Core Viewpoint - The recent case of an 11-year-old boy diagnosed with Toxic Epidermal Necrolysis (TEN) after improper medication highlights the urgent need for improved medication safety for children in China [1][2]. Group 1: TEN and Its Risks - TEN is a rare but severe drug-induced skin reaction with a mortality rate ranging from 14.8% to 30% [2]. - Symptoms of TEN progress in stages, starting with fever and fatigue, followed by skin lesions and potential multi-organ involvement [2]. - Children are at higher risk for TEN due to their immature immune systems and skin barriers, with clinical data indicating that 40% of affected children may experience liver damage [2][3]. Group 2: Medication Safety and Guidelines - Medications are responsible for over 90% of TEN cases, with Nimesulide identified as a common trigger for children [3]. - The use of Nimesulide is prohibited for children under 12 in China due to its potential to cause liver damage and immune reactions [3]. - Parents are advised to avoid self-purchasing unverified combination medications and to consult medical professionals regarding their children's medication history [3][4]. Group 3: Broader Implications of Improper Medication - Incorrect medication can lead to various health issues in children, including Reye's syndrome from aspirin and severe allergic reactions from other medications [4]. - The lack of pediatric-specific medications and appropriate dosing information remains a significant challenge in China, with only 3.2% of drugs approved specifically for children [4][5]. Group 4: Policy and Future Directions - The Chinese government has initiated several policies to enhance pediatric medication safety, including encouraging the development of child-specific drugs and improving clinical trial foundations [5][6]. - Local governments are also taking steps to address the imbalance in pediatric drug availability and to ensure that child-specific formulations are prioritized in healthcare systems [5][6].

Group 1 - The core message emphasizes the importance of children's health for family happiness and national future, highlighting the launch of the "Health Journey: Nurturing the Future" 2025 Children's Health Science Popularization Initiative by JD Health in collaboration with People's Health [1] - The initiative aims to gather social forces to build a solid defense for children's healthy growth through scientific popularization [1][2] - The National Health Commission and ten other departments plan to enhance children's health knowledge dissemination, urging localities to focus on high-quality development of children's medical services [2] Group 2 - Experts stress the need for a collaborative model involving hospitals, schools, and families to improve children's health management and prevent diagnostic errors [2][3] - JD Health is committed to creating a comprehensive platform for children's medication, offering 24/7 online health consultation services supported by professionals [2][4] - Pharmaceutical companies are called to innovate in children's medication and actively engage in social responsibility through various educational initiatives [3][4] Group 3 - The initiative encourages a proactive approach to children's health, focusing on prevention and early education to alleviate parental anxiety and reduce healthcare resource pressure [7] - Collaborations between medical institutions and JD Health will include live broadcasts on children's health topics, aiming to explore innovative service models in "Internet + healthcare" [7][8] - A roundtable discussion among industry leaders highlighted the importance of multi-party collaboration to establish a comprehensive service system for children's health [8]