Core Viewpoint - China's invasive brain-computer interface (BCI) devices are rapidly entering clinical trials, marking a significant advancement in the field and positioning China as the second country globally to reach this stage after the United States [1][3]. Group 1: Clinical Trials and Developments - The first prospective clinical trial of invasive BCI in China has been successfully conducted by the Chinese Academy of Sciences and Fudan University, meeting medical device registration standards [1]. - Several companies, including Shanghai Ladder Medical Technology, are developing BCI devices aimed at treating patients with motor function disorders, such as spinal cord injuries and amyotrophic lateral sclerosis [3][4]. - Ladder Medical's BCI system has shown promising results, allowing patients to perform tasks like playing chess and racing games after just 2-3 weeks of training [3]. Group 2: Patient Recruitment and Research - The clinical cohort study led by Fudan University and Beijing Xuanwu Hospital has begun patient recruitment to validate the efficacy and safety of invasive BCI treatment [3]. - Companies like Beijing Chip Intelligence and Hangzhou Jialiang Medical have also announced plans for clinical research on BCI devices [3][4]. Group 3: Patient Impact and Demand - There is a significant demand for BCI technology, with over a thousand requests from paralyzed patients seeking participation in clinical trials [6][7]. - The development of BCI devices is seen as a beacon of hope for approximately 4 million spinal cord injury patients in China [7]. Group 4: Technological Advancements - Jialiang Medical has completed nearly 100 clinical implants for epilepsy treatment, with plans to submit data for product approval [8]. - Brain Tiger Technology has developed a next-generation wireless BCI product, which has shown capabilities in controlling complex games and smart devices [8]. Group 5: Industry Challenges and Future Outlook - Experts emphasize that while progress has been made, there is still a considerable gap between China's BCI development and that of leading global competitors [9]. - Companies are advised to focus on long-term research collaboration rather than immediate profit from BCI product sales [9].

Core Insights - Neuralink has successfully enabled a monkey to "see" virtual objects through its brain-machine interface technology, which has potential applications for helping blind individuals perceive the world [1] - The device, named Blindsight, stimulates areas of the brain associated with vision, tricking the monkey's visual system into recognizing non-existent objects [1] - This marks the first public demonstration of Blindsight's experimental results, highlighting the cutting-edge nature of brain device development aimed at treating traditionally difficult medical conditions like blindness [1] Summary by Sections Technology and Innovation - Blindsight is a brain-implanted chip designed to simulate eye functions and directly stimulate the visual cortex [1] - During experiments, the monkey looked at the location of a virtual object over two-thirds of the time, indicating it perceived the non-existent target [1] Future Applications - The short-term goal of Blindsight is to assist blind individuals in seeing, while the long-term vision includes achieving "superhuman vision," such as the ability to see infrared light [2] - Neuralink is also advancing another project aimed at helping paralyzed individuals interact with computers using their thoughts [2] Human Trials - Currently, five humans have received Neuralink implants, with three implanted in 2024 and two in 2025, and some participants reportedly use the brain-machine device for up to 60 hours per week [2]

作为迅速发展的脑机科技领域中的公司之一，Neuralink还在为瘫痪患者植入脑机接口设备， 使其可以直接与计算机交互。 据马斯克介绍，目前已有5位人类接受了Neuralink的植入。其中3人在2024年完成，另外2人 在2025年接受了植入。根据O'Doherty的演讲，有些患者每周使用设备的时间多达60小时。 马斯克表示，未来类似的脑机接口设备可能会让瘫痪人士重新获得行动能力，甚至恢复行走。 结果显示，猴子在测试过程中至少三分之二的时间内，都会将视线转向研究人员"试图让其大 脑产生视觉效果的物体"。 这是Neuralink首次公开Blindsight的实验数据，这个脑机接口设备旨在模拟眼睛的功能，是 脑机接口技术的前沿探索领域之一，正试图打破传统医学无法治愈疾病的边界。 需要指出的是，与其他所有动物实验一样，目前尚不清楚这些结果能否应用于人类，这一设备 尚未获得在美国获准用于人体。 马斯克曾表示，Blindsight的短期目标是"让人类重新获得视力"，长期目标则是实现"超人的 视觉"，比如感知红外线。 Neuralink过去几年一直在猴子身上测试该设备，并希望今年能开始人体实验——马斯克曾在 今年3月公开表 ...

