Core Viewpoint - The recent case of an 11-year-old boy diagnosed with Toxic Epidermal Necrolysis (TEN) after improper medication highlights the urgent need for improved medication safety for children in China [1][2]. Group 1: TEN and Its Risks - TEN is a rare but severe drug-induced skin reaction with a mortality rate ranging from 14.8% to 30% [2]. - Symptoms of TEN progress in stages, starting with fever and fatigue, followed by skin lesions and potential multi-organ involvement [2]. - Children are at higher risk for TEN due to their immature immune systems and skin barriers, with clinical data indicating that 40% of affected children may experience liver damage [2][3]. Group 2: Medication Safety and Guidelines - Medications are responsible for over 90% of TEN cases, with Nimesulide identified as a common trigger for children [3]. - The use of Nimesulide is prohibited for children under 12 in China due to its potential to cause liver damage and immune reactions [3]. - Parents are advised to avoid self-purchasing unverified combination medications and to consult medical professionals regarding their children's medication history [3][4]. Group 3: Broader Implications of Improper Medication - Incorrect medication can lead to various health issues in children, including Reye's syndrome from aspirin and severe allergic reactions from other medications [4]. - The lack of pediatric-specific medications and appropriate dosing information remains a significant challenge in China, with only 3.2% of drugs approved specifically for children [4][5]. Group 4: Policy and Future Directions - The Chinese government has initiated several policies to enhance pediatric medication safety, including encouraging the development of child-specific drugs and improving clinical trial foundations [5][6]. - Local governments are also taking steps to address the imbalance in pediatric drug availability and to ensure that child-specific formulations are prioritized in healthcare systems [5][6].

Core Viewpoint - The article emphasizes the importance of recognizing and differentiating between dengue fever and chikungunya, both transmitted by mosquitoes, and provides guidance on symptoms, management, and prevention strategies [2][16]. Group 1: Disease Differentiation - Dengue fever and chikungunya are both transmitted by Aedes mosquitoes, but they exhibit distinct symptoms and risks [2][16]. - Typical symptoms of dengue include sudden high fever lasting 2-7 days, severe headaches, muscle and joint pain, and potential bleeding [3]. - Chikungunya typically presents with high fever above 39°C, joint pain that can last for months, and a shorter fever duration [3]. Group 2: Management Guidelines - For fever above 39°C, it is crucial to manage temperature actively, avoiding aspirin due to its potential to worsen dengue bleeding and chikungunya joint damage, with acetaminophen recommended instead [5]. - Hydration is essential, with a daily intake of at least 2000 milliliters, and intravenous fluids may be necessary if vomiting prevents oral intake [6]. - Isolation and protective measures are vital during the first five days of illness to prevent mosquito bites and further transmission [8]. Group 3: Prevention Strategies - Effective prevention involves eliminating standing water where mosquitoes breed, with recommendations to regularly clean and empty containers that can hold water [10][11]. - Personal protection includes using mosquito nets, repellents, and wearing light-colored clothing to reduce mosquito attraction [12][13]. - Travelers to endemic areas should carry mosquito repellent and monitor their health for 12 days post-return, seeking medical attention if symptoms arise [15][16].

Core Viewpoint - The SynBioCon 2025 conference will focus on the integration of AI with biomanufacturing, green chemicals and new materials, future food, and future agriculture, aiming to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period [1]. Organizers and Support Units - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. and supported by various institutions including Peking University Ningbo Institute of Ocean Medicine and the China Society of Biotechnology [2]. Expert Guests - Notable experts include Zhang Xian'en, Dean of the School of Synthetic Biology at Shenzhen University, and other prominent figures from various universities and research institutes who will share insights on biomanufacturing innovations [4][5][6][7]. Conference Agenda - The event will feature a series of forums and discussions, including a high-level roundtable on biomanufacturing, thematic forums on green chemicals and new materials, AI in biomanufacturing, and future food and agriculture [36][37]. Key Topics of Discussion - Topics will cover the construction of efficient cell factories for aromatic compounds, biomanufacturing of polyamide materials, and advancements in enzyme engineering for low-carbon biomanufacturing [8][11][27]. Networking and Collaboration - The conference aims to facilitate technology transfer, product scaling, and talent acquisition within the biomanufacturing sector, promoting collaboration among industry leaders, researchers, and government entities [1]. Event Details - The conference will take place from August 20 to 22, 2025, in Ningbo, Zhejiang, featuring registration, networking opportunities, and a showcase of technological achievements in biomanufacturing [1][36].

