Core Viewpoint - The establishment of a comprehensive intellectual property (IP) value assessment system is crucial for transforming "intellectual property" into "assets" and achieving deep integration of technology and finance [1][2]. Group 1: Current State of IP Valuation - The modern asset assessment system in China began during the early reform period, primarily focusing on tangible assets, with IP valuation initially serving state-owned enterprises and research institutions [2]. - Over the past decade, the role of IP valuation has shifted from a supporting role to a central role in risk control within financial institutions, as the value of IP as an innovative asset has become increasingly recognized [2][3]. - Challenges in IP valuation include high uncertainty, difficulty in revenue forecasting, and a lack of comparable market cases, which hinder asset pricing and financing decisions [2][3]. Group 2: Challenges in IP Valuation - Insufficient market transaction information and a lack of a transparent pricing data mechanism in the IP trading market limit the effectiveness of market-based assessments [3]. - There is a shortage of cross-disciplinary talent in China, as domestic assessors often lack the comprehensive knowledge of IP law, financial analysis, and risk management that their foreign counterparts possess [3]. - The absence of an efficient information-sharing and standard-building mechanism among IP management, financial regulatory bodies, and assessment organizations hampers the development of a robust assessment framework [3]. Group 3: Proposed Solutions - The National Intellectual Property Administration should lead the development of more actionable classification assessment guidelines and parameter standards for different types of IP, enhancing the credibility of assessment results [4]. - Innovation in assessment methods and technologies should be encouraged, incorporating big data analysis, AI modeling, and blockchain verification to support reliable valuation models [4]. - There is a need to establish a comprehensive training system for IP valuation professionals, integrating IP knowledge into ongoing education and promoting the development of interdisciplinary talent [4].

Core Insights - The research presents a comprehensive human proteome profile across a 50-year lifespan, revealing aging trajectories and signatures [2][3][21] - It identifies a significant aging turning point around the age of 50, with blood vessels being the earliest and most affected tissue [4][12][21] - The study highlights the decline in protein homeostasis as a core mechanism of aging, with implications for chronic inflammatory diseases and conditions like Alzheimer's [9][10][22] Group 1: Research Methodology - The study utilized ultra-sensitive mass spectrometry combined with machine learning algorithms to construct a proteomic aging map across seven physiological systems and 13 key tissues [3][21] - A total of 516 samples from 76 individuals aged 14-68 were collected, covering various organs such as the heart, aorta, lungs, and muscles [6][21] - The research identified 12,771 proteins, establishing organ-specific protein expression characteristics [7][21] Group 2: Key Findings on Aging - The research found that the correlation between mRNA and its translated proteins significantly decreases with age, particularly in the spleen, muscles, and lymph nodes [7][21] - Aging leads to a collapse of protein homeostasis, characterized by decreased synthesis capabilities, impaired folding and transport, and accumulation of amyloid proteins and immunoglobulins [9][21] - Blood vessels are identified as a "senohub," driving systemic aging processes through the expression of pro-aging proteins like GAS6 [14][15][21] Group 3: Implications for Anti-Aging Strategies - The study suggests potential anti-aging interventions targeting pro-aging proteins, such as developing CAR-T cell therapies against membrane proteins like GPNMB and neutralizing circulating proteins like GAS6 [18][21] - It emphasizes the importance of early intervention before the age of 50 to protect blood vessels and potentially delay systemic aging [18][21] - The findings provide a new paradigm for understanding systemic aging mechanisms through the lens of protein homeostasis imbalance and vascular aging [22]