Core Viewpoint - The article highlights the successful implementation of China's first invasive brain-computer interface (BCI) clinical trial, marking the country as the second globally to enter this phase of BCI technology [1][3]. Group 1: Clinical Trial Details - The subject of the trial is a male who lost all four limbs due to an electric shock accident. Since the implantation of the BCI device in March 2025, he has achieved functionalities such as playing chess and racing games within 2-3 weeks of training, reaching a level comparable to that of an average person using a computer touchpad [3]. - The BCI system aims to improve the quality of life for patients with spinal cord injuries and amputations through motor function replacement technology [3]. Group 2: Technological Innovations - The neural electrodes developed by the Chinese Academy of Sciences are the smallest and most flexible in the world, with a cross-sectional area only 1/5 to 1/7 of those used by Neuralink, and flexibility exceeding theirs by over a hundred times, minimizing damage to brain tissue [7]. - The BCI implant has a diameter of 26mm and a thickness of less than 6mm, making it the smallest brain-controlled implant globally, about half the size of Neuralink's product. This allows for a less invasive surgical procedure, reducing risks and recovery time [10]. Group 3: Surgical Precision - The success of the surgery relies on precise localization and implantation of the electrodes. Various brain function localization methods were employed, including functional MRI and 3D modeling, to create a detailed functional map of the patient's motor cortex, ensuring accurate implantation [11]. Group 4: Future Applications - The project team plans to enable the subject to use a robotic arm for physical tasks such as grasping and holding objects. Future developments will also include controlling complex physical devices like robotic dogs and intelligent agents to further expand the subject's capabilities [12].

Core Viewpoint - China's first prospective clinical trial of an invasive brain-computer interface (BCI) has been successfully conducted, making it the second country globally to enter the clinical trial phase after the United States [1] Group 1: Clinical Trial Details - The clinical trial's subject is a 37-year-old male who lost his limbs due to a high-voltage accident. Since the implantation of the BCI device in March, the system has operated stably without infections or electrode failures for over a month [3] - The subject has achieved a level of control over a computer touchpad comparable to that of a normal person, allowing him to play chess and racing games using only his thoughts after 2-3 weeks of adaptive training [3] Group 2: Technological Advancements - The implanted device is the smallest brain-controlled implant globally, measuring 26mm in diameter and less than 6mm in thickness, which is half the size of Neuralink's product [8] - The flexible neural electrodes developed by the research team are 1/5 to 1/7 the cross-sectional area of those used by Neuralink, providing better compatibility with brain tissue and reducing damage [5] Group 3: Research and Development - The research team has established a comprehensive approach to BCI research, covering various aspects such as motion perception, neural function repair, decoding algorithms, and wireless system development since 2022 [5] - The dynamic optimization of the neural decoder has been achieved through an online learning framework, allowing real-time motion decoding and overcoming the limitations of traditional static decoding models [9] Group 4: Future Prospects - The BCI system is expected to improve the quality of life for patients with complete spinal cord injuries, double upper limb amputations, and amyotrophic lateral sclerosis by enabling them to control external devices [12] - Future trials will aim to allow the subject to use robotic arms for physical tasks, expanding the potential applications of the technology [12]

Core Insights - The article discusses the successful implementation of China's first invasive brain-computer interface (BCI) clinical trial, marking a significant advancement in the field of neuroscience and technology [1][3][12] - The trial involved a participant, Li Feng, who regained the ability to control a cursor using brain signals after 13 years of disability, showcasing the potential of BCI technology to improve the quality of life for patients with severe motor impairments [1][9] Group 1: Clinical Trial Details - The invasive BCI system was implanted in March 2025, utilizing ultra-flexible electrodes that are one-hundredth the diameter of a human hair to collect brain signals related to hand movement [1][5] - The procedure was completed in under 30 minutes, significantly reducing surgical risks and recovery time, with the system achieving stable signal output shortly after implantation [7][9] - The trial aims to recruit more patients with conditions like high-level spinal cord injuries and amyotrophic lateral sclerosis (ALS), with plans for additional clinical trials in 2025 and 2026 [11][12] Group 2: Technological Advancements - The BCI system features the smallest and most flexible electrodes, which are made from polyimide material, allowing for minimal foreign body reaction and high durability [11] - The system's design includes a data energy transmitter housed in a cap, enabling real-time processing of neural signals for precise control of external devices [9][11] - The research team has built a micro-nano electronic processing center to facilitate the mass production of BCI products, aiming to serve millions of patients with severe motor disabilities [12]

Core Insights - The article highlights the significant progress in brain-machine interface (BMI) technology, particularly focusing on China's first invasive BMI clinical trial, marking a milestone in the medical application of this technology [1][2][11] - The Chinese research team has developed the world's smallest and most flexible neural electrodes, which are now in clinical trials, positioning China as the second country after the United States to enter this phase [1][5] Group 1: Clinical Trial Details - The invasive BMI clinical trial was successfully conducted by a collaboration between the Chinese Academy of Sciences and Fudan University, with the first subject being a male patient who lost his limbs due to an electrical accident [2][11] - The system has shown stable operation since its implantation in March 2025, with no infections or electrode failures reported, allowing the patient to perform tasks like playing chess and racing games within 2 to 3 weeks of training [4][10] Group 2: Technological Advancements - The neural electrodes developed by the Chinese team have a cross-sectional area that is 1/5 to 1/7 of those used by Neuralink, with flexibility exceeding Neuralink's by over 100 times, minimizing damage to brain tissue [5][8] - The implanted BMI system is capable of long-term stable collection of single-neuron spike signals, providing a solid data foundation for applications in neuroprosthetics [5][7] Group 3: Surgical and Operational Innovations - The BMI system features a compact design with a diameter of 26mm and a thickness of less than 6mm, allowing for a minimally invasive surgical procedure that reduces risks and recovery time [7][11] - The surgical procedure utilized advanced imaging techniques to create a detailed 3D model of the patient's brain, ensuring precise electrode placement [11][13] Group 4: Future Applications and Research Directions - The research team aims to expand the functionality of the BMI system to enable patients to control robotic arms and other external devices, enhancing their quality of life [11][12] - Future developments may incorporate machine learning and artificial intelligence to interpret more complex signals, potentially allowing for communication through thought [11][12]

