Group 1 - Masks are recommended when experiencing flu-like symptoms such as fever, sore throat, and cough [2] - Masks should be worn when visiting medical institutions, accompanying patients, or during hospital visits [2] - It is advisable to wear masks in crowded and enclosed spaces, such as supermarkets and public transport [2] Group 2 - Masks are suggested in places with vulnerable populations, such as nursing homes, social welfare institutions, and kindergartens, especially for visitors and public service workers [4] - Vulnerable groups, including the elderly, children, chronic disease patients, and pregnant women, should wear masks in crowded indoor public places [6] - Masks are recommended when in close contact with individuals showing respiratory symptoms, such as coughing or fever [6]

2025.12. 04 本文字数：1786，阅读时长大约3分钟 作者 | 第一财经 林志吟 根据中国疾控发布的2025年第48周中国流感监测周报，南、北方省份流感活动上升，全国共报告 1541起流感样病例暴发疫情。 第一财经记者根据中国流感监测周报统计的数据显示，从2025年11月3日以来，截至11月30日，全 国共报告流感样病例暴发疫情已达到4351起，其中3313起跟A(H3N2）流感有关，占比约76.14%。 而像奥司他韦这样的抗流感病毒药物是否已产生了耐药性？该问题近日也引发市场关注。 奥司他韦是否耐药了 根据中国流感监测周报，2025年第48周（2025年11月24日－2025年11月30日），南方省份哨点医 院报告的ILI（流感样病例）%为10.3%，高于前一周水平（7.8%），高于2022年、2023年和2024 年同期水平（3.2%、8.7%和3.5%）。 2025年第48周，北方省份哨点医院报告的ILI%为9.1%，高于前一周水平 （8.6%）， 高于2022 年、2023年和2024年同期水平（2.0%、7.3%和4.4%）。 近日中国疾控中心方面也预计，全国在12月上中旬流感达峰的可能性 ...

北京青年报记者昨日从市疾控中心了解到，当前本市呼吸道传染病以流感为主，未出现流感与其他 呼吸道传染病的叠加流行，全市发热门诊就诊人数也低于前两年高峰水平。今年10月底以来，本市流感 活动强度持续上升，于11月中旬进入流行期，较2024—2025流行季提前约四周。当前流感样病例病毒阳 性率虽高于2024-25流行季峰值，但仍低于2023年3月高峰，目前流感上升势头已经减缓，本市流感活动 强度或已达峰。后续需要关注老年人、慢性基础病患者等人群感染后加重基础疾病的风险。 市疾控中心传染病地方病控制所所长张代涛介绍，本次流感流行株为甲型H3N2亚型，占比为 99.8%。疫苗保护效果预计与往年H3N2流行时相似，对神经氨酸酶抑制剂和聚合酶抑制剂等常用流感 治疗药物敏感。张代涛提醒，接种流感疫苗是预防流感及其严重并发症的最有效手段。 养老机构要严格落实健康监测和发热报告制度，做到"早发现、早检测、早治疗"；发现老人出现发 热、咳嗽等流感样症状时，及时就医诊治，畅通重症患者绿色转诊通道，提升重症救治效率；加强工作 人员健康管理和个人防护，规范佩戴口罩，发热及时离岗；做好环境卫生，对房间、食堂等人员聚集的 场所要经常开窗，保 ...

Financial Data and Key Metrics Changes - The company anticipates a greater than $5 billion commercial opportunity starting at the end of the decade and escalating into the early 2030s [10] - The influenza program is expected to provide protection to approximately 110 million people in the U.S., with 85 million being high-risk or immunocompromised individuals [9] Business Line Data and Key Metrics Changes - The launch of Ohtuvayre for COPD treatment has received excellent feedback, and the company sees a significant opportunity to scale this product [17][18] - Winrevair in pulmonary arterial hypertension (PAH) is meeting high expectations, with continuous positive feedback from the medical community [28][29] Market Data and Key Metrics Changes - In the last influenza season, there were 1.6 million hospitalizations due to influenza in the U.S., highlighting the high unmet medical need [10] - The company is seeing strong uptake in the triple segment of the PAH population, with plans to penetrate further into the dual category [32] Company Strategy and Development Direction - The company is focusing on the commercialization of CD388, an antiviral treatment for influenza that is strain agnostic and effective across various populations [6][8] - The strategy includes leveraging existing commercial capabilities to enhance the launch and market penetration of new products like Ohtuvayre and Winrevair [20][21] Management's Comments on Operating Environment and Future Outlook - Management acknowledges the significant unmet need in the influenza market and the potential for CD388 to address this issue effectively [5][6] - The company is optimistic about the future of its respiratory portfolio and the potential for new products to transform patient outcomes [19][20] Other Important Information - The company is preparing for the launch of an oral PCSK9 inhibitor, which is expected to improve access and adherence for patients needing cholesterol management [40][46] - The company is also exploring multiple indications for its TL1A mechanism, which has shown promise in inflammatory and fibrotic diseases [67][68] Q&A Session Summary Question: Insights on the Cidara deal and its growth opportunity - Management highlighted the high unmet medical need for influenza treatment and the strain-agnostic efficacy of CD388, which is expected to be a significant commercial opportunity [5][6] Question: Commercial approach for high-risk patients - The company plans to include both vaccinated and unvaccinated high-risk individuals in the phase 3 program, with payer research indicating a favorable price point for the treatment [12][13] Question: Feedback on Ohtuvayre and its market potential - The feedback from customers has been excellent, and the company believes it can significantly scale the product using its commercial engine [17][18] Question: Future steps for Winrevair in PAH - Management expressed confidence in the product's performance and noted that they are seeing positive feedback and uptake in the market [28][29] Question: Expectations for the oral PCSK9 program - The company anticipates that the oral PCSK9 will provide robust LDL lowering and improve access for patients, potentially changing treatment guidelines [40][46] Question: Update on Gardasil and vaccine portfolio - The company expects modest growth for Gardasil moving forward, with ongoing efforts to drive vaccination rates globally [54][55] Question: TL1A mechanism and future indications - Management is optimistic about the TL1A mechanism's potential across multiple indications, with several phase 2 studies planned [67][68]