Core Viewpoint - The recent emergence of Chikungunya fever in some southern cities of China has raised public concern, but experts emphasize that the disease is preventable and controllable through effective mosquito control, water management, and bite prevention measures [1] Group 1: Disease Overview - Chikungunya fever is an acute infectious disease caused by the Chikungunya virus, primarily transmitted by Aedes mosquitoes [2] - The disease was first identified in Africa in 1952 and has since been reported in over 100 countries, mainly in Southeast Asia, Africa, Europe, and parts of the Americas [2] - Symptoms include sudden onset fever, joint pain, and rash, with joint pain often persisting for months in some patients [2][3] Group 2: Symptoms and Diagnosis - The main symptoms of Chikungunya fever include high fever (up to 39°C), severe joint pain, and rash, collectively referred to as the "Chikungunya triad" [3] - Chikungunya fever can be confused with dengue fever, as both are transmitted by Aedes mosquitoes; however, Chikungunya typically causes longer-lasting joint pain, while dengue poses a higher risk of severe complications [3] Group 3: Treatment and Management - In case of infection, management includes temperature control, with a recommendation to avoid aspirin due to the risk of bleeding, especially during dengue outbreaks [5] - Hydration is crucial, and patients are advised to use oral rehydration salts and maintain fluid intake [5] - Isolation and mosquito protection measures should be implemented within the first five days of illness to prevent further transmission [5] Group 4: Vulnerable Populations - Newborns and elderly individuals, particularly those with underlying health conditions, are at higher risk for severe complications from Chikungunya fever [6] - Newborns can contract the virus during delivery if the mother is viremic, potentially leading to serious conditions like myocarditis and encephalitis [6] Group 5: Prevention Strategies - Effective prevention of Chikungunya fever focuses on mosquito control, water management, and bite prevention [8] - Mosquito control can be achieved through various household insecticides, while water management involves eliminating standing water where mosquitoes breed [8] - Personal protective measures include installing screens, using mosquito nets, and applying repellents when outdoors [8]

Core Viewpoint - The article discusses the recent outbreak of Chikungunya fever in Guangdong, highlighting the number of reported cases, symptoms, and treatment recommendations [1][2]. Summary by Sections Recent Cases and Statistics - From July 20 to July 26, 2025, Guangdong reported 2,940 new local cases of Chikungunya fever, with no severe cases or deaths reported. The majority of cases were in Foshan (2,882 cases), followed by Guangzhou (22 cases) and others [1]. - As of July 26, 2025, the total number of reported local cases in Guangdong reached 4,824, all classified as mild, with 3,224 cases having recovered or been released from medical observation [2]. Transmission and Symptoms - Chikungunya fever is transmitted through bites from infected Aedes mosquitoes, primarily characterized by fever, severe joint pain, and rashes. Most symptoms are mild, with recovery typically occurring within 1 to 2 weeks, although some patients may experience chronic joint pain lasting months or years [2]. - All age groups are susceptible, but high-risk groups include newborns infected during the perinatal period, individuals aged 65 and older, and those with underlying health conditions such as hypertension, diabetes, or heart disease [2]. Treatment Recommendations - Treatment focuses on supportive care, including fever reduction, pain relief for arthritis, and alleviating rashes. The use of aspirin and other non-steroidal anti-inflammatory drugs is not recommended due to the risk of bleeding [3][4]. - In cases of fever, patients are advised to seek medical attention promptly, especially if they have a history of travel to areas with Chikungunya outbreaks or have been bitten by mosquitoes [5]. Comparison with Dengue Fever - Chikungunya fever shares similar transmission vectors and symptoms with Dengue fever, which is also currently a focus of prevention efforts. Patients exhibiting fever symptoms should consult a healthcare professional for proper diagnosis before self-medicating [5].

Core Insights - The article discusses the recent outbreak of Chikungunya fever in Guangdong, with a total of 4,824 reported local cases as of July 26, 2025, all classified as mild without severe cases or deaths reported [1][2] - The primary symptoms include fever, severe joint pain, and rash, with most patients recovering within 1 to 2 weeks [2] - The article emphasizes the importance of seeking medical attention for symptoms and provides guidance on treatment, highlighting the avoidance of certain medications like aspirin [3] Summary by Sections Outbreak Statistics - Guangdong reported 2,940 new local cases of Chikungunya fever from July 20 to July 26, 2025, with the majority in Foshan (2,882 cases) [1] - Cumulatively, there have been 4,824 cases this year, all mild, with 3,224 patients having recovered and discharged [1] Transmission and Symptoms - Chikungunya fever is transmitted by infected Aedes mosquitoes, with symptoms primarily including fever, joint pain, and rash [2] - All age groups are susceptible, but high-risk groups include newborns, elderly individuals over 65, and those with underlying health conditions [2] Treatment Recommendations - Treatment focuses on supportive care for fever, joint pain, and rash, with a recommendation against using non-steroidal anti-inflammatory drugs like aspirin due to bleeding risks [3] - Patients are advised to seek medical attention if they exhibit symptoms, especially if they have a history of travel to affected areas or mosquito bites [2][3]

Core Viewpoint - The article emphasizes the importance of controlling the Chikungunya virus outbreak in Guangdong, highlighting the government's proactive measures and the need for public cooperation in prevention efforts [3][4]. Group 1: Current Situation and Response - Guangdong reported 2,940 new local cases of Chikungunya fever from July 20 to July 26, 2025, with no severe cases or deaths reported [1]. - The Guangdong Provincial Committee held a meeting on July 25 to strategize on effectively eliminating the outbreak and ensuring public health safety [3]. - The World Health Organization indicates that 119 countries and regions have reported local transmission, with approximately 5.5 million people at risk of infection, primarily in the Americas, Asia, and Africa [3]. Group 2: Prevention Measures - Key prevention strategies include mosquito control, environmental sanitation, and public health campaigns, with local governments actively organizing mosquito eradication efforts [4]. - Experts suggest that while the virus may spread quickly due to a lack of prior immunity, effective and rapid measures can still control the outbreak in southern regions [4]. - Public awareness and adherence to scientific prevention methods are crucial, including reading reliable information and avoiding misinformation [5].

