新华社耶路撒冷1月4日电（记者王卓伦 路一凡）以色列一项新研究发现，细菌可通过两种本质不同 的"生长停摆"状态，在面临抗生素治疗的情况下存活下来。这一发现为未来开发更有效的抗感染治疗策 略提供了新方向。 抗生素本应清除有害细菌，但在许多顽固的感染中，仍有少量细菌在抗生素作用下存活下来，随后重新 增殖并导致感染复发。这一现象被称为"抗生素持久性"，是导致治疗失败且难以根治感染的主要因素之 一。 耶路撒冷希伯来大学日前发布公报说，该校研究团队通过数学建模和多种高分辨率实验手段发现，在抗 生素作用下，部分细菌会进入一种受调控、具有保护性的生长停摆状态，这种状态可以屏蔽抗生素的致 死作用；而另一部分细菌则处于一种失调的生长停摆状态，表现出细胞膜稳定性明显受损等特点。 研究人员说，这两种机制在生物学本质上截然不同，却都可能导致"抗生素持久性"现象。 公报说，在受控生长停摆状态下，细菌处于稳定、防御性较强的休眠状态，杀灭难度较大；而在失调生 长停摆状态下，细菌虽能存活，但其细胞膜稳态等关键功能受损，这一弱点可能成为新的治疗靶点。研 究人员指出，通过识别细菌的这两种不同机制，有助于制定更具针对性的治疗方案，防止感染复发。 ...

记者探访了位于委内瑞拉首都加拉加斯东北郊的一家大型药品超市，当地消费者在这里暂时还可以买到 多数的日常药品，但部分抗生素已经售罄。此外，部分急救药品和医疗用品价格高昂，民众难以负担。 例如，这里销售的唯一一款胰岛素注射器，价格是国际市场上同类产品的三倍以上。（央视新闻） 每经AI快讯，近几个月来，美国政府不断加码对委内瑞拉的武力威胁和制裁封锁，委内瑞拉的国际航 线大量中断，海运物流严重受阻。委内瑞拉的部分药品和医疗设备出现短缺，一些"救命药"的价格更是 飙升至普通民众难以负担的水平。 ...

[话筒]二是症状一好就停药。抗病毒药需要吃够疗程才能把病毒压下去，擅自停药等于给病毒"留活 路"。 [话筒]三是多种药叠加吃。很多复方感冒药里含有对乙酰氨基酚（退烧药成分），再额外吃退烧药容易 过量。药物过量会加重肝肾负担，严重时可能引发中毒。 【注意！#流感用药3大误区请绕行#】#感冒药退烧药抗病毒药别一起吃# [话筒]另外，奥司他韦、玛巴洛沙韦等抗病毒药的作用是抑制病毒复制，不是直接杀死病毒，出现症状 48小时内是用药的黄金窗口期，早用比多用更重要。（人民日报） [话筒]一是发烧就用抗生素。流感是病毒引起的，抗生素只针对细菌，对病毒没用。 ...

（文章来源：证券日报） 证券日报网12月25日讯 ，联环药业在接受投资者提问时表示，公司隶属于联环集团，联环集团聚焦医 药制造、医疗器械和医养健康三大板块，联环药业作为核心子公司，主要产品有泌尿系统药、抗组胺 药、心血管药、甾体激素、抗生素等几大系列，涵盖化学原料药和注射剂、固体制剂多种药物剂型，包 含国家一类新药爱普列特片（川流）、二类新药依巴斯汀片（苏迪）以及非洛地平片（联环尔定）、达 那唑胶囊及栓剂、二甲双胍格列齐特片（度和）、蚓激酶胶囊、盐酸舍曲林胶囊（联环优定）、盐酸达 泊西汀片、他达拉非片、替莫唑胺胶囊、醋酸阿比特龙片、盐酸莫西沙星片、依巴斯汀口服液等产品。 近年来，公司重点拓展内分泌、肿瘤、呼吸系统等新兴治疗领域，形成"传统优势+新兴战略"的产品发 展格局，同时布局了达泊西汀、他达拉非等男科产品及孕妇专用药叶酸片等特色品种，构建了多元化、 梯度化的产品管线。 ...