齐鲁晚报·齐鲁壹点 姜曼 不管流感流行毒株如何变化，专家介绍，它们的防护措施是一致的，做好个人防护是预防流感的关键， 主要是养成良好的个人卫生习惯；加强学校、家庭内的疾病预防；及时接种流感疫苗。 据悉，目前，全市共设立252家预防接种门诊开展流感疫苗接种服务，市民可以关注"临沂疾控"微信公 众号，在《疾控服务》栏目中点击"流感疫苗接种点"查找，根据需要就近接种。由于每年流感流行的毒 株会有变化，相对应的流感疫苗也是不断调整的，因此建议大家每年都要接种疫苗，进而降低感染的风 险。需要提醒的是，如果已经出现了发烧、咳嗽等流感样症状，或者确诊了流感，需要等症状消失，身 体基本恢复后再接种。 普通感冒主要是由鼻病毒、呼吸道合胞病毒等常见病原体感染引起，传染性和一般症状较轻，多表现为 鼻塞、咳嗽等症状，高烧症状少见，并且病程较短。流行性感冒是由流感病毒感染引起的，相比普通感 冒，传染性更强、发病更急、症状更重，常会出现高热、咳嗽、身体酸痛、乏力等全身症状，部分患者 可能出现肺炎、脑炎等并发症，重症者可能危及生命。 根据监测，临沂市本轮流感流行的主要毒株是甲型H3N2亚型。甲型H3N2是常见的季节性流感病毒之 一，在全球 ...

Core Points - The article provides a comprehensive guide on flu prevention and management during the flu season, emphasizing the importance of vaccination and proper treatment methods [1] Group 1: Flu Diagnosis and Symptoms - Influenza is primarily caused by type A and B flu viruses, with common symptoms including fever above 38°C, headaches, muscle aches, and fatigue [3] - Diagnosis can be confirmed through throat swab tests for flu virus antigens or nucleic acids, which typically take 15 minutes to 1 hour [3] Group 2: Treatment Recommendations - Antiviral medications should be taken within 48 hours of symptom onset for effective treatment, while antibiotics are ineffective against viral infections [3] - Overuse of antipyretics to control symptoms is discouraged, especially in vulnerable populations such as the elderly and infants [4] Group 3: Emergency Situations - High-risk individuals should seek immediate medical attention if they experience persistent high fever, excessive phlegm, difficulty breathing, or severe symptoms [4] Group 4: Vaccination Importance - Vaccination remains one of the most effective and economical methods for flu prevention, even for those who have previously contracted the flu [5] - Different flu virus subtypes may circulate in a single season, and vaccination can provide protection against multiple strains [5]

Core Insights - The flu positivity rate in China has reached nearly 45%, indicating a significant rise in flu cases, with some provinces experiencing high epidemic levels [1] - The peak of flu activity typically occurs from late December to early January, followed by a decline [2] Group 1: Flu Characteristics - Influenza is an acute respiratory infectious disease caused by the influenza virus, primarily the H3N2 subtype in China this season [3] - The flu virus can spread through droplets from sneezing, coughing, or talking, as well as through contact with contaminated surfaces [4] Group 2: Symptoms and Risks - Flu symptoms are severe and include sudden high fever (often reaching 39°C to 40°C), chills, severe headaches, muscle aches, and extreme fatigue, posing a higher risk of serious complications for vulnerable populations [7][10] - In contrast, common colds primarily affect the nose and throat, with milder symptoms and a lower risk of severe complications [5][6] Group 3: Prevention and Vaccination - Vaccination is crucial for flu prevention, with experts stating that it is never too late to get vaccinated, as antibodies develop within 2 to 4 weeks [17] - The flu vaccine significantly reduces the risk of severe illness and death, with estimates showing a reduction of over 40% in risk for the general population [18] - The World Health Organization recommends annual vaccination due to the changing nature of circulating flu strains [19]

