Core Viewpoint - The article emphasizes that China is poised to play a significant role in the future of biomanufacturing, which is expected to create an economic value exceeding $30 trillion by 2050, marking it as a core driver of the next industrial revolution [2][7]. Summary by Sections What is Biomanufacturing? - Biomanufacturing transforms living organisms, such as microorganisms and cells, into "smart factories" that produce various substances needed by humans. This process marks a fundamental shift from traditional manufacturing, which relies on fossil resources, to using renewable resources like sugar, straw, and carbon dioxide [2][3]. Importance of Biomanufacturing - Biomanufacturing is crucial for achieving carbon neutrality as it significantly reduces carbon emissions by utilizing renewable resources instead of fossil fuels. It allows for a broader range of raw materials and a greener manufacturing process, making factories resemble ecosystems [3]. - The potential for programmable manufacturing is immense, as scientists can design microorganisms to produce specific molecules, akin to writing code, thus unlocking vast possibilities [3]. Impact on Daily Life - In the food sector, cell-cultured meat and new food ingredients like microbial proteins are becoming mainstream. - The fashion industry is seeing innovations such as bio-silk from bacteria and biodegradable textiles from algae and fungi. - In construction, "bio-bricks" made from fungal mycelium can self-repair and absorb carbon dioxide, potentially transforming buildings into "green life forms." - Transportation is advancing with the production of aviation fuel from carbon dioxide, and biomanufacturing is also contributing to greener lubricants and tire rubbers. - In healthcare, biomanufacturing can streamline drug synthesis, enabling personalized medicine and potentially allowing hospitals to "print" drugs and organs [4]. Challenges and Future Trends - Biomanufacturing faces challenges such as the need for improved foundational capabilities in gene editing and enzyme engineering, difficulties in scaling from lab to industrial production, and the lack of a comprehensive policy and standards framework [5]. - Future trends include the integration of artificial intelligence in biomanufacturing, enabling rapid strain improvement, carbon cycling in manufacturing processes, and cross-industry collaborations that will create new industrial ecosystems [6]. Opportunities for China - China has advantages in fermentation capacity, industrial scale, and engineering experience. The government is actively promoting biomanufacturing as a new growth engine, positioning the country to take a leading role in this transformative industry [7].

Core Viewpoint - Biomanufacturing is emerging as a transformative industry that utilizes living organisms to produce essential materials, marking a shift from traditional manufacturing methods reliant on fossil fuels to more sustainable practices using renewable resources [5][6]. Group 1: Definition and Importance of Biomanufacturing - Biomanufacturing involves using microorganisms, animal, or plant cells to produce desired substances by designing and controlling their metabolic pathways [5]. - This industry combines traditional fermentation techniques with synthetic biology, allowing for the production of pharmaceuticals, flavors, plastics, and fuels from renewable resources like sugar and carbon dioxide [5][6]. - It is considered a future industry because it represents a new manufacturing path driven by life, rather than an extension of traditional industries [5]. Group 2: Environmental and Economic Impact - Biomanufacturing is crucial for achieving carbon neutrality goals, as it utilizes renewable resources instead of fossil fuels, enabling a "carbon cycle" approach [6]. - Predictions suggest that by 2050, approximately 60% of industrial products could be produced through biomanufacturing, potentially generating an economic value exceeding $30 trillion [6]. Group 3: Current Developments in China - China is accelerating its biomanufacturing industry, with government reports emphasizing the need to cultivate new growth engines, including biomanufacturing [7]. - The country has established leading advantages in fermentation capacity, industrial scale, and engineering experience, positioning itself favorably in the future development of this industry [7]. Group 4: Innovations and Applications - Biomanufacturing is reshaping traditional production logic, enabling the cultivation of lab-grown meat and the production of microbial proteins and synthetic dairy products without livestock [8]. - In the fashion industry, biomanufacturing offers sustainable alternatives, such as bio-silk and mycelium leather, which can replace petroleum-based textiles [8]. - In construction, "bio-bricks" made from fungal mycelium and mineral particles can self-repair and absorb carbon dioxide, contributing to eco-friendly building practices [8]. Group 5: Challenges and Future Trends - Key challenges include the need for foundational capabilities in gene editing, strain design algorithms, and metabolic pathway databases, which are currently weak in China [10]. - The transition from laboratory success to industrial application faces hurdles, including process complexity and cost control [11]. - Future trends indicate a convergence of artificial intelligence with biomanufacturing, enhancing the design of living organisms, and a shift towards carbon circular manufacturing, where factories can utilize carbon dioxide as a raw material [12].

Group 1 - The article highlights the advancements in new materials, particularly in the field of glass, showcasing various innovative products such as ultra-thin flexible glass and high-performance hollow glass microspheres [1] - The establishment of a national key laboratory for advanced glass materials aims to focus on critical technologies in ultra-thin electronic glass and new energy glass, with over a hundred technical bottlenecks successfully overcome [1] - The new materials industry in Bengbu, Anhui, has seen significant growth, with 411 companies and an industry scale exceeding 66 billion yuan, forming a collaborative industrial system featuring silicon-based and bio-based new materials [1] Group 2 - Anhui Fengyuan Group is dedicated to the research and development of bio-based new materials, successfully creating a complete industrial chain from upstream lactic acid bacteria preparation to downstream polylactic acid products [3] - The company emphasizes the integration of artificial intelligence and bio-manufacturing to drive a comprehensive green transformation in the economy and society [3] - Anhui Yishitong Material Technology Co., Ltd. has become a national manufacturing "single champion" in the lithium battery safety materials sector, holding nearly 50% of the global market share with its independently developed new materials [3][4] Group 3 - The Anhui North Microelectronics Research Institute has developed a brain-machine interface health cap, showcasing the application of AI and new materials in innovative technologies [6] - The company is focused on overcoming technical bottlenecks in non-invasive gel electrodes and brain signal acquisition chips, promoting the application of brain-machine interface products in various fields [6] - The fifth International New Materials Industry Conference held in Bengbu attracted global participants, aiming to outline a new development blueprint for the new materials industry [6]

Key Policies - The Ministry of Industry and Information Technology and the National Health Commission have initiated a call for innovative biomanufacturing technology applications in the food processing sector, focusing on areas such as food raw materials, additives, and related products [1] - Hainan Province has introduced measures to support the high-quality development of the biopharmaceutical industry, including financial rewards for product R&D and clinical trials ranging from 400,000 to 10 million yuan [2][3] - Hainan encourages mergers and acquisitions among local pharmaceutical companies, providing interest subsidies for bank loans related to these activities [2] Key Events - The 2025 China Biomanufacturing Technology Innovation Forum will be held in Changde, Hunan, on September 25-26, aiming to promote deep integration of technology innovation and industry [10][12] - The fourth Synthetic Biology and Green Biomanufacturing Conference was successfully held in Ningbo, highlighting AI technology as a new engine for synthetic biology [21] - A biomanufacturing pilot platform alliance has been launched in Binhai New Area, focusing on fermentation, cell, nucleic acid, and vaccine directions [22] Key Companies - Qilu Pharmaceutical has launched 15 biological drugs, including a globally first PD-1/CTLA-4 dual-function combination antibody, marking a significant achievement in China's biopharmaceutical innovation [25][26] - Shenzhen Jingtai Technology's incubated company, Signet Therapeutics, has been nominated for the 2025 Prix Galien USA for its AI-driven gastric cancer drug, showcasing the potential of AI in drug development [29][30] - Saiye Bio has been recognized for its AI application in antibody drug discovery, reflecting the growing trend of integrating AI in biomanufacturing [46]