"一躺下就咳，坐起来稍缓" "夜里咳得厉害，翻来覆去睡不着" …… 你是否也经历过这样的夜？ 不少人都被夜间咳嗽缠上 尝试了各种方法却收效甚微 为什么咳嗽总在夜间加剧？ 那些口口相传的"止咳妙招" ▶胃食管反流病，躺着的时候，胃里的胃酸容易往上涌，流到食管和喉咙，刺激得人想干咳，有时还会觉得胸口烧心、不舒服。 1 一躺就咳？找准原因是关键 夜间咳嗽是一种常见症状，可能由这些原因引起。 1.体位因素：躺下后，呼吸道会因周围组织压迫而轻度塌陷，咳出异物或黏液的难度增加。尤其是平躺时，分泌物易积聚在咽喉或气管，持续刺激咳嗽感 受器。同时，膈肌上抬可能限制肺部舒张，进一步加重咳嗽。 2.身体昼夜变化：晚上，"迷走神经"会变得活跃，它一活跃，气道就容易收缩、变敏感；同时，皮质醇等激素分泌处于低谷，对炎症抑制作用减弱，咳嗽 就会加重。 3.环境因素：夜间空气干燥、温度低，或者房间不通风，都会刺激呼吸道。另外，床上的尘螨、这些容易让人过敏的东西，晚上接触得更多，也会诱发过 敏性咳嗽。 4.可能是某些疾病的信号：主要包括支气管炎、肺炎等，咳嗽是这类疾病的主要症状之一。 ▶呼吸道感染，比如支气管炎、肺炎等，夜间分泌物增多，持续 ...

Core Viewpoint - The article discusses the anticipated flu season in China, highlighting the expected peak in December and January, along with the current trends in flu virus strains and the availability of antiviral medications [3][4]. Group 1: Flu Season Forecast - The peak of the flu season in China is expected to occur in mid to late December and early January [3]. - Shanghai has reported a rising positive detection rate for flu, indicating the onset of the flu epidemic season [3]. Group 2: Virus Strain Variations - The dominant flu strain in Shanghai has shifted from H1N1 in the first half of the year to H3N2 in the latter half [3]. - Current strains remain highly sensitive to existing antiviral medications, including neuraminidase inhibitors and polymerase inhibitors [3]. Group 3: Antiviral Drug Availability - Hospitals in Shanghai have sufficient supplies of medications to combat respiratory infections, including azithromycin for mycoplasma infections [3]. - The price of the antiviral drug Marbalozav (Sufuda) remains stable at approximately 200 yuan for a 40mg tablet, with children's formulations priced around 250 yuan [4]. Group 4: New Domestic Antiviral Drugs - Two new domestic antiviral drugs, Masurazav (Yisuda) and Masilozav (Jikeshou), have been approved, both requiring only a single dose for treatment [4]. - The prices for these new drugs are lower than Marbalozav, with Jikeshou priced at about 160 yuan for a 40mg tablet and Yisuda at 200 yuan for two 20mg tablets [4]. Group 5: Resistance Issues - Clinical studies indicate low resistance rates for the new antiviral drugs, with mutation rates for H1N1 and H3N2 strains at 0.7% and 0.9% respectively, suggesting a low risk of resistance [4].

Core Insights - Respiratory infections, such as influenza, may activate dormant cancer cells, potentially leading to cancer metastasis [1][2] - A study conducted on mice showed that respiratory infections can trigger the awakening and proliferation of dormant breast cancer cells, leading to significant tumor growth within two weeks [2] - Analysis of human data revealed that cancer patients who experienced respiratory infections had double the risk of cancer-related mortality, with breast cancer patients facing over a 40% increased risk of lung metastasis post-infection [2] Group 1 - The study published in *Nature* highlights the potential link between respiratory infections and the reactivation of dormant cancer cells [1] - Dormant cancer cells can remain in a state of inactivity, but respiratory infections may serve as a catalyst for their reactivation [2] - The immune response to infections may inadvertently create a favorable environment for cancer cells to thrive [2] Group 2 - The research emphasizes the importance of preventing respiratory infections, especially for cancer survivors [3] - Simple preventive measures such as wearing masks, getting vaccinated, and practicing good hygiene can help reduce the risk of infections [3] - The findings call for further research to expand sample sizes and deepen analysis on the relationship between respiratory infections and cancer [3]