Core Insights - A brain-computer interface system developed by American researchers utilizes artificial intelligence to decode brain activity of users attempting to speak, aiding individuals with severe speech impairments to communicate effectively [1] Group 1: Research Overview - The study was led by researchers from the University of California, Davis, involving a 45-year-old male participant who lost clear speech ability due to amyotrophic lateral sclerosis (ALS) [1] - The system implanted 256 microelectrodes in the participant's brain to capture relevant signals every 10 milliseconds, allowing for real-time speech generation [1] - The system can convey pitch variations and emphasize chosen words, enabling the participant to hum notes in three different pitches [1] Group 2: Technological Advancements - Unlike earlier models that required 3 seconds to output speech or only produced speech after complete sentence imitation, the new system can replicate the speaker's voice and produce speech within 10 milliseconds of detecting neural signals [1] - The system not only conveys the speaker's intent but also captures natural speech features such as tone, pitch, and stress [1] Group 3: Challenges Ahead - Despite the breakthroughs, the widespread application of brain-computer interface technology faces challenges, including risks associated with electrode implantation surgery and the need for further validation of device stability and durability [2] - Protecting user privacy and data security remains a critical issue that needs to be addressed in the future [2]

Group 1: Event Overview - The 11th China (Shanghai) International Technology Import and Export Fair was held from June 11 to June 13, focusing on "hard technology" and future industries, showcasing nearly a hundred breakthrough achievements in fields like brain-machine interfaces, embodied intelligence, quantum technology, and synthetic biology [1][2] - The event highlighted significant innovations such as the world's first sound tweezers single-cell sorting technology and the debut of self-developed lunar soil fiber technology and equipment, indicating a promising future for the technology industry [1][2] Group 2: Innovations in Lunar Technology - East China University of Science and Technology showcased the "in-situ preparation of lunar soil fiber modular equipment," which is included in China's lunar base construction plan, utilizing lunar soil from the Chang'e 5 mission to create fibers for lunar base construction [2] - The technology aims to convert lunar soil into high-performance fibers, enabling local resource utilization and meeting the material performance needs for lunar base construction [2] Group 3: Advancements in Biotechnology - The Soundpen CB system developed by Oubino Biotechnology employs non-contact, label-free acoustic tweezers to manipulate cells with precision, significantly enhancing experimental efficiency by minimizing cell damage [3] - The event also featured brain-machine interface technologies that allow patients with central nervous system injuries to control exoskeletons for rehabilitation, demonstrating practical applications in hospitals and rehabilitation centers [5][6] Group 4: Robotics and Automation - The fair showcased various robots, including a six-legged robot designed for Antarctic research, which can assist in transporting materials and ensuring safety by detecting cracks in the ice [3][4] - Nanjing University presented a multimodal interactive robot capable of intelligent dialogue and music synchronization, which is already in mass production and available in North America [4] Group 5: 3D Printing in Pharmaceuticals - The company San Diego demonstrated its 3D printing technology for pharmaceuticals, achieving continuous and large-scale production of printed drugs, with an annual capacity of 75 million to 300 million tablets [6] - Lepu Medical introduced the MemoSorb biodegradable occluder series, the first of its kind globally, providing innovative treatment solutions for congenital heart disease and stroke prevention [6]

Core Insights - The article discusses the establishment of a "Technology Assistance for the Disabled Brain-Computer Interface Research Base" in Longgang District, Shenzhen, aimed at advancing brain-computer interface technology for assisting individuals with disabilities [1][2] - A collaborative meeting was held involving Tsinghua University, local healthcare institutions, and the Longgang District Disabled Persons' Federation to outline the development and application of this technology [1] Group 1 - The meeting reached a consensus on five major construction directions for the research base: research base, industrial incubation base, clinical trial base, technology achievement display base, and popular science education base [1] - The team emphasized that Longgang District's practices in technology assistance for the disabled serve as a model for Shenzhen, with plans to deepen collaboration and establish a national benchmark [1] - Participants conducted a site visit to the brain-computer interface platform and rehabilitation facilities at Longgang District's Eighth People's Hospital to explore a collaborative mechanism integrating research, clinical practice, and industry [1] Group 2 - In March 2025, Shenzhen was designated as a key national area for technology assistance for the disabled, with Longgang District actively engaging with universities and enterprises to promote projects like precision medicine for autism and brain-computer interface technology [2] - The Longgang District Disabled Persons' Federation plans to collaborate with Tsinghua University, medical institutions, and high-tech enterprises to accelerate the transformation of technological achievements and explore new avenues in rehabilitation [2]