼ Pharma收入端增长整体有所放缓：2025Q1，礼来及诺和诺德在GLP-1类药物驱动下，收入端分别+45%/+18%，其中诺和诺德由于美 国compounded GLP-1药物影响，销售低于预期并下调全年收入指引；诺华、艾伯维、阿斯利康、赛诺菲分别依靠诺欣妥/可善挺、 Skyrizi/Rinvoq、Farxiga/Enhertu、Dupixent等核心品种 ...

Core Viewpoint - Novo Nordisk's stock experienced a 3% increase due to positive developments in the GLP-1 weight loss market, particularly involving Noom's entry into the market with compounded versions of Wegovy [1]. Group 1: Company Developments - Noom has started selling smaller doses of compounded versions of Novo Nordisk's Wegovy GLP-1 drug, indicating a potential collaboration or coexistence between Noom and Novo Nordisk [2]. - The compounded version of semaglutide offered by Noom is a 0.125-milligram dose, which is personalized for patients and is half the usual 0.25-mg dose sold by Novo Nordisk [4]. - It appears that Noom may be repackaging Wegovy from Novo Nordisk rather than creating its own generic version, which could lead to increased sales for Novo Nordisk as Noom acts as a reseller [4]. Group 2: Market Implications - The collaboration with Noom could provide a pathway for compounding pharmacies to remain operational despite stricter FDA regulations, especially since Wegovy production is currently sufficient to meet demand [5]. - If this partnership leads to a reacceleration of sales growth for Novo Nordisk, it could positively impact the company's stock performance [6].