格隆汇11月25日丨济川药业(600566.SH)在互动平台表示，N3H2N3是甲型流感病毒的一种亚型，抗流感 1类创新药济可舒适应症适用于既往健康的成人单纯性甲型和乙型流感患者的治疗，该药品上市为患者 提供了新的治疗选择。相关药品的使用请遵循药品说明书及专业医师的用药指导。 ...

11月以来，全国整体进入流感流行季。 据央视新闻消息，在国家疾控局11月10日举行的新闻发布会上，中国疾病预防控制中心病毒病所研究员 王大燕介绍，预计今年秋冬季我国流感疫情高峰可能出现在12月中下旬和1月初。 电商平台中，部分流感药已悄悄降价，意图抢占市场。11月13日，新京报贝壳财经记者在京东大药房看 到，20mg2片规格的伊速达显示原价320元，自11月3日零点起，到手价为196元。 同类竞品中，2024年流感季曾爆火的速福达，40mg1片装售价210元/盒。0.2g15片的安睿威标价则为179 元/盒；40mg2片规格的济可舒，标价为320元/盒。 凭借"单剂量给药"的便捷性，此前，速福达一度成为市场新宠，搅动传统流感药市场格局。不过，2025 年，多款国产流感创新药密集上市，曾经一盒难求的"流感神药"正被包围。 曾抢手的"流感神药"，药店供应充足 "去年来问的人特别多，一到货就卖得特别快，今年也有很多人咨询，目前还都有货。"11月17日，当问 及速福达的供应情况，北京市通州区一家药店的店员对新京报贝壳财经记者表示。 当天，新京报贝壳财经记者走访多家药店了解到，速福达目前供应充足，线下药店售价在239元 ...

Core Viewpoint - The flu season in China is expected to peak in mid to late December and early January, leading to increased competition among flu medication manufacturers as prices drop to capture market share [5][8]. Group 1: Market Dynamics - Some flu medications have seen price reductions on e-commerce platforms, with the price of 20mg of Isodax dropping from 320 yuan to 196 yuan since November 3 [6]. - The market for flu medications is becoming increasingly competitive, with several new domestic flu drugs set to launch in 2025, challenging the previously dominant "miracle drug" status of Sufuda [8][23]. - Sufuda, a product of Roche, was initially priced at 498 yuan per box before being included in the national medical insurance directory, which reduced its price to 222.36 yuan [14]. Group 2: Supply and Demand - Sufuda is currently in ample supply, with prices in physical pharmacies ranging from 239 yuan to 258 yuan per box, and no immediate price adjustments are anticipated [10]. - The demand for Sufuda remains high, with reports indicating that it sells out quickly during peak seasons [9]. Group 3: Competitive Landscape - Oseltamivir, a traditional flu antiviral, holds over 80% market share in China's flu medication market, with prices significantly reduced due to increased competition and centralized procurement [16][19]. - The lowest bid price for Oseltamivir capsules has dropped to less than 1 yuan per capsule, marking an 85% decrease from previous prices [21]. - New domestic flu drugs, such as Isodax and Anruwei, are entering the market, aiming to capture a share of the growing demand for flu treatments [24][30]. Group 4: Regulatory Developments - The National Medical Products Administration has accepted new drug applications for several flu medications, indicating a proactive approach by domestic companies to expand their product offerings [28]. - Companies are also working to include their products in the medical insurance directory to enhance accessibility for patients [30][31].

Core Viewpoint - The article discusses the anticipated flu season in China, highlighting the expected peak in December and January, along with the current trends in flu virus strains and the availability of antiviral medications [3][4]. Group 1: Flu Season Forecast - The peak of the flu season in China is expected to occur in mid to late December and early January [3]. - Shanghai has reported a rising positive detection rate for flu, indicating the onset of the flu epidemic season [3]. Group 2: Virus Strain Variations - The dominant flu strain in Shanghai has shifted from H1N1 in the first half of the year to H3N2 in the latter half [3]. - Current strains remain highly sensitive to existing antiviral medications, including neuraminidase inhibitors and polymerase inhibitors [3]. Group 3: Antiviral Drug Availability - Hospitals in Shanghai have sufficient supplies of medications to combat respiratory infections, including azithromycin for mycoplasma infections [3]. - The price of the antiviral drug Marbalozav (Sufuda) remains stable at approximately 200 yuan for a 40mg tablet, with children's formulations priced around 250 yuan [4]. Group 4: New Domestic Antiviral Drugs - Two new domestic antiviral drugs, Masurazav (Yisuda) and Masilozav (Jikeshou), have been approved, both requiring only a single dose for treatment [4]. - The prices for these new drugs are lower than Marbalozav, with Jikeshou priced at about 160 yuan for a 40mg tablet and Yisuda at 200 yuan for two 20mg tablets [4]. Group 5: Resistance Issues - Clinical studies indicate low resistance rates for the new antiviral drugs, with mutation rates for H1N1 and H3N2 strains at 0.7% and 0.9% respectively, suggesting a low risk of resistance [4].

Core Insights - Nanjing Biomedicine Valley has introduced over 50 innovative products and technologies that are first in the world or country, highlighting its role as a key player in the biomedicine industry [1] - The region is focusing on precision medicine and niche areas such as brain science and gene therapy, aiming to establish a comprehensive innovation ecosystem [2][3] - Two new class 1 drugs have been approved this year, marking a significant achievement for the Nanjing Biomedicine Valley [3][4] Industry Overview - The global biomedicine industry is accelerating towards precision diagnosis and treatment, with Nanjing Biomedicine Valley positioning itself in niche markets [2] - The region has established a full industrial chain in gene and cell therapy, including gene testing, diagnostics, and CAR-T cell therapy [3] - The Nanjing Biomedicine Valley has attracted over 1,300 companies, with 7 companies successfully listed and 6 class 1 drugs approved [5] Innovation and Development - The Nanjing Biomedicine Valley is enhancing its innovation capabilities by collaborating with universities and establishing technology transfer centers [6] - A total of 84 billion yuan fund support plan has been launched to facilitate the transformation of scientific achievements from universities [6] - The region is focusing on building a robust innovation ecosystem that integrates innovation chains, industry chains, capital chains, and talent chains [7] Recent Achievements - The approval of two class 1 drugs, Enze Shou and Ji Ke Shu, represents a milestone for the biomedicine valley, with the former being the first targeted drug for platinum-resistant ovarian cancer in China [3][4] - The establishment of the Jiangsu Brain Intelligence Technology Innovation Center aims to make breakthroughs in brain science over the next five years [2] - The Nanjing Biomedicine Valley has successfully facilitated the listing of companies and the approval of innovative drugs, showcasing its supportive environment for biomedicine enterprises [5][6]

Core Viewpoint - The article discusses the dramatic rise and subsequent fall of the stock price of Yaojie Ankang, a biotechnology company, highlighting the volatility and speculative nature of the biotech market in Hong Kong [2][3][4]. Stock Performance - Yaojie Ankang's stock price surged from 70.7 HKD on September 10 to a peak of 679.5 HKD on September 16, resulting in a market capitalization of nearly 270 billion HKD [2][3]. - Following this peak, the stock experienced a sharp decline, dropping 75% to a low of 165 HKD, and closing at 192 HKD, representing a 53.73% decrease on the same day [3][4]. Market Context - The company, which has not generated any revenue since its inception, achieved a market valuation that surpassed established players like Kangfang Biotech and Innovent Biologics [2][4]. - The surge in stock price was attributed to its inclusion in the Hang Seng Index and the announcement of clinical trial approvals for its lead product, Tiengotein [5][6]. Product Pipeline and Clinical Trials - Tiengotein, a multi-target kinase inhibitor, is in Phase II clinical trials for treating HR+/HER2- breast cancer, a significant market segment [5][6]. - The drug has shown promise in previous trials for other cancers, with an objective response rate exceeding 40% in resistant patients [6][7]. Financial Health - Yaojie Ankang reported a net loss of 123 million CNY in the first half of 2025, with R&D expenses of 98.43 million CNY, indicating a need for continued funding to support its clinical trials [7][13]. - The company has raised over 1.7 billion CNY through nine rounds of financing since its establishment, with significant backing from local investors [13][14]. Founder's Background - The founder, Wu Yongqian, has extensive experience in drug development and has focused on multi-target inhibitors to address drug resistance in cancer treatment [9][10][11]. - Wu's strategic pivot towards oncology and inflammation has positioned Yaojie Ankang to capitalize on emerging trends in the biotech sector [11][12]. Industry Trends - The article notes a growing trend of innovation in the Nanjing region, with several biotech companies, including Yaojie Ankang, successfully entering the capital markets [16][17]. - The supportive regulatory environment and increasing investment in innovative drugs are expected to drive further growth in the sector [16][17].

Core Insights - The article highlights the successful launch of two class 1 new drugs, Enzeshushu and Jike Shushu, from companies in the Nanjing Biopharmaceutical Valley, marking a significant achievement in the biopharmaceutical industry [1][2][3] Group 1: Drug Development and Innovation - Jike Shushu, a new anti-influenza drug, was developed in just 6 years, significantly faster than the typical 10-year timeline for class 1 new drugs [2] - Enzeshushu, targeting ovarian cancer, took 17 years from inception to approval, showcasing the long-term commitment required in drug development [3] - The successful development of these drugs reflects a combination of innovation and perseverance, particularly during challenging times such as the COVID-19 pandemic [2][3] Group 2: Supportive Ecosystem - The Nanjing Biopharmaceutical Valley provides essential support services, including regulatory guidance and infrastructure, which facilitate the drug development process for companies [4][5] - The Jiangbei New District has completed nearly 1,800 product technical reviews and over 300 on-site verifications, aiding companies like Xiansheng Pharmaceutical and Reindeer Biotech in accelerating their product launches [5] - The establishment of a public service platform allows startups to access necessary research facilities without the burden of high initial costs, fostering innovation [5] Group 3: Future Prospects - There are currently over 200 class 1 new drugs in development within the biopharmaceutical valley, indicating a robust pipeline for future approvals [5] - The presence of regional technology transfer centers is expected to further enhance the innovation landscape, leading to more new drug developments [5][6] - The Nanjing Biopharmaceutical Valley is becoming a prominent hub for both established and emerging companies, contributing to the growth of the biopharmaceutical industry in the region [6]

Core Insights - The article highlights the rapid development and success of the Nanjing Biopharmaceutical Valley, showcasing the approval of new drugs and the establishment of biotech companies in the region [1][2][4]. Group 1: New Drug Approvals - Nanjing Zhengxiang Pharmaceutical's new flu drug, Jike Shou (Marcelosavir), received approval from the National Medical Products Administration on July 18 [1]. - The antibody drug, Suweishitamon (Enzeshu), developed by Xiansheng Pharmaceutical, was approved just half a month earlier [1]. - The Nanjing Biopharmaceutical Valley has over 200 new drugs in development, with a total of 405 approved drugs, including six new drugs [3]. Group 2: Innovative Drug Development - Jike Shou was developed in just six years, breaking the conventional "three tens" rule of a 10-year development cycle, $1 billion investment, and a success rate below 10% [2]. - The drug demonstrated rapid efficacy, with significant symptom relief achieved in just 23.6 hours during clinical trials [2]. - The success of Zhengxiang Pharmaceutical is attributed to a team of experts returning from the San Francisco Bay Area, focusing on unmet clinical needs in oncology and infectious diseases [2]. Group 3: Company Growth and Listings - Nanjing Weilizhibo Biotechnology successfully listed on the Hong Kong Stock Exchange on July 25, following the earlier listing of Yaojie Ankang [1][5]. - Weilizhibo has developed 14 innovative drug candidates, with six in clinical stages, including the globally leading PD-L1×4-1BB dual antibody [4][5]. - The company’s rapid growth is supported by its pilot production base established in the Biopharmaceutical Valley [5]. Group 4: Ecosystem and Collaboration - The Nanjing Biopharmaceutical Valley fosters a collaborative ecosystem, integrating research, production, and application to support company growth [6][9]. - The establishment of the Nanjing Biopharmaceutical Center has facilitated technology transfer and innovation, with over 1,300 biopharmaceutical companies in the area [6][9]. - The center has partnered with over 100 research institutions and companies, significantly reducing research and development costs [7]. Group 5: Future Development and Urban Integration - The Nanjing Biopharmaceutical Valley aims to become a leading technology city, enhancing living spaces and ecological networks [11]. - Plans include the construction of scenic areas and improved infrastructure to support both innovation and quality of life for residents and professionals [11].

Core Viewpoint - Nanjing Weili Zhizhi Bio-Tech Co., Ltd. successfully listed on the Hong Kong Stock Exchange, raising up to $189 million, marking the second listing in Nanjing Jiangbei New Area this year [1] Company Overview - Founded in 2012, Weili Zhizhi is a clinical-stage biotech company focused on discovering, developing, and commercializing new therapies for cancer, autoimmune diseases, and other major diseases [1] - The company has a diverse product portfolio with 14 innovative drug candidates, including 4 core products, all of which are leading in global clinical progress [1] Product Highlights - LBL-024, a dual-targeting antibody drug, is the first and only candidate drug globally to enter the registration clinical stage targeting PD-L1 and 4-1BB [2] - LBL-024's initial indication is for lung neuroendocrine carcinoma, a malignancy with limited effective treatment options [2] - Clinical data shows LBL-024 demonstrates good efficacy and safety in both monotherapy and combination therapy, providing new hope for patients facing treatment challenges [2] - The drug has received breakthrough therapy designation from the National Medical Products Administration and orphan drug status from the FDA for treating neuroendocrine carcinoma [2] - LBL-024 is also approved for clinical research in several other cancers, including small cell lung cancer, cholangiocarcinoma, ovarian cancer, non-small cell lung cancer, esophageal squamous cell carcinoma, liver cancer, and gastric cancer [2] Industry Context - The Nanjing Jiangbei New Area is experiencing rapid development in the life and health industry, with a total of 405 listed drug products, including 6 first-class new drugs [3] - The area is focused on creating an innovative ecosystem for the biopharmaceutical industry, integrating research, production, and application [3]