Core Viewpoint - The SynBioCon 2025 conference will focus on the integration of AI with biomanufacturing, green chemicals and new materials, future food, and future agriculture, aiming to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period [1]. Group 1: Conference Overview - The conference will take place from August 20 to 22, 2025, in Ningbo, Zhejiang [1]. - It aims to promote the transfer and transformation of scientific and technological achievements, product scaling, and talent acquisition in the biomanufacturing sector [1]. Group 2: Organizers and Supporters - Organized by Ningbo Detaizhongyan Information Technology Co., Ltd. (DT New Materials) and co-organized by several academic and research institutions [2]. - Supported by various associations and alliances, including the Chinese Society of Biotechnology and the Zhejiang Synthetic Biology Industry Technology Alliance [2]. Group 3: Expert Guests - Notable experts include Zhang Xian'en, Dean of the School of Synthetic Biology at Shenzhen University of Technology, and other prominent figures from various universities and research institutes [4][5][6][7][10][12][14][18][20][22][30][32]. Group 4: Conference Agenda - The agenda includes a series of forums and discussions on topics such as green chemicals, new materials, AI in biomanufacturing, and future food and agriculture [36][37]. - Specific sessions will focus on the construction of efficient cell factories for the production of aromatic compounds and the biomanufacturing of polyamide materials [8][11].

Core Viewpoint - The SynBioCon 2025 conference will focus on the integration of AI with biomanufacturing, green chemicals and new materials, future food, and future agriculture, aiming to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period [1]. Organizers and Support Units - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. and supported by various institutions including Peking University Ningbo Institute of Ocean Medicine and the China Society of Biotechnology [2]. Expert Guests - Notable experts include Zhang Xian'en, Dean of the School of Synthetic Biology at Shenzhen University, and other prominent figures from various universities and research institutes who will share insights on biomanufacturing innovations [4][5][6][7]. Conference Agenda - The event will feature a series of forums and discussions, including a high-level roundtable on biomanufacturing, thematic forums on green chemicals and new materials, AI in biomanufacturing, and future food and agriculture [36][37]. Key Topics of Discussion - Topics will cover the construction of efficient cell factories for aromatic compounds, biomanufacturing of polyamide materials, and advancements in enzyme engineering for low-carbon biomanufacturing [8][11][27]. Networking and Collaboration - The conference aims to facilitate technology transfer, product scaling, and talent acquisition within the biomanufacturing sector, promoting collaboration among industry leaders, researchers, and government entities [1]. Event Details - The SynBioCon 2025 will take place from August 20 to 22 in Ningbo, Zhejiang, featuring registration, networking opportunities, and a showcase of technological achievements in the biomanufacturing field [1][36].

Core Viewpoint - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI with bio-manufacturing, green chemicals and new materials, future food, and future agriculture [1]. Group 1: Conference Overview - The conference aims to explore the development trends of the bio-manufacturing industry during the 14th Five-Year Plan, innovations driven by AI in bio-manufacturing, and the technologies and products that will sustain the vitality of the bio-manufacturing sector [1]. - The event will facilitate the transfer and transformation of scientific achievements, product scaling, and talent acquisition [1]. Group 2: Organizers and Support Units - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by several institutions including Peking University Ningbo Institute of Ocean Medicine and Ningbo Enzyme Science Bioengineering Co., Ltd. [2]. - Supporting units include the Chinese Society of Biotechnology's Bio-based Materials Committee, Zhejiang Synthetic Biology Industry Technology Alliance, and Shanghai Future Industry Bio-Manufacturing Committee [2]. Group 3: Expert Speakers - Notable speakers include Zhang Xian'en, Dean of the Synthetic Biology Institute at Shenzhen University, who is recognized for his contributions to synthetic biology and bio-manufacturing [6][7]. - Other experts include professors from various universities who will share insights on topics such as the construction of efficient cell factories for aromatic compound production and the biomanufacturing of polyamide materials [10][15][28]. Group 4: Conference Agenda - The agenda includes a series of forums and discussions on topics such as green chemicals and new materials, AI in bio-manufacturing, and future food and agriculture [41]. - The first day features a macro forum on the bio-manufacturing industry, while subsequent days will include specialized forums and networking opportunities [41]. Group 5: Registration and Participation - Registration for the conference is open, and participants can sign up to engage in discussions and networking opportunities related to synthetic biology and bio-manufacturing [42][44].