生物制造是未来物质生产重要形式，国际社会普遍认为生物制造有望成为第四次工业革命的核心驱动力 之一。 "我国工业体系完善，应用产品丰富，需求牵引强，拥有全球规模最大、最完备的发酵工业基础，为生 物制造发展和产品应用提供了广阔空间。"近日，以"生机无限制造未来"为主题的2025生物制造大会在 重庆举办，赛迪研究院消费品工业研究所所长李博洋在会上说。 他表示，要强化资源汇聚、平台搭建、服务保障，基于自身和制度优势，打造全球领先的先进高效绿色 的生物制造产业，"定义新一代工业标准，让每次发酵都替代一块油田，让每克碳排放都成为一种有用 的原料，让细胞工程成为中国制造的新名片。" 创新动能持续增强 "生物制造是以工业生物技术为核心，利用生物体如酶、细胞等作为催化剂，结合过程工程技术进行目 标产品生产的制造过程。与依赖石化原料和高能耗的制造方式相比，生物制造以可再生生物质为原料， 过程温和、污染小、能效高、可持续性强，是典型的'绿色制造'和'循环经济'代表。"中国工程院院士、 北京化工大学校长谭天伟表示，目前，全球约70%的制造业产品在技术上具备采用生物制造方式生产的 可能性。生物制造并非意味着对传统制造方式的全面替代，而 ...

耳朵痒大多数是外耳道区域瘙痒（图中红色圆圈区域），导致耳痒的原因可能有以下几种。 1 在我们日常生活中，有时候会遇到一种微妙的困扰：耳朵痒。 对许多人来说，这似乎只是一个小问题。但耳朵痒，可能不只是痒那么简单，也可能是身体内部出现了一些问题的信号，我们应该注意并及时处 理。 耳朵瘙痒 可能是这些原因 相信每个人都体验过瘙痒这种感觉，这是一种常见的症状，而非特定的疾病，可见于多种皮肤病，此外，瘙痒也可能是系统性疾病、神经系统疾 病和精神疾病等非皮肤疾病的表现。 耵聍 俗称耳屎，或多或少的耵聍在外耳道内，都有可能引起耳朵的瘙痒。但这个"屎"它不仅是"排泄物"，它还有保护我们耳道的功能。 耵聍是由外耳道的外侧1/3皮肤的耵聍腺和皮脂腺分泌产生的淡黄色黏稠物，耵聍在耳朵里扮演着重要角色。 △耳，分为外耳、中耳、内耳。 首先，它可以挡住一些外来物的进入，比如小飞虫。其次，耵聍还有助于形成酸性耳道环境，来抑制细菌和真菌生长。再者，耵聍还具有疏水 性，能够排斥水分，从而防止微生物理想生长环境的形成；最后耵聍的黏性也有助于粘住环境中的细小碎屑，这些功能共同构成了我们耳朵的"皮 肤 - 耵聍屏障"。 治疗方法：在正常情况下，耵 ...

会议发布"高性能生物反应器创新任务入围揭榜单位名单""生物制造中试能力建设平台名单(第一批)""生 物制造标志性产品名单(第一批)"三项名单，同时举办生物制造百人会以及科技创新与数智发展、标准 化与产业化、企业培育与投融资等6场分论坛。(完) （文章来源：中国新闻网） 会议指出，生物制造是未来物质生产重要形式，国际社会普遍认为生物制造有望成为第四次工业革命的 核心驱动力之一。 会议强调，要加强科技研发和创新攻关，瞄准生物制造产业面临的基础科学问题和重大工程化瓶颈，加 强原始创新和关键核心技术攻关，促进科技创新和产业创新深度融合；要推进产学研用金协同发展，发 挥"龙头企业—细分产业链—大品种"牵引带动作用，加快构建生物制造产品矩阵和企业矩阵，将企业自 身优势转变为产业生态优势；要筑牢产业基础、拓展应用场景，积极推动生物制造产品在未来食品、医 疗健康、日化美妆、新型材料、绿色能源等领域广泛应用。 中新网重庆12月18日电 (记者刘育英)2025生物制造大会18日在重庆举办。记者从大会获悉，中国生物制 造总规模达到1.1万亿元(人民币，下同)，生物发酵产品产量占全球70%以上，其中食品及添加剂生物制 药两个细分领域 ...

Core Viewpoint - The article discusses the financing difficulties faced by small and medium-sized medical enterprises and presents four practical supply chain financing models as solutions to alleviate these challenges [1]. Group 1: Inventory Financing - Inventory financing allows medical companies to convert their stock into liquid funds, particularly beneficial for consumables and pharmaceuticals [3]. - The front-end procurement model enables companies to purchase goods with the help of financing partners, requiring only a 20% deposit while the rest is covered by the financier [3]. - The dynamic pledge model allows companies to pledge their inventory to obtain approximately 70% of its value in loans, providing flexibility in sales during peak seasons [5]. Group 2: Accounts Receivable Financing - The accounts receivable financing model addresses the slow cash flow due to hospital payment terms, allowing suppliers to transfer their receivables to a financing platform for immediate cash [7]. - This model can significantly speed up the funding process, with some transactions completed in as little as one hour, improving efficiency by 90% compared to traditional methods [9]. - The model emphasizes the importance of assessing the payment capabilities of hospitals to ensure the reliability of the financing [9]. Group 3: Joint Venture Profit Sharing - The joint venture profit-sharing model involves shared risk and profit between the financing partner and the medical enterprise, with the financier covering 80% of the costs [11]. - This model requires close collaboration and transparency between the parties, ensuring that funds are used appropriately and that profit-sharing agreements are clear [13]. - It is particularly suitable for projects with high profits but long payment terms, such as medical equipment procurement [11][13]. Group 4: Future Outlook - The article concludes that traditional credit methods are not the only option for medical enterprises, and supply chain financing offers adaptable solutions [15]. - With advancements in financial technology, these financing models are expected to become more accessible, enabling companies to manage their operations effectively and overcome funding challenges [15].

Core Insights - Japan is experiencing a significant flu outbreak, with over 190,000 reported cases in the week ending November 23, marking a 1.4 times increase from the previous week [1] - The flu epidemic has reached "alert" levels in 39 out of 47 prefectures, with the situation in Fukushima being particularly severe, reporting the highest infection levels in nearly a decade [2][4] Summary by Sections Flu Cases and Trends - As of November 23, Japan reported 196,900 flu cases, averaging 51.12 cases per reporting medical institution, with a continuous increase for 14 weeks [1] - The flu outbreak is approaching last year's peak levels, which saw an average of 64.39 cases per institution [1] Regional Impact - 39 prefectures have reached flu epidemic alert levels, an increase of 15 from the previous week, with Miyagi, Fukushima, and Iwate being the most affected [3] - In Fukushima, 4,162 cases were reported from 48 medical institutions, a rise of over 1,300 cases from the previous week, marking the highest level since 2015 [4] Educational Impact - Due to the flu spread, 8,817 schools have closed or partially closed classes across Japan [3] Healthcare System Strain - Medical institutions are under significant pressure due to the rapid increase in flu cases, with shortages of common cold medications and antibiotics reported [6] - The upcoming year-end period will further complicate access to medical care as many institutions will reduce services [7] Early Flu Season Factors - Japan entered the flu season earlier than last year, attributed to decreased public health measures and increased international travel [9][10] - Factors such as climate change and lower vitamin D synthesis due to less sun exposure may have contributed to a decline in immunity among the population [10]

Core Insights - Chronic Obstructive Pulmonary Disease (COPD) affects nearly 100 million patients in China, making breathing a daily struggle for them [1] - The upcoming World COPD Day on November 19 highlights the need for better management and awareness of the disease [1] Group 1: Disease Awareness and Prevention - COPD is characterized by chronic cough, sputum production, and shortness of breath, with increased risks during winter due to respiratory infections [2] - The Chinese Center for Disease Control and Prevention reports a rise in respiratory infections, emphasizing the importance of flu vaccinations and preventive measures for COPD patients [2] Group 2: Integrated Treatment Approaches - Combining traditional Chinese medicine (TCM) with Western medicine can enhance the management of COPD, with TCM focusing on root causes and Western medicine addressing acute symptoms [3] - Clinical practices show that integrating TCM can improve patient outcomes during acute exacerbations and stabilize conditions during stable periods [3] Group 3: Community Health Initiatives - Community screening programs have identified many undiagnosed COPD cases, highlighting the need for early detection and treatment [4] - The prevalence of COPD in individuals aged 40 and above exceeds 13%, yet awareness remains low, necessitating improved education and screening efforts [4] - The National Health Commission has included COPD in public health services, advocating for annual lung function checks for high-risk populations [4]