Core Viewpoint - The flu is currently on the rise in China, with a positivity rate nearing 45%, indicating a shift to epidemic levels, and some provinces reaching high epidemic levels [1] Group 1: Flu Overview - Influenza is an acute respiratory infectious disease caused by the influenza virus, which has four types: A, B, C, and D. The predominant strain in China is currently the H3N2 subtype [3] - The flu typically peaks between late December and early January, followed by a decline [2] Group 2: Transmission and Symptoms - The flu spreads primarily through respiratory droplets from sneezing, coughing, or talking, and can also spread via contact with contaminated surfaces [4] - Typical symptoms of the flu include sudden high fever (often reaching 39°C to 40°C), chills, severe headaches, muscle aches, and extreme fatigue, distinguishing it from the common cold, which mainly affects the nose and throat [8] Group 3: Prevention and Vaccination - Vaccination is crucial for flu prevention, and it is still effective to get vaccinated even as flu activity rises, as antibodies take 2 to 4 weeks to develop [18] - The World Health Organization estimates that seasonal flu can lead to 3 million to 5 million severe cases and 290,000 to 650,000 respiratory disease-related deaths annually [19] - The flu vaccine significantly reduces the risk of severe illness and death, with a risk reduction of over 40% for the general population and even higher for vulnerable groups [19] Group 4: High-Risk Groups and Recommendations - High-risk groups for severe flu complications include infants, pregnant women, the elderly, and individuals with chronic health conditions [10] - It is advised that individuals in these high-risk categories seek medical attention promptly if flu symptoms develop [10]

11月27日，中国疾病预防控制中心发布数据显示，在全国门急诊流感样病例中，流感阳性率接近45%， 整体进入中流行水平，部分省份已达高流行水平。 监测数据显示，流行高峰一般出现在12月中下旬至1月初，之后将进入下降阶段。 认清流感 别把它和普通感冒混为一谈 接触传播：如触摸口鼻、眼睛等部位后病毒可能通过手传播到物体上，如把手放在键盘、门把手、开关 等处，他人再接触这些被病毒污染的物体后极易发生被感染。 流感的典型症状有哪些？ 与普通感冒有什么不同？ 普通感冒主要"折腾"鼻子和喉咙。 病原：可由不同种类病毒感染引发，为自限性疾病。 症状：集中在鼻咽部，如鼻塞、流涕、打喷嚏、喉咙痛。全身症状轻微，一般不发烧或仅低烧，通常一 周内自愈。 引起流感的病原体是什么？ 有什么特点？ 流感是流感病毒导致的急性呼吸道传染病。流感病毒分为甲、乙、丙、丁四型，当前我国流感流行毒株 以甲型H3N2亚型为主。每年的流行毒株是甲型H3N2亚型、甲型H1N1流感、乙型Victoria系中的一个亚 型或多个亚型，每年优势毒株不同是流感的正常规律。 流感是如何传播的？ 飞沫传播：如打喷嚏、咳嗽或说话时会产生带有病毒的飞沫，他人吸入这些飞沫后， ...

Group 1: Flu Situation in China - The positive rate of flu cases in emergency departments across China is approaching 45%, indicating that the flu has reached a moderate epidemic level, with some provinces experiencing high epidemic levels [1] - The peak of flu activity is generally expected between late December and early January, after which a decline is anticipated [1] Group 2: Understanding Influenza - Influenza is an acute respiratory infectious disease caused by the influenza virus, which is categorized into four types: A, B, C, and D. The predominant strain currently in China is the H3N2 subtype of type A [3] - The typical symptoms of influenza include sudden high fever (often reaching 39°C to 40°C), chills, severe headaches, muscle aches, and extreme fatigue, distinguishing it from the common cold, which primarily affects the nose and throat [9] Group 3: Transmission and Prevention - Influenza spreads primarily through respiratory droplets produced when an infected person coughs, sneezes, or talks, as well as through contact with contaminated surfaces [5] - Recommended preventive measures include frequent handwashing, wearing masks, maintaining good ventilation, and avoiding crowded places during peak flu season [15] Group 4: Vaccination Insights - Vaccination against influenza is crucial, and it is not too late to get vaccinated even during the flu season, as antibodies take 2 to 4 weeks to develop [17] - The World Health Organization estimates that seasonal influenza can lead to 3 million to 5 million severe cases and 290,000 to 650,000 respiratory disease-related deaths annually, highlighting the importance of vaccination in reducing severe illness and mortality [19] - The effectiveness of the flu vaccine typically lasts for 6 to 9 months, necessitating annual vaccination to ensure optimal protection against circulating strains [20][21]