Core Insights - Signet Therapeutics, a company incubated by Crystal Technology, has been nominated for the 2025 Prix Galien USA for its targeted drug SIGX1094R, making it the only Chinese biopharmaceutical company nominated for the Best Biotechnology Product Award [1][2] - The Prix Galien is considered one of the highest honors in the pharmaceutical industry, emphasizing scientific innovation and the actual health improvement value of drugs [2] - SIGX1094R is the first-in-class targeted drug developed using an "organoid + AI" platform, specifically targeting diffuse gastric cancer, and has received orphan drug designation and fast track designation from the FDA [1][4] Company Achievements - Crystal Technology's collaboration with Signet Therapeutics has led to the successful development of SIGX1094R, which has shown promising results in early clinical trials at Peking University Cancer Hospital [4][10] - The drug has demonstrated good safety profiles and initial anti-tumor activity, with a patient showing stable disease after treatment [10] - Crystal Technology's AI platform has proven capable of designing competitive first-in-class drug molecules and efficiently translating them into clinical applications [5][11] Industry Context - The 2025 Prix Galien USA nominations include 16 products from leading global pharmaceutical companies such as Amgen, AstraZeneca, Johnson & Johnson, Pfizer, Merck, and Novartis [1][2] - The award's evaluation committee consists of prominent figures, including Nobel laureates and leaders from the Gates Foundation, highlighting the competitive nature of the award [2] - The development of SIGX1094R represents a significant advancement in the treatment of diffuse gastric cancer, which is a major health concern, particularly in China where nearly 50% of new cases occur [6][7] Technological Innovation - The drug discovery process for SIGX1094R utilized advanced AI and robotic platforms, significantly shortening the timeline from target discovery to IND approval to just over three years [7][9] - The identification of SRC as a new potential target alongside FAK has led to the development of dual-target inhibitors, showcasing the innovative approach of combining AI with organoid technology [8][9] - Crystal Technology's platform has been recognized for its ability to validate targets and design molecules effectively, contributing to the rapid advancement of new drug candidates [8][11]

Group 1 - The 2025 Prix Galien USA nominations were announced, with Signet Therapeutics being the only Chinese biopharmaceutical company nominated for the Best Biotechnology Award for its drug SIGX1094R, a targeted therapy for diffuse gastric cancer [1][2] - SIGX1094R is the world's first drug developed using the "organoid + AI" platform and has received IND approvals from both the FDA and China's National Medical Products Administration, along with orphan drug designation and fast track designation from the FDA [1] - The drug is currently undergoing Phase I clinical trials at Peking University Cancer Hospital and is expected to enter Phase II clinical trials by the end of 2025 [1] Group 2 - Signet Therapeutics is the world's first "organoid + AI" innovative drug development company, recognized as a national high-tech enterprise and a specialized and innovative enterprise [2] - The founding team of the company comes from prestigious institutions such as Harvard University, MIT, and the Chinese Academy of Sciences, with over 20 groundbreaking research papers published in high-impact journals in the field of gastric and esophageal cancer [2] - The company has completed nearly 220 million yuan in financing and project funding, holding over 40 core intellectual properties [2]