智通财经APP获悉，近日，晶泰科技(02228)孵化企业默达生物(META Pharmaceuticals Inc.)宣布，其针对 炎症性肠病(IBD)开发的首个临床开发候选分子(PCC)MP-5342已确定，目前正积极准备新药临床试验 (IND)申请，预计最早于2026年下半年启动正式临床试验注册。MP-5342是晶泰科技赋能默达生物开发 的全球首款口服小分子乳酸脱氢酶(LDH)抑制剂。 随着晶泰科技参与发现和优化的创新药管线陆续进入临床阶段，公司将持续积累研发数据驱动AI算法 迭代升级，赋能更多合作伙伴加速源头创新突破，推动全球突破性疗法更快惠及患者，加速兑现人工智 能在生物医药领域的巨大社会价值与经济潜力。 关于默达生物 默达生物(META Pharmaceuticals Inc.)是一家专注于自身免疫疾病及代谢疾病药物研发的创新药物公司， 由AI制药先锋企业晶泰科技、Forcefield Ventures、IMO Ventures共同孵化，天图资本、雅亿资本、方圆 资本、新产业创投、德迅投资、博普资本参与投资。默达生物基于前沿的新兴生物学理论，通过调节细 胞新陈代谢的活力实现对免疫系统功能及其他生理系 ...

Core Insights - In 2025, significant advancements in immunology research were achieved across basic, translational, and clinical domains, particularly in areas such as mechanobiology, immunometabolism, neuroimmunology, and immunosenescence [1] Group 1: Mechanobiology - Research in mechanobiology and immunity has intensified, revealing that immune cells can convert mechanical stimuli into precise immune regulatory information [2] - A team successfully uncoupled the proliferation and differentiation of CAR-T cells using biomechanical signals, establishing a method to produce application-grade CAR-T cells in just 4.5 days, showing enhanced tumor infiltration and persistent anti-tumor effects against various solid tumors [2] - Findings from a collaboration between Mount Sinai and Harvard demonstrated that intestinal cholinergic neurons sense intraluminal pressure changes through the Piezo1 channel, linking mechanical signals to gut motility regulation and offering new therapeutic insights for inflammatory bowel disease [2] - Research from Shanghai Jiao Tong University identified that mechanical signals reshape neutrophil phenotypes to maintain lung tissue homeostasis, establishing pulmonary capillaries as critical sites for neutrophil functional remodeling [2] Group 2: Immunometabolism - The field of immunometabolism has shifted from "metabolic support of immune function" to "metabolic shaping of immune fate and tissue ecology," becoming a central hub connecting tumor microenvironments, immune exhaustion, and treatment responses [4] - A study revealed the dual impact of metabolism on inflammation and tumor immunotherapy, highlighting the role of the enzyme GLO2 in sepsis and age-related inflammation, and proposing targeting tumor cell metabolism to enhance immunogenicity and overcome PD-1 therapy resistance [4] - Research established the critical role of succinate in maintaining CD8+ T cell stemness, improving mitochondrial quality and epigenetic status to support long-term survival and function of stem-like T cells [4] - A study introduced a metabolic reprogramming approach in CAR-T cells to reduce reliance on high-intensity glycolysis, enhancing anti-tumor effects in hypoxic and nutrient-deprived environments [5] Group 3: Neuroimmunology - Research identified a novel type of macrophage in the peripheral nervous system, challenging the long-held belief that microglia do not exist in this area, thus expanding the understanding of immune cell distribution and function [6] - A study revealed the role of specific neural pathways in behavioral changes induced by cancer cachexia, providing insights into the connection between chronic inflammation and depressive symptoms [6] Group 4: Immunosenescence - Research demonstrated that targeted delivery of three nutritional mRNAs to the liver can significantly alleviate age-related immune system decline, presenting a potential strategy to combat immunosenescence [7] - Findings indicated that the aging adaptive immune system loses its ability to respond to new antigens, leading to a shift from immune defense to immune attack, which may accelerate tissue microenvironment deterioration [8] - A model was developed to predict immune age based on the dynamic changes of peripheral immune cells throughout the human lifespan, aiding in early identification of immunosenescence-related risks and personalized immunotherapy [8] Conclusion - Overall, 2025 marked a systematic advancement in immunology, with groundbreaking discoveries in mechanobiology, immunometabolism, neuroimmunology, and immunosenescence, propelling the field into a new phase of deepened mechanisms and translational